eRapport

Same genes, different disorders: understanding the developmental emergence of different psychiatric problems in the context of common genetic liabilities (MoBa-Dev)

Prosjekt
Prosjektnummer
2020023
Ansvarlig person
Laurie Hannigan
Institusjon
Lovisenberg Diakonale Sykehus
Prosjektkategori
Doktorgradsstipend
Helsekategori
Mental Health
Forskningsaktivitet
2. Aetiology
Rapporter
2024
In 2024, one of the core outputs of MoBa-Dev was published as a Registered Report in BMC Medicine, the first of its kind using this format for a MoBa project. In addition, another core paper was accepted for publication in Biological Psychiatry. Finally, the PhD fellow submitted and successfully defended the PhD thesis.In the MoBa-Dev project, we seek to understand the factors underlying the developmental emergence of different psychiatric conditions, focusing on childhood and adolescence. In the first core output published in BMC Medicine in 2024, we found that having an earlier age at menarche (or, age at onset of menses) is a causal factor involved in the development of adolescent depression, but not other mental health conditions. This project was a major undertaking studying the development of symptoms and diagnoses of mental health conditions in over 13,000 adolescents. We followed the Registered Report format, which meant that we prepared a detailed protocol of the study before accessing the data, including hypotheses, inference criteria, power analyses, and analytic code, which was rigorously peer reviewed before any analyses were done. After gaining "in-principle acceptance", we conducted the analyses as described in the protocol, whilst being reassured that the eventual article would be published by the journal regardless of the results. This format has the potential to help avoid many problems associated with research in general and scientific publishing in particular, especially the widespread phenomenon known as "publication bias". The PhD fellow also communicated the findings to a general audience through an interview with VG. In the interview, he sought to highlight that due to the small effect size, most girls experiencing an early menarche will not be at increased risk of developing depression. In the second core output of MoBa-Dev, currently in press in Biological Psychiatry (a flagship journal in the field of psychiatry), we explored the complex genetic factors underlying the development of behavioural and emotional difficulties in early childhood. This project involved a range of genomic analyses, including genome-wide association studies of longitudinal traits, a relatively novel approach within the field. We found that genetic liabilities to neurodevelopmental conditions (such as attention-deficit hyperactivity disorder and autism) were robustly associated with both general and specific traits underlying the development of behavioural and emotional difficulties in early life. The findings shed light on the nuanced genetic architecture of early childhood behavioural and emotional traits, which have been critically understudied in the past. Alongside finalising two core analytic projects and disseminating the findings in leading journals, the PhD fellow submitted and successfully defended his doctoral dissertation (on 19.09.24), titled "The differentiation of mental health problems in early life: Causes and consequences". The thesis was described as "very strong" overall by the opponents, showcasing a robust set of analyses and adherence to "best practices" for transparent and reproducible science. In between submitting and defending the dissertation, the PhD fellow was on parental leave from mid April-24 to August-24. His employment in the MoBa-Dev project ended with the defence of the dissertation, though he continues to work on some dissemination activities and analytic work related to the project's aims. MoBa-Dev will continue into 2025, as final outputs linked to the core aims of the project are published and disseminated.

No

2023
In 2023, the first core analytic project from MoBa-Dev was published in the Journal of Child Psychology and Psychiatry Advances. The second analytic project was completed, uploaded as a preprint, and is currently under review for publication. The MoBa-Dev candidate finished the year by completing further analyses and writing up his PhD thesis.In the first main paper from the MoBa-Dev project, we investigated the differentiation of behavioral and emotional problems in children. We used data from approximately 79,000 children in the Norwegian Mother, Father, and Child Cohort Study, combined with health care registries. Our study emphasizes that differentiation of these problems in early childhood, beyond the total level of problems, is an indicator of specific mental health risks in later stages of childhood and adolescence. We explored various early life exposures and their association with the differentiation of behavioral and emotional problems. The study found that factors like maternal at-risk drinking were linked to differentiation toward behavioral problems in children, whereas maternal prenatal distress was associated with more emotional problems. Our research underscores the value of understanding the differentiation of behavioral and emotional problems in early childhood. This insight may inform early detection and intervention strategies in mental health. The findings suggest that specific early life factors can influence the trajectory of behavioral and emotional problems, which may help in tailoring early interventions to prevent the progression of mental health issues in later life. In the second main paper for the project, now available prior to publication as a preprint, we explored the complex genetic factors associated with the differentiation of behavioral and emotional problems in around 79,000 children. We discovered that certain genetic factors, especially those linked to neurodevelopmental conditions, play a significant role in how these problems develop and differ among children. This insight is crucial for understanding the nuanced nature of child behavioral and emotional conditions and the role genetics play in them. We also observed that the influence of these genetic factors was not uniform across behavioral and emotional problems. Certain genetic predispositions are more strongly associated with specific types of issues, underscoring the diverse genetic architecture underlying child behavioral and emotional conditions. This variation in genetic influence highlights the complexity of understanding and addressing childhood behavioral and emotional problems. The study contributes to the field of child psychology and psychiatry by illuminating the specific genetic factors involved in the development of behavioral and emotional problems, thus providing a more nuanced understanding of their genetic underpinnings. This knowledge is crucial for developing better-informed strategies for early identification and prevention in child mental health. The project will conclude in 2024, as the MoBa-Dev team carries out the final analyses for the project, works to get all outputs published in leading scientific journals, and the PhD candidate completes the defense of his thesis.

The PhD candidate carried out a research visit to the MRC Integrative Epidemiology Unit at the University of Bristol as planned in the previous period. The duration of the visit (~2 weeks) was substantially reduced due for family reasons, but the candidate was still able to present his ongoing work in the visited department, receiving important methodological feedback. He also participated in discussion groups about Mendelian randomization (an important method used in MoBa-Dev), liaised with collaborators, and discussed preliminary results with important coauthors.

2022
In 2022, the PhD candidate 1) submitted a manuscript on the differentiation of behavioural and emotional problems in children, 2) presented further analyses on the genomics of differentiation at a conference, and 3) received in-principle acceptance for a Registered Report investigating links between pubertal timing and adolescent mental health.Since the last reporting period, the first analytic project on the differentiation of emotional and behavioural problems in early childhood has been written up, uploaded as a pre-print for early review by the scientific community, and submitted for publication (currently under review). In this project, we have identified several environmental factors associated with differentiation across childhood. That is, as well as demonstrating that some factors are linked to generalised vulnerability to developing emotional and behavioural problems, we have found that others are more associated with a process of differentiation toward either behavioural or emotional problems. Maternal drinking behaviour is one such factor - we found that this was linked to children having relatively more behavioural problems than emotional problems. The candidate has followed up the work in the first project by conducting extensive genomic analyses of psychiatric symptom differentiation in early life. These analyses have been preregistered, and preliminary findings were presented in a talk at the World Congress of Psychiatric Genetics in Florence, Italy in 2022. In this project, genetic liability to developing attention deficit hyperactivity disorder (ADHD) was seen to be an important factor driving the differentiation of symptoms towards behavioural problems. The candidate is currently working on finalising the analyses and writing up the results for publication. Also in 2022, a Registered Report on the impact of pubertal timing on adolescent mental health was awarded acceptance-in-principle in BMC Medicine, based on a thorough review of the Stage 1 protocol. This highly detailed protocol was prepared before data was available to the researchers, protecting against many forms of biases that can affect hypothesis-testing research. Towards the end of 2022, the 14-year data in MoBa became available, enabling the candidate to begin on the analyses and preparing the Stage 2 Registered Report. In this format, the Stage 2 report will be published regardless of what the results look like, provided that the Stage 1 protocol is followed. In this project, the MoBa-Dev team aims to establish whether early onset of menses (as a marker of early pubertal timing) has a causal impact on the development of different mental health problems in adolescents, using advanced statistical and genetic methods. During the reporting period, the candidate has also contributed to 3 additional publications as part of large-scale projects focusing on replication efforts and the Covid-19 pandemic, and to an analytic project now under review and available as a preprint, in which the role of maternal at-risk drinking in early life behavioural and emotional problems was investigated in the context of genetic susceptibility. During the next reporting period, the candidate aims to pre-print and submit the paper on the genomics of psychiatric symptom differentiation and the Stage 2 Registered Report, in addition to preparing the PhD dissertation for submission. Work on the MoBa-Dev project will continue until November 2023.

