Regional Core Facility for Structural Biology and Bioinformatics
- Prosjektnummer
- 2015095
- Ansvarlig person
- Bjørn Dalhus
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regional teknologisk kjernefasilitet
- Helsekategori
- Cancer, Cardiovascular, Neurological
- Forskningsaktivitet
- 1. Underpinning
Overview of structurally homologous flavoprotein oxidoreductases containing the low M
Arch Biochem Biophys 2021 05 15;702():108826. Epub 2021 mar 5
PMID: 33684359
Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding.
Thromb Haemost 2021 Dec;121(12):1588-1598. Epub 2021 mar 19
PMID: 33742435
CdgL is a degenerate nucleotide cyclase domain protein affecting flagellin synthesis and motility in Bacillus thuringiensis.
Res Microbiol 2021 Jun-Aug;172(4-5):103850. Epub 2021 jun 1
PMID: 34082027
A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome.
Hum Mol Genet 2021 10 13;30(21):1919-1931.
PMID: 34124757
Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex.
Commun Biol 2021 07 15;4(1):876. Epub 2021 jul 15
PMID: 34267321
Thioredoxin reductase from Bacillus cereus exhibits distinct reduction and NADPH-binding properties.
FEBS Open Bio 2021 11;11(11):3019-3031. Epub 2021 sep 23
PMID: 34492167
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics.
Sci Transl Med 2020 10 14;12(565).
PMID: 33055243
Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis.
Nucleic Acids Res 2020 06 04;48(10):5540-5554.
PMID: 32347931
An intact C-terminal end of albumin is required for its long half-life in humans.
Commun Biol 2020 04 20;3(1):181. Epub 2020 apr 20
PMID: 32313072
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily.
Sci Rep 2020 03 27;10(1):5656. Epub 2020 mar 27
PMID: 32221390
N
Nat Genet 2020 01;52(1):48-55. Epub 2019 des 16
PMID: 31844323
The Crystal Structures of Bacillithiol Disulfide Reductase Bdr (YpdA) Provide Structural and Functional Insight into a New Type of FAD-Containing NADPH-Dependent Oxidoreductase.
Biochemistry 2020 Dec 29;59(51):4793-4798. Epub 2020 des 16
PMID: 33326741
Specificity of
Int J Mol Sci 2019 Feb 06;20(3). Epub 2019 feb 6
PMID: 30736336
Structural and Thermodynamic Signatures of Ligand Binding to the Enigmatic Chitinase D of Serratia proteamaculans.
J Phys Chem B 2019 Mar 14;123(10):2270-2279. Epub 2019 mar 4
PMID: 30789732
Biallelic POLR3A variants confirmed as a frequent cause of hereditary ataxia and spastic paraparesis.
Brain 2019 04 01;142(4):e12.
PMID: 30847471
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca
Circ Arrhythm Electrophysiol 2019 04;12(4):e007045.
PMID: 30943765
The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein.
J Biol Chem 2019 Oct 18;294(42):15480-15494. Epub 2019 sep 4
PMID: 31484725
Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation.
Br J Pharmacol 2019 Nov;176(22):4360-4372. Epub 2019 okt 27
PMID: 31412132
Additive manufacturing of laminar flow cells for single-molecule experiments.
Sci Rep 2019 Nov 14;9(1):16784. Epub 2019 nov 14
PMID: 31727950
A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes.
Sci Rep 2019 Dec 02;9(1):18021. Epub 2019 des 2
PMID: 31792234
Biallelic variants in KIF14 cause intellectual disability with microcephaly.
Eur J Hum Genet 2018 03;26(3):330-339. Epub 2018 jan 17
PMID: 29343805
Structural determinants of bacterial lytic polysaccharide monooxygenase functionality.
