eRapport

Understanding the development of mental disorders: How does genetic risk manifest across age, gender and environmental factors? (MoBa-Psych)

Prosjekt
Prosjektnummer
2018058
Ansvarlig person
Anne-Siri Øyen
Institusjon
Lovisenberg Diakonale Sykehus
Prosjektkategori
Postdoktorstipend
Helsekategori
Mental Health
Forskningsaktivitet
2. Aetiology
Rapporter
2023 - sluttrapport
The MoBa-Psych project concluded in 2023. The over-arching aim of this project was to advance our understanding of the development of mental health problems, and to identify early signs of risk, by investigating how genetic risk for mental disorders is expressed in the general population. Here, we describe how this aim was achieved with respect to the 3 key questions outlined at the outset of the project. 1) How does genetic risk for mental disorders manifest at different stages of development? Two of the core outputs of this project addressed this question. In the first, entitled "Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders" and published in the journal Psychological Medicine, we asked whether the manifestations of genetic risk for neurodevelopmental conditions could be observed at the earliest phases of development, as children begin to walk and talk. Here we found that the age of walking - but not talking - could be significantly linked to genetic liability to autism and attention-deficit hyperactivity disorder (ADHD). In the second, entitled "Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population" and published in the journal Schizophrenia Bulletin, we focused in on genetic risk for schizophrenia, observing that it was associated with a characteristic pattern of behavioural and emotional problems and symptoms in middle childhood - long before the onset of schizophrenia itself. In other analyses undertaken as part of collaborative efforts linked to this project, we looked into similar questions with respect to risk for bipolar disorder, emotional problems, and more. Overall, the results show a pattern of genetic risk manifesting early and diffusely - but generally with only a small portion of these manifestations directly explicable by specific genetic variants. 2) Do manifestations of genetic risk for mental disorders vary between males and females? Our investigation "Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders", described above, identified sex-linked variability in manifestations of genetic risk. Specifically, girls' elevated genetic liability to autism was linked to them walking slightly later than peers, but the same effect was not observed for boys. Despite this finding, the predominant pattern across our core and collaborative projects has been one of relative consistency of genetic manifestations across sex. For example, in "Early manifestations of genetic risk for neurodevelopmental disorders"(Journal of Child Psychology and Psychiatry), we looked for differences in the associations between genetic liabilities related to ADHD, autism, and schizophrenia and a range of behavioural outcomes across 5 timepoints spanning 7 years of childhood, and found little evidence. 3) Which environmental factors affect resilience to genetic risk for mental disorders? Pinpointing systematically meaningful environmental factors is one of the great research challenges in our field. In order for an environmental factor to influence resilience to genetic risk, it must be independent of that risk. The predominant finding of relevant genetically-informed studies in recent years, confirmed by our findings in collaborative work linked to this project, is that many environmental factors that show links with mental disorders do so because they are influenced - via the behaviour of individuals themselves or their relatives - by the same genes. Put another way, these links are confounded. In a collaborative study on the processes by which different mental health conditions differentiate from one another ("Exploring the differentiation of behavioural and emotional problems across childhood: A prospective longitudinal cohort study", JCPP Advances) we identified parental education as a one potentially protective factor that was at least partly independent of genetic risk for childhood problems. Health services benefit from upstream, aetiological research in numerous ways. However, these are often indirect, and can take years to manifest fully. It is not the case that our results have immediate short-term implications for the clinic - nor was it ever anticipated to be so. Nonetheless, an awareness of the developing picture of the aetiology of mental health difficulties can profoundly and positively influence the way health services operate. As an example, over recent decades, psychiatric health services have changed dramatically in response to an increased understanding that the environment-only models of the aetiology of conditions like autism, ADHD, and schizophrenia that used to dominate the clinical landscape, are demonstrably wrong. This has made for profound changes in the way in which individuals with these conditions and their families experience their interactions with clinical services. Health services should continue to be open to modifying practices to accord with new insights about the aetiology of the conditions they treat and the needs of the patients they serve. In the longer term, it seems likely that the incorporation of individualised genetic information into the clinic will become a reality. In the case of neurodevelopmental and psychiatric conditions - this is unlikely (based on our findings in this project and those of others) to take the form of personalised prediction and early intervention. At least, genetic information will only ever be a small part of this process. However, novel insights about the ways in which genetic risks manifest across the early part of the lifespan can help inform the possible uses of this information in the healthcare services of the future. While individuals may not be identified for treatment on the basis of genetic tests, those who have already been referred to the clinic may benefit from clinicians having - and communicating back to them and their families - a fuller picture of their genetic profile of liabilities for co-occurring problems or functional impairments. Most importantly, by incorporating findings about the overlap between genetics and apparently significant environments into clinical models, service providers can more efficiently target interventions towards genuinely modifiable environmental sources.

