Longitudinal genomics and drug screens for improved treatment efficacy in colorectal cancer
- Prosjektnummer
- 2016123
- Ansvarlig person
- Ragnhild A. Lothe
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis, 5. Treatment Developement
NEI
NEI
NEI
Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases.
J Transl Med 2021 09 08;19(1):384. Epub 2021 sep 8
PMID: 34496878
Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity.
Clin Cancer Res 2020 Aug 01;26(15):4107-4119. Epub 2020 apr 16
PMID: 32299813
Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer.
ESMO Open 2020 11;5(6):e001040.
PMID: 33219056 - Inngår i doktorgradsavhandlingen
Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2.
Lab Invest 2020 01;100(1):120-134. Epub 2019 okt 22
PMID: 31641225 - Inngår i doktorgradsavhandlingen
A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis.
Gastric Cancer 2020 09;23(5):811-823. Epub 2020 mar 25
PMID: 32215766
Exploratory analyses of consensus molecular subtype-dependent associations of
ESMO Open 2019;4(3):e000523. Epub 2019 jun 24
PMID: 31321083
Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients.
J Pathol 2018 Apr;244(4):421-431. Epub 2018 feb 5
PMID: 29282718
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors.
Mol Oncol 2017 Sep;11(9):1156-1171. Epub 2017 jul 5
PMID: 28556483
Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer
Innsendt manus, 2022 inngår i doktoravhandling
Flourescence-based multiplex immunohistochemistry in precision medicine of colorectal cancer
Innlevert avhandling (okt 2021) for graden PhD; forventer disputas vår 2022
Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2.
Lab Invest. 2020 Jan;100(1):120-134.
- Arild Nesbakken Prosjektdeltaker
- Anita Sveen Forsker (annen finansiering)
- Jarle Bruun Medveileder
- Christian Holst Bergsland Doktorgradsstipendiat (finansiert av denne bevilgning)
- Ragnhild A Lothe Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport