Preclinical MRI Core Facility Oslo
- Prosjektnummer
- 2015101
- Ansvarlig person
- Ivar Sjaastad
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regional teknologisk kjernefasilitet
- Helsekategori
- Cancer, Cardiovascular, Generic Health Relevance
- Forskningsaktivitet
- 1. Underpinning, 4. Detection and Diagnosis
Clinical efficacy of buprenorphine after oral dosing in rats undergoing major surgery.
Lab Anim 2023 Sep 05. Epub 2023 sep 5
PMID: 37669442
Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction.
Cardiovasc Res 2023 Aug 19;119(10):1915.
PMID: 37216909
Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice.
Am J Physiol Heart Circ Physiol 2023 Jun 01;324(6):H881. Epub 2023 apr 28
PMID: 37115627
Temporal expression and spatial distribution of the proteoglycan versican during cardiac fibrosis development.
Matrix Biol Plus 2023 Dec;19-20():100135. Epub 2023 nov 10
PMID: 38076279
Inflammatory augmentation of the delayed type hypersensitivity arthritis mouse model.
Basic Clin Pharmacol Toxicol 2023 Jun;132(6):551. Epub 2023 mar 29
PMID: 36946742
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models.
Nanomedicine 2023 Feb;48():102656. Epub 2023 jan 14
PMID: 36646195
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo.
Nat Cancer 2023 Oct;4(10):1474. Epub 2023 okt 2
PMID: 37783807
Efficient chimeric antigen receptor targeting of a central epitope of CD22.
J Biol Chem 2023 Jul;299(7):104883. Epub 2023 jun 1
PMID: 37269947
Cytokine Levels in Saliva Are Associated with Salivary Gland Fibrosis and Hyposalivation in Mice after Fractionated Radiotherapy of the Head and Neck.
Int J Mol Sci 2023 Oct 16;24(20). Epub 2023 okt 16
PMID: 37894899
Acute normal tissue responses in a murine model following fractionated irradiation of the head and neck with protons or X-rays.
Acta Oncol 2023 Nov;62(11):1574. Epub 2023 sep 13
PMID: 37703217
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
Circ Res 2022 Jan 07;130(1):27. Epub 2021 nov 24
PMID: 34814703
One step closer to myocardial physiology: From PV loop analysis to state-of-the-art myocardial imaging.
Acta Physiol (Oxf) 2022 Feb;234(2):e13759. Epub 2022 jan 16
PMID: 34978759
Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice.
PLoS One 2022;17(1):e0262821. Epub 2022 jan 25
PMID: 35077491
MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy.
Cells 2022 Feb 09;11(4). Epub 2022 feb 9
PMID: 35203255
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart.
Am J Physiol Heart Circ Physiol 2022 Jun 01;322(6):H1057. Epub 2022 mai 6
PMID: 35522553
The effects of geometry on stiffness measurements in high-field magnetic resonance elastography: A study on rodent cardiac phantoms.
J Mech Behav Biomed Mater 2022 Sep;133():105302. Epub 2022 jun 2
PMID: 35688038
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure.
Elife 2022 Aug 01;11(). Epub 2022 aug 1
PMID: 35913125
Development of STEAP1 targeting chimeric antigen receptor for adoptive cell therapy against cancer.
Mol Ther Oncolytics 2022 Sep 15;26():189. Epub 2022 jun 22
PMID: 35860008
miR-200a/b/-429 downregulation is a candidate biomarker of tumor radioresistance and independent of hypoxia in locally advanced cervical cancer.
Mol Oncol 2022 Mar;16(6):1402. Epub 2022 feb 15
PMID: 35064630
Incorporating cross-voxel exchange for the analysis of dynamic contrast-enhanced imaging data: pre-clinical results.
Phys Med Biol 2022 Dec 12;67(24). Epub 2022 des 12
PMID: 36541560
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse.
Front Physiol 2021;12():744730. Epub 2021 okt 12
PMID: 34712150
Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for
Front Pharmacol 2021;12():638646. Epub 2021 jun 7
PMID: 34163352
A 4D continuous representation of myocardial velocity fields from tissue phase mapping magnetic resonance imaging.