No

2021
In 2021, the PhD candidate has continued with the statistical analyses for a study of differentiation of mental health problems in children, and developed a Registered Report investigating the causal role of pubertal timing in different adolescent mental health disorders.The first project develops a novel approach to study differentiation of emotional and behavioural problems in early childhood and how this relates to mental health disorders later in childhood and adolescence. Furthermore, the project aims to identify which aspects of the child's early environment contribute to this differentiation, accounting for unobserved familial risk. The analysis plan for the project has been preregistered. Preliminary results validate the approach, and tentatively show that multiple environmental factors predict symptom differentiation in early childhood. The findings from this analysis will be written up, pre-printed, and submitted for publication during the next reporting period. In the second project, the MoBa-Dev team aims to establish whether early onset of menses (as a marker of early pubertal timing) has a causal impact on the development of different mental health problems in adolescents, using advanced statistical and genetic methods. With the help of a broad team of collaborators, the candidate has prepared and submitted a Stage 1 Registered Report on this topic (a highly detailed protocol that is peer reviewed and can be accepted in principle before analyses are done, meaning that the eventual Stage 2 article will be published regardless of results). For this project they plan to use the 14-year MoBa data, which is yet to be released. This approach ensures that analyses are free from biases that can arise when the data is already available, following open science principles. Next, the candidate plans to investigate genetic and environmental moderators of risk and resilience in children whose mothers have symptoms of mental health problems such as anxiety and depression. The candidate has completed all of the compulsory courses in the PhD programme at the Department of Psychology (UiO) in 2021, and started a social network with 100 PhD candidates from the department, organising regular academic and social events. On the side, the candidate has contributed to large-scale research projects related to the Covid-19 pandemic, of which one was published in Nature Human Behaviour and another was accepted in PNAS in 2021. Work on the MoBa-Dev project will continue until November 2023.

No

2020
The main aim of the project is to investigate why young people develop different mental health problems, exploring the impact of genetic and environmental factors.Progress in psychiatric genetics has shown that genetic risk for mental health problems is more generalized than disorder-specific. However, even people with a similar genetic ‘starting point’ go on to develop specific mental health problems such as 'panic disorder' and 'ADHD'. So why, in the context of generalized genetic risk, do specific disorders emerge? Are there environmental exposures that contribute to symptom differentiation throughout an individual’s lifespan? Are the effects of subtle differences in individuals’ genetic risk profiles amplified over time? The MoBa-Dev team will address these questions by applying a unique combination of methods to data from the Norwegian Mother, Father, and Child Cohort Study (MoBa). MoBa is a longitudinal pregnancy cohort study including more than 114,000 children, 90,000 mothers and 70,000 fathers. The ultimate goal of this research is to provide clinicians with information about who is at risk, and for which mental health disorders. Adrian Dahl Askelund, Cand. Psychol., was employed as the PhD candidate of this project on the 1st of November 2020. The project is conducted as part of the Psychiatric Genetic Epidemiology (PaGE) group at Nic Waals Institute within Lovisenberg Diaconal Hospital, in collaboration with the Norwegian Institute of Public Health, the MRC Integrative Epidemiology Unit at the University of Bristol (MRC IEU), King's College London and University College London. The PhD candidate is currently undertaking the statistical analyses for a study of differentiation of mental health problems in children. Next, he plans to investigate the factors and mechanisms behind symptom differentiation and resilience in adolescents, pending the release of the 14-year data. He finally aims to establish the potential causal role of any identified mechanisms using state-of-the-art genetic methods.

