Disentangling clinical heterogeneity in Parkinson´s disease - moving towards individualized therapy
- Prosjektnummer
- 2016057
- Ansvarlig person
- Mathias Toft
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Karrierestipend
- Helsekategori
- Neurological
- Forskningsaktivitet
- 2. Aetiology
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Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.
Mov Disord 2023 Apr;38(4):604. Epub 2023 feb 14
PMID: 36788297
Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes.
Acta Neuropathol 2023 Aug;146(2):227. Epub 2023 jun 22
PMID: 37347276
Pleiotropy with sex-specific traits reveals genetic aspects of sex differences in Parkinson's disease.
Brain 2023 Sep 06. Epub 2023 sep 6
PMID: 37671566
Epigenome-wide association study of peripheral immune cell populations in Parkinson's disease.
NPJ Parkinsons Dis 2023 Oct 31;9(1):149. Epub 2023 okt 31
PMID: 37903812
Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.
Nat Commun 2022 Aug 22;13(1):4932. Epub 2022 aug 22
PMID: 35995800
Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.
Neurology 2022 Aug 16;99(7):e698. Epub 2022 mai 26
PMID: 35970579
The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited.
Mov Disord 2022 Sep;37(9):1929. Epub 2022 jul 10
PMID: 35810454
Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study.
Mov Disord 2022 Apr;37(4):857. Epub 2022 jan 8
PMID: 34997937
Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease.
J Parkinsons Dis 2022;12(1):267.
PMID: 34633332
Fine mapping of the HLA locus in Parkinson's disease in Europeans.
NPJ Parkinsons Dis 2021 Sep 21;7(1):84. Epub 2021 sep 21
PMID: 34548497
Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease.
Ann Neurol 2021 07;90(1):35-42. Epub 2021 mai 24
PMID: 33901317
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Front Neurol 2021;12():631145. Epub 2021 feb 5
PMID: 33613437
Integrative analysis identifies bHLH transcription factors as contributors to Parkinson's disease risk mechanisms.
Sci Rep 2021 02 10;11(1):3502. Epub 2021 feb 10
PMID: 33568722
Allele-specific expression of Parkinson's disease susceptibility genes in human brain.
Sci Rep 2021 01 12;11(1):504. Epub 2021 jan 12
PMID: 33436766
Differences in the Presentation and Progression of Parkinson's Disease by Sex.
Mov Disord 2021 01;36(1):106-117. Epub 2020 okt 1
PMID: 33002231
Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci.
Biol Psychiatry 2021 02 01;89(3):227-235. Epub 2020 feb 8
PMID: 32201043
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.
Brain 2020 01 01;143(1):234-248.
PMID: 31755958
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.
Ann Neurol 2020 04;87(4):584-598. Epub 2020 feb 12
PMID: 31976583
Subthalamic deep brain stimulation improves sleep and excessive sweating in Parkinson's disease.
NPJ Parkinsons Dis 2020;6():29. Epub 2020 okt 14
PMID: 33083523
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.
Mov Disord 2019 06;34(6):866-875. Epub 2019 apr 7
PMID: 30957308
GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study.
Sci Rep 2019 May 07;9(1):7013. Epub 2019 mai 7
PMID: 31065058
Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.
Neurol Genet 2019 Aug;5(4):e348. Epub 2019 jul 9
PMID: 31404238
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.
Mov Disord 2019 12;34(12):1839-1850. Epub 2019 sep 10
PMID: 31505070
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.
Lancet Neurol 2019 Dec;18(12):1091-1102.
PMID: 31701892
A paradoxical relationship between family history, onset age, and genetic risk in Parkinson's disease.
Mov Disord 2019 02;34(2):298-299. Epub 2018 nov 28
PMID: 30484896
A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease.
Ann Neurol 2018 Jul;84(1):117-129. Epub 2018 aug 26
PMID: 30146727
Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study.
BMC Neurol 2018 Feb 21;18(1):20. Epub 2018 feb 21
PMID: 29466944
The GBA variant E326K is associated with Parkinson's disease and explains a genome-wide association signal.
Neurosci Lett 2017 Sep 29;658():48-52. Epub 2017 aug 19
PMID: 28830825
A cumulative genetic risk score predicts progression in Parkinson's disease.
Mov Disord 2016 Apr;31(4):487-90. Epub 2016 feb 8
PMID: 26853697
Low frequency of GCH1 and TH mutations in Parkinson's disease.
Parkinsonism Relat Disord 2016 Aug;29():109-11. Epub 2016 mai 7
PMID: 27185167
Rare variants in dementia genes and Parkinson's disease.
Eur J Hum Genet 2016 Dec;24(12):1661-1662. Epub 2016 jun 22
PMID: 27329738
Genetic studies of sporadic Parkinson’s disease – On the identification of genetic risk factors
- Disputert:
- februar 2022
- Hovedveileder:
- Mathias Toft
- Chiara Cappelletti Prosjektdeltaker
- Natasha Demic Prosjektdeltaker
- Wilma van de Berg Prosjektdeltaker
- Margrete Langmyhr Doktorgradsstipendiat (annen finansiering)
- Lasse Pihlstrøm Prosjektdeltaker
- Victoria Berge Doktorgradsstipendiat (finansiert av denne bevilgning)
- Mathias Toft Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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