PLoS One 2021;16(3):e0247826. Epub 2021 mar 1
PMID: 33647070
Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload.
ESC Heart Fail 2021 04;8(2):918-927. Epub 2021 jan 26
PMID: 33497525
Analysis of right ventricular mass from magnetic resonance imaging data: a simple post-processing algorithm for correction of partial-volume effects.
Am J Physiol Heart Circ Physiol 2021 02 01;320(2):H912-H922. Epub 2020 des 18
PMID: 33337965
How to generate graded spinal cord injuries in swine - tools and procedures.
Dis Model Mech 2021 08 01;14(8). Epub 2021 aug 31
PMID: 34464444
Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells.
Int J Pharm 2021 Mar 15;597():120217. Epub 2021 jan 21
PMID: 33486035
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft.
Nanomaterials (Basel) 2021 Apr 28;11(5). Epub 2021 apr 28
PMID: 33924869
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes.
Nat Biotechnol 2022 Apr;40(4):488. Epub 2021 des 6
PMID: 34873326
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma.
Sci Rep 2021 03 18;11(1):6317. Epub 2021 mar 18
PMID: 33737576
Assessment of Hypoxic Tissue Fraction and Prediction of Survival in Cervical Carcinoma by Dynamic Contrast-Enhanced MRI.
Front Oncol 2021;11():668916. Epub 2021 mai 20
PMID: 34094964
Assessment of Intratumor Heterogeneity in Parametric Dynamic Contrast-Enhanced MR Images: A Comparative Study of Novel and Established Methods.
Front Oncol 2021;11():722773. Epub 2021 sep 21
PMID: 34621674
Quantifying left ventricular function in heart failure: What makes a clinically valuable parameter?
Prog Cardiovasc Dis 2020 Sep - Oct;63(5):552-560. Epub 2020 jun 2
PMID: 32502560
Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats.
Philos Trans A Math Phys Eng Sci 2020 Jun 12;378(2173):20190334. Epub 2020 mai 25
PMID: 32448071
Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy.
Epilepsy Res 2020 03;161():106300. Epub 2020 feb 24
PMID: 32126491
Regional right ventricular function in rats: a novel magnetic resonance imaging method for measurement of right ventricular strain.
Am J Physiol Heart Circ Physiol 2020 01 01;318(1):H143-H153. Epub 2019 nov 27
PMID: 31774693
Cardiovascular rEmodelling in living kidNey donorS with reduced glomerular filtration rate: rationale and design of the CENS study.
Blood Press 2020 04;29(2):123-134. Epub 2019 nov 13
PMID: 31718316
MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer.
Cancer Res 2020 09 15;80(18):3993-4003. Epub 2020 jun 30
PMID: 32606004
Bevacizumab treatment of meningeal melanoma metastases.
J Transl Med 2020 01 08;18(1):13. Epub 2020 jan 8
PMID: 31915016
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction.
JACC Basic Transl Sci 2020 Dec;5(12):1210-1224. Epub 2020 des 9
PMID: 33426377
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin.
J Am Heart Assoc 2020 02 04;9(3):e013518. Epub 2020 jan 31
PMID: 32000579
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload.
Cardiology 2020;145(3):187-198. Epub 2020 jan 22
PMID: 31968347
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes.
Cardiovasc Res 2020 01 01;116(1):78-90.
PMID: 30949686
NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity.
Front Immunol 2019;10():1621. Epub 2019 jul 16
PMID: 31379826
Accelerated magnetic resonance imaging tissue phase mapping of the rat myocardium using compressed sensing with iterative soft-thresholding.
PLoS One 2019;14(7):e0218874. Epub 2019 jul 5
PMID: 31276508
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension.
Am J Physiol Lung Cell Mol Physiol 2019 Jun 01;316(6):L999-L1012. Epub 2019 mar 25
PMID: 30908936
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression.
Cardiovasc Res 2019 03 15;115(4):752-764.
PMID: 30351410
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload.
Sci Rep 2019 Jun 24;9(1):9206. Epub 2019 jun 24
PMID: 31235849
Development of a Multimodal Apparatus to Generate Biomechanically Reproducible Spinal Cord Injuries in Large Animals.
Front Neurol 2019;10():223. Epub 2019 mar 19
PMID: 30941086
DCE-MRI and Quantitative Histology Reveal Enhanced Vessel Maturation but Impaired Perfusion and Increased Hypoxia in Bevacizumab-Treated Cervical Carcinoma.
Int J Radiat Oncol Biol Phys 2019 07 01;104(3):666-676. Epub 2019 mar 8
PMID: 30858145
Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model.
Breast Cancer Res 2019 01 22;21(1):9. Epub 2019 jan 22
PMID: 30670061
Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist.
Cancer Imaging 2019 Dec 19;19(1):88. Epub 2019 des 19
PMID: 31856923
Light-enhanced VEGF
J Control Release 2018 Oct 28;288():161-172. Epub 2018 sep 11
PMID: 30217739
Diffusion-Weighted MRI Is Insensitive to Changes in the Tumor Microenvironment Induced by Antiangiogenic Therapy.
Transl Oncol 2018 Oct;11(5):1128-1136. Epub 2018 jul 21
PMID: 30036782
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts.
Neoplasia 2018 07;20(7):734-744. Epub 2018 jun 19
PMID: 29886124
Patterns of Invasive Growth in Malignant Gliomas-The Hippocampus Emerges as an Invasion-Spared Brain Region.
Neoplasia 2018 07;20(7):643-656. Epub 2018 mai 21
PMID: 29793116
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice.
Cardiovasc Res 2018 Oct 01;114(12):1680-1690.
PMID: 29878127
Regional Dysfunction After Myocardial Infarction in Rats.
Circ Cardiovasc Imaging 2017 Sep;10(9).
PMID: 28838960
Overexpression of integrin α11 induces cardiac fibrosis in mice.
Acta Physiol (Oxf) 2018 Feb;222(2). Epub 2017 aug 30
PMID: 28771943
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice.
Mediators Inflamm 2017;2017():9450439. Epub 2017 apr 11
PMID: 28490840
Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids.
J Exp Biol 2017 Jul 15;220(Pt 14):2545-2553. Epub 2017 mai 5
PMID: 28476893
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy.
Cardiovasc Res 2017 Aug 01;113(10):1161-1172.
PMID: 28472418
Noninvasive stratification of postinfarction rats based on the degree of cardiac dysfunction using magnetic resonance imaging and echocardiography.
Am J Physiol Heart Circ Physiol 2017 May 01;312(5):H932-H942. Epub 2017 feb 10
PMID: 28188213
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell Rep 2017 01 03;18(1):82-92.
PMID: 28052262
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.
J Clin Invest 2017 Jan 03;127(1):335-348. Epub 2016 nov 28
PMID: 27893464
A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data.
Magn Reson Med 2017 Sep;78(3):1199-1207. Epub 2016 okt 3
PMID: 27699840
DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment.
J Transl Med 2017 Nov 03;15(1):225. Epub 2017 nov 3
PMID: 29100521
Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer.
Oncotarget 2017 Dec 01;8(62):105682-105691. Epub 2017 nov 11
PMID: 29285283
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts.
Acta Oncol 2017 Dec;56(12):1754-1762. Epub 2017 jun 29
PMID: 28661213
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis.
Cardiovasc Res 2016 Oct;112(1):443-51. Epub 2016 mai 25
PMID: 27226008
Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance.
PLoS One 2016;11(3):e0150536. Epub 2016 mar 1
PMID: 26930073
Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases.
Clin Exp Metastasis 2017 01;34(1):51-62. Epub 2016 nov 3
PMID: 27812769
Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content.
J Transl Med 2016 Jun 07;14(1):161. Epub 2016 jun 7
PMID: 27268062
Intracranial Tumor Cell Migration and the Development of Multiple Brain Metastases in Malignant Melanoma.
Transl Oncol 2016 Jun;9(3):211-8. Epub 2016 mai 17
PMID: 27267839
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.
PLoS One 2015;10(10):e0139715. Epub 2015 okt 13
PMID: 26461521
Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.
Circ Res 2015 Sep 25;117(8):707-19. Epub 2015 aug 4
PMID: 26243800
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.
Am J Physiol Lung Cell Mol Physiol 2015 Aug 15;309(4):L378-87. Epub 2015 jun 12
PMID: 26071556
Surgical anatomy of the superior orbit on ultra-high-resolution MRI at 9.4 Tesla.
J Plast Surg Hand Surg 2015 May 7. Epub 2015 mai 7
PMID: 25946966
Assessment of regional myocardial work in rats.
Circ Cardiovasc Imaging 2015 Feb;8(2):e002695.
PMID: 25673647
IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice.
Acta Physiol (Oxf) 2015 Feb;213(2):492-504. Epub 2014 sep 24
PMID: 25182570
Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy.
Oncogene 2015 Oct 29;34(44):5582-92. Epub 2015 feb 16
PMID: 25684137
Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging.
BMC Cancer 2015;15(1):900. Epub 2015 nov 14
PMID: 26573613
Proteoglycans and integrins as keyregulators of cardiac remodelling in response to increased left ventricular afterload
- Disputert:
- januar 2020
- Hovedveileder:
- Geir Arve Christensen
Regulation of cardiomyocyte structure and function by workload
- Disputert:
- november 2020
- Hovedveileder:
- William Edward Louch
Cardiac remodeling responses to increased afterload: Roles and regulation of cell surface proteoglycans and integrins
- Disputert:
- juni 2020
- Hovedveileder:
- Ida Gjervold Lunde
Heart failure beyond global systolic dysfunction – active, passive and regional mechanisms of diastolic dysfunction
- Disputert:
- mars 2020
- Hovedveileder:
- William Edward Louch
Hypoxia-Induced Pulmonary Hypertension and Cardiac Dysfunction; The Role of Inflammasomes and related Cytokines
- Disputert:
- november 2019
- Hovedveileder:
- Ole Henning Skjønsberg
Molecular mediators of chronic heart disease - A search for novel, specific cardioprotective therapies
- Disputert:
- mars 2018
- Hovedveileder:
- Ivar Sjaastad
Pathogenic consequences of NLRP3 inflammasome activation in metabolic disturbances
- Disputert:
- oktober 2018
- Hovedveileder:
- Arne Yndestad
Toll-like receptor 9 signalling in heart failure
- Disputert:
- februar 2018
- Hovedveileder:
- Leif Erik Vinge
Adrenergic regulation of the Ca2+ homeostasis in the heart - Cardioprotective effects in ischemia-reperfusion injury...
- Disputert:
- desember 2017
- Hovedveileder:
- Kjetil Tasken
To the Heart of NEIL3 –Experimental studies on NEIL3 DNA glycosylase in cardiac disease
- Disputert:
- oktober 2017
- Hovedveileder:
- Alexandra Vanessa Finsen
Diastolic Dysfunction and Pulmonary Hypertension: The Role of Innate Immunity and New Therapeutic Strategies.
- Disputert:
- juni 2015
- Hovedveileder:
- Geir Arve Christensen
- Idun Dale Rein Prosjektdeltaker
- Linn Espeland Prosjektdeltaker
- Haelin Kim Prosjektdeltaker
- Tiril Hillestad Prosjektdeltaker
- Trond Stokke Prosjektdeltaker
- Tord Hompland Prosjektdeltaker
- Emil Knut Stenersen Espe Postdoktorstipendiat (annen finansiering)
- Ida-Marie Henriksen Prosjektdeltaker
- Ioanni Veras Prosjektdeltaker
- Lili Zhang Prosjektdeltaker
- Ivar Sjaastad Prosjektleder
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