The candidate concluded the research visit abroad begun during the prior period. The overall duration of the research visit (at the Integrative Epidemiology Unit, Bristol Medical School, University of Bristol) was 11 months, during which the candidate worked with collaborators on analyses for the project.

2022
2022 saw the MoBa-Psych candidate undertake the remainder of a 12-month stay at the University of Bristol, UK, which had begun in 2019 but was disrupted by the global coronavirus pandemic. This visit was a core part of the MoBa-Psych plan, designed to support the project methodologically and build the relevant international collaborative networks.The completion of a delayed research visit to the Integrative Epidemiology Unit in the Population Health Sciences department of the University of Bristol in 2022 (and into early 2023) ensures that the MoBa-Psych project makes good on its aim to strengthen collaborative links between this department and the candidate's home institution, Lovisenberg Diaconal Hospital. It has also secured key methodological support and training for the candidate for the final stage of the project. Analytic work in the MoBa-Psych project in 2022 was primarily focused on two projects. The first involved a substantial methodological contribution to an investigation, now published in the journal Acta Psychiatrica Scandanavica, into childhood temperamental, emotional, and behavioural characteristics and their links to adolescent mood and anxiety disorders. Building on a previous MoBa-Psych study in which we modelled different developmental profiles of co-developing emotional and behavioural problems among MoBa participants, this investigation a profile consistent with disruptive mood dysregulation across childhood to be most associated with both mood and anxiety disorders in adolescence, suggesting childhood represents a formative period for the later development of diagnosable mental health conditions - and highlighting the potential value of successful early intervention. The second major focus for analysis in 2022 has been developing a model to tackle the third explicit research question outlined in the project plan, namely: Which environmental factors affect resilience to genetic risk for mental disorders? Answering this question requires an approach that takes into account interplay between environmental and genetic factors. However, we know from previous work that the environmental context for child development is often confounded by genetics, because of the important roles of other family members in shaping it. Such approaches also have to account for this confounding in order to yield meaningful results. In 2022, MoBa-Psych researchers focused on maternal-drinking as a potential environmental risk factor, developing an approach that separates out the genetic and environmental pathways that link it to early life emotional and behavioural problems, and tests whether or not the strength of the environmental pathway differs according to the child's genetic makeup. In this investigation, now submitted for publication and currently available as a preprint, giving the scientific community immediate access to its findings, we found limited evidence that this particular environment interacts with child genetic sensitivities to influence risk and reslience to mental health problems. In 2023, a similar approach will be applied to a set of prenatal environmental exposures, and this will represent the final core empirical output for the MoBa-Psych project. The over-arching goal of the MoBa-Psych project has been to advance our understanding of the development of mental health problems by investigating how genetic risk for mental disorders is expressed in the general population. In 2022, members of the core MoBa-Psych team wrote an editorial (published in the Journal of the American Academy of Child & Adolescent Psychiatry; see publications list) summarising, based on experiences carrying out work and reviewing literature for the project, the challenges and necessary next steps associated with meeting this goal. The MoBa-Psych project will conclude in 2023.

In 2022 the candidate embarked upon the remainder of a 12-month stay at the University of Bristol, UK, which had begun in 2019 but was ultimately disrupted by the global coronavirus pandemic. During the research visit, the candidate worked with collaborators at the MRC Integrative Epidemiology Unit (IEU), based in the Population Health Sciences department of the University. The is a globally renowned centre of methodological expertise on methods of causal inference using population data, and the candidate was able to develop skills in this area and in techniques to handle missing data in cohort studies, which can be brought back to and disseminated in the candidate's home institution. The visit began in June 2022 and is scheduled to last until May 2023, by which time the candidate will have further strengthened existing collaborative links between the two departments, and carried out an specific analytic project linked to the stay abroad.

2021
The MoBa-Psych fellow is Laurie Hannigan. He leads the project in collaboration with Anne-Siri Øyen and Alexandra Havdahl as part of the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute, Lovisenberg Diaconal Hospital.In 2021, two papers first-authored by the MoBa-Psych fellow were published in international journals. These were, respectively, an investigation of the associations between genetic risk for schizophrenia and a range of childhood emotional and behavioural problems, and an investigation of the relationship between genetic risk for neurodevelopmental conditions and children's timely attainment of developmental milestones early in life. The latter investigation also explored - and revealed - differences between boys and girls in terms of the relationship between their genes and their early development, fulfilling key aim of the MoBa Psych project overall. At the end of the last reporting period, we described our ongoing investigation into how genetic risk for mental disorders is associated with continued participation in research cohorts, and findings that genetic risk for disorders like schizophrenia and ADHD is associated with an increased likelihood of dropping out during the course of a study. In 2021, this work was presented at the Nordic Society for Human Genetics and Precision Medicine conference, and is currently being updated to include all genotyped participants in the MoBa cohort (where previously only a sub-sample were available). This project will be pre-printed and submitted for peer review during the next reporting period. An important facet of the MoBa-Psych project is to understand how environmental factors play a role in the development and manifestation of mental disorders and related traits in early life. To this end, MoBa-Psych researchers have contributed to work published during this reporting period on, respectively, parental neuroticism and parental criticism as potential environmental risk factors for childhood emotional problems, on environmental and genetic influences on co-occurring emotional problems and attention-deficit hyperactivity disorder (ADHD), and on maternal prenatal depression as a potential risk factor for later ADHD in children. In the final part of the project, this theme will be developed further as we investigate whether prenatal maternal stress represents an environmental risk factor for offspring emotional and behavioural problems, and if this risk interacts with the genetics of the mother, such that it is accentuated if the mother has more genetic susceptibility to stress-related disorders. Using a similar approach, MoBa-Psych researchers will also contribute to investigations of the effects of maternal drinking on child behavioural and emotional development., and of risk and resilience-promoting factors that moderate the influences of potentially stressful environmental factors to which children are exposed. Importantly, all of these analyses will exploit features of the MoBa sample's design that allow us to account for the fact that shared genes between parents and children may also explain links between maternal behaviours/experiences and child outcomes. Finally, the MoBa-Psych project has continued this year to produce unanticipated benefits, including the development of free-to-use software tools (e.g., https://github.com/psychgen/phenotools) that will help researchers around the world to work more efficiently and reproducibly with MoBa and linked data sources. The work will continue into 2022, with a Covid-delayed research visit to the University of Bristol for the postdoctoral fellow aiding its conclusion.