No

Vitenskapelige artikler
Askelund AD, Wootton RE, Torvik FA, Lawn RB, Ask H, Corfield EC, Magnus MC, Reichborn-Kjennerud T, Magnus PM, Andreassen OA, Stoltenberg C, Davey Smith G, Davies NM, Havdahl A, Hannigan LJ

Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study.

BMC Med 2024 Apr 12;22(1):155. Epub 2024 apr 12

PMID: 38609914 - Inngår i doktorgradsavhandlingen

Hannigan LJ, Lund IO, Dahl Askelund A, Ystrom E, Corfield EC, Ask H, Havdahl A

Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems.

Psychol Med 2024 Jan;54(1):203. Epub 2023 nov 6

PMID: 37929303

Hegemann L, Corfield EC, Askelund AD, Allegrini AG, Askeland RB, Ronald A, Ask H, St Pourcain B, Andreassen OA, Hannigan LJ, Havdahl A

Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.

Mol Autism 2024 Jun 07;15(1):25. Epub 2024 jun 7

PMID: 38849897

Askelund AD, Ask H, Ystrom E, Havdahl A, Hannigan LJ

Exploring the differentiation of behavioural and emotional problems across childhood: A prospective longitudinal cohort study.

JCPP Adv 2023 Dec;3(4):e12176. Epub 2023 jun 30

PMID: 38054063 - Inngår i doktorgradsavhandlingen

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The Psychological Science Accelerator's COVID-19 rapid-response dataset.

Sci Data 2023 Feb 11;10(1):87. Epub 2023 feb 11

PMID: 36774440

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In COVID-19 Health Messaging, Loss Framing Increases Anxiety with Little-to-No Concomitant Benefits: Experimental Evidence from 84 Countries.

Affect Sci 2022 Sep;3(3):577. Epub 2022 sep 26

PMID: 36185503

A global experiment on motivating social distancing during the COVID-19 pandemic.

