eRapport

Manifestations of genetic risk and intergenerational transmission of risk for eating disorders (MoBa-Eat)

Prosjekt
Prosjektnummer
2019097
Ansvarlig person
Alexandra Karoline Saasen Havdahl
Institusjon
Lovisenberg Diakonale Sykehus
Prosjektkategori
Postdoktorstipend
Helsekategori
Mental Health
Forskningsaktivitet
1. Underpinning, 2. Aetiology
Rapporter
2024
In 2024, MoBa-Eat researchers have continued to work on analyses to answer the core questions of the project: how and why do eating disorders develop early in life, and what are the role of familial risk transmission processes?In 2024 we have written several papers which are submitted or ready for submission. In one study, we estimated the prevalence of avoidant/restrictive food intake in a general population sample, examined developmental characteristics across childhood, and investigated its genetic architecture using genome-wide association analysis. In data from 35 5751 children in MoBa, we identified children with avoidant/restrictive food intake (ARFI-Broad), separating between children with persistent (present at both ages 3 and 8), transient (only at age 3), and emergent (only at age 8) symptoms. Relevant register-based diagnostic codes were used as indicators of clinical significance to identify children with more severe problems (ARFI-Clinical). We found that prevalence of persistent avoidant/restrictive eating was 6%, while 18% had transient and 8% emergent symptoms. Children with persistent avoidant/restrictive eating exhibited more developmental difficulties across multiple domains from infancy to adolescence. We identified significant genome-wide heritability and a potential genetic variant association for avoidant/restrictive eating. Our findings point to substantial prevalence of avoidant and restrictive food intake and elevated risk for other developmental difficulties in affected children, the need for broad support interventions, and advance understanding of genetic influences on avoidant and restrictive eating. In another study, we examined eating problems among adolescent boys and girls before and during the Covid-19 Pandemic. Based on a preregistered analysis plan, we used cross-sectional data collected from 22,706 14-16-year-olds over 6 years (55% during the pandemic) in the Norwegian Mother, Father, and Child Cohort. We used measurement invariance analyses to compare the level of eating restraint and body concern before and during the pandemic, and multi-group structural equation models to estimate pre-pandemic and pandemic patterns of associations. We found there was a general increase in eating problems among 14-16-year-olds over time. Adjusting for this trend, the pandemic appeared to exacerbate problems among girls. Although the mechanisms are unclear, our results point to factors susceptible to change that could have been intensified during the pandemic (e.g., screen time, mental distress). Our results highlight the importance of recognizing sex-specific differences in eating problems. In a third study, we investigated associations between genetic liability to eating disorders indexed by polygenic scores (PGSs), exposure to childhood maltreatment, and lifetime risk of anorexia nervosa, bulimia nervosa, binge-eating disorder, purging disorder, and binge-eating spectrum disorder. The lifetime prevalence of eating disorders ranged from 0.52% (purging disorder) to 11.72% (binge-eating spectrum disorder). All forms of childhood maltreatment were robustly associated with elevated risk of eating disorders. Eating disorder PGSs also predicted a higher risk of eating disorders. We did not find consistent evidence of statistically significant interaction effects between childhood maltreatment and eating disorder PGSs. Our findings highlight substantial associations between both childhood maltreatment and genetic risk for eating disorders in mothers. A fourth study on parental BMI and offspring childhood body size and eating behaviour is under review. The MoBa-Eat team has also contributed as co-authors on several other publications.

NO

2023
In 2023, MoBa-Eat researchers have continued to work on analyses to answer the core questions of the project: how and why do eating disorders develop early in life, and what are the role of familial risk transmission processes? We anticipate new data from the Norwegian Patient Registry in 2024 to bolster our analytic efforts.As the MoBa-Eat project heads into its final stages, the research team are focused on ensuring that our methods and data give us the best opportunities to provide robust answers to the questions that motivate the project. In 2023, we applied to the Norwegian Patient Registry to update our records to include the most recent instances of individuals enrolled in the Norwegian Mother, Father, and Child Cohort receiving diagnoses of eating disorders via specialist healthcare. The relative rarity of eating disorders in the general population, whilst reassuring from a societal perspective, means that every effort must be made to include as much information as possible in analyses to ensure sufficient statistical sensitivity to be able to answer research questions. When these data are delivered in 2024, the team will be able to run the final iteration of the core analyses from the project, and share the results via conferences and publications. To ensure we are well prepared to maximise the impact of the new data when it arrives, MoBa-Eat researchers and collaborators have worked this year on relevant and structurally analogous projects that have allowed us to further develop the within-family methodological approaches that will be used on the projects main outcomes. Intergenerational Mendelian randomization and trio-polygenic scoring are two such approaches, and both have yielded co-authorships for MoBa-Eat researchers this year. Investigating the potential for intergenerational risk transmission in the context of eating disorders is one of the main aims of the project. One influential factor on the mechanism involved in this transmission is the extent to which eating disorder-related health characteristics and behaviours affect fertility in the first place. This year, in collaboration with researchers at the University of Bristol, we established that body mass index (BMI) was consistently associated with time to conception, and Mendelian randomization analyses suggested that this link may be causal. The paper describing these results was entitled "Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)", and has been published in BMC Medicine. The MoBa-Eat project continues into 2024, with results expected from core analyses and new work investigating avoidant and restrictive food intake disorder (ARFID).

No

2022
The over-arching aim of MoBa-Eat is to advance our understanding of the development of eating disorders in the general population and within families. In 2022, MoBa-Eat researchers have refined methodologies that will be deployed to achieve this aim in the remaining years of the project, while contributing to several relevant external projects.Preliminary results relating to the first aim of the MoBa-Eat project - identifying the phenotypic manifestations of genetic risk for eating disorders in males and females at different stages of development - were reported last year. Recognition of the need to increase the analytic sample size in order to robustly detect small associations between genetic risk for eating disorders and early life behaviours in both boys and girls led to the MoBa-Eat team re-doubling efforts to support the completion of the quality-control of the full sample of genotyped individuals in the MoBa sample. This was achieved in spring of this year, and MoBa-Eat researchers contributions resulted in co-authorship of a preprint describing the process and resultant data. MoBa-Eat aim 1 analyses using these data have been re-run and the results are currently being written up for submission to a journal in 2023. The second aim of the MoBa-Eat project involves understanding the intergenerational transmission of risk for eating disorders. Last year, we reported on the plans to address this aim and the resulting analytic project - entitled "Parental body mass index (BMI) and offspring childhood body size and eating behaviour: causal inference via parental comparisons and extended children of twins structural equation modelling" - has now been completed, and will shortly be uploaded to a preprint server and submitted for publication. In it, we found that higher parental BMI was linked to offspring eating behaviours, but that the fact parents and their children share some of the same genetic risk factors was a better explanation of this link than any causal process involving parental behaviour. In addition to this work, methodological refinement has again been a focus of the team in respect of the second aim in 2022. MoBa-Eat researchers have been a key part of a paper published in the journal Molecular Psychiatry (see publications list) using a novel method designed to separate the effects of different members of a family on the behaviours - in this case, those related to attention-deficit hyperactivity disorder - exhibited by children. Application of this method to measures of eating behaviours in the MoBa sample will help to shed further light on the mechanisms by which risk for eating disorders is transmitted within families during the remainder of the project. The third aim of the MoBa-Eat project involves assessing whether or not early life environmental factors interact with genetic propensities to increase risk for developing eating disorders. In 2022, MoBa-Eat researchers have been actively developing models suitable for achieving this aim. One such model is introduced in a preprint (uploaded to the medRxiv preprint server - see publications list - and currently under-going peer review for formal publication), in which the associations between maternal at-risk drinking and child emotional and behavioural problems are first adjusted for confounding by factors that differ between families, and then assessed depending on genetic vulnerabilities to stressful environments among children. Application of this approach to associations between a range of early-life environmental factors and measures of eating behaviours among children is planned for 2023, and will help in fulfilling the remaining aim of MoBa-Eat.

NO

2021
This project is part of the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute of Lovisenberg Diaconal Hospital, led by Alexandra Havdahl. It started in July 2019 with the recruitment of postdoctoral fellow Ziada Ayorech, and continues into 2022 with research fellow Laurie Hannigan working in collaboration with Dr Ayorech.The results of primary analyses addressing the project's first research question: "How does genetic risk for eating disorders manifest in females and males at different stages of development?" are now available in pre-print form (https://psyarxiv.com/w57h9). The MoBa-Eat team is in the process of updating these analyses using newly available genetic data from a larger sub-sample of the MoBa cohort, allowing findings to be reported with increased precision and certainty. This is especially important given the nature of the effects we have uncovered, which are generally very small. The updated results will be preprinted and submitted for peer review and formal publication during the next reporting period. Based on the need, identified during the first analytic project, to be better able to distinguish small effects from random variation, MoBa-Eat researchers have been developing a new framework to carry out these kinds of analyses, and will submit this for publication during 2022. The secondary aim of the MoBa-Eat project was to leverage the family structure of the MoBa sample to disentangle genetic and environmental modes of risk transmission from parents to offspring. To address this aim, the MoBa-Eat team have been working on an analytic project entitled "Parental body mass index and offspring birth weight, body mass index and eating behaviour: genetic analyses in the Norwegian Mother, Father and Child Cohort". The specific aims of this project are to investigate associations between maternal BMI and offspring weight and BMI (measured from birth until the latest time point in childhood at which sufficient data are available), as well as with offspring eating behaviour traits (e.g. emotional over- and under-eating, satiety responsiveness and binge eating disorder). The project will then compare the magnitude of such associations to that of paternal BMI with the same outcomes. Finally, pedigree-based statistical models will be used to partition the overlap between parental BMI and offspring outcomes into components explained by genetic transmission, extended family environment, and residual covariance. These analyses are due to be completed and written up for submission during the next reporting period. To help understand the broader context in which eating disorders exist, MoBa-Eat researchers are investigating "social patterning" in eating disorders, in a cross-cultural study using data sources from the UK (the Avon Longitudinal Study of Parents and Children), Denmark (the Danish National Birth Cohort), and MoBa. In this project, we compare the magnitude and direction of associations between socioeconomic position and eating disorders as measured by self-report versus registry-based diagnosis, and explore international differences in these patterns. Results from these analyses will be written up during the next reporting period. This year, MoBa-Eat researchers also contributed to a major international collaborative publication on the influence on common genetic variation on the age of onset of anorexia nervosa. In addition, 2021 saw the presentation of results at the IEA World Congress of Epidemiology of work involving several MoBa-Eat team members among its authors, examining the causal effect of BMI on neurodevelopment using a novel within-family research design. The MoBa-Eat fellow has also contributed as co-author to several papers on psychiatric genetics over the past year (see publication list).

No.

2020
Eating disorders (ED) are common psychiatric conditions associated with disability, impaired life quality, chronicity, and a high mortality rate. We capitalise on recent advances in genetic methods to investigate the early manifestations of genetic risk to ED and the transmission of ED risk from one generation to the next.This postdoctoral project is conducted as part of the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute of Lovisenberg Diaconal Hospital, led by Alexandra Havdahl. The fellowship started in July 2019 with the recruitment of postdoctoral fellow Ziada Ayorech who has a PhD in behavioral genetics from King’s College London and expertise in genetic analyses of complex traits. We have completed analyses addressing the project's first research question: How does genetic risk for eating disorders manifest in females and males at different stages of development. First, a genetic score that indicates the number of anorexia nervosa risk variants that a person carries, was calculated for over 15 000 Norwegian children participating in the Norwegian, Mother, Father and Child Cohort Study (MoBa). This genetic score was then systematically related to broad behavioural domains capturing growth, eating problems, neurodevelopmental and internalising problems, disruptive behaviour and personality traits, measured from birth to 8 years. The findings will offer an important contribution to the literature demonstrating whether genetic risk for eating disorders is manifested in observational traits in early childhood, which has important implications for these under-detected and under-diagnosed conditions. The paper is in submission. Analyses have also been carried out to address the project's second research aim: Investigate causality in associations between early life exposures and child symptoms of eating disorders. Here the postdoctoral researcher seeks to combine epidemiological methods of causal inference with genetic data in order to test whether metabolic, inflammatory and psychiatric exposures are causally related to childhood symptoms of disordered eating. This second research aim capitalises on new genomic evidence supporting a reconceptualisation of anorexia nervosa as a metabo-psychiatric disorder. The causal inference results will be an integral first step in addressing the urgent need for findings that contribute to more effective detection, prevention and treatment of eating disorders. The paper is in preparation for submission. Analyses are ongoing for multiple additional papers addressing the fellowship aims. Ziada Ayorech has contributed to publishing several other research articles as part of PaGE in 2020, which are listed under research papers (preprint articles are specified). She has also presented the project plans and outputs at conferences and seminars, including oral presentation at the 2020 World Congress of Psychiatric Genetics (WCPG) and an invited talk at the Psychiatric Genomics Consortium Eating Disorders Working Group meeting in Oct 2020. She presented on the methodology of calculating polygenic scores to social scientists as invited talk for the Oslo Meeting for Genetics & Social Sciences in Jan 2020. During the first year of the fellowship, Ziada Ayorech was supported by the PaGE group in applying for international funding. The fellow has received a prestigious Horizon 2020 Marie Skłodowska-Curie actions (MSCA) Individual Fellowship from the European Research Council (supervisors: Eivind Ystrøm at the University of Oslo and Alexandra Havdahl from the PaGE group at Lovisenberg).

The candidate completed a 12-month research stay at the University of Bristol MRC Integrative Epidemiology Unit, an epicentre for the UK's most advanced population health science research. She received advanced training in causal inference modelling and genetic epidemiology methods that are key to achieve the project aims. The stay was well placed early in the project, ensuring the analytical skills gained in the first year are efficiently implemented. The exchange fellowship has contributed to further extending the collaboration between the Psychiatric Genetic Epidemiology (PaGE) group at Lovisenberg and the MRC Integrative Epidemiology Unit.

2019
Eating disorders (ED) are common psychiatric conditions associated with disability, impaired life quality, chronicity, and a high mortality rate. We capitalise on recent advances in genetic methods to investigate the early manifestations of genetic risk to ED and the transmission of ED risk from one generation to the nextThe project started in July 2019 by hiring a postdoctoral researcher with expertise in genetic analyses of complex traits. Within the first 6 months, the postdoctoral researcher has completed analyses addressing the project's first research question: How does genetic risk for eating disorders manifest in females and males at different stages of development. First, a genetic score that indicates the number of anorexia nervosa risk variants that a person carries, was calculated for over 15 000 Norwegian children participating in the Norwegian, Mother, Father and Child Cohort Study (MoBa). This genetic score was then systematically related to broad behavioural domains capturing growth, eating problems, neurodevelopmental and internalising problems, disruptive behaviour and personality traits, measured from birth to 8 years. The findings will offer an important contribution to the literature demonstrating that genetic risk for eating disorders is expressed in behaviourally modifiable traits in early childhood, which has important implications for these under-detected and under-diagnosed conditions. The first draft of the research paper has been written and will be revised and submitted for publication this year. Since the project start date, the postdoctoral researcher has also begun to design analyses addressing the project's second research aim: Investigate causality in associations between early life exposures and child symptoms of eating disorders. Here the postdoctoral researcher seeks to combine epidemiological methods of causal inference with genetic data in order to test whether metabolic, inflammatory and psychiatric exposures are causally related to childhood symptoms of disordered eating. This second research aim capitalises on new genomic evidence supporting a reconceptualisation of anorexia nervosa as a metabo-psychiatric disorder. The causal inference results will be an integral first step in addressing the urgent need for findings that contribute to more effective detection, prevention and treatment of eating disorders. To facilitate analyses on the project's second aim, the postdoctoral researcher has now completed an advanced causal inference training course, led by experts in Mendelian Randomization, a method which uses genetic variation to examine the causal effect of modifiable exposures on health-related outcomes. Importantly, the postdoctoral researcher has begun the project with a one-year research exchange at the University of Bristol, which has provided valuable access to experts in genetic epidemiology with extensive experience in translating empirical results into clinical and public health impact.

The candidate is currently participating in a one-year (July 2019 to July 2020) research stay abroad, at the department of Population Health Sciences, at the University of Bristol in Bristol United Kingdom. Here, she will attend advanced training courses in causal inference modelling and genetic epidemiology. These new methods are integral for the design and analyses of the projects key publications. The stay is well placed early in the project, ensuring the analytical skills gained in the first year can be directly and efficiently implemented over the second and third project years. In the 4th month of her abroad stay, the candidate attended a data visualisation course, during which, she honed the skills to produce high quality publishable figures. She then visited Oslo in December 2019 to translate these skills to the wider research team at Lovisenberg, including researchers and PhD candidates at the Norwegian Institutes of Public Health. The stay abroad has also benefitted the candidate's professional development through collaboration with the Integrative Epidemiology Unit (IEU), an epicentre for the UK's most advanced population health science research. Through the IEU the candidate has met new international researchers, attended statistical journal clubs, presented in departmental meetings and science communication events. In March she will represent the University of Bristol at the Genetics and Genomics Roadshow, a science event for 12 and 13 year old students.