NO

2020
In 2020, the postdoctoral fellow and other members of the project team have continued to explore how genetic risk for specific psychiatric conditions manifests in middle childhood. Additionally, MoBa-Psych has contributed to the development of new approaches for studying the intergenerational transmission of psychiatric problems within families.Progress has been made on three main fronts in MoBa-Psych this year. Firstly, the dissemination of results from last year's analyses among the scientific community has begun in earnest, as the two analytic projects described in the 2020 report were written up and submitted for peer-review in leading international journals. The first of these (entitled "Genetic liability for schizophrenia and childhood psychopathology in the general population") is now published in Schizophrenia Bulletin, while the second ("Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders") is still under review. However, a version of this article is already freely available online at the pre-print server PsyArXiv (https://psyarxiv.com/x8wst/). Secondly, the MoBa-Psych team have been carrying out new analyses in order answer questions about how genetic risk for mental disorders is expressed in the general population. In one of these sets of analyses, preliminary findings suggest that individuals' level of genetic risk for autism and ADHD is associated with emotional and behavioural development - both in the case of those children who eventually receive diagnoses of these neurodevelopmental disorders, and in those who do not. The next stage of this project will be to establish whether or not these genetically-influenced differences in emotional and behavioural development explain differences in educational performance, school engagement, and social functioning within these groups. Variability among the social and educational outcomes of individuals with neurodevelopmental disorders (where some children experience serious difficulties, while others fare much better) is important to understand, and we hope the results of these analyses will shed some light on this phenomenon. In separate analyses, we have also begun to investigate how genetic risk for mental disorders is associated with continued participation in research cohorts, finding that genetic risk for disorders like schizophrenia and ADHD is associated with an increased likelihood of dropping out during the course of a study. This too is important to understand, as it has a bearing on how the results from our other analytic projects - and those of many researchers using data from similar samples - should be interpreted. As we prepare this work for publication in 2021, we will also develop strategies for handling potential biases introduced by this kind of selective participation in research. Finally, MoBa-Psych researchers have been involved, this year, in several projects to develop methodological approaches for understanding how risk for psychiatric problems is transmitted within families. Primarily, these involved different ways of estimating the extent of "genetic nurture" - a term used to describe environmental effects parents have on their children that are detectable in the association between their own genes and their child's behaviour (after accounting for the fact that some of those genes are passed on to the child directly). These new techniques offer exciting possibilities, and their application to relevant questions in the MoBa-Psych project will be one particular focus as we move into its final year. Work on the MoBa-Psych project will continue until November 2021. The MoBa-Psych fellow is Laurie Hannigan. He leads the project in collaboration with Anne-Siri Øyen and Alexandra Havdahl as part of the Psychiatric Genetic Epidemiology (PaGE) group.

NO

2019
In 2019, the postdoctoral fellow and other members of the project team have processed genetic data from the MoBa sample, and begun to analyse the extent to which genetic risk for specific psychiatric conditions manifests in a wide range of domains, including early motor and language development, and general psychopathology in middle childhood.One of the key sets of tools available to researchers on this project (MoBa-Psych) investigating how genetic risk for mental disorders is expressed in symptoms and disorders during development are polygenic scores. Polygenic scores are useful as they summarise information from other, much larger studies aimed at discovering which of the many common genetic variants in our inherited genetic code are linked to differences in susceptibility to different forms of illness (including mental disorders). When this information - that is, the strength of the association between each individual genetic variant and the risk of illness - is aggregated to form individual-level scores, it can be used alongside other, measured variables (such as, in a sample of children like MoBa, maternal reports of children's anxiety levels) to establish whether the same genetic variants that influence illness risk also play a role in different behaviours, symptoms, and disorders across the lifespan. This allows us to learn more about the origins of both the illnesses for which the genetic variants were originally identified, and other problems that people experience for which specific genetic influences may not yet be known. During 2019, the MoBa-Psych team have been working on producing polygenic scores for a range of disorders using newly available genetic data for approximately 15,000 family trios (mothers, fathers, and children) in the MoBa sample. These scores are now being incorporated into analytic models designed to uncover how genetic risk for mental disorders manifest during the early years of development. Two projects have been completed so far and are due to be submitted for publication early in 2020. The results of these projects, summarised briefly below, are beginning to shed light on how genetic risk for schizophrenia - a disorder most commonly diagnosed in adulthood - actually manifests in behaviours and developmental patterns that emerge remarkably early in life. The first project aimed to investigate associations between indices of genetic liability to schizophrenia (as well as autism and ADHD) and early-life language and motor developmental milestones. Given that some previous work has suggested that timely attainment of these milestones might be disrupted among children who go on to develop schizophrenia, it is of interest to see whether such an effect may be underpinned by the influences of genetic variants conferring risk to schizophrenia. The second project aimed to explore how the effects of schizophrenia risk manifest in terms of psychopathology across childhood. In these analyses, we examined whether effects of schizophrenia polygenic scores on emotional and behavioural problems in early childhood were stable, influencing the overall level and rates of change in symptoms, or age-specific (i.e., transient or emerging developmentally). We also explored whether there is specificity in the effects of schizophrenia polygenic scores on different domains of psychopathology. Work on the MoBa-Psych project will continue until November 2021.

The project as a whole includes 12 months for the postdoctoral fellow to spend at the Integrative Epidemiology Unit (IEU) at the University of Bristol, UK. The first two months of this period were used June and July 2019, wherein the fellow worked at the IEU attending specialist training courses (in Genetic Epidemiology and Mendelian Randomization) and holding meetings with collaborators to lay groundwork for projects to be completed during the remainder of the period, which will take place in 2021.

2018
The main aim of the project is to assess how genetic risk for mental disorders is expressed in symptoms and disorders during development, and to examine the interplay between genetic risk and environmental factors.Mental disorders are heritable conditions that constitute a leading cause of disability and impaired life quality. Recent advances in genetic methods and collection of biological samples in population cohorts have made it possible to prospectively examine the manifestations (i.e., signs, symptoms and disorders) of genetic risk for mental disorders. While studies have begun to examine these manifestations, central unanswered questions remain. Main research questions are: 1) How does genetic risk for mental disorders manifest at different stages of development?, 2) Do manifestations of genetic risk for mental disorders vary between males and females? and 3) Which environmental factors affect resilience to genetic risk for mental disorders? The project uses data from the Norwegian Mother and Child Study (MoBa), a prospective pregnancy cohort including more than 114,000 children, 90,000 mothers and 70,000 fathers. Laurie Hannigan, PhD, was employed as the postdoctoral research fellow of this project on 5 November 2018. The project is conducted at Nic Waals Institute within Lovisenberg Diaconal Hospital, in collaboration with the Norwegian Institute of Public Health, the MRC Integrative Epidemiology Unit at the University of Bristol (MRC IEU), Cardiff University and Columbia University. The postdoctoral research fellow is currently undertaking the statistical analyses for a study of genetic liability for schizophrenia and childhood psychopathology. Next, he plans to investigate relations between genetic liability for a range of mental disorders and developmental milestones in infancy and early childhood. He also aims to examine the potential interplay between genetic risk factors and maternal perinatal stress in influencing children's risk of mental health problems.

No.

Vitenskapelige artikler
Lu L, Hannigan LJ, Brandlistuen RE, Nesvåg R, Trogstad L, Magnus P, Unnarsdóttir AB, Valdimarsdóttir UA, Andreassen OA, Ask H

Mental Distress Among Norwegian Adults During the COVID-19 Pandemic: Predictors in Initial Response and Subsequent Trajectories.

Int J Public Health 2023;68():1606164. Epub 2023 okt 25

PMID: 38024210

Askelund AD, Ask H, Ystrom E, Havdahl A, Hannigan LJ

Exploring the differentiation of behavioural and emotional problems across childhood: A prospective longitudinal cohort study.

JCPP Adv 2023 Dec;3(4):e12176. Epub 2023 jun 30

PMID: 38054063

Wechsler DL, Rijsdijk FV, Adamo N, Eilertsen EM, Ahmadzadeh YI, Badini I, Hannigan LJ, Ystrom E, McAdams TA

Assessing aetiological overlap between child and adult attention-deficit hyperactivity disorder symptoms in an extended family design.

BJPsych Open 2023 Sep 06;9(5):e169. Epub 2023 sep 6

PMID: 37671545

Askeland RB, Hannigan LJ, O'Connell KS, Corfield EC, Frei O, Thapar A, Smith GD, Reichborn-Kjennerud T, Andreassen OA, Ask H, Havdahl A

Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood.

Transl Psychiatry 2023 Jun 23;13(1):222. Epub 2023 jun 23

PMID: 37353490

Pingault JB, Barkhuizen W, Wang B, Hannigan LJ, Eilertsen EM, Corfield E, Andreassen OA, Ask H, Tesli M, Askeland RB, Davey Smith G, Stoltenberg C, Davies NM, Reichborn-Kjennerud T, Ystrom E, Havdahl A

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study.

Mol Psychiatry 2023 Apr;28(4):1731. Epub 2022 nov 16

PMID: 36385167

Hannigan LJ, Askeland RB, Ask H, Tesli M, Corfield E, Ayorech Z, Magnus P, Njølstad PR, Øyen AS, Stoltenberg C, Andreassen OA, Ronald A, Smith GD, Reichborn-Kjennerud T, Havdahl A

Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders.

Psychol Med 2023 Apr;53(5):1750. Epub 2021 sep 21

PMID: 37310338

Bakken NR, Hannigan LJ, Shadrin A, Hindley G, Ask H, Reichborn-Kjennerud T, Tesli M, Andreassen OA, Havdahl A

Childhood temperamental, emotional, and behavioral characteristics associated with mood and anxiety disorders in adolescence: A prospective study.

Acta Psychiatr Scand 2023 Feb;147(2):217. Epub 2022 nov 25

PMID: 36398468

Hannigan LJ, Havdahl A

Editorial: Developmental Psychiatric Genetic Epidemiology: Where Are We, and What Challenges Do We Face Going Forward?

J Am Acad Child Adolesc Psychiatry 2022 Feb;61(2):125. Epub 2021 mai 28

PMID: 34058325

Havdahl A, Wootton RE, Leppert B, Riglin L, Ask H, Tesli M, Bugge Askeland R, Hannigan LJ, Corfield E, Øyen AS, Andreassen OA, Tilling K, Davey Smith G, Thapar A, Reichborn-Kjennerud T, Stergiakouli E

Associations Between Pregnancy-Related Predisposing Factors for Offspring Neurodevelopmental Conditions and Parental Genetic Liability to Attention-Deficit/Hyperactivity Disorder, Autism, and Schizophrenia: The Norwegian Mother, Father and Child Cohort Study (MoBa).

JAMA Psychiatry 2022 Aug 01;79(8):799.

PMID: 35793100

Eilertsen EM, Hannigan LJ, McAdams TA, Rijsdijk FV, Czajkowski N, Reichborn-Kjennerud T, Ystrom E, Gjerde LC

Parental Prenatal Symptoms of Depression and Offspring Symptoms of ADHD: A Genetically Informed Intergenerational Study.

J Atten Disord 2021 09;25(11):1554-1563. Epub 2020 apr 26

PMID: 32338109

Ahmadzadeh YI, Eley TC, Hannigan L, Creswell C, Lichtenstein P, Spotts E, Ganiban J, Neiderhiser J, Rijsdijk F, McAdams TA

Parental criticism and adolescent internalising symptoms: using a Children-of-Twins design with power calculations to account for genetic influence.

J Child Psychol Psychiatry 2021 Aug 10. Epub 2021 aug 10

PMID: 34374994

Gustavson K, Torvik FA, Eilertsen EM, Ask H, McAdams TA, Hannigan LJ, Reichborn-Kjennerud T, Ystrom E, Gjerde LC

Genetic and environmental contributions to co-occurring ADHD and emotional problems in school-aged children.

Dev Psychol 2021 Aug;57(8):1359-1371.

PMID: 34591578

Hannigan LJ, Havdahl A

Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021).

J Child Psychol Psychiatry 2021 05;62(5):631-634. Epub 2021 mar 21

PMID: 33748961

Eilertsen EM, Jami ES, McAdams TA, Hannigan LJ, Havdahl AS, Magnus P, Evans DM, Ystrom E

Direct and Indirect Effects of Maternal, Paternal, and Offspring Genotypes: Trio-GCTA.

Behav Genet 2021 03;51(2):154-161. Epub 2021 jan 2

PMID: 33387132

Hannigan LJ, Askeland RB, Ask H, Tesli M, Corfield E, Ayorech Z, Helgeland Ø, Magnus P, Njølstad PR, Øyen AS, Stoltenberg C, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population.

Schizophr Bull 2021 07 08;47(4):1179-1189.

PMID: 33561255

Askeland RB, Hannigan LJ, Ask H, Ayorech Z, Tesli M, Corfield E, Magnus P, Njølstad PR, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Early manifestations of genetic risk for neurodevelopmental disorders.

J Child Psychol Psychiatry 2022 Jul;63(7):810. Epub 2021 okt 4

PMID: 34605010

Cheesman R, Eilertsen EM, Ahmadzadeh YI, Gjerde LC, Hannigan LJ, Havdahl A, Young AI, Eley TC, Njølstad PR, Magnus P, Andreassen OA, Ystrom E, McAdams TA

How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa).

BMC Med 2020 10 27;18(1):284. Epub 2020 okt 27

PMID: 33106172

Krebs G, Hannigan LJ, Gregory AM, Rijsdijk FV, Eley TC

Reciprocal links between anxiety sensitivity and obsessive-compulsive symptoms in youth: a longitudinal twin study.

J Child Psychol Psychiatry 2020 Sep;61(9):979-987. Epub 2020 jan 16

PMID: 31950513

Hannigan, L. J., Lund, I. O., Askelund, A. D., Ystrom, E., Corfield, E. C., Ask, H., & Havdahl, A.

Genotype–environment interplay in associations between maternal drinking and offspring emotional and behavioral problems

Psychological Medicine 2023, 54(1), 203–214. https://doi.org/10.1017/S0033291723003057

NR Bakken, LJ Hannigan, A Shadrin, G Hindley, H Ask, T Reichborn-Kjennerud, M Tesli, OA Andreassen, A Havdahl

Childhood temperamental, emotional, and behavioral characteristics associated with mood and anxiety disorders in adolescence: A prospective study

Acta Psychiatrica Scandanavica https://doi.org/10.1111/acps.13522, 2022

Laurie John Hannigan, Ingunn Olea Lund, Adrian Dahl Askelund, Eivind Ystrom, Elizabeth Corfield, Helga Ask, Alexandra Havdahl

Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems

PsyArXiv doi:10.31234/osf.io/g5p9f, 2022

Helga Ask, Espen M Eilertsen, Line C Gjerde, Laurie J Hannigan, Kristin Gustavson, Alexandra Havdahl, Rosa Cheesman, Tom A McAdams, John M Hettema, Ted Reichborn‐Kjennerud, Fartein A Torvik, Eivind Ystrom

Intergenerational transmission of parental neuroticism to emotional problems in 8‐year‐old children: Genetic and environmental influences

JCPP Advances, 2021

Hannigan, L. J., Askeland, R. B., Ask, H., Tesli, M., Corfield, E., Ayorech, Z., Magnus, P., Njølstad, P. R., Øyen, A.-S., Stoltenberg, C., Andreassen, O. A., Ronald, A., Smith, G. D., Reichborn-Kjennerud, T., & Havdahl, A.

Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders

Psychological Medicine, 2021

Laurie Hannigan, Robyn Wootton, Laura Hegemann, Adrian Dahl Askelund, Alexandra Havdahl

TU59. A FRAMEWORK TO IMPROVE POLYGENIC QUESTIONS AND STRENGTHEN INFERENCES IN PSYCHIATRIC GENETIC EPIDEMIOLOGY

European Neuropsychopharmacology, 2021

Fartein Ask Torvik, Espen Moen Eilertsen, Laurie John Hannigan, Rosa Cheesman, Laurence Howe, Per Magnus, Ted Reichborn-Kjennerud, Ole A Andreassen, Pål Rasmus Njølstad, Alexandra Havdahl, Eivind Ystrom

Consequences of assortative mating for genetic similarities between partners, siblings, and in-laws

PsyArXiv, 2021

Torvik F, Eilertsen EM, Hannigan LJ, Cheesman R, Howe L, Magnus P, Reichborn-Kjennerud T, Andreassen O, Njølstad P, Havdahl A, Ystrom E

Consequences of assortative mating for genetic similarities between partners, siblings, and in-laws

PsyArXiv (Preprint), 2020

Hannigan LJ, Askeland R, Ask H, Tesli M, Corfield E, Ayorech Z, Magnus P, Njølstad P, Øyen A-S, Stoltenberg C, Andreassen O, Ronald A, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders

PsyArXiv (Preprint), 2020

Askeland R, Hannigan LJ, Ask H, Ayorech Z,Tesli M, Corfield E, Per Magnus P, Njølstad P, Andreassen O, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Early manifestations of genetic risk for neurodevelopmental disorders

PsyArXiv (Preprint), 2020

Ahmadzadeh YI, Eley TC, Hannigan LJ, Creswell C, Lichtenstein P, Reiss D, Spotts E, Ganiban J, Neiderhiser JM, Rijsdijk FV, McAdams TA

Parental criticism and adolescent internalising symptoms: Associations remain after accounting for shared genetic effects

medRxiv (Preprint), 2020

Eilertsen EM, Jami ES, McAdams TA, Hannigan LJ, Havdahl A, Magnus P, Evans DM, Ystrom E

Direct and indirect effects of maternal, paternal, and offspring genotypes: Trio-GCTA

bioRxiv (Preprint), 2020

Hannigan, L. J., Askeland, R. B., Ask, H., Tesli, M., Corfield, E., Ayorech, Z., Helgeland, Ø., Magnus, P., Njolstad, P. R., Øyen, A.-S., Stoltenberg, C., Andreassen, O. A., Davey Smith, G., Reichborn-Kjennerud, T., & Havdahl, A.

Genetic liability for schizophrenia and childhood psychopathology in the general population

medRxiv (Preprint), 2020

Deltagere
  • Elise Robinson Internasjonal samarbeidspartner
  • Somer Bishop Internasjonal samarbeidspartner
  • Ziada Ayorech Prosjektdeltaker
  • Ole Andreas Andreassen Prosjektdeltaker
  • David Evans Prosjektdeltaker
  • Ian Lipkin Prosjektdeltaker
  • Gun Peggy Knudsen Prosjektdeltaker
  • Per Magnus Prosjektdeltaker
  • Camilla Stoltenberg Prosjektdeltaker
  • Pål Surén Prosjektdeltaker
  • Ezra Susser Prosjektdeltaker
  • Anita Thapar Prosjektdeltaker
  • Neil Davies Prosjektdeltaker
  • George Davey Smith Prosjektdeltaker
  • Ted Reichborn-Kjennerud Prosjektdeltaker
  • Alexandra Havdahl Forskningsgruppeleder
  • Laurie Hannigan Postdoktorstipendiat (finansiert av denne bevilgning)
  • Anne-Siri Øyen Prosjektleder

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

Alle henvendelser rettes til eRapport

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