Proc Natl Acad Sci U S A 2022 May 31;119(22):e2111091119. Epub 2022 mai 27

PMID: 35622891

Ruggeri K, Panin A, Vdovic M, Veckalov B, Abdul-Salaam N, Achterberg J, Akil C, Amatya J, Amatya K, Andersen TL, Aquino SD, Arunasalam A, Ashcroft-Jones S, Askelund AD, Ayacaxli N, Sheshdeh AB, Bailey A, Barea Arroyo P, Mejía GB, Benvenuti M, Berge ML, Bermaganbet A, Bibilouri K, Bjørndal LD, Black S, Lyshol JKB, Brik T, Buabang EK, Burghart M, Bursalioglu A, Buzayu NM, Cadek M, de Carvalho NM, Cazan AM, Çetinçelik M, Chai VE, Chen P, Chen S, Clay G, D'Ambrogio S, Damnjanovic K, Duffy G, Dugue T, Dwarkanath T, Envuladu EA, Erceg N, Esteban-Serna C, Farahat E, Farrokhnia RA, Fawad M, Fedryansyah M, Feng D, Filippi S, Fonollá MA, Freichel R, Freira L, Friedemann M, Gao Z, Ge S, Geiger SJ, George L, Grabovski I, Gracheva A, Gracheva A, Hajian A, Hasan N, Hecht M, Hong X, Hubená B, Ikonomeas AGF, Ilic S, Izydorczyk D, Jakob L, Janssens M, Jarke H, Kácha O, Kalinova KN, Kapingura FM, Karakasheva R, Kasdan DO, Kemel E, Khorrami P, Krawiec JM, Lagidze N, Lazarevic A, Lazic A, Lee HS, Lep Ž, Lins S, Lofthus IS, Macchia L, Mamede S, Mamo MA, Maratkyzy L, Mareva S, Marwaha S, McGill L, McParland S, Melnic A, Meyer SA, Mizak S, Mohammed A, Mukhyshbayeva A, Navajas J, Neshevska D, Niazi SJ, Nieves AEN, Nippold F, Oberschulte J, Otto T, Pae R, Panchelieva T, Park SY, Pascu DS, Pavlovic I, Petrovic MB, Popovic D, Prinz GM, Rachev NR, Ranc P, Razum J, Rho CE, Riitsalu L, Rocca F, Rosenbaum RS, Rujimora J, Rusyidi B, Rutherford C, Said R, Sanguino I, Sarikaya AK, Say N, Schuck J, Shiels M, Shir Y, Sievert EDC, Soboleva I, Solomonia T, Soni S, Soysal I, Stablum F, Sundström FTA, Tang X, Tavera F, Taylor J, Tebbe AL, Thommesen KK, Tobias-Webb J, Todsen AL, Toscano F, Tran T, Trinh J, Turati A, Ueda K, Vacondio M, Vakhitov V, Valencia AJ, Van Reyn C, Venema TAG, Verra SE, Vintr J, Vranka MA, Wagner L, Wu X, Xing KY, Xu K, Xu S, Yamada Y, Yosifova A, Zupan Z, García-Garzon E

The globalizability of temporal discounting.

