eRapport

Psychiatric Genetic Epidemiology (PaGE) group: Integrating causally informative designs and large data resources to understand the development of psychiatric disorders

Prosjekt
Prosjektnummer
2020022
Ansvarlig person
Alexandra Karoline Saasen Havdahl
Institusjon
Lovisenberg Diakonale Sykehus
Prosjektkategori
Karrierestipend
Helsekategori
Mental Health
Forskningsaktivitet
2. Aetiology, 4. Detection and Diagnosis
Rapporter
2024
In 2024, the first doctoral student in the project successfully defended the PhD and published 3 articles, the second doctoral student submitted the first article and completed all PhD courses. The research group has also published a range of articles in recognized international journals.*Milestones achieved in 2024 for PhD student 1 Laura Hegemann* The candidate successfully defended the dissertation "Etiology of Neurodevelopmental Traits: Measurement, Specificity, and Within-Family Transmission", including 3 lead-authored publications: In the 1st paper, published in Autism, we examine the Social Communication Questionnaire (SCQ) in a general population sample, assessing the factor structure and measurement invariance across birth sex and autism diagnostic status. This work contributes valuable knowledge on how the SCQ performs in general population samples. The 2nd paper, published in Molecular Autism, we explore the genetic and phenotypic structure of neurodevelopmental traits in preschool-aged children from the general population. We did not find support for a single general factor of liability across all early neurodevelopmental traits. Instead, genetic factors are associated with more specific areas of neurodevelopment. While there is evidence of shared genetic factors in social and communication traits, the study also reports increased heterogeneity in other areas, such as motor development. The study opens avenues for research into the distinct genetic mechanisms underlying various neurodevelopmental traits. In the 3rd paper, published in Journal of Child Psychology and Psychiatry, we investigate genetic effects on children’s neurodevelopment at age 3 years by assessing the contributions of both direct genetic effects of inherited variants and indirect genetic effects from parental variants not inherited by the child. We find that direct genetic effects contribute to early neurodevelopment traits, with differing levels of importance across the areas of neurodevelopment. In addition, we find evidence of indirect genetic effects on inattention, hyperactivity, and restrictive and repetitive behaviors and interests, contrasting with evidence of direct effects only for social communication traits, language, and motor development. This advances our understanding of the complexity in genetic processes influencing neurodevelopment. * Milestones achieved in 2024 for PhD student 2 Meseret Mamo Bazezew* The candidate completed the required PhD courses and seminars at the Department of Psychology at the University of Oslo. In addition, the candidate has completed several elective courses. The candidate presented a poster at the international Behavior Genetics Association (BGA) conference in London. The candidate also completed and submitted the first PhD paper, entitled “The Reporting and Handling of Missing Data in Genetic Epidemiological Studies of Mental Health in Children and Adolescence: A Systematic Review” for publication. Further, she prepared the analysis plan and preregistration for the second PhD paper. As a member of the Open and Reproducible Science Working Group, the candidate is contributing to the development of guidelines for analysis plans and preregistration for the entire research group, and to organizing events for researchers at Lovisenberg and collaborative partners to enhance research transparency. The candidate has also organized and hosted the PaGE group's weekly scientific meetings with the PsychGen Centre at the Norwegian Institute of Public Health. * Milestones achieved in 2024 for the career fellow Alexandra Havdahl* The fellow led the research group, supervised the two PhD students, and contributed to publications. The project group contributed to 16 articles published in 2024.

PhD-student Laura Hegemann spent 3 months at Rutgers University and the Broad Institute of Harvard and MIT in the US. The stay had great value for the learning and career development of the student, and for the collaborative network of our research group. By visiting the LifeSPAN Autism Lab at Rutgers University, the PhD candidate was be able to receive world-leading training in approaches to studying screening, diagnosis, and wellbeing in autism. Additionally, she received expert advice and consultation on approaches to enhance user involvement in research projects, which is an important focus in the PaGE research group at Lovisenberg hospital. The visit at the Broad Institute at Harvard University and MIT provided the PhD candidate and the research group with an advanced understanding of the genetics of neurodiversity and important methods development to advance the research field, which was shared with the research group at Lovisenberg hospital. The research stay has led to strengthened collaboration between the PaGE group and the research environments at Rutgers University and the Broad Institute.

2023
In 2023, the third-year PhD student published one first-author paper and submitted two additional first-author papers to high-impact journals. A new PhD student started their project and completed the analysis plan for their first paper. In addition, the group published a range of articles in recognised peer-reviewed international journals.The PaGE career grant team published several papers in high-impact journals, as listed below. Meseret Bazezew started her PhD project. PhD student Laura Hegemann completed her three first-author papers to be included in her thesis "Etiology of Neurodevelopmental Traits: Measurement, Specificity, and Within-Family Transmission". Neurodevelopmental conditions, such as ADHD and autism, frequently co-occur with each other, as well as other mental and physical health conditions. Understanding the etiology of neurodevelopmental conditions and their potential shared and differing factors can help identify ways to best support individuals with these conditions and provide a basis to study etiological overlap with other mental and physical health conditions. The first paper in the thesis addresses the measurement of neurodevelopmental traits, specifically repetitive and restrictive behaviors and interests, as well as social and communication traits. In this paper we find that, in a general population, the Social Communication Questionnaire (SCQ) measures these traits equivalently across males and females. However, there is evidence for differences in how the items measure the underlying trait dimensions across those with and without autism, suggesting careful consideration of the interpretation of findings using this instrument in general population samples. The factor structure underlying neurodevelopmental traits in the general population is investigated in both the first and second papers of the thesis. Results from both papers indicate many specific dimensions underlying neurodevelopmental traits, more so than if these trait dimensions corresponded directly to the diagnostic criteria domains for neurodevelopmental conditions. Additionally, we find that early variation in neurodevelopmental traits at age 3 in the general population is associated with receiving various diagnoses of neurodevelopmental conditions, psychiatric inpatient stays, and perceived impact in daily life at later ages. The second and third papers of the thesis investigate the genetic architecture, genetic overlap with neurodevelopmental conditions, and contribution of indirect genetic effects neurodevelopmental traits. Indirect genetics effects being, in the context of the thesis, the genetic effects of parents on their children’s traits over and above genetic transmission. In these studies, we find that common genetic variation contributes to early differences in neurodevelopment to varying degrees across different areas of development. We find that the common genetic variation influencing these early differences includes genetic liability to neurodevelopmental conditions. Additionally, while direct genetic effects contribute to most areas of early neurodevelopment, indirect genetic effects appear to be important contributors to variability in early measures of attention, hyperactivity-impulsivity, and repetitive and restrictive behaviors and interests. Overall, the thesis provides a basis for how early neurodevelopmental traits in the general population are measured, how they are related to each other and to neurodevelopmental conditions, and the genetic contributions to their variability. This can be used to inform how studies of neurodevelopmental traits in general population samples can best be used in etiological work, as well as provide potential avenues of inquiry on shared and differing factors in the development of neurodevelopmental conditions and traits.

Laura Hegemann received funding for a research stay at Harvard and Rutgers University, and is spending 3 months there in early 2024 to gain further methodological and genetics training, and finish her PhD.

2022
In 2022, we published several high-impact articles, including a Lancet Commission. The PhD student completed drafts of two papers, and presented at international conferences. The PI received international funding, including two EU projects as workpackage PI, allowing us to recruit an additional PhD student as part of the PaGE group career grant.Researchers in the PaGE group have published a range of scientific articles in 2022, as shown in the research output list. The PI has also acquired international funding from the European Union and several other sources in the United Kingdom (e.g. Wolfson Foundation) and United States (e.g., SFARI). We are also hiring an additional PhD student to start in June 2023. The PhD fellow has completed severala analyses exploring assumptions surrounding measurement, shared liability, and heritability of neurodevelopmental traits in childhood. We have continued to investigate comorbidity in neurodevelopmental conditions and the etiology of common genetic variance underlying these conditions. We have taken an exploratory approach to identify 11 domains that explain variance in early neurodevelopmental traits in MoBa. This has allowed us to examine how the items from these questionnaires group together to capture different neurodevelopmental traits, independent of traditional diagnostic boundaries. We have shown that all of these domains identified in a general population are associated with receiving a diagnosis for various neurodevelopmental conditions. We have additionally run genome-wide association studies on these domains and shown that many share common genetic variance with ADHD, autism, and schizophrenia. We have also found support that many of these genetic associations seem to be directly associated with the different domains (or even specific traits) rather than influencing early neurodevelopmental traits via a more general pathway. This work was presented as a poster at the 2022 World Congress of Psychiatric Genetics and will be submitted for publication in 2023. Additionally, we’ve made progress in investigating measurement biases, in particular, we’ve looked at the Social Communication Questionnaire. We’ve looked at how both the sex of the child as well as if the child has an autism diagnosis or not influences what is being measured by the questionnaire. Importantly, this can inform interpretations of research using this questionnaire. For example, it can give us insight into interpreting results from our other work that contains items from this questionnaire, such as reasoning for the differences in genetic effects associated with the neurodevelopmental domains we have identified and that which is associated with autism. This work will also be submitted for publication in 2023. In 2023, we will be using trio-based methods in which much of the analytic structure has been established and the analysis pre-registered to investigate indirect and direct genetic contributions to the neurodevelopmental domains we’ve identified. Here we plan to estimate indirect and direct genetic effects contributing to early neurodevelopmental traits and how much of these effects can be attributable to genetic liability for specific neurodevelopmental conditions, giving some insight into within-family pathways of the genetic effects influencing these traits.

Nei

2021
The core scientific objectives of the PaGE group are to elucidate how genetic risk for psychiatric disorders is expressed in early development, distinguish genetic and environmental pathways of within-family transmission of psychiatric disorders, and identify causal environmental risk and protective factors for psychiatric disorders.Psychiatric disorders are highly heritable and constitute a leading cause of disability and impaired life quality. In spite of decades of research and interventions, knowledge about how psychiatric problems develop is still severely limited, and the burden is rising globally. Novel approaches are necessary to advance the field. The ultimate goal of the work of the Psychiatric Genetic Epidemiology (PaGE) group is to reduce disability, loss of productivity and need for services, and to increase the quality of life for individuals at risk for psychiatric disorders. We will achieve this by answering urgent questions with targeted research that contributes to more effective detection, prevention, and treatment of psychiatric disorders. The three core scientific objectives of the PaGE group are 1) Elucidating how genetic risk for psychiatric disorder is expressed in early development, 2) Distinguishing genetic and environmental pathways of within-family transmission of psychiatric disorders, and 3) Identifying causal environmental risk and protective factors for psychiatric disorders. In PaGE, we are in a unique position to generate valuable insights by combining recent advancements across multiple disciplines, and by leveraging data from multiple population cohorts such as the Norwegian Mother, Father and Child Cohort (MoBa) of more than 200,000 participants. In support of achieving our core objectives, the specific aims of this career grant are to: - Build PaGE into a robust, independent research group producing scientific outputs at the forefront of international research. - Develop efficient workflows and analytic pipelines to facilitate an increasing number of publications and collaborations in each of the three core scientific objectives. - Recruit a talented PhD fellow to develop an analytic pipeline to optimize several different analyses which each makes use of the family structure within MoBa. We made progress on all aims in 2021 (see list of publications). Alexandra Havdahl has been funded by the career grant as PaGE research group leader since 30.11.2020. In addition to the publications listed, she is one of the three most contributing authors of the Lancet Commission on the future of care and clinical research in autism, which was published in January 2022 (https://doi.org/10.1016/S0140-6736(21)01541-5). Laura Hegemann is the PhD fellow recruited as part of the career grant and started 25.01.2021. She has a BA in Genetics from Rutgers University where she was awarded outstanding undergraduate researcher by the Rutgers University Center for Alcohol Studies, and an MSc from King's College London in the field of Genes, Environment, and Development in Psychology and Psychiatry. In 2021, she has completed several PhD courses at the University of Oslo and made significant progress in her PhD work.

No.

2020
The core scientific objectives of the PaGE group are to elucidate how genetic risk for psychiatric disorder is expressed in early development, distinguish genetic and environmental pathways of within-family transmission of psychiatric disorders, and identify causal environmental risk and protective factors for psychiatric disorders.Psychiatric disorders are highly heritable and constitute a leading cause of disability and impaired life quality. In spite of decades of research and interventions, knowledge about how psychiatric problems develop is still severely limited, and the burden is rising globally. Novel approaches are necessary to advance the field. The ultimate goal of the work of the Psychiatric Genetic Epidemiology (PaGE) group is to reduce disability, loss of productivity and need for services, and to increase the quality of life for individuals at risk for psychiatric disorders. We will achieve this by answering urgent questions with targeted research that contributes to more effective detection, prevention, and treatment of psychiatric disorders. The PaGE group, located at Nic Waals Institute at Lovisenberg, currently consists of Alexandra Havdahl (research group leader and PI of 2 subprojects), Anne-Siri Øyen (senior researcher and PI of 2 subprojects), Laurie Hannigan (postdoctoral fellow and PI of two subprojects), Ziada Ayorech (postdoctoral fellow), Robyn Wootton (postdoctoral fellow), Adrian Dahl Askelund (PhD fellow), Laura Hegemann (PhD fellow) and Stian Valand (part-time project coordinator). The three core scientific objectives of the PaGE group are 1) Elucidating how genetic risk for psychiatric disorder is expressed in early development, 2) Distinguishing genetic and environmental pathways of within-family transmission of psychiatric disorders, and 3) Identifying causal environmental risk and protective factors for psychiatric disorders. In PaGE, we are in a unique position to generate valuable insights by combining recent advancements across multiple disciplines, and by leveraging data from multiple population cohorts such as the Norwegian Mother, Father and Child Cohort (MoBa) of more than 200,000 participants. In support of achieving our core objectives, the specific aims of this career grant are to: - Build PaGE into a robust, independent research group producing scientific outputs at the forefront of international research. - Develop efficient workflows and analytic pipelines to facilitate an increasing number of publications and collaborations in each of the three core scientific objectives. - Recruit a talented PhD fellow to develop an analytic pipeline to optimize several different analyses which each makes use of the family structure within MoBa. We made progress on all aims in 2020 (see list of publications). Alexandra Havdahl has been funded by the career grant as PaGE research group leader since 30.11.2020. She is working on several lead-authored and senior-authored papers, has received acceptance of a review paper in Psychological Medicine (first author), and has submitted a Lancet Commission as third author and Chair of a working group. She has also been supervising a PaGE project led by Laurie Hannigan to develop software (R package) facilitating efficient reproducible workflows for researchers using MoBa data. Laura Hegemann is the PhD fellow recruited as part of the career grant and started 25.01.2021. She has a BA in Genetics from Rutgers University where she was awarded outstanding undergraduate researcher by the Rutgers University Center for Alcohol Studies, and an MSc from King's College London in the field of Genes, Environment, and Development in Psychology and Psychiatry. She has submitted her project description for enrollment in the PhD program at the University of Oslo and is working on the first paper.

No.

Vitenskapelige artikler
Wootton RE, Dack K, Jones HJ, Riglin L, Madley-Dowd P, Borges C, Pagoni P, Roth C, Brantsæter AL, Corfield EC, Stoltenberg C, Øyen AS, Davey Smith G, Ask H, Thapar A, Stergiakouli E, Havdahl A

Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.

Psychol Med 2024 Sep 09;54(12):1. Epub 2024 sep 9

PMID: 39248077

Hernáez Á, Lee Y, Page CM, Skåra KH, Håberg SE, Magnus P, Njølstad PR, Andreassen OA, Corfield EC, Havdahl A, Fraser A, Burgess S, Lawlor DA, Magnus MC

Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father, and Child Cohort Study.

Hum Reprod 2024 Feb 01;39(2):436.

PMID: 37949105

Hernáez Á, Skåra KH, Page CM, Mitter VR, Hernández MH, Magnus P, Njølstad PR, Andreassen OA, Corfield EC, Havdahl A, Næss Ø, Brumpton B, Åsvold BO, Lawlor DA, Fraser A, Magnus MC

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study.

BMC Med 2024 Jan 25;22(1):35. Epub 2024 jan 25

PMID: 38273336

Hughes AM, Torvik FA, van Bergen E, Hannigan LJ, Corfield EC, Andreassen OA, Ystrom E, Ask H, Smith GD, Davies NM, Havdahl A

Parental education and children's depression, anxiety, and ADHD traits, a within-family study in MoBa.

NPJ Sci Learn 2024 Jul 18;9(1):46. Epub 2024 jul 18

PMID: 39025869

Ayorech Z, Torvik FA, Cheesman R, Eilertsen EM, Valstad M, Bjørndal LD, Røysamb E, Havdahl A, Ystrøm E

The structure of psychiatric comorbidity without selection and assortative mating.

Transl Psychiatry 2024 Feb 26;14(1):121. Epub 2024 feb 26

PMID: 38409260

Havdahl A, Farmer C, Surén P, Øyen AS, Magnus P, Susser E, Lipkin WI, Reichborn-Kjennerud T, Stoltenberg C, Bishop S, Thurm A

Attainment and loss of early social-communication skills across neurodevelopmental conditions in the Norwegian Mother, Father and Child Cohort Study.

J Child Psychol Psychiatry 2024 May;65(5):610. Epub 2023 mar 27

PMID: 36973172

Hernandez MH, Cohen JM, Skåra KH, Grindstad TK, Lee Y, Magnus P, Njølstad PR, Andreassen OA, Corfield EC, Havdahl A, Molden E, Furu K, Magnus MC, Hernaez A

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort.

iScience 2024 Mar 15;27(3):109285. Epub 2024 feb 20

PMID: 38455980

Ferschmann L, Overweg I, Dégeilh F, Bekkhus M, Havdahl A, von Soest T, Tamnes CK

Development of prosocial behavior and inhibitory control in late childhood: A longitudinal exploration of sex differences and reciprocal relations.

Child Dev 2024 Jan-Feb;95(1):313. Epub 2023 jul 31

PMID: 37525404

Frach L, Barkhuizen W, Allegrini AG, Ask H, Hannigan LJ, Corfield EC, Andreassen OA, Dudbridge F, Ystrom E, Havdahl A, Pingault JB

Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study.

Mol Psychiatry 2024 Apr;29(4):951. Epub 2024 jan 16

PMID: 38225381

D'Urso S, Wootton RE, Ask H, Brito Nunes C, Andreassen OA, Hwang LD, Moen GH, Evans DM, Havdahl A

Mendelian randomization analysis of maternal coffee consumption during pregnancy on offspring neurodevelopmental difficulties in the Norwegian Mother, Father and Child Cohort Study (MoBa).

Psychol Med 2024 Oct 09;54(12):1. Epub 2024 okt 9

PMID: 39382486

Hegemann L, Bugge Askeland R, Barbo Valand S, Øyen AS, Schjølberg S, Bal VH, Bishop SL, Stoltenberg C, von Soest T, Hannigan LJ, Havdahl A

Measuring autism-associated traits in the general population: Factor structure and measurement invariance across sex and diagnosis status of the Social Communication Questionnaire.

Autism 2024 Aug;28(8):2105. Epub 2023 des 30

PMID: 38159069

D'Urso S, Moen GH, Hwang LD, Hannigan LJ, Corfield EC, Ask H, Johannson S, Njølstad PR, Beaumont RN, Freathy RM, Evans DM, Havdahl A

Intrauterine Growth and Offspring Neurodevelopmental Traits: A Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa).

JAMA Psychiatry 2024 Feb 01;81(2):144.

PMID: 37878341

Bakken NR, Parker N, Hannigan LJ, Hagen E, Parekh P, Shadrin A, Jaholkowski P, Frei E, Birkenæs V, Hindley G, Hegemann L, Corfield EC, Tesli M, Havdahl A, Andreassen OA

Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders.

J Child Psychol Psychiatry 2024 Oct 27. Epub 2024 okt 27

PMID: 39462222

Hannigan LJ, Lund IO, Dahl Askelund A, Ystrom E, Corfield EC, Ask H, Havdahl A

Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems.

Psychol Med 2024 Jan;54(1):203. Epub 2023 nov 6

PMID: 37929303

Hegemann L, Corfield EC, Askelund AD, Allegrini AG, Askeland RB, Ronald A, Ask H, St Pourcain B, Andreassen OA, Hannigan LJ, Havdahl A

Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.

Mol Autism 2024 Jun 07;15(1):25. Epub 2024 jun 7

PMID: 38849897

Budin-Ljøsne I, Fredheim NAG, Jevne CA, Kleven BM, Charles MA, Felix JF, Flaig R, García MP, Havdahl A, Islam S, Kerr SM, Meder IK, Molloy L, Morton SMB, Pizzi C, Rahman A, Willemsen G, Wood D, Harris JR

Participant engagement and involvement in longitudinal cohort studies: qualitative insights from a selection of pregnancy and birth, twin, and family-based population cohort studies.

BMC Med Res Methodol 2024 Dec 03;24(1):297. Epub 2024 des 3

PMID: 39623293

Guintivano J, Byrne EM, Kiewa J, Yao S, Bauer AE, Aberg KA, Adams MJ, Campbell A, Campbell ML, Choi KW, Corfield EC, Havdahl A, Hucks D, Koen N, Lu Y, Mægbæk ML, Mullaert J, Peterson RE, Raffield LM, Sallis HM, Sealock JM, Walker A, Watson HJ, Xiong Y, Yang JMK, Anney RJL, Gordon-Smith K, Hubbard L, Jones LA, Mihaescu R, Nyegaard M, Pardiñas AF, Perry A, Saquib N, Shadyab AH, Viktorin A, Andreassen OA, Bigdeli TB, Davis LK, Dennis CL, Di Florio A, Dubertret C, Feng YA, Frey BN, Grigoriadis S, Gloaguen E, Jones I, Kennedy JL, Krohn H, Kunovac Kallak T, Li Y, Martin NG, McIntosh AM, Milgrom J, Munk-Olsen T, Oberlander T, Olsen CM, Ramoz N, Reichborn-Kjennerud T, Robertson Blackmore E, Rubinow D, Skalkidou A, Smoller JW, Stein DJ, Stowe ZN, Taylor V, Tebeka S, Tesli M, Van Lieshout RJ, van den Oord EJCG, Vigod SN, Werge T, Westlye LT, Whiteman DC, Zar HJ, , Wray N, Meltzer-Brody S, Sullivan P

Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression.

Am J Psychiatry 2023 Dec 01;180(12):884. Epub 2023 okt 18

PMID: 37849304

Hannigan LJ, Askeland RB, Ask H, Tesli M, Corfield E, Ayorech Z, Magnus P, Njølstad PR, Øyen AS, Stoltenberg C, Andreassen OA, Ronald A, Smith GD, Reichborn-Kjennerud T, Havdahl A

Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders.

Psychol Med 2023 Apr;53(5):1750. Epub 2021 sep 21

PMID: 37310338

Wootton RE, Lawn RB, Magnus MC, Treur JL, Corfield EC, Njølstad PR, Andreassen OA, Lawlor DA, Munafò MR, Håberg SE, Davey Smith G, Reichborn-Kjennerud T, Magnus P, Havdahl A

Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa).

BMC Med 2023 Apr 03;21(1):125. Epub 2023 apr 3

PMID: 37013617

Oddsson A, Sulem P, Sveinbjornsson G, Arnadottir GA, Steinthorsdottir V, Halldorsson GH, Atlason BA, Oskarsson GR, Helgason H, Nielsen HS, Westergaard D, Karjalainen JM, Katrinardottir H, Fridriksdottir R, Jensson BO, Tragante V, Ferkingstad E, Jonsson H, Gudjonsson SA, Beyter D, Moore KHS, Thordardottir HB, Kristmundsdottir S, Stefansson OA, Rantapää-Dahlqvist S, Sonderby IE, Didriksen M, Stridh P, Haavik J, Tryggvadottir L, Frei O, Walters GB, Kockum I, Hjalgrim H, Olafsdottir TA, Selbaek G, Nyegaard M, Erikstrup C, Brodersen T, Saevarsdottir S, Olsson T, Nielsen KR, Haraldsson A, Bruun MT, Hansen TF, , Steingrimsdottir T, Jacobsen RL, Lie RT, Djurovic S, Alfredsson L, Lopez de Lapuente Portilla A, Brunak S, Melsted P, Halldorsson BV, Saemundsdottir J, Magnusson OT, Padyukov L, Banasik K, Rafnar T, Askling J, Klareskog L, Pedersen OB, Masson G, Havdahl A, Nilsson B, Andreassen OA, Daly M, Ostrowski SR, Jonsdottir I, Stefansson H, Holm H, Helgason A, Thorsteinsdottir U, Stefansson K, Gudbjartsson DF

Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality.

Nat Commun 2023 Jun 10;14(1):3453. Epub 2023 jun 10

PMID: 37301908

Askeland RB, Hannigan LJ, O'Connell KS, Corfield EC, Frei O, Thapar A, Smith GD, Reichborn-Kjennerud T, Andreassen OA, Ask H, Havdahl A

Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood.

Transl Psychiatry 2023 Jun 23;13(1):222. Epub 2023 jun 23

PMID: 37353490

Bakken NR, Hannigan LJ, Shadrin A, Hindley G, Ask H, Reichborn-Kjennerud T, Tesli M, Andreassen OA, Havdahl A

Childhood temperamental, emotional, and behavioral characteristics associated with mood and anxiety disorders in adolescence: A prospective study.

Acta Psychiatr Scand 2023 Feb;147(2):217. Epub 2022 nov 25

PMID: 36398468

Pingault JB, Barkhuizen W, Wang B, Hannigan LJ, Eilertsen EM, Corfield E, Andreassen OA, Ask H, Tesli M, Askeland RB, Davey Smith G, Stoltenberg C, Davies NM, Reichborn-Kjennerud T, Ystrom E, Havdahl A

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study.

Mol Psychiatry 2023 Apr;28(4):1731. Epub 2022 nov 16

PMID: 36385167

Askelund AD, Ask H, Ystrom E, Havdahl A, Hannigan LJ

Exploring the differentiation of behavioural and emotional problems across childhood: A prospective longitudinal cohort study.

JCPP Adv 2023 Dec;3(4):e12176. Epub 2023 jun 30

PMID: 38054063

Jami ES, Hammerschlag AR, Sallis HM, Qiao Z, Andreassen OA, Magnus PM, Njølstad PR, Havdahl A, Pingault JB, Evans DM, Munafò MR, Ystrom E, Bartels M, Middeldorp C

Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?

Transl Psychiatry 2023 Mar 18;13(1):94. Epub 2023 mar 18

PMID: 36934099

Ayorech Z, Cheesman R, Eilertsen EM, Bjørndal LD, Røysamb E, McAdams TA, Havdahl A, Ystrom E

Maternal depression and the polygenic p factor: A family perspective on direct and indirect effects.

J Affect Disord 2023 Jul 01;332():159. Epub 2023 mar 22

PMID: 36963516

Kleppesto TH, Eilertsen EM, van Bergen E, Sunde HF, Zietsch B, Nordmo M, Eftedal NH, Havdahl A, Ystrom E, Torvik FA

Intergenerational transmission of ADHD behaviors: genetic and environmental pathways.

Psychol Med 2023 Nov 03. Epub 2023 nov 3

PMID: 37920986

Birkenæs V, Refsum Bakken N, Frei E, Jaholkowski P, Smeland OB, Tesfaye M, Agartz I, Susser E, Bresnahan M, Røysamb E, Nordbø Jørgensen K, Nesvåg R, Havdahl A, Andreassen OA, Elken Sønderby I

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men.

Schizophr Bull 2023 Sep 07;49(5):1229.

PMID: 37262330

Havdahl A, Hughes AM, Sanderson E, Ask H, Cheesman R, Reichborn-Kjennerud T, Andreassen OA, Corfield EC, Hannigan L, Magnus P, Njølstad PR, Stoltenberg C, Torvik FA, Brandlistuen R, Smith GD, Ystrom E, Davies NM

Intergenerational effects of parental educational attainment on parenting and childhood educational outcomes: Evidence from MoBa using within-family Mendelian randomization.

medRxiv 2023 Sep 21. Epub 2023 sep 21

PMID: 36865116

Diemer EW, Havdahl A, Andreassen OA, Munafò MR, Njolstad Pr, Tiemeier H, Zuccolo L, Swanson SA

Bounding the average causal effect in Mendelian randomisation studies with multiple proposed instruments: An application to prenatal alcohol exposure and attention deficit hyperactivity disorder.

Paediatr Perinat Epidemiol 2023 May;37(4):326. Epub 2023 feb 1

PMID: 36722651

Solberg BS, Kvalvik LG, Instanes JT, Hartman CA, Klungsøyr K, Li L, Larsson H, Magnus P, Njølstad PR, Johansson S, Andreassen OA, Bakken NR, Bekkhus M, Austerberry C, Smajlagic D, Havdahl A, Corfield EC, Haavik J, Gjestad R, Zayats T

Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study.

Biol Psychiatry 2024 May 01;95(9):839. Epub 2023 des 22

PMID: 38142720

Warrier V, Zhang X, Reed P, Havdahl A, Moore TM, Cliquet F, Leblond CS, Rolland T, Rosengren A, , , , Rowitch DH, Hurles ME, Geschwind DH, Børglum AD, Robinson EB, Grove J, Martin HC, Bourgeron T, Baron-Cohen S

Genetic correlates of phenotypic heterogeneity in autism.

Nat Genet 2022 Sep;54(9):1293. Epub 2022 jun 2

PMID: 35654973

Sadik A, Dardani C, Pagoni P, Havdahl A, Stergiakouli E, , Khandaker GM, Sullivan SA, Zammit S, Jones HJ, Davey Smith G, Dalman C, Karlsson H, Gardner RM, Rai D

Parental inflammatory bowel disease and autism in children.

Nat Med 2022 Jul;28(7):1406. Epub 2022 jun 2

PMID: 35654906

Havdahl A, Wootton RE, Leppert B, Riglin L, Ask H, Tesli M, Bugge Askeland R, Hannigan LJ, Corfield E, Øyen AS, Andreassen OA, Tilling K, Davey Smith G, Thapar A, Reichborn-Kjennerud T, Stergiakouli E

Associations Between Pregnancy-Related Predisposing Factors for Offspring Neurodevelopmental Conditions and Parental Genetic Liability to Attention-Deficit/Hyperactivity Disorder, Autism, and Schizophrenia: The Norwegian Mother, Father and Child Cohort Study (MoBa).

JAMA Psychiatry 2022 Aug 01;79(8):799.

PMID: 35793100

Torvik FA, Eilertsen EM, Hannigan LJ, Cheesman R, Howe LJ, Magnus P, Reichborn-Kjennerud T, Andreassen OA, Njølstad PR, Havdahl A, Ystrom E

Modeling assortative mating and genetic similarities between partners, siblings, and in-laws.

Nat Commun 2022 Mar 01;13(1):1108. Epub 2022 mar 1

PMID: 35233010

Askeland RB, Hannigan LJ, Ask H, Ayorech Z, Tesli M, Corfield E, Magnus P, Njølstad PR, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Early manifestations of genetic risk for neurodevelopmental disorders.

J Child Psychol Psychiatry 2022 Jul;63(7):810. Epub 2021 okt 4

PMID: 34605010

Magnus MC, Havdahl A, Wilcox AJ, Goisis A

Parental fecundability and neurodevelopmental delays and difficulties in offspring.

Int J Epidemiol 2022 Oct 13;51(5):1511.

PMID: 35536321

Dack K, Fell M, Taylor CM, Havdahl A, Lewis SJ

Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review.

Int J Environ Res Public Health 2022 Feb 10;19(4). Epub 2022 feb 10

PMID: 35206164

Howe LJ, Nivard MG, Morris TT, Hansen AF, Rasheed H, Cho Y, Chittoor G, Ahlskog R, Lind PA, Palviainen T, van der Zee MD, Cheesman R, Mangino M, Wang Y, Li S, Klaric L, Ratliff SM, Bielak LF, Nygaard M, Giannelis A, Willoughby EA, Reynolds CA, Balbona JV, Andreassen OA, Ask H, Baras A, Bauer CR, Boomsma DI, Campbell A, Campbell H, Chen Z, Christofidou P, Corfield E, Dahm CC, Dokuru DR, Evans LM, de Geus EJC, Giddaluru S, Gordon SD, Harden KP, Hill WD, Hughes A, Kerr SM, Kim Y, Kweon H, Latvala A, Lawlor DA, Li L, Lin K, Magnus P, Magnusson PKE, Mallard TT, Martikainen P, Mills MC, Njølstad PR, Overton JD, Pedersen NL, Porteous DJ, Reid J, Silventoinen K, Southey MC, Stoltenberg C, Tucker-Drob EM, Wright MJ, , , Hewitt JK, Keller MC, Stallings MC, Lee JJ, Christensen K, Kardia SLR, Peyser PA, Smith JA, Wilson JF, Hopper JL, Hägg S, Spector TD, Pingault JB, Plomin R, Havdahl A, Bartels M, Martin NG, Oskarsson S, Justice AE, Millwood IY, Hveem K, Naess Ø, Willer CJ, Åsvold BO, Koellinger PD, Kaprio J, Medland SE, Walters RG, Benjamin DJ, Turley P, Evans DM, Davey Smith G, Hayward C, Brumpton B, Hemani G, Davies NM

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.

Nat Genet 2022 May;54(5):581. Epub 2022 mai 9

PMID: 35534559

Caramaschi D, Neumann A, Cardenas A, Tindula G, Alemany S, Zillich L, Pesce G, Lahti JMT, Havdahl A, Mulder R, Felix JF, Tiemeier H, Sirignano L, Frank J, Witt SH, Rietschel M, Deuschle M, Huen K, Eskenazi B, Send TS, Ferrer M, Gilles M, de Agostini M, Baïz N, Rifas-Shiman SL, Kvist T, Czamara D, Tuominen ST, Relton CL, Rai D, London SJ, Räikkönen K, Holland N, Annesi-Maesano I, Streit F, Hivert MF, Oken E, Sunyer J, Cecil CAM, Sharp G

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.

Mol Psychiatry 2022 Apr;27(4):2126. Epub 2022 feb 10

PMID: 35145228

Riglin L, Tobarra-Sanchez E, Stergiakouli E, Havdahl A, Tilling K, O'Donovan M, Nigg J, Langley K, Thapar A

Early manifestations of genetic liability for ADHD, autism and schizophrenia at ages 18 and 24 months.

JCPP Adv 2022 Sep;2(3). Epub 2022 jul 21

PMID: 36545360

Madley-Dowd P, Dardani C, Wootton RE, Dack K, Palmer T, Thurston R, Havdahl A, Golding J, Lawlor D, Rai D

Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study.

Mol Autism 2022 Nov 12;13(1):44. Epub 2022 nov 12

PMID: 36371219

Wootton RE, Riglin L, Blakey R, Agnew-Blais J, Caye A, Cadman T, Havdahl A, Gonçalves H, Menezes AMB, Wehrmeister FC, Rimfeld K, Davey Smith G, Eley TC, Rohde LA, Arseneault L, Moffitt TE, Stergiakouli E, Thapar A, Tilling K

Decline in attention-deficit hyperactivity disorder traits over the life course in the general population: trajectories across five population birth cohorts spanning ages 3 to 45 years.

Int J Epidemiol 2022 Jun 13;51(3):919.

PMID: 35403686

Haan E, Sallis HM, Zuccolo L, Labrecque J, Ystrom E, Reichborn-Kjennerud T, Andreassen O, Havdahl A, Munafò MR

Prenatal smoking, alcohol and caffeine exposure and maternal-reported attention deficit hyperactivity disorder symptoms in childhood: triangulation of evidence using negative control and polygenic risk score analyses.

Addiction 2022 May;117(5):1458. Epub 2021 des 5

PMID: 34791750

Lord C, Charman T, Havdahl A, Carbone P, Anagnostou E, Boyd B, Carr T, de Vries PJ, Dissanayake C, Divan G, Freitag CM, Gotelli MM, Kasari C, Knapp M, Mundy P, Plank A, Scahill L, Servili C, Shattuck P, Simonoff E, Singer AT, Slonims V, Wang PP, Ysrraelit MC, Jellett R, Pickles A, Cusack J, Howlin P, Szatmari P, Holbrook A, Toolan C, McCauley JB

The Lancet Commission on the future of care and clinical research in autism.

Lancet 2022 Jan 15;399(10321):271. Epub 2021 des 6

PMID: 34883054

Haan E, Sallis HM, Ystrom E, Njølstad PR, Andreassen OA, Reichborn-Kjennerud T, Munafò MR, Havdahl A, Zuccolo L

Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring.

Alcohol Clin Exp Res 2021 10;45(10):2090-2102. Epub 2021 sep 6

PMID: 34486127

Friel C, Leyland AH, Anderson JJ, Havdahl A, Borge T, Shimonovich M, Dundas R

Prenatal Vitamins and the Risk of Offspring Autism Spectrum Disorder: Systematic Review and Meta-Analysis.

Nutrients 2021 Jul 26;13(8). Epub 2021 jul 26

PMID: 34444717

Ip HF, van der Laan CM, Krapohl EML, Brikell I, Sánchez-Mora C, Nolte IM, St Pourcain B, Bolhuis K, Palviainen T, Zafarmand H, Colodro-Conde L, Gordon S, Zayats T, Aliev F, Jiang C, Wang CA, Saunders G, Karhunen V, Hammerschlag AR, Adkins DE, Border R, Peterson RE, Prinz JA, Thiering E, Seppälä I, Vilor-Tejedor N, Ahluwalia TS, Day FR, Hottenga JJ, Allegrini AG, Rimfeld K, Chen Q, Lu Y, Martin J, Soler Artigas M, Rovira P, Bosch R, Español G, Ramos Quiroga JA, Neumann A, Ensink J, Grasby K, Morosoli JJ, Tong X, Marrington S, Middeldorp C, Scott JG, Vinkhuyzen A, Shabalin AA, Corley R, Evans LM, Sugden K, Alemany S, Sass L, Vinding R, Ruth K, Tyrrell J, Davies GE, Ehli EA, Hagenbeek FA, De Zeeuw E, Van Beijsterveldt TCEM, Larsson H, Snieder H, Verhulst FC, Amin N, Whipp AM, Korhonen T, Vuoksimaa E, Rose RJ, Uitterlinden AG, Heath AC, Madden P, Haavik J, Harris JR, Helgeland Ø, Johansson S, Knudsen GPS, Njolstad Pr, Lu Q, Rodriguez A, Henders AK, Mamun A, Najman JM, Brown S, Hopfer C, Krauter K, Reynolds C, Smolen A, Stallings M, Wadsworth S, Wall TL, Silberg JL, Miller A, Keltikangas-Järvinen L, Hakulinen C, Pulkki-Råback L, Havdahl A, Magnus P, Raitakari OT, Perry JRB, Llop S, Lopez-Espinosa MJ, Bønnelykke K, Bisgaard H, Sunyer J, Lehtimäki T, Arseneault L, Standl M, Heinrich J, Boden J, Pearson J, Horwood LJ, Kennedy M, Poulton R, Eaves LJ, Maes HH, Hewitt J, Copeland WE, Costello EJ, Williams GM, Wray N, Järvelin MR, McGue M, Iacono W, Caspi A, Moffitt TE, Whitehouse A, Pennell CE, Klump KL, Burt SA, Dick DM, Reichborn-Kjennerud T, Martin NG, Medland SE, Vrijkotte T, Kaprio J, Tiemeier H, Davey Smith G, Hartman CA, Oldehinkel AJ, Casas M, Ribasés M, Lichtenstein P, Lundström S, Plomin R, Bartels M, Nivard MG, Boomsma DI

Genetic association study of childhood aggression across raters, instruments, and age.

Transl Psychiatry 2021 07 30;11(1):413. Epub 2021 jul 30

PMID: 34330890

Dack K, Fell M, Taylor CM, Havdahl A, Lewis SJ

Mercury and Prenatal Growth: A Systematic Review.

Int J Environ Res Public Health 2021 07 03;18(13). Epub 2021 jul 3

PMID: 34281082

Peyre H, Schoeler T, Liu C, Williams CM, Hoertel N, Havdahl A, Pingault JB

Combining multivariate genomic approaches to elucidate the comorbidity between autism spectrum disorder and attention deficit hyperactivity disorder.

J Child Psychol Psychiatry 2021 11;62(11):1285-1296. Epub 2021 jul 7

PMID: 34235737

Hannigan LJ, Havdahl A

Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021).

J Child Psychol Psychiatry 2021 05;62(5):631-634. Epub 2021 mar 21

PMID: 33748961

Havdahl A, Niarchou M, Starnawska A, Uddin M, van der Merwe C, Warrier V

Genetic contributions to autism spectrum disorder.

Psychol Med 2021 10;51(13):2260-2273. Epub 2021 feb 26

PMID: 33634770

Hannigan LJ, Askeland RB, Ask H, Tesli M, Corfield E, Ayorech Z, Helgeland Ø, Magnus P, Njølstad PR, Øyen AS, Stoltenberg C, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A

Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population.

Schizophr Bull 2021 07 08;47(4):1179-1189.

PMID: 33561255

Magnus MC, Havdahl A, Morken NH, Wensaas KA, Wilcox AJ, Håberg SE

Risk of miscarriage in women with psychiatric disorders.

Br J Psychiatry 2021 Sep;219(3):501-506.

PMID: 33448259

Eilertsen EM, Jami ES, McAdams TA, Hannigan LJ, Havdahl AS, Magnus P, Evans DM, Ystrom E

Direct and Indirect Effects of Maternal, Paternal, and Offspring Genotypes: Trio-GCTA.

Behav Genet 2021 03;51(2):154-161. Epub 2021 jan 2

PMID: 33387132

Havdahl A, Farmer C, Schjølberg S, Øyen AS, Surén P, Reichborn-Kjennerud T, Magnus P, Bresnahan M, Hornig M, Susser E, Lipkin WI, Lord C, Stoltenberg C, Thurm A, Bishop S

Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study.