J Biol Chem 2018 01 26;293(4):1397-1412. Epub 2017 des 8
PMID: 29222333
Publisher Correction: Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Sci Rep 2018 Apr 12;8(1):6010. Epub 2018 apr 12
PMID: 29651030
Hb Oslo [β42(CD1)Phe→Ile; HBB: c.127T>A]: A Novel Unstable Hemoglobin Variant Found in a Norwegian Patient.
Hemoglobin 2018 Mar;42(2):78-83. Epub 2018 jul 23
PMID: 30032685
Key Residues Affecting Transglycosylation Activity in Family 18 Chitinases: Insights into Donor and Acceptor Subsites.
Biochemistry 2018 Jul 24;57(29):4325-4337. Epub 2018 jul 11
PMID: 29939724
The Characterization of Different Flavodoxin Reductase-Flavodoxin (FNR-Fld) Interactions Reveals an Efficient FNR-Fld Redox Pair and Identifies a Novel FNR Subclass.
Biochemistry 2018 Sep 18;57(37):5427-5436. Epub 2018 sep 7
PMID: 30142264
Human and mouse albumin bind their respective neonatal Fc receptors differently.
Sci Rep 2018 Oct 02;8(1):14648. Epub 2018 okt 2
PMID: 30279529
Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V.
Nat Commun 2018 12 19;9(1):5381. Epub 2018 des 19
PMID: 30568191
Novel UCHL1 mutations reveal new insights into ubiquitin processing.
Hum Mol Genet 2017 03 15;26(6):1031-1040.
PMID: 28007905
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites.
Nucleus 2017 Jul 04;8(4):404-420. Epub 2017 apr 12
PMID: 28402725
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions.
JCI Insight 2017 Sep 07;2(17). Epub 2017 sep 7
PMID: 28878121
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Sci Rep 2017 Nov 08;7(1):15050. Epub 2017 nov 8
PMID: 29118367
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease.
JCI Insight 2017 Sep 07;2(17). Epub 2017 sep 7
PMID: 28878138
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman.
J Biol Chem 2016 Feb 26;291(9):4561-79. Epub 2015 des 14
PMID: 26668322
Structural and functional characterization of a small chitin-active lytic polysaccharide monooxygenase domain of a multi-modular chitinase from Jonesia denitrificans.
FEBS Lett 2016 Jan;590(1):34-42. Epub 2015 des 28
PMID: 26763108
Structural and Functional Analysis of a Lytic Polysaccharide Monooxygenase Important for Efficient Utilization of Chitin in Cellvibrio japonicus.
J Biol Chem 2016 Apr 01;291(14):7300-12. Epub 2016 feb 8
PMID: 26858252
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity.
J Immunol 2016 Apr 15;196(8):3452-9. Epub 2016 mar 9
PMID: 26962230
Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease.
Sci Rep 2016 Apr 25;6():24979. Epub 2016 apr 25
PMID: 27108838
Axitinib blocks Wnt/ß-catenin signaling and directs asymmetric cell division in cancer.
Proc Natl Acad Sci U S A 2016 Aug 16;113(33):9339-44. Epub 2016 aug 1
PMID: 27482107
Activation of the Class Ib Ribonucleotide Reductase by a Flavodoxin Reductase in Bacillus cereus.
Biochemistry 2016 Sep 13;55(36):4998-5001. Epub 2016 aug 30
PMID: 27559930
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction.
Mol Genet Genomic Med 2016 Nov;4(6):604-616. Epub 2016 sep 17
PMID: 27896283
Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules.
J Biol Chem 2016 Oct 07;291(41):21786-21801. Epub 2016 aug 29
PMID: 27573237
Characterization of the Neisseria meningitidis Helicase RecG.
PLoS One 2016;11(10):e0164588. Epub 2016 okt 13
PMID: 27736945
Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene.
Clin Immunol 2015 Dec;161(2):366-72. Epub 2015 okt 19
PMID: 26482871
TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity.
Immunol Rev 2015 Nov;268(1):328-39.
PMID: 26497531
Generalized epilepsy in a family with basal ganglia calcifications and mutations in SLC20A2 and CHRNB2.
Eur J Med Genet 2015 Nov;58(11):624-8. Epub 2015 okt 19
PMID: 26475232
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation.
PLoS One 2015;10(8):e0134954. Epub 2015 aug 6
PMID: 26248334
Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease.
J Biol Chem 2015 Aug 28;290(35):21365-75. Epub 2015 jul 9
PMID: 26160175
The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery.
J Control Release 2015 Aug 10;211():144-62. Epub 2015 jun 6
PMID: 26055641
Structural Features of a Bacteroidetes-Affiliated Cellulase Linked with a Polysaccharide Utilization Locus.
Sci Rep 2015;5():11666. Epub 2015 jul 2
PMID: 26133573
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling.
J Am Coll Cardiol 2015 Feb 3;65(4):339-51.
PMID: 25634832
Synthesis and Evaluation of Fused Pyrimidines as E. coli Thymidylate Monophosphate Kinase Inhibitors
ChemistrySelect, Vol 6, 45, 12852-12857
In situ cofactor regeneration enables selective CO2 reduction in a stable and efficient enzymatic photoelectrochemical cell
Appl. Catal. B-Environ., 296, 120349
High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting
Catal. Today, 361, 57-62
High performance and toxicity assessment of Ta3N5 nanotubes for photoelectrochemical water splitting
Catalysis Today, 361, 57-62
Measurement of FNR-NrdI Interaction by Microscale Thermophoresis (MST)
Bio-protocol, 7(8), s e2223, 2017
Molecular analysis of maple syrup urine disease in Jordanian families
Meta Gene, 2015, doi:10.1016/j.mgene.2015.10.002
Cellular signaling and molecular regulation governing motility, biofilm formation, and virulence in the Bacillus cereus group
- Disputert:
- mars 2021
- Hovedveileder:
- Ole Andreas Løchen Økstad
Of Shellfish and Men: Applying X-ray and neutron techniques to investigate surface-active bacterial colonization factors
- Disputert:
- juni 2021
- Hovedveileder:
- Ute Krengel
Antibody-based therapeutics for treatment of eye diseases: New insights and tailored procedures
- Disputert:
- oktober 2021
- Hovedveileder:
- Jan Terje Andersen
IgA-based antibody formats with extended plasma half-life and potent effector functions
- Disputert:
- november 2021
- Hovedveileder:
- Jan Terje Andersen
Artificial photosynthesis – Advanced nanomaterials and use of biocatalysts for novel photoelectrochemical cells
- Disputert:
- april 2020
- Hovedveileder:
- Truls Eivind Norby
Estimation and measurement of glomerular filtration rate in children
- Disputert:
- mai 2020
- Hovedveileder:
- Lars Mørkrid
Novel causes and refined phenotypes of hereditary spastic paraparesis. Studies of subgroups of hereditary spinocerebell.......
- Disputert:
- juni 2017
- Hovedveileder:
- Kaja Kristine Selmer
Unmasking the Assassin— A structural and functional analysis of the anti-tumour antibody 14F7: providing.......
- Disputert:
- august 2020
- Hovedveileder:
- Ute Krengel
Development of novel approaches for treatment of leukemia
- Disputert:
- august 2020
- Hovedveileder:
- Jorrit Enserink
Identifying new avenues for leukemia treatment using genomewide CRISPR/Cas9 and ex vivo drug sensitivity screens
- Disputert:
- september 2017
- Hovedveileder:
- Jorrit Enserink
Novel Roles of the N6-methyladenosine Reader YTHDF2 in Genome Stability and Neuronal Development
- Disputert:
- september 2020
- Hovedveileder:
- Arne Klungland
Studies of the structure-activity relationships, signaling properties and functions of Connective Tissue Growth Factor
- Disputert:
- februar 2019
- Hovedveileder:
- Håvard Attramadal
Pulling the “sweet tooth” of bacterial toxins – An investigation using X-ray and carbohydrate interaction analysis
- Disputert:
- mars 2019
- Hovedveileder:
- Ute Krengel
Single-molecule investigation of DNA scanning by DNA base repair proteins
- Disputert:
- april 2019
- Hovedveileder:
- Bjørn Dalhus
Of Mice and Men: Dissecting the albumin-FcRn interaction across species
- Disputert:
- september 2019
- Hovedveileder:
- Jan Terje Andersen
Intracellular signaling in T cells: Mapping of binding partners and structural analyses of Src homology domains
- Disputert:
- september 2019
- Hovedveileder:
- Anne Spurkland
Discovery and characterization of small-molecule inhibitors of 8-oxoguanine DNA glycosylase 1
- Disputert:
- mai 2018
- Hovedveileder:
- Bjørn Dalhus
Characterisation of flavodoxins and ferredoxin/flavodoxin reductases from Bacillus cereus and their interactions
- Disputert:
- august 2018
- Hovedveileder:
- Hans-Petter Hersleth
Novel reagents for studies of antigen presentation in celiac disease
- Disputert:
- februar 2018
- Hovedveileder:
- Inger Sandlie
The FcRn-albumin interaction
- Disputert:
- februar 2017
- Hovedveileder:
- Inger Sandlie
Activation pathways of the class Ib ribonucleotide reductase in Bacillus cereus
- Disputert:
- februar 2017
- Hovedveileder:
- Hans-Petter Hersleth
Functional aspects of granin proteins in cardiac disease
- Disputert:
- mars 2017
- Hovedveileder:
- Helge Røsjø
The genetics of primary immunodeficiencies
- Disputert:
- mai 2017
- Hovedveileder:
- Robert Lyle
Promyelocytic leukemia protein and post-mitotic nuclear import
- Disputert:
- juni 2017
- Hovedveileder:
- Stig Ove Bøe
The Sodium-Calcium Exchanger 1: Novel Regulatory Mechanisms and Interacting Partners
- Disputert:
- juni 2017
- Hovedveileder:
- Cathrine Rein Carlson
Engineering of the albumin-FcRn interaction
- Disputert:
- august 2017
- Hovedveileder:
- Inger Sandlie
b. Anti-transglutaminase 2 autoantibodies in celiac disease: Structural basis for antigen recognition and functional properties
- Disputert:
- februar 2017
- Hovedveileder:
- Ludvig Magne Sollid
Design, synthesis and biological evaluation of 8-oxoguanine derivatives as DNA glycosylases inhibitors and ...
- Disputert:
- september 2016
- Hovedveileder:
- Lise-Lotte Gundersen
Molecular and Cellular Insights into Mammalian Endonuclease V
- Disputert:
- november 2016
- Hovedveileder:
- Ingrun Alseth
Intracellular Fc receptors: Role in transcytosis and protection against human adenovirus 5 infection
- Disputert:
- september 2016
- Hovedveileder:
- Inger Sandlie
Molecular Regulatory Mechanisms of the Sodium-Calcium Exchanger 1 in heart
- Disputert:
- juni 2015
- Hovedveileder:
- Cathrine R. Carlson
Cholera toxin - carbohydrate interaction as the basis for cholera blood-group dependence
- Disputert:
- juni 2015
- Hovedveileder:
- Ute Krengel
Molecular and pathophysiological functions of promyelocytic leukemia protein
- Disputert:
- mars 2015
- Hovedveileder:
- Stig Ove Bøe
- Rune Forstrøm Johansen Prosjektdeltaker
- Pernille Blicher Prosjektdeltaker
- Paul Hoff Backe Forsker (annen finansiering)
- Bjørn Dalhus Prosjektleder
- Magnar Bjørås Prosjektdeltaker
- Lene Svendsen Kittelsen Prosjektdeltaker
- Jon Kristen Lærdahl Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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