Vitenskapelige artikler
Hughes AM, Torvik FA, van Bergen E, Hannigan LJ, Corfield EC, Andreassen OA, Ystrom E, Ask H, Smith GD, Davies NM, Havdahl A

Parental education and children's depression, anxiety, and ADHD traits, a within-family study in MoBa.

NPJ Sci Learn 2024 Jul 18;9(1):46. Epub 2024 jul 18

PMID: 39025869

D'Urso S, Moen GH, Hwang LD, Hannigan LJ, Corfield EC, Ask H, Johannson S, Njølstad PR, Beaumont RN, Freathy RM, Evans DM, Havdahl A

Intrauterine Growth and Offspring Neurodevelopmental Traits: A Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa).

JAMA Psychiatry 2024 Feb 01;81(2):144.

PMID: 37878341

Hannigan LJ, Lund IO, Dahl Askelund A, Ystrom E, Corfield EC, Ask H, Havdahl A

Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems - CORRIGENDUM.

Psychol Med 2024 Jan;54(1):218. Epub 2023 des 1

PMID: 38037393

Ayorech Z, Torvik FA, Cheesman R, Eilertsen EM, Valstad M, Bjørndal LD, Røysamb E, Havdahl A, Ystrøm E

The structure of psychiatric comorbidity without selection and assortative mating.

Transl Psychiatry 2024 Feb 26;14(1):121. Epub 2024 feb 26

PMID: 38409260

Frach L, Barkhuizen W, Allegrini AG, Ask H, Hannigan LJ, Corfield EC, Andreassen OA, Dudbridge F, Ystrom E, Havdahl A, Pingault JB

Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study.

Mol Psychiatry 2024 Apr;29(4):951. Epub 2024 jan 16

PMID: 38225381

Wootton RE, Lawn RB, Magnus MC, Treur JL, Corfield EC, Njølstad PR, Andreassen OA, Lawlor DA, Munafò MR, Håberg SE, Davey Smith G, Reichborn-Kjennerud T, Magnus P, Havdahl A

Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa).

BMC Med 2023 Apr 03;21(1):125. Epub 2023 apr 3

PMID: 37013617

Pingault JB, Barkhuizen W, Wang B, Hannigan LJ, Eilertsen EM, Corfield E, Andreassen OA, Ask H, Tesli M, Askeland RB, Davey Smith G, Stoltenberg C, Davies NM, Reichborn-Kjennerud T, Ystrom E, Havdahl A

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study.

Mol Psychiatry 2023 Apr;28(4):1731. Epub 2022 nov 16

PMID: 36385167

Askeland RB, Hannigan LJ, Ask H, Ayorech Z, Tesli M, Corfield E, Magnus P, Njølstad PR, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Early manifestations of genetic risk for neurodevelopmental disorders.

J Child Psychol Psychiatry 2022 Jul;63(7):810. Epub 2021 okt 4

PMID: 34605010

Hannigan LJ, Askeland RB, Ask H, Tesli M, Corfield E, Ayorech Z, Helgeland Ø, Magnus P, Njølstad PR, Øyen AS, Stoltenberg C, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population.

Schizophr Bull 2021 07 08;47(4):1179-1189.

PMID: 33561255

Bond, T. A., McAdams, T. A., Warrington, N. M., Hannigan, L. J., Eilertsen, E. M., Ayorech, Z., Torvik, F. A., Smith, G. D., Lawlor, D. A., Ystrøm, E., Havdahl, A., & Evans, D. M.

Parental body mass index and offspring childhood body size and eating behaviour: Causal inference via parental comparisons and extended children of twins structural equation modelling

medRxiv 2023. https://doi.org/10.1101/2023.02.06.23284912

Havdahl A, Hughes AM, Sanderson E, Ask H, Cheesman R, Reichborn-Kjennerud T, Andreassen OA, Corfield EC, Hannigan LJ, Magnus P, Njølstad PR, Stoltenberg C, Torvik FA, Brandlistuen R, Davey Smith G, Ystrom E, & Davies NM.

Intergenerational effects of parental educational attainment on parenting and childhood educational outcomes: Evidence from MoBa using within-family Mendelian randomization.

medRxiv 2023, 2023.02.22.23285699. https://doi.org/10.1101/2023.02.22.23285699

AM Hughes, E Sanderson, T Morris, Z Ayorech, M Tesli, H Ask, T Reichborn-Kjennerud, OA Andreassen, P Magnus, Ø Helgeland, S Johansson, P Njølstad, G Davey Smith, A Havdahl, LD Howe, NM Davies

Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

eLife, 2022

EC Corfield, O Frei, AA Shadrin, ... , OA Andreassen, A Havdahl

The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1

bioRxiv, 2022

Laurie John Hannigan, Ingunn Olea Lund, Adrian Dahl Askelund, Eivind Ystrom, Elizabeth Corfield, Helga Ask, Alexandra Havdahl

Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems

PsyArXiv doi:10.31234/osf.io/g5p9f, 2022

Ayorech, Z., Davies, N., Watson, H., Yilmaz, Z., Tesli, M., Hannigan, L. J., ... Havdahl A. (equal senior author) & Ask, H.

Childhood phenotypic manifestations of genetic risk for anorexia nervosa in the Norwegian Mother, Father and Child Cohort Study (MoBa).

PsyArXiv (Preprint, 2021, March 4). https://doi.org/10.31234/osf.io/w57h9.

Hughes, A. M., Morris, T. T., Ayorech, Z., Tesli, M., Ask, H., Reichborn-Kjennerud, T., ... Havdahl A., Howe, L. & Davies, N. M. (2021).

The causal effects of body mass index (BMI) on childhood symptoms of depression, anxiety disorder, and attention-deficit hyperactivity disorder: a within family Mendelian randomization study

MedRxiv (Preprint, September 22, 2021). https://doi.org/10.1101/2021.09.17.21263612

Hannigan, L. J., Askeland, R. B., Ask, H., Tesli, M., Corfield, E., Ayorech, Z., Helgeland, Ø., Magnus, P., Njolstad, P. R., Øyen, A.-S., Stoltenberg, C., Andreassen, O. A., Davey Smith, G., Reichborn-Kjennerud, T., & Havdahl, A.

Genetic liability for schizophrenia and childhood psychopathology in the general population

Schizophrenia Bulletin, In press (https://doi.org/10.1093/schbul/sbaa193)

Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Ziada Ayorech; Tesli, Martin Steen; Corfield, Elizabeth; Magnus, Per; Njølstad, Pål Rasmus; Andreassen, Ole Andreas; Davey smith, George; Reichborn-Kjennerud, Ted; Havdahl, Alexandra

Early manifestations of genetic risk for neurodevelopmental disorders

PsyArXiv (Preprint article), 2020; https://psyarxiv.com/qbvw8/

Hannigan, L., Askeland, R. B., Ask, H., Tesli, M., Corfield, E., Ayorech, Z., Magnus, P., Njolstad, P. R., Øyen, A.-S., Stoltenberg, C., Andreassen, O. A., Davey Smith, G., Reichborn-Kjennerud, T., & Havdahl, A.

Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders

PsyArXiv (Preprint article). https://doi.org/10.31234/osf.io/x8wst

Deltagere
  • Johanne Pettersen Prosjektdeltaker
  • Ludvig Bjørndal Prosjektdeltaker
  • Laurie Hannigan Forsker (finansiert av denne bevilgning)
  • Elizabeth Corfield Prosjektdeltaker
  • Ole Andreas Andreassen Prosjektdeltaker
  • Hunna Watson Prosjektdeltaker
  • Cynthia Bulik Internasjonal samarbeidspartner
  • Neil Davies Internasjonal samarbeidspartner
  • George Davey Smith Internasjonal samarbeidspartner
  • Per Magnus Prosjektdeltaker
  • Gun Peggy Knudsen Prosjektdeltaker
  • Camilla Stoltenberg Prosjektdeltaker
  • Ted Reichborn-Kjennerud Prosjektdeltaker
  • Helga Ask Prosjektdeltaker
  • Anne-Siri Øyen Prosjektdeltaker
  • Alexandra Karoline Saasen Havdahl Prosjektleder
  • Ziada Ayorech Postdoktorstipendiat (finansiert av denne bevilgning)

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

Alle henvendelser rettes til eRapport

Personvern  -  Informasjonskapsler