J Child Psychol Psychiatry 2021 09;62(9):1070-1078. Epub 2020 des 28

PMID: 33369747

Sallis HM, Croft J, Havdahl A, Jones HJ, Dunn EC, Davey Smith G, Zammit S, Munafò MR

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood.

Psychol Med 2020 Apr 01. Epub 2020 apr 1

PMID: 32234096

Akingbuwa WA, Hammerschlag AR, Jami ES, Allegrini AG, Karhunen V, Sallis H, Ask H, Askeland RB, Baselmans B, Diemer E, Hagenbeek FA, Havdahl A, Hottenga JJ, Mbarek H, Rivadeneira F, Tesli M, van Beijsterveldt C, Breen G, Lewis CM, Thapar A, Boomsma DI, Kuja-Halkola R, Reichborn-Kjennerud T, Magnus P, Rimfeld K, Ystrom E, Jarvelin MR, Lichtenstein P, Lundstrom S, Munafò MR, Plomin R, Tiemeier H, Nivard MG, Bartels M, Middeldorp CM,

Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-analysis.

JAMA Psychiatry 2020 07 01;77(7):715-728.

PMID: 32293669

Brumpton B, Sanderson E, Heilbron K, Hartwig FP, Harrison S, Vie GÅ, Cho Y, Howe LD, Hughes A, Boomsma DI, Havdahl A, Hopper J, Neale M, Nivard MG, Pedersen NL, Reynolds CA, Tucker-Drob EM, Grotzinger A, Howe L, Morris T, Li S, , , Auton A, Windmeijer F, Chen WM, Bjørngaard JH, Hveem K, Willer C, Evans DM, Kaprio J, Davey Smith G, Åsvold BO, Hemani G, Davies NM

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.

Nat Commun 2020 07 14;11(1):3519. Epub 2020 jul 14

PMID: 32665587

Torvik FA, Eilertsen EM, McAdams TA, Gustavson K, Zachrisson HD, Brandlistuen R, Gjerde LC, Havdahl A, Stoltenberg C, Ask H, Ystrom E

Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in The Norwegian Mother, Father and Child Cohort Study.

J Child Psychol Psychiatry 2020 Sep;61(9):1009-1018. Epub 2020 jan 19

PMID: 31957030

Cheesman R, Eilertsen EM, Ahmadzadeh YI, Gjerde LC, Hannigan LJ, Havdahl A, Young AI, Eley TC, Njølstad PR, Magnus P, Andreassen OA, Ystrom E, McAdams TA

How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa).

BMC Med 2020 10 27;18(1):284. Epub 2020 okt 27

PMID: 33106172

Hughes, AM et al

Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study

eLife. pmid 36537070

Hannigan, L. J., Askeland, R. B., Ask, H., Tesli, M., Corfield, E., Ayorech, Z., Helgeland, Ø., Magnus, P., Njolstad, P. R., Øyen, A.-S., Stoltenberg, C., Andreassen, O. A., Davey Smith, G., Reichborn-Kjennerud, T., & Havdahl, A.

Genetic liability for schizophrenia and childhood psychopathology in the general population

Schizophrenia Bulletin, In press (https://doi.org/10.1093/schbul/sbaa193)

Havdahl A, Niarchou M, Starnawska A, Uddin M, van der Merwe C, Warrier V

Genetic contributions to autism spectrum disorder

Psychological Medicine, In press (doi: 10.1017/S0033291721000192)

Askeland, Ragna Bugge; Hannigan, Laurie John; Ask, Helga; Lennox, Ziada Ayorech; Tesli, Martin Steen; Corfield, Elizabeth; Magnus, Per; Njølstad, Pål Rasmus; Andreassen, Ole Andreas; Davey smith, George; Reichborn-Kjennerud, Ted; Havdahl, Alexandra

Early manifestations of genetic risk for neurodevelopmental disorders

PsyArXiv (Preprint), 2020; https://psyarxiv.com/qbvw8/

Hannigan, L., Askeland, R. B., Ask, H., Tesli, M., Corfield, E., Ayorech, Z., Magnus, P., Njolstad, P. R., Øyen, A.-S., Stoltenberg, C., Andreassen, O. A., Davey Smith, G., Reichborn-Kjennerud, T., & Havdahl, A.

Developmental milestones in early childhood and genetic liability to neurodevelopmental disorders

PsyArXiv (Preprint). https://doi.org/10.31234/osf.io/x8wst

Doktorgrader
Laura Elizabeth Hegemann

Etiology of Neurodevelopmental Traits: Measurement, Specificity, and Within-Family Transmission.

Disputert:
mai 2024
Hovedveileder:
Alexandra Karoline Saasen Havdahl
Deltagere
  • Meseret Mamo Bazezew Doktorgradsstipendiat (finansiert av denne bevilgning)
  • Jean-Baptiste Pingault Internasjonal samarbeidspartner
  • Cynthia Bulik Internasjonal samarbeidspartner
  • Helga Ask Prosjektdeltaker
  • David Evans Internasjonal samarbeidspartner
  • Neil Davies Internasjonal samarbeidspartner
  • Elise Robinson Internasjonal samarbeidspartner
  • Per Magnus Prosjektdeltaker
  • Camilla Stoltenberg Prosjektdeltaker
  • George Davey Smith Internasjonal samarbeidspartner
  • Anita Thapar Internasjonal samarbeidspartner
  • Ole Andreas Andreassen Prosjektdeltaker
  • Jo Adrian Dahl Askelund Prosjektdeltaker
  • Robyn Wootton Prosjektdeltaker
  • Ziada Ayorech Prosjektdeltaker
  • Stian Barbo Valand Prosjektkoordinator
  • Ted Reichborn-Kjennerud Medveileder
  • Laurie Hannigan Medveileder
  • Anne-Siri Øyen Prosjektdeltaker
  • Laura Hegemann Doktorgradsstipendiat (finansiert av denne bevilgning)
  • Alexandra Karoline Saasen Havdahl Prosjektleder

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