Regional Technological Core Facility for Large Animal Research
- Prosjektnummer
- 2015100
- Ansvarlig person
- Håvard Attramadal
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regional teknologisk kjernefasilitet
- Helsekategori
- Generic Health Relevance
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
Myocardial oxidative stress is increased in early reperfusion, but systemic antioxidative therapy does not prevent ischemia-reperfusion arrhythmias in pigs.
Front Cardiovasc Med 2023;10():1223496. Epub 2023 sep 26
PMID: 37823177
Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy.
Europace 2023 Mar 30;25(3):1183.
PMID: 36734281
A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation.
J Vis Exp 2023 Jan 13. Epub 2023 jan 13
PMID: 36715405
Long Non-Coding RNAs in Hypoxia and Oxidative Stress: Novel Insights Investigating a Piglet Model of Perinatal Asphyxia.
Biology (Basel) 2023 Apr 04;12(4). Epub 2023 apr 4
PMID: 37106749
Gene expression in the intestine of newborn piglets after hypoxia-reoxygenation.
Pediatr Res 2023 Oct;94(4):1365. Epub 2023 mai 19
PMID: 37208432
Assessing nuclear versus mitochondrial cell-free DNA (cfDNA) by qRT-PCR and droplet digital PCR using a piglet model of perinatal asphyxia.
Mol Biol Rep 2023 Feb;50(2):1533. Epub 2022 des 13
PMID: 36512170
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Antioxidants (Basel) 2023 Mar 19;12(3). Epub 2023 mar 19
PMID: 36978997
Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys.
Front Immunol 2022;13():831371. Epub 2022 jul 13
PMID: 35911712
Utilization of dielectric properties for assessment of liver ischemia-reperfusion injury in vivo and during machine perfusion.
Sci Rep 2022 Jul 01;12(1):11183. Epub 2022 jul 1
PMID: 35778457
Microdialysis and CO2 sensors detect pancreatic ischemia in a porcine model.
PLoS One 2022;17(2):e0262848. Epub 2022 feb 10
PMID: 35143517
Tracking Early Systolic Motion for Assessing Acute Response to Cardiac Resynchronization Therapy in Real Time.
Front Physiol 2022;13():903784. Epub 2022 jun 2
PMID: 35721553
A Novel Porcine Model of Ischemia-Reperfusion Injury After Cross-Clamping the Thoracic Aorta Revealed Substantial Cardiopulmonary, Thromboinflammatory and Biochemical Changes Without Effect of C1-Inhibitor Treatment.
Front Immunol 2022;13():852119. Epub 2022 apr 1
PMID: 35432333
Neonatal Impedance Cardiography in Asphyxiated Piglets-A Feasibility Study.
Front Pediatr 2022;10():804353. Epub 2022 feb 25
PMID: 35281226
Splanchnic oxygen saturation during reoxygenation with 21% or 100% O
Pediatr Res 2021 Nov 01. Epub 2021 nov 1
PMID: 34725499
Automatic Prediction of Ischemia-Reperfusion Injury of Small Intestine Using Convolutional Neural Networks: A Pilot Study.
Sensors (Basel) 2021 Oct 08;21(19). Epub 2021 okt 8
PMID: 34641009
Cerebral perfusion and metabolism with mean arterial pressure 90 vs. 60 mmHg in a porcine post cardiac arrest model with and without targeted temperature management.
Resuscitation 2021 10;167():251-260. Epub 2021 jun 21
PMID: 34166747
Intraperitoneal microdialysis detects intestinal leakage earlier than hemodynamic surveillance and systemic inflammation in a pig model.
Scand J Gastroenterol 2021 Feb;56(2):219-227. Epub 2020 des 28
PMID: 33356757
Live Tissue Training on Anesthetized Pigs for Air Ambulance Crews.
Air Med J 2021 Jan-Feb;40(1):60-64. Epub 2020 nov 7
PMID: 33455629
Left bundle branch block increases left ventricular diastolic pressure during tachycardia due to incomplete relaxation.
J Appl Physiol (1985) 2020 04 01;128(4):729-738. Epub 2020 jan 30
PMID: 31999529
Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy.
JACC Cardiovasc Imaging 2020 Jul;13(7):1475-1484. Epub 2020 jan 15
PMID: 31954643
Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia.
PLoS One 2019;14(12):e0227066. Epub 2019 des 31
PMID: 31891615
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.
PLoS One 2019;14(6):e0218624. Epub 2019 jun 27
PMID: 31247004
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar.
JACC Cardiovasc Imaging 2019 Dec;12(12):2402-2413. Epub 2019 feb 13
PMID: 30772230
Left ventricular end-systolic volume is a more sensitive marker of acute response to cardiac resynchronization therapy than contractility indices: insights from an experimental study.
Europace 2019 Feb 01;21(2):347-355.
PMID: 30418572
Afterload Hypersensitivity in Patients With Left Bundle Branch Block.
JACC Cardiovasc Imaging 2019 06;12(6):967-977. Epub 2018 jan 17
PMID: 29361486
Validation of a Holographic Display for Quantification of Mitral Annular Dynamics by Three-Dimensional Echocardiography.
J Am Soc Echocardiogr 2019 02;32(2):303-316.e4. Epub 2018 okt 5
PMID: 30293779
Esmolol for cardioprotection during resuscitation with adrenaline in an ischaemic porcine cardiac arrest model.
Intensive Care Med Exp 2019 Dec 04;7(1):65. Epub 2019 des 4
PMID: 31802327
Haemodynamic outcomes during piston-based mechanical CPR with or without active decompression in a porcine model of cardiac arrest.
Scand J Trauma Resusc Emerg Med 2018 Apr 24;26(1):31. Epub 2018 apr 24
PMID: 29690910
Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets.
J Perinat Med 2018 Dec 19;47(1):82-89.
PMID: 30110254
Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia.
PLoS One 2018;13(11):e0206601. Epub 2018 nov 26
PMID: 30475817
Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs.
Nucl Med Biol 2018 11;66():49-57. Epub 2018 aug 24
PMID: 30257223
DHA and therapeutic hypothermia in a short-term follow-up piglet model of hypoxia-ischemia: Effects on H+MRS biomarkers.
PLoS One 2018;13(8):e0201895. Epub 2018 aug 7
PMID: 30086156
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide.
Dis Markers 2018;2018():5046372. Epub 2018 jan 30
PMID: 29651324
Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.
Neonatology 2018;113(4):322-330. Epub 2018 feb 27
PMID: 29486477
DHA reduces oxidative stress following hypoxia-ischemia in newborn piglets: a study of lipid peroxidation products in urine and plasma.
J Perinat Med 2018 Feb 23;46(2):209-217.
PMID: 28632497
Geometry as a Confounder When Assessing Ventricular Systolic Function: Comparison Between Ejection Fraction and Strain.
J Am Coll Cardiol 2017 Aug 22;70(8):942-954.
PMID: 28818204
Estimating Left Ventricular Filling Pressure by Echocardiography.
J Am Coll Cardiol 2017 Apr 18;69(15):1937-1948.
PMID: 28408024
Assessment of cerebral perfusion with contrast-enhanced ultrasound during constriction of the neck mimicking malposition of the BD Odon Device™: a study in newborn piglets.
BJOG 2017 Sep;124 Suppl 4():26-34.
PMID: 28940870
High-Dose Cannabidiol Induced Hypotension after Global Hypoxia-Ischemia in Piglets.
Neonatology 2017;112(2):143-149. Epub 2017 jun 1
PMID: 28564654
Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia.
Redox Biol 2017 Aug;12():1-7. Epub 2017 feb 7
PMID: 28209514
DHA Reduces Oxidative Stress after Perinatal Asphyxia: A Study in Newborn Piglets.
Neonatology 2017;112(1):1-8. Epub 2017 feb 1
PMID: 28142140
Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study.
Sci Rep 2017 Jan 10;7():40315. Epub 2017 jan 10
PMID: 28071721
Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets.
Neonatology 2017;111(2):133-139. Epub 2016 okt 18
PMID: 27750254
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis.
J Intensive Care 2017;5():21. Epub 2017 feb 27
PMID: 28261486
Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets.
Pediatr Res 2016 Nov;80(5):710-718. Epub 2016 jul 21
PMID: 27441365
Changes of the plasma metabolome of newly born piglets subjected to postnatal hypoxia and resuscitation with air.
Pediatr Res 2016 08;80(2):284-92. Epub 2016 apr 7
PMID: 27055187
In vivo characterization of ischemic small intestine using bioimpedance measurements.
Physiol Meas 2016 Feb;37(2):257-75. Epub 2016 jan 25
PMID: 26805916
Factors determining the magnitude of the pre-ejection leftward septal motion in left bundle branch block.
Europace 2016 Dec;18(12):1905-1913. Epub 2015 nov 26
PMID: 26612883
Protein-bound tyrosine oxidation, nitration and chlorination by-products assessed by ultraperformance liquid chromatography coupled to tandem mass spectrometry.
Anal Chim Acta 2016 Mar 24;913():104-10. Epub 2016 feb 3
PMID: 26944994
Detection of intraneural needle-placement with multiple frequency bioimpedance monitoring: a novel method.
J Clin Monit Comput 2016 Apr;30(2):185-92. Epub 2015 apr 23
PMID: 25902898
Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs.
PLoS One 2015;10(10):e0140966. Epub 2015 okt 26
PMID: 26501201
Regulation of CCN1 (Cyr61) in a porcine model of intestinal ischemia/reperfusion.
Innate Immun 2015 Jul;21(5):453-62. Epub 2015 mar 16
PMID: 25783840
Calcium dependent arrhythmia mechanisms in CPVT and ischemia-reperfusion
- Disputert:
- november 2023
- Hovedveileder:
- Mathis Korseberg Stokke
Evaluation of Left Ventricular Function by Pressure-Volume and Pressure-Dimension Analyses
- Disputert:
- juni 2018
- Hovedveileder:
- Helge Skulstad
Cardiac tissue plasminogen activcator. Experimental studies on stimulated release, ... in pigs.
- Disputert:
- januar 2015
- Hovedveileder:
- Torstein Lyberg
- Marie Stugaard Prosjektdeltaker
- Runar James Strand-Amundsen Forsker (annen finansiering)
- William Edward Louch Prosjektdeltaker
- Mathis Korseberg Stokke Prosjektdeltaker
- Jannicke Hanne Andresen Prosjektdeltaker
- Otto A. Smiseth Prosjektdeltaker
- Kjetil Sunde Prosjektdeltaker
- Alessandro Cataliotti Prosjektdeltaker
- Helge Skulstad Prosjektdeltaker
- Espen W. Remme Prosjektdeltaker
- Ivar Sjaastad Prosjektdeltaker
- Morten Eriksen Prosjektdeltaker
- Rønnaug Solberg Prosjektdeltaker
- Søren Pischke Prosjektdeltaker
- Tor Inge Tønnessen Prosjektdeltaker
- Håvard Attramadal Prosjektleder
- Ole M Sejersted Prosjektdeltaker
- Ola Didrik Saugstad Prosjektdeltaker
- Petter Andreas Steen Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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