The Proteomics Core Facility at Oslo University Hospital (Rikshospitalet)
- Prosjektnummer
- 2015098
- Ansvarlig person
- Tuula Nyman
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regional teknologisk kjernefasilitet
- Helsekategori
- Generic Health Relevance
- Forskningsaktivitet
- 1. Underpinning
Lipopolysaccharide Primes Human Macrophages for Noncanonical Inflammasome-Induced Extracellular Vesicle Secretion.
J Immunol 2023 Feb 01;210(3):322.
PMID: 36525001
Bacterial Brain Abscesses Expand Despite Effective Antibiotic Treatment: A Process Powered by Osmosis Due to Neutrophil Cell Death.
Neurosurgery 2023 Dec 12. Epub 2023 des 12
PMID: 38084989
Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular cartilage implants.
Front Bioeng Biotechnol 2023;11():1116513. Epub 2023 feb 21
PMID: 36896010
Progressive mitochondrial dysfunction in cerebellar synaptosomes of cystatin B-deficient mice.
Front Mol Neurosci 2023;16():1175851. Epub 2023 mai 12
PMID: 37251643
and
mSystems 2023 Jun 29;8(3):e0107322. Epub 2023 mai 15
PMID: 37184670
Scalable production of tissue-like vascularized liver organoids from human PSCs.
Exp Mol Med 2023 Sep;55(9):2005. Epub 2023 sep 1
PMID: 37653039
Towards optimised extracellular vesicle proteomics from cerebrospinal fluid.
Sci Rep 2023 Jun 12;13(1):9564. Epub 2023 jun 12
PMID: 37308520
SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation.
Metabol Open 2023 Jun;18():100234. Epub 2023 feb 10
PMID: 37013149
Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism.
Biomedicines 2023 Oct 27;11(11). Epub 2023 okt 27
PMID: 38001909
A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis.
Brain 2023 Aug 01;146(8):3513.
PMID: 36917474
Low-density lipoprotein particles carrying proinflammatory proteins with altered aggregation pattern detected in COVID-19 patients 3 months after hospitalization.
J Infect 2023 May;86(5):489. Epub 2023 feb 21
PMID: 36822413
Distinct microRNA and protein profiles of extracellular vesicles secreted from myotubes from morbidly obese donors with type 2 diabetes in response to electrical pulse stimulation.
Front Physiol 2023;14():1143966. Epub 2023 mar 30
PMID: 37064893
Identification of a Phage Display-Derived Peptide Interacting with the N-Terminal Region of Factor VII Activating Protease (FSAP) Enables Characterization of Zymogen Activation.
ACS Chem Biol 2022 Sep 16;17(9):2631. Epub 2022 sep 7
PMID: 36070465
Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors.
Fluids Barriers CNS 2022 Jun 04;19(1):45. Epub 2022 jun 4
PMID: 35659255
Label-free quantitative proteomics and immunoblotting identifies immunoreactive and other excretory-secretory (E/S) proteins of
Front Immunol 2022;13():1045468. Epub 2022 nov 16
PMID: 36466892
Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation.
BMC Neurol 2022 Aug 15;22(1):299. Epub 2022 aug 15
PMID: 35971119
Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome.
Front Physiol 2022;13():928195. Epub 2022 jul 6
PMID: 35874526
Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.
Breast Cancer Res 2022 Jul 18;24(1):52. Epub 2022 jul 18
PMID: 35850772
Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins.
Front Immunol 2022;13():977353. Epub 2022 sep 15
PMID: 36189227
Progress and challenges in mass spectrometry-based analysis of antibody repertoires.
Trends Biotechnol 2022 Apr;40(4):463. Epub 2021 sep 14
PMID: 34535228
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics.
Nat Commun 2022 Oct 21;13(1):6283. Epub 2022 okt 21
PMID: 36270994
Energy metabolism in skeletal muscle cells from donors with different body mass index.
Front Physiol 2022;13():982842. Epub 2022 nov 17
PMID: 36467688
Inflammasomes and SARS-CoV-2 Infection.
Viruses 2021 12 14;13(12). Epub 2021 des 14
PMID: 34960782
Chronic treatment with terbutaline increases glucose and oleic acid oxidation and protein synthesis in cultured human myotubes.
Curr Res Pharmacol Drug Discov 2021;2():100039. Epub 2021 jun 11
PMID: 34909668
Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk.
Sci Rep 2021 11 09;11(1):21936. Epub 2021 nov 9
PMID: 34754007
Proteomic study of apheresis platelets made HLA class I deficient for transfusion of refractory patients.
Proteomics Clin Appl 2021 Nov;15(6):e2100022. Epub 2021 sep 22
PMID: 34510746
Liquid chromatography, a key tool for the advancement of single-cell omics analysis.
Anal Chim Acta 2021 Sep 15;1178():338551. Epub 2021 apr 22
PMID: 34482862
Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia.
Eur Heart J 2021 10 14;42(39):4064-4072.
PMID: 34405870
Tyr
J Immunol 2021 08 15;207(4):1128-1137. Epub 2021 jul 28
PMID: 34321230
Surfaceome and Exoproteome Dynamics in Dual-Species
Front Microbiol 2021;12():672975. Epub 2021 jun 25
PMID: 34248881
Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for
Front Pharmacol 2021;12():638646. Epub 2021 jun 7
PMID: 34163352
Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence.
mSystems 2021 Jun 29;6(3):e0050021. Epub 2021 jun 22
PMID: 34156290
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.
Atherosclerosis 2021 05;324():123-132. Epub 2021 feb 23
PMID: 33714552
In Well-Treated Celiac Patients Low-Level Mucosal Inflammation Predicts Response to 14-day Gluten Challenge.
Adv Sci (Weinh) 2021 Feb;8(4):2003526. Epub 2021 jan 4
PMID: 33643806
Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer.
Carcinogenesis 2021 05 28;42(5):685-693.
PMID: 33609362
GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Nat Commun 2021 10 20;12(1):6101. Epub 2021 okt 20
PMID: 34671015
Interaction Proteomics Identifies ERbeta Association with Chromatin Repressive Complexes to Inhibit Cholesterol Biosynthesis and Exert An Oncosuppressive Role in Triple-negative Breast Cancer.
Mol Cell Proteomics 2020 Feb;19(2):245-260. Epub 2020 des 2
PMID: 33451386
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction.
JACC Basic Transl Sci 2020 Dec;5(12):1210-1224. Epub 2020 des 9
PMID: 33426377
Quantitative Changes in the Mitochondrial Proteome of Cerebellar Synaptosomes From Preclinical Cystatin B-Deficient Mice.
Front Mol Neurosci 2020;13():570640. Epub 2020 nov 13
PMID: 33281550
Distinct Pattern of Endoplasmic Reticulum Protein Processing and Extracellular Matrix Proteins in Functioning and Silent Corticotroph Pituitary Adenomas.
Cancers (Basel) 2020 Oct 14;12(10). Epub 2020 okt 14
PMID: 33066652
The Cardiac Syndecan-2 Interactome.
Front Cell Dev Biol 2020;8():792. Epub 2020 aug 28
PMID: 32984315
Inflammasomes: Exosomal miRNAs loaded for action.
J Cell Biol 2020 Oct 05;219(10).
PMID: 32970793
Identification of Antiestrogen-Bound Estrogen Receptor α Interactomes in Hormone-Responsive Human Breast Cancer Cell Nuclei.
Proteomics 2020 10;20(19-20):e2000135. Epub 2020 sep 16
PMID: 32865868
Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome.
J Immunol 2020 Jun 15;204(12):3063-3069.
PMID: 32513874
Pancreatic cancer cells show lower oleic acid oxidation and their conditioned medium inhibits oleic acid oxidation in human myotubes.
Pancreatology 2020 Jun;20(4):676-682. Epub 2020 apr 22
PMID: 32360002
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia.
J Cell Mol Med 2020 03;24(6):3534-3548. Epub 2020 feb 10
PMID: 32040259
Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence of
Microorganisms 2020 Jan 12;8(1). Epub 2020 jan 12
PMID: 31940921
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Atherosclerosis 2020 03;296():74-82. Epub 2019 des 14
PMID: 31870625
Interaction Proteomics Identifies ERbeta Association with Chromatin Repressive Complexes to Inhibit Cholesterol Biosynthesis and Exert An Oncosuppressive Role in Triple-negative Breast Cancer.
Mol Cell Proteomics 2020 02;19(2):245-260. Epub 2019 des 2
PMID: 31792072
An intact C-terminal end of albumin is required for its long half-life in humans.
Commun Biol 2020 04 20;3(1):181. Epub 2020 apr 20
PMID: 32313072
Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor.
Cells 2020 01 16;9(1). Epub 2020 jan 16
PMID: 31963309
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP).
J Biol Chem 2019 05 31;294(22):8717-8731. Epub 2019 apr 9
PMID: 30967474
Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis.
J Neuroimmunol 2019 Aug 15;333():576966. Epub 2019 mai 16
PMID: 31153015
Structural and Functional Dynamics of
Microorganisms 2019 Nov 20;7(12). Epub 2019 nov 20
PMID: 31756969
The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.
Sci Data 2019 09 16;6(1):173. Epub 2019 sep 16
PMID: 31527615
Low Cellular NAD
J Immunol 2019 Sep 15;203(6):1598-1608. Epub 2019 aug 19
PMID: 31427442
Growth Mode and Carbon Source Impact the Surfaceome Dynamics of
Front Microbiol 2019;10():1272. Epub 2019 jun 5
PMID: 31231350
Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells.
Sci Adv 2019 02;5(2):eaav5590. Epub 2019 feb 6
PMID: 30775443
Mitochondrial stress response triggered by defects in protein synthesis quality control.
Life Sci Alliance 2019 02;2(1). Epub 2019 jan 25
PMID: 30683687
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding.
Curr Biol 2019 Oct 21;29(20):3538-3548.e7. Epub 2019 okt 10
PMID: 31607533
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.
Nat Commun 2019 06 28;10(1):2850. Epub 2019 jun 28
PMID: 31253801
Desumoylation of RNA polymerase III lies at the core of the Sumo stress response in yeast.
J Biol Chem 2019 Dec 06;294(49):18784-18795. Epub 2019 nov 1
PMID: 31676685
A high-throughput pipeline for validation of antibodies.
Nat Methods 2018 Nov;15(11):909-912. Epub 2018 okt 30
PMID: 30377371
From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?
Front Immunol 2018;9():2188. Epub 2018 sep 25
PMID: 30319640
Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells.
Sci Data 2018 03 06;5():180031. Epub 2018 mar 6
PMID: 29509190
Secretome profiling of Propionibacterium freudenreichii reveals highly variable responses even among the closely related strains.
Microb Biotechnol 2018 05;11(3):510-526. Epub 2018 feb 28
PMID: 29488359
Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications.
Sci Rep 2018 01 11;8(1):498. Epub 2018 jan 11
PMID: 29323256
Proteomics to study macrophage response to viral infection.
J Proteomics 2018 May 30;180():99-107. Epub 2017 jun 21
PMID: 28647517
The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus.
J Neurosurg 2018 Sep;129(3):829-837. Epub 2017 okt 20
PMID: 29053067
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors.
Mol Cell Proteomics 2018 May;17(5):850-870. Epub 2018 jan 25
PMID: 29371290
Proteome analysis of an Escherichia coli ptsN-null strain under different nitrogen regimes.
J Proteomics 2018 Mar 01;174():28-35. Epub 2017 des 21
PMID: 29274402
Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry.
Am J Pathol 2018 Jul;188(7):1563-1579. Epub 2018 apr 22
PMID: 29684362
The SysteMHC Atlas project.
Nucleic Acids Res 2018 Jan 04;46(D1):D1237-D1247.
PMID: 28985418
Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins.
Cell Rep 2017 Sep 05;20(10):2357-2367.
PMID: 28877470
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1).
Proteomics 2017 Sep;17(17-18).
PMID: 28755400
A tool for integrating genetic and mass spectrometry-based peptide data: Proteogenomics Viewer: PV: A genome browser-like tool, which includes MS data visualization and peptide identification parameters.
Bioessays 2017 Jul;39(7). Epub 2017 jun 5
PMID: 28582591
Dynamics of the Escherichia coli proteome in response to nitrogen starvation and entry into the stationary phase.
Biochim Biophys Acta 2017 03;1865(3):344-352. Epub 2016 des 8
PMID: 27939605
The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading.
Genome Biol 2017 Oct 06;18(1):189. Epub 2017 okt 6
PMID: 29017520
Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.
Viruses 2017 Sep 25;9(10). Epub 2017 sep 25
PMID: 28946654
Proprotein convertase Furin1 expression in the Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense.
FASEB J 2017 Nov;31(11):4770-4782. Epub 2017 jul 13
PMID: 28705811
PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease.
FASEB J 2017 Sep;31(9):3978-3990. Epub 2017 mai 26
PMID: 28550045
Mass spectrometry-based proteomic exploration of the human immune system: focus on the inflammasome, global protein secretion, and T cells.
Expert Rev Proteomics 2017 May;14(5):395-407. Epub 2017 apr 24
PMID: 28406322
Food-Like Growth Conditions Support Production of Active Vitamin B12 by Propionibacterium freudenreichii 2067 without DMBI, the Lower Ligand Base, or Cobalt Supplementation.
Front Microbiol 2017;8():368. Epub 2017 mar 8
PMID: 28337185
Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation.
Mol Cell Proteomics 2017 Apr;16(4 suppl 1):S187-S199. Epub 2017 feb 14
PMID: 28196878
Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion.
Exp Cell Res 2017 Jan 15;350(2):336-348. Epub 2016 des 20
PMID: 28011197
Regulation of kynurenine biosynthesis during influenza virus infection.
FEBS J 2017 01;284(2):222-236. Epub 2016 des 14
PMID: 27860276
Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection.
J Proteome Res 2017 Jan 06;16(1):217-227. Epub 2016 nov 15
PMID: 27723984
Identification of new FGF1 binding partners-Implications for its intracellular function.
IUBMB Life 2016 Mar;68(3):242-51. Epub 2016 feb 2
PMID: 26840910
Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport.
J Proteome Res 2016 Oct 07;15(10):3841-3855. Epub 2016 sep 26
PMID: 27615514
MetaMass, a tool for meta-analysis of subcellular proteomics data.
Nat Methods 2016 Oct;13(10):837-40. Epub 2016 aug 29
PMID: 27571551
Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes.
Sci Rep 2016 May 05;6():25565. Epub 2016 mai 5
PMID: 27146306
Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells.
Mol Cell Proteomics 2016 Mar;15(3):1007-16. Epub 2015 des 4
PMID: 26637539
Label-free based quantitative proteomics analysis of primary neonatal porcine Leydig cells exposed to the persistent contaminant 3-methylsulfonyl-DDE.
J Proteomics 2016 Mar 30;137():68-82. Epub 2015 des 9
PMID: 26691841
Label-free Proteomic Reveals that Cowpea Severe Mosaic Virus Transiently Suppresses the Host Leaf Protein Accumulation During the Compatible Interaction with Cowpea (Vigna unguiculata [L.] Walp.).
J Proteome Res 2016 Dec 02;15(12):4208-4220. Epub 2016 nov 16
PMID: 27934294
Comparative protein profiling of B16 mouse melanoma cells susceptible and non-susceptible to alphavirus infection: Effect of the tumor microenvironment.
Cancer Biol Ther 2016 Aug 11. Epub 2016 aug 11
PMID: 27636533
microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1ß-induced Osteoarthritis.
Mol Ther Nucleic Acids 2016 Oct 11;5(10):e373. Epub 2016 okt 11
PMID: 27727249
Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.
Mol Cell Proteomics 2016 Oct;15(10):3203-3219. Epub 2016 aug 2
PMID: 27486199
Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.
Viruses 2016 Sep 29;8(10). Epub 2016 sep 29
PMID: 27690086
Tumors Escape CD4+ T-cell-Mediated Immunosurveillance by Impairing the Ability of Infiltrating Macrophages to Indirectly Present Tumor Antigens.
Cancer Res 2015 Aug 15;75(16):3268-78. Epub 2015 jun 2
PMID: 26038231
Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires.
Immunogenetics 2015 Feb;67(2):73-84. Epub 2014 des 12
PMID: 25502872
Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: Equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome.
Clin Immunol 2015 Oct;160(2):211-25. Epub 2015 jun 6
PMID: 26055752
Identification of amyloid beta mid-domain fragments in human cerebrospinal fluid.
Biochimie 2015 Jun;113():86-92. Epub 2015 apr 10
PMID: 25866191
Identification of prostate cancer biomarkers in urinary exosomes.
Oncotarget 2015 Oct 6;6(30):30357-76.
PMID: 26196085
Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: expanding the mycobacterial phosphoproteome catalog.
Front Microbiol 2015;6():6. Epub 2015 feb 10
PMID: 25713560
Mechanisms underlying AQP4 accumulation in astrocyte endfeet.
Glia 2015 Jun 29. Epub 2015 jun 29
PMID: 26119521
Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization.
PLoS One 2015;10(8):e0134922. Epub 2015 aug 5
PMID: 26244572
Serologic Assay for Diagnosis of Celiac Disease Based on a Patient-Derived Monoclonal Antigliadin Antibody.
Gastroenterology 2015 Nov;149(6):1530-1540.e3. Epub 2015 jul 21
PMID: 26208894
Proteomic and Bioinformatic Characterization of EVs Released from Human Macrophages upon Influenza A Virus Infection
J Proteome Res. 2016 Oct 11. [Epub ahead of print]
- Jorunn Stamnæs Prosjektdeltaker
- Joseph Robertson Prosjektdeltaker
- Maria Stensland Prosjektdeltaker
- Tuula Anneli Nyman Prosjektleder
- Sachin Kumar Singh Prosjektdeltaker
- Gustavo Antonio De Souza Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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