Nat Hum Behav 2022 Oct;6(10):1386. Epub 2022 jul 11

PMID: 35817934

Wang K, Goldenberg A, Dorison CA, Miller JK, Uusberg A, Lerner JS, Gross JJ, Agesin BB, Bernardo M, Campos O, Eudave L, Grzech K, Ozery DH, Jackson EA, Garcia EOL, Drexler SM, Jurkovic AP, Rana K, Wilson JP, Antoniadi M, Desai K, Gialitaki Z, Kushnir E, Nadif K, Bravo ON, Nauman R, Oosterlinck M, Pantazi M, Pilecka N, Szabelska A, van Steenkiste IMM, Filip K, Bozdoc AI, Marcu GM, Agadullina E, Adamkovic M, Roczniewska M, Reyna C, Kassianos AP, Westerlund M, Ahlgren L, Pöntinen S, Adetula GA, Dursun P, Arinze AI, Arinze NC, Ogbonnaya CE, Ndukaihe ILG, Dalgar I, Akkas H, Macapagal PM, Lewis S, Metin-Orta I, Foroni F, Willis M, Santos AC, Mokady A, Reggev N, Kurfali MA, Vasilev MR, Nock NL, Parzuchowski M, Espinoza Barría MF, Vranka M, Kohlová MB, Ropovik I, Harutyunyan M, Wang C, Yao E, Becker M, Manunta E, Kaminski G, Marko D, Evans K, Lewis DMG, Findor A, Landry AT, Aruta JJB, Ortiz MS, Vally Z, Pronizius E, Voracek M, Lamm C, Grinberg M, Li R, Valentova JV, Mioni G, Cellini N, Chen SC, Zickfeld J, Moon K, Azab H, Levy N, Karababa A, Beaudry JL, Boucher L, Collins WM, Todsen AL, van Schie K, Vintr J, Bavolar J, Kaliska L, Križanic V, Samojlenko L, Pourafshari R, Geiger SJ, Beitner J, Warmelink L, Ross RM, Stephen ID, Hostler TJ, Azouaghe S, McCarthy R, Szala A, Grano C, Solorzano CS, Anjum G, Jimenez-Leal W, Bradford M, Pérez LC, Cruz Vásquez JE, Galindo-Caballero OJ, Vargas-Nieto JC, Kácha O, Arvanitis A, Xiao Q, Cárcamo R, Zorjan S, Tajchman Z, Vilares I, Pavlacic JM, Kunst JR, Tamnes CK, von Bastian CC, Atari M, Sharifian M, Hricova M, Kacmár P, Schrötter J, Rahal RM, Cohen N, FatahModarres S, Zrimsek M, Zakharov I, Koehn MA, Esteban-Serna C, Calin-Jageman RJ, Krafnick AJ, Štrukelj E, Isager PM, Urban J, Silva JR, Martoncik M, Ocovaj SB, Šakan D, Kuzminska AO, Djordjevic JM, Almeida IAT, Ferreira A, Lazarevic LB, Manley H, Ricaurte DZ, Monteiro RP, Etabari Z, Musser E, Dunleavy D, Chou W, Godbersen H, Ruiz-Fernández S, Reeck C, Batres C, Kirgizova K, Muminov A, Azevedo F, Alvarez DS, Butt MM, Lee JM, Chen Z, Verbruggen F, Ziano I, Tümer M, Charyate ACA, Dubrov D, Tejada Rivera MDCMC, Aberson C, Pálfi B, Maldonado MA, Hubena B, Sacakli A, Ceary CD, Richard KL, Singer G, Perillo JT, Ballantyne T, Cyrus-Lai W, Fedotov M, Du H, Wielgus M, Pit IL, Hruška M, Sousa D, Aczel B, Szaszi B, Adamus S, Barzykowski K, Micheli L, Schmidt ND, Zsido AN, Paruzel-Czachura M, Bialek M, Kowal M, Sorokowska A, Misiak M, Mola D, Ortiz MV, Correa PS, Belaus A, Muchembled F, Ribeiro RR, Arriaga P, Oliveira R, Vaughn LA, Szwed P, Kossowska M, Czarnek G, Kielinska J, Antazo B, Betlehem R, Stieger S, Nilsonne G, Simonovic N, Taber J, Gourdon-Kanhukamwe A, Domurat A, Ihaya K, Yamada Y, Urooj A, Gill T, Cadek M, Bylinina L, Messerschmidt J, Kurfali M, Adetula A, Baklanova E, Albayrak-Aydemir N, Kappes HB, Gjoneska B, House T, Jones MV, Berkessel JB, Chopik WJ, Çoksan S, Seehuus M, Khaoudi A, Bokkour A, El Arabi KA, Djamai I, Iyer A, Parashar N, Adiguzel A, Kocalar HE, Bundt C, Norton JO, Papadatou-Pastou M, De la Rosa-Gomez A, Ankushev V, Bogatyreva N, Grigoryev D, Ivanov A, Prusova I, Romanova M, Sarieva I, Terskova M, Hristova E, Kadreva VH, Janak A, Schei V, Sverdrup TE, Askelund AD, Pineda LMS, Krupic D, Levitan CA, Johannes N, Ouherrou N, Say N, Sinkolova S, Janjic K, Stojanovska M, Stojanovska D, Khosla M, Thomas AG, Kung FYH, Bijlstra G, Mosannenzadeh F, Balci BB, Reips UD, Baskin E, Ishkhanyan B, Czamanski-Cohen J, Dixson BJW, Moreau D, Sutherland CAM, Chuan-Peng H, Noone C, Flowe H, Anne M, Janssen SMJ, Topor M, Majeed NM, Kunisato Y, Yu K, Daches S, Hartanto A, Vdovic M, Anton-Boicuk L, Forbes PAG, Kamburidis J, Marinova E, Nedelcheva-Datsova M, Rachev NR, Stoyanova A, Schmidt K, Suchow JW, Koptjevskaja-Tamm M, Jernsäther T, Olofsson JK, Bialobrzeska O, Marszalek M, Tatachari S, Afhami R, Law W, Antfolk J, Žuro B, Van Doren N, Soto JA, Searston R, Miranda J, Damnjanovic K, