eRapport

How do maternal lifestyle and health-related exposures during pregnancy affect child neurodevelopment? (MoBa-Preg)

Prosjekt
Prosjektnummer
2018059
Ansvarlig person
Alexandra Karoline Saasen Havdahl
Institusjon
Lovisenberg Diakonale Sykehus
Prosjektkategori
Postdoktorstipend
Helsekategori
Mental Health, Neurological
Forskningsaktivitet
1. Underpinning, 2. Aetiology
Rapporter
2024
Dette året er flere viktige artikler i prosjektet publisert i anerkjente internasjonale tidsskrift. Gjennom å bruke flere genetisk informative metoder har vi økt kunnskapen om hvordan blant annet ernæringsfaktorer er knyttet til nevroutvikling.I 2024 har prosjektet hatt fokus på fullføring av studiene i prosjektet og brukermedvirkning i tolkning og formidling av resultater. Prosjektsgruppens arbeid har ført til flere artikler publisert i 2024. Her følger en populærvitenskapelig oppsummering av en av kjernestudiene: * Bakgrunn: Tidligere studier har funnet at lavere nivåer av vitamin D og omega-3 fettsyrer blant mødre under svangerskapet i gjennomsnitt er knyttet til forskjeller i barns språklige, sosiale, kognitive og motoriske utvikling. Men disse studiene har ikke tatt hensyn til at nivåer av vitamin D og omega-3 fettsyrer kan være knyttet til genetisk predisposisjon for autisme eller ADHD. Hvis mødre med høyere genetisk predisposisjon for disse tilstandene også har en tendens til å ha lavere vitamin-D og omega-3, kan dette føre til en kunstig sammenheng mellom vitamin-D/omega-3 hos mødre og nevroutvikling hos barna, selv om det ikke er noen årsakssammenheng. * Metode: Vi brukte data fra Den norske mor, far og barn-undersøkelsen, en av verdens største familieundersøkelser med over 100,000 barn og deres foreldre. Vi brukte også data fra to store internasjonale studier av autisme og ADHD. * Resultatene for forskningsspørsmålene i denne studien: Er det en sammenheng mellom mødres nivåer av vitamin-D/omega-3 og barns nevroutvikling når man kontrollerer for felles gener? - Nei, våre funn støttet ikke dette. Er genetiske varianter som predisponerer for lavere nivå av vitamin-D er omega-3 også knyttet til høyere sannsynlighet for autisme eller ADHD? - Nei, våre funn støttet ikke dette. Er genetiske varianter som predisponerer for autisme eller ADHD også knyttet til lavere nivå av vitamin D eller omega-3? - Ja, våre funn støttet dette. De samme genetiske variantene som predisponerte for autisme var også knyttet til lavere nivåer av vitamin-D. De samme genetiske variantene som predisponerte for ADHD var også knyttet til lavere nivåer av omega-3 fettsyrer. * Konklusjon: Våre resultater tyder på at det ikke er en årsakssammenheng mellom mødres nivåer av vitamin D eller omega-3 og barns nevropsykologiske utvikling. Derimot fant vi støtte for at genetiske varianter som predisponerer for autisme er knyttet til lavere nivå av vitamin D, mens genetiske varianter som predisponerer for ADHD er knyttet til lavere nivå av omega-3. Dette betyr at personer med en høyere genetisk predisposisjon for autisme eller ADHD i gjennomsnitt har lavere nivåer av henholdsvis vitamin D og omega-3 enn personer med lavere genetisk predisposisjon for disse tilstandene. Vi kan ikke fra denne studien vite hvorfor det er slik. Det kan være relatert til forskjeller i spisemønster eller andre faktorer som ikke ble undersøkt i denne studien. Dette bør undersøkes videre fordi lavere nivåer av disse ernæringsfaktorene kan ha betydning for helsen blant personer på autismespekteret eller med ADHD. I 2025 fortsetter arbeidet med brukermedvirkning og formidling av resultater med ytterligere publikasjoner. Prosjektet avsluttes innen desember 2025.

NO

2023
This project aims to increase understanding of how prenatal and early life factors are involved in child neurodevelopment, using general population data from the Norwegian MoBa cohort.This project aims to increase understanding of how prenatal and early life factors are involved in child neurodevelopment, using general population data from the Norwegian MoBa cohort. The MoBa-Preg project is carried out as part of the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute of Lovisenberg Diaconal Hospital, a research group led by Alexandra Havdahl. Publications in 2023 are listed under scientific papers. The final papers addressing the core aims will be published in international peer-reviewed journals in 2024.

No

2022
This project aims to increase understanding of how prenatal and early life factors are involved in child neurodevelopment, using general population data from the Norwegian MoBa cohort. In 2022, the MoBa-Preg team published multiple papers.The MoBa-Preg project is carried out as part of the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute of Lovisenberg Diaconal Hospital, a research group led by Alexandra Havdahl. Publications in 2022 are listed under scientific papers, which include publications in high ranking international journals such as Nature Medicine, JAMA Psychiatry and Molecular Psychiatry. Several papers addressing the core aims of the fellowship are underway and will be published in international peer-reviewed journals in 2023.

Nei

2021
Neurodevelopmental conditions such as ADHD and autism affect 5-10% of children and are associated with functional impairments, reduced quality of life and parental stress. This project aims to determine which factors in prenatal and early life play a role in their development.Over the past decade, there has been a dramatic increase in studies showing associations between a broad range of exposures in pregnant women and neurodevelopmental conditions in their children. However, it is unclear whether the associations are causal or not. Shared familial factors, such as genetic risk, might explain the association between maternal exposure and child neurodevelopmental traits. Misleading evidence about the causes of neurodevelopmental conditions can result in unnecessary worry for pregnant mothers, misspent resources, and deflected attention from more appropriate intervention targets. The over-arching aim of this project, called MoBa-Preg, is to advance our understanding of causality between maternal pregnancy exposures and child neurodevelopment. We hypothesize that only some of the many suggested pregnancy risk factors adversely affect child neurodevelopment. The MoBa-Preg project is carried out as part of the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute of Lovisenberg Diaconal Hospital, a research group led by Alexandra Havdahl. Publications in 2021 are listed under scientific papers. Several papers addressing the core aims of the fellowship are underway and will be published in international peer-reviewed journals in 2022.

No, due to covid-19 it was not possible.

2020
Neurodevelopmental disorders such as ADHD and autism affect 5-10% of children and are associated with lifelong functional impairments, reduced quality of life and parental stress. Determining which factors increase or reduce the risk of neurodevelopmental disorders is important to identify potential intervention targets.Over the past decade, there has been a dramatic increase in studies showing associations between a broad range of exposures in pregnant women and neurodevelopmental disorders in their children. However, it is unclear whether the associations are causal or not. Shared familial factors, such as genetic risk, might explain the association between the maternal exposure and child neurodevelopmental problems. Misleading evidence about the causes of neurodevelopmental deficits can result in unnecessary worry for pregnant mothers, misspent resources, and deflected attention from more appropriate intervention targets. The over-arching aim of this project, called MoBa-Preg, is to advance our understanding of causality between maternal pregnancy exposures and child neurodevelopment. We hypothesize that only some of the many suggested pregnancy risk factors adversely affect child neurodevelopment. The MoBa-Preg project is carried out as part of the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute of Lovisenberg Diaconal Hospital, a research group led by Alexandra Havdahl. She is now PI of the MoBa-Preg fellowship. The fellowship has resulted in 14 peer-reviewed papers and several preprints. Publications in 2020 are listed under scientific papers (preprints are specified). Several papers addressing the core aims of the fellowship are underway and will be published in international peer-reviewed journals during 2021.

No, due to covid-19 it was not possible.

2019
Neurodevelopmental disorders such as ADHD and autism affect 5-10% of children and are associated with lifelong functional impairments, reduced quality of life and parental stress. Determining which factors increase or reduce the risk of neurodevelopmental disorders is important to identify potential intervention targets.Over the past decade, there has been a dramatic increase in studies showing associations between a broad range of exposures in pregnant women and neurodevelopmental disorders in their children. However, it is unclear whether the associations are causal or not. Shared familial factors, such as genetic risk, might explain the association between the maternal exposure and child neurodevelopmental problems. Misleading evidence about the causes of neurodevelopmental deficits can result in unnecessary worry for pregnant mothers, misspent resources, and deflected attention from more appropriate intervention targets. In a study published in JAMA Psychiatry, we tested whether maternal genetic risk for neurodevelopmental disorders predict exposure to potentially adverse exposures during pregnancy. Among almost 8,000 mothers from the UK, we found that their genetic risk for ADHD was associated with a range of pregnancy exposures, including infections, non-use of nutritional supplements, and use of paracetamol. In the Norwegian Mother, Father and Child Cohort Study (MoBa), we have been able to extend the study to a wider range of pregnancy exposures and to compare associations between mothers and fathers. Our findings suggest that mothers with high genetic liability to ADHD may be at increased risk for many adverse pregnancy factors. The results also highlight the need to account for shared genetic risk when investigating effects of pregnancy exposures on child neurodevelopmental disorders. Several such investigations are ongoing in the project, including studies of the potential causal effects of nutritional, immune-related, cardiometabolic and lifestyle factors in pregnancy on child neurodevelopmental outcomes. In 2019, the postdoctoral candidate published 9 papers (3 of these were preprints) and more than 9 peer-reviewed conference proceedings. She also secured memberships of internationally recognized research collaborations such as the Lancet Commission of the Future of Care and Research in Autism, the Psychiatric Genomics Consortium (PGC) and the Within-Family Consortium.

Alexandra Havdahl spent 4 months abroad. Two months were spent at the University of Bristol, Bristol, UK, to collaborate with Professor George Davey Smith and Neil Davies and strengthen her network of collaborators in Bristol. The stay added significant value to the project both in terms of strengthening the quality of the ongoing analyses, increased number of publications, network building and career development. Havdahl also spent two months at the University of California Los Angeles (UCLA) on invitation from Professor Catherine Lord, to collaborate on papers in MoBa-Preg and the Lancet Commission on the Future of Autism Care and Research. The work produced, experience gained, and membership of a Lancet Commission provided substantial value to the project and Havdahl's career development.

2018
The over-arching aim of this project, called MoBa-Preg, is to advance our understanding of causality between maternal pregnancy exposures and child neurodevelopment. The specific objectives are to determine which maternal lifestyle and health-related exposures causally affect child neurodevelopment, and which of these effects are intrauterine.Over the past decade, there has been a dramatic increase in studies showing associations between a broad range of lifestyle (e.g., smoking and alcohol intake) and health-related exposures (e.g., whether they experience gestational diabetes) in pregnant women and neurodevelopmental deficits in their children. These exposures are proposed to have intrauterine effects; exert a biological effect on the developing fetus. However, it is unclear whether the associations are causal or not. Many observed associations between pregnancy exposures and offspring neurodevelopment may be spurious, simply reflecting unmeasured shared familial factors that influence both the maternal exposure and offspring neurodevelopmental deficits. Understanding the causality is important. Misleading evidence about the causes of neurodevelopmental deficits can result in unnecessary worry for pregnant mothers, misspent resources, and deflected attention from more appropriate intervention targets. Determining which exposures are truly causal, and whether their effects are intrauterine, will identify potential intervention targets to reduce the burden of neurodevelopmental disorders such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD). This is a critical step to developing effective health service interventions, improving child outcomes, and reducing the personal, family and societal costs of impaired neurodevelopment. In this project, we are in a unique position to assess intrauterine effects by triangulating multiple methods and pregnancy cohorts. We use data from the Norwegian Mother and Child Cohort Study (MoBa), a prospective pregnancy cohort including more than 114,000 children, 90,000 mothers and 70,000 fathers. In addition, we use data from a prospective pregnancy cohort from the United Kingdom, the Avon Longitudinal Study of Parents and Children (ALSPAC). Although ALSPAC is smaller than MoBa in size (approximately 14,000 pregnancies), it contains more detailed symptom and biomarker measures. The research fellow of the postdoctoral project is Alexandra Havdahl. The project is carried out at Nic Waals Institute at Lovisenberg Diaconal Hospital, in collaboration with researchers from the Norwegian Institute of Public Health (e.g., Ted Reichborn-Kjennerud), the University of Oslo (e.g., Ole Andreassen), the MRC Integrative Epidemiology Unit at the University of Bristol (e.g., George Davey Smith, Neil Davies), Cardiff University (e.g., Anita Thapar), Columbia University (e.g., Ezra Susser) and Queensland University (e.g., David Evans). To kick-start the research project, the research fellow organized a 3-day international conference in Bristol, entitled "the Norwegian and British population cohorts meeting 2018". The conference had 35 speakers and included study planning sessions to identify fruitful areas of collaboration across institutions and cohorts. Since the project started on 1 April 2018, the research fellow has two accepted research papers (one published and one in press) and one additional research paper is under review. She has given six presentations at conferences/scientific meetings during 2018.

No.

Vitenskapelige artikler
Wootton RE, Dack K, Jones HJ, Riglin L, Madley-Dowd P, Borges C, Pagoni P, Roth C, Brantsæter AL, Corfield EC, Stoltenberg C, Øyen AS, Davey Smith G, Ask H, Thapar A, Stergiakouli E, Havdahl A

Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.

Psychol Med 2024 Sep 09;54(12):1. Epub 2024 sep 9

PMID: 39248077

Hernáez Á, Skåra KH, Page CM, Mitter VR, Hernández MH, Magnus P, Njølstad PR, Andreassen OA, Corfield EC, Havdahl A, Næss Ø, Brumpton B, Åsvold BO, Lawlor DA, Fraser A, Magnus MC

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study.

BMC Med 2024 Jan 25;22(1):35. Epub 2024 jan 25

PMID: 38273336

Hernandez MH, Cohen JM, Skåra KH, Grindstad TK, Lee Y, Magnus P, Njølstad PR, Andreassen OA, Corfield EC, Havdahl A, Molden E, Furu K, Magnus MC, Hernaez A

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort.

iScience 2024 Mar 15;27(3):109285. Epub 2024 feb 20

PMID: 38455980

D'Urso S, Wootton RE, Ask H, Brito Nunes C, Andreassen OA, Hwang LD, Moen GH, Evans DM, Havdahl A

Mendelian randomization analysis of maternal coffee consumption during pregnancy on offspring neurodevelopmental difficulties in the Norwegian Mother, Father and Child Cohort Study (MoBa).

Psychol Med 2024 Oct 09;54(12):1. Epub 2024 okt 9

PMID: 39382486

D'Urso S, Moen GH, Hwang LD, Hannigan LJ, Corfield EC, Ask H, Johannson S, Njølstad PR, Beaumont RN, Freathy RM, Evans DM, Havdahl A

Intrauterine Growth and Offspring Neurodevelopmental Traits: A Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa).

JAMA Psychiatry 2024 Feb 01;81(2):144.

PMID: 37878341

Guintivano J, Byrne EM, Kiewa J, Yao S, Bauer AE, Aberg KA, Adams MJ, Campbell A, Campbell ML, Choi KW, Corfield EC, Havdahl A, Hucks D, Koen N, Lu Y, Mægbæk ML, Mullaert J, Peterson RE, Raffield LM, Sallis HM, Sealock JM, Walker A, Watson HJ, Xiong Y, Yang JMK, Anney RJL, Gordon-Smith K, Hubbard L, Jones LA, Mihaescu R, Nyegaard M, Pardiñas AF, Perry A, Saquib N, Shadyab AH, Viktorin A, Andreassen OA, Bigdeli TB, Davis LK, Dennis CL, Di Florio A, Dubertret C, Feng YA, Frey BN, Grigoriadis S, Gloaguen E, Jones I, Kennedy JL, Krohn H, Kunovac Kallak T, Li Y, Martin NG, McIntosh AM, Milgrom J, Munk-Olsen T, Oberlander T, Olsen CM, Ramoz N, Reichborn-Kjennerud T, Robertson Blackmore E, Rubinow D, Skalkidou A, Smoller JW, Stein DJ, Stowe ZN, Taylor V, Tebeka S, Tesli M, Van Lieshout RJ, van den Oord EJCG, Vigod SN, Werge T, Westlye LT, Whiteman DC, Zar HJ, , Wray N, Meltzer-Brody S, Sullivan P

Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression.

Am J Psychiatry 2023 Dec 01;180(12):884. Epub 2023 okt 18

PMID: 37849304

Wootton RE, Lawn RB, Magnus MC, Treur JL, Corfield EC, Njølstad PR, Andreassen OA, Lawlor DA, Munafò MR, Håberg SE, Davey Smith G, Reichborn-Kjennerud T, Magnus P, Havdahl A

Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa).

BMC Med 2023 Apr 03;21(1):125. Epub 2023 apr 3

PMID: 37013617

Pingault JB, Barkhuizen W, Wang B, Hannigan LJ, Eilertsen EM, Corfield E, Andreassen OA, Ask H, Tesli M, Askeland RB, Davey Smith G, Stoltenberg C, Davies NM, Reichborn-Kjennerud T, Ystrom E, Havdahl A

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study.

Mol Psychiatry 2023 Apr;28(4):1731. Epub 2022 nov 16

PMID: 36385167

Jami ES, Hammerschlag AR, Sallis HM, Qiao Z, Andreassen OA, Magnus PM, Njølstad PR, Havdahl A, Pingault JB, Evans DM, Munafò MR, Ystrom E, Bartels M, Middeldorp C

Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?

Transl Psychiatry 2023 Mar 18;13(1):94. Epub 2023 mar 18

PMID: 36934099

Diemer EW, Havdahl A, Andreassen OA, Munafò MR, Njolstad Pr, Tiemeier H, Zuccolo L, Swanson SA

Bounding the average causal effect in Mendelian randomisation studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder.

Paediatr Perinat Epidemiol 2023 May;37(4):326. Epub 2023 feb 1

PMID: 36722651

Solberg BS, Kvalvik LG, Instanes JT, Hartman CA, Klungsøyr K, Li L, Larsson H, Magnus P, Njølstad PR, Johansson S, Andreassen OA, Bakken NR, Bekkhus M, Austerberry C, Smajlagic D, Havdahl A, Corfield EC, Haavik J, Gjestad R, Zayats T

Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study.

Biol Psychiatry 2024 May 01;95(9):839. Epub 2023 des 22

PMID: 38142720

Sadik A, Dardani C, Pagoni P, Havdahl A, Stergiakouli E, , Khandaker GM, Sullivan SA, Zammit S, Jones HJ, Davey Smith G, Dalman C, Karlsson H, Gardner RM, Rai D

Parental inflammatory bowel disease and autism in children.

Nat Med 2022 Jul;28(7):1406. Epub 2022 jun 2

PMID: 35654906

Havdahl A, Wootton RE, Leppert B, Riglin L, Ask H, Tesli M, Bugge Askeland R, Hannigan LJ, Corfield E, Øyen AS, Andreassen OA, Tilling K, Davey Smith G, Thapar A, Reichborn-Kjennerud T, Stergiakouli E

Associations Between Pregnancy-Related Predisposing Factors for Offspring Neurodevelopmental Conditions and Parental Genetic Liability to Attention-Deficit/Hyperactivity Disorder, Autism, and Schizophrenia: The Norwegian Mother, Father and Child Cohort Study (MoBa).

JAMA Psychiatry 2022 Aug 01;79(8):799.

PMID: 35793100

Magnus MC, Havdahl A, Wilcox AJ, Goisis A

Parental fecundability and neurodevelopmental delays and difficulties in offspring.

Int J Epidemiol 2022 Oct 13;51(5):1511.

PMID: 35536321

Dack K, Fell M, Taylor CM, Havdahl A, Lewis SJ

Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review.

Int J Environ Res Public Health 2022 Feb 10;19(4). Epub 2022 feb 10

PMID: 35206164

Madley-Dowd P, Dardani C, Wootton RE, Dack K, Palmer T, Thurston R, Havdahl A, Golding J, Lawlor D, Rai D

Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study.

Mol Autism 2022 Nov 12;13(1):44. Epub 2022 nov 12

PMID: 36371219

Haan E, Sallis HM, Zuccolo L, Labrecque J, Ystrom E, Reichborn-Kjennerud T, Andreassen O, Havdahl A, Munafò MR

Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses.

Addiction 2022 May;117(5):1458. Epub 2021 des 5

PMID: 34791750

Askeland RB, Hannigan LJ, Ask H, Ayorech Z, Tesli M, Corfield E, Magnus P, Njølstad PR, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Early manifestations of genetic risk for neurodevelopmental disorders.

J Child Psychol Psychiatry 2022 Jul;63(7):810. Epub 2021 okt 4

PMID: 34605010

Haan E, Sallis HM, Ystrom E, Njølstad PR, Andreassen OA, Reichborn-Kjennerud T, Munafò MR, Havdahl A, Zuccolo L

Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring.

Alcohol Clin Exp Res 2021 10;45(10):2090-2102. Epub 2021 sep 6

PMID: 34486127

Friel C, Leyland AH, Anderson JJ, Havdahl A, Borge T, Shimonovich M, Dundas R

Prenatal Vitamins and the Risk of Offspring Autism Spectrum Disorder: Systematic Review and Meta-Analysis.

Nutrients 2021 Jul 26;13(8). Epub 2021 jul 26

PMID: 34444717

Dack K, Fell M, Taylor CM, Havdahl A, Lewis SJ

Mercury and Prenatal Growth: A Systematic Review.

Int J Environ Res Public Health 2021 07 03;18(13). Epub 2021 jul 3

PMID: 34281082

Havdahl A, Niarchou M, Starnawska A, Uddin M, van der Merwe C, Warrier V

Genetic contributions to autism spectrum disorder.

Psychol Med 2021 10;51(13):2260-2273. Epub 2021 feb 26

PMID: 33634770

Hannigan LJ, Askeland RB, Ask H, Tesli M, Corfield E, Ayorech Z, Helgeland Ø, Magnus P, Njølstad PR, Øyen AS, Stoltenberg C, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population.

Schizophr Bull 2021 07 08;47(4):1179-1189.

PMID: 33561255

Magnus MC, Havdahl A, Morken NH, Wensaas KA, Wilcox AJ, Håberg SE

Risk of miscarriage in women with psychiatric disorders.

Br J Psychiatry 2021 Sep;219(3):501-506.

PMID: 33448259

Eilertsen EM, Jami ES, McAdams TA, Hannigan LJ, Havdahl AS, Magnus P, Evans DM, Ystrom E

Direct and Indirect Effects of Maternal, Paternal, and Offspring Genotypes: Trio-GCTA.

Behav Genet 2021 03;51(2):154-161. Epub 2021 jan 2

PMID: 33387132

Havdahl A, Farmer C, Schjølberg S, Øyen AS, Surén P, Reichborn-Kjennerud T, Magnus P, Bresnahan M, Hornig M, Susser E, Lipkin WI, Lord C, Stoltenberg C, Thurm A, Bishop S

Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study.

J Child Psychol Psychiatry 2021 09;62(9):1070-1078. Epub 2020 des 28

PMID: 33369747

Akingbuwa WA, Hammerschlag AR, Jami ES, Allegrini AG, Karhunen V, Sallis H, Ask H, Askeland RB, Baselmans B, Diemer E, Hagenbeek FA, Havdahl A, Hottenga JJ, Mbarek H, Rivadeneira F, Tesli M, van Beijsterveldt C, Breen G, Lewis CM, Thapar A, Boomsma DI, Kuja-Halkola R, Reichborn-Kjennerud T, Magnus P, Rimfeld K, Ystrom E, Jarvelin MR, Lichtenstein P, Lundstrom S, Munafò MR, Plomin R, Tiemeier H, Nivard MG, Bartels M, Middeldorp CM,

Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-analysis.

JAMA Psychiatry 2020 07 01;77(7):715-728.

PMID: 32293669

Brumpton B, Sanderson E, Heilbron K, Hartwig FP, Harrison S, Vie GÅ, Cho Y, Howe LD, Hughes A, Boomsma DI, Havdahl A, Hopper J, Neale M, Nivard MG, Pedersen NL, Reynolds CA, Tucker-Drob EM, Grotzinger A, Howe L, Morris T, Li S, , , Auton A, Windmeijer F, Chen WM, Bjørngaard JH, Hveem K, Willer C, Evans DM, Kaprio J, Davey Smith G, Åsvold BO, Hemani G, Davies NM

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.

Nat Commun 2020 07 14;11(1):3519. Epub 2020 jul 14

PMID: 32665587

Cheesman R, Eilertsen EM, Ahmadzadeh YI, Gjerde LC, Hannigan LJ, Havdahl A, Young AI, Eley TC, Njølstad PR, Magnus P, Andreassen OA, Ystrom E, McAdams TA

How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa).

BMC Med 2020 10 27;18(1):284. Epub 2020 okt 27

PMID: 33106172

Torvik FA, Eilertsen EM, McAdams TA, Gustavson K, Zachrisson HD, Brandlistuen R, Gjerde LC, Havdahl A, Stoltenberg C, Ask H, Ystrom E

Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study.

J Child Psychol Psychiatry 2020 Sep;61(9):1009-1018. Epub 2020 jan 19

PMID: 31957030

Kiselev Y, Handal M, Hjellvik V, Reichborn-Kjennerud T, Stoltenberg C, Suren P, Havdahl A, Skurtveit S

Nationwide Study of Neuropsychiatric Comorbidity and Medicines Use in Children With Autism Spectrum Disorder in Norway.

Front Psychiatry 2020;11():596032. Epub 2020 des 8

PMID: 33363486

Sallis HM, Croft J, Havdahl A, Jones HJ, Dunn EC, Davey Smith G, Zammit S, Munafò MR

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood.

Psychol Med 2020 Apr 01. Epub 2020 apr 1

PMID: 32234096

Davies NM, Howe LJ, Brumpton B, Havdahl A, Evans DM, Davey Smith G

Within family Mendelian randomization studies.

Hum Mol Genet 2019 Nov 21;28(R2):R170-R179.

PMID: 31647093

Surén P, Havdahl A, Øyen AS, Schjølberg S, Reichborn-Kjennerud T, Magnus P, Bakken IJL, Stoltenberg C

Diagnosing autism spectrum disorder among children in Norway.

Tidsskr Nor Laegeforen 2019 Oct 08;139(14). Epub 2019 okt 7

PMID: 31592612

Havdahl A, Bishop S

Heterogeneity in prevalence of co-occurring psychiatric conditions in autism.

Lancet Psychiatry 2019 10;6(10):794-795. Epub 2019 aug 22

PMID: 31447416

Leppert B, Havdahl A, Riglin L, Jones HJ, Zheng J, Davey Smith G, Tilling K, Thapar A, Reichborn-Kjennerud T, Stergiakouli E

Association of Maternal Neurodevelopmental Risk Alleles With Early-Life Exposures.

JAMA Psychiatry 2019 May 01. Epub 2019 mai 1

PMID: 31042271

Havdahl A, Mitchell R, Paternoster L, Davey Smith G

Investigating causality in the association between vitamin D status and self-reported tiredness.

Sci Rep 2019 Feb 27;9(1):2880. Epub 2019 feb 27

PMID: 30814568

Surén P, Saasen-Havdahl A, Bresnahan M, Hirtz D, Hornig M, Lord C, Reichborn-Kjennerud T, Schjølberg S, Øyen AS, Magnus P, Susser E, Lipkin WI, Stoltenberg C

Sensitivity and specificity of early screening for autism.

BJPsych Open 2019 May 17;5(3):e41. Epub 2019 mai 17

PMID: 31530312

Caramaschi D, Taylor AE, Richmond RC, Havdahl KA, Golding J, Relton CL, Munafò MR, Davey Smith G, Rai D

Maternal smoking during pregnancy and autism: using causal inference methods in a birth cohort study.

Transl Psychiatry 2018 Nov 29;8(1):262. Epub 2018 nov 29

PMID: 30498225

Hannigan, L., Askeland, R. B., Ask, H., Tesli, M., Corfield, E., Ayorech, Z., Magnus, P., Njolstad, P. R., Øyen, A.-S., Stoltenberg, C., Andreassen, O. A., Davey Smith, G., Reichborn-Kjennerud, T., & Havdahl, A.

Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders

PsyArXiv (Preprint). https://doi.org/10.31234/osf.io/x8wst

Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Ziada Ayorech; Tesli, Martin Steen; Corfield, Elizabeth; Magnus, Per; Njølstad, Pål Rasmus; Andreassen, Ole Andreas; Davey smith, George; Reichborn-Kjennerud, Ted; Havdahl, Alexandra

Early manifestations of genetic risk for neurodevelopmental disorders

PsyArXiv (Preprint), 2020; https://psyarxiv.com/qbvw8/

Sallis H, Croft J, Havdahl A, Jones H, Dunn EC, Davey Smith G, Zammit S, Munafó M.

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood.

MedRxiv [Pre-print], 19006577, Sep 2019, doi: https://doi.org/10.1101/19006577

Hill FI, van der Laan C, Brikell I, Sánchez-Mora C, Nolte IM, ..., Havdahl A, ..., Boomsma D.

Genetic Association Study of Childhood Aggression across raters, instruments and age

BioRxiv [Preprint], 854927, Nov 2019, doi: https://doi.org/10.1101/854927.

Brumpton, B., Sanderson, E., Hartwig, F. P., Harrison, S., Vie, G. A., Cho, Y., ... Havdahl A, ... & Hopper, J.

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

BioRxiv [Preprint], 602516, Apr 2019, doi: http://dx.doi.org/10.1101/602516

Deltagere
  • Robyn Wootton Prosjektdeltaker
  • Catherine Lord Internasjonal samarbeidspartner
  • Elizabeth Diemer Internasjonal samarbeidspartner
  • Elis Haan Internasjonal samarbeidspartner
  • Laurie Hannigan Prosjektdeltaker
  • Ziada Ayorech Prosjektdeltaker
  • Ole Andreas Andreassen Prosjektdeltaker
  • Pål Surén Prosjektdeltaker
  • Gun Peggy Knudsen Prosjektdeltaker
  • Camilla Stoltenberg Prosjektdeltaker
  • Per Magnus Prosjektdeltaker
  • Deborah Lawlor Prosjektdeltaker
  • Ian Lipkin Prosjektdeltaker
  • Ezra Susser Prosjektdeltaker
  • David Evans Prosjektdeltaker
  • Neil Davies Prosjektdeltaker
  • Anita Thapar Prosjektdeltaker
  • George Davey Smith Prosjektdeltaker
  • Ted Reichborn-Kjennerud Prosjektdeltaker
  • Anne-Siri Øyen Prosjektleder
  • Alexandra Havdahl Postdoktorstipendiat (finansiert av denne bevilgning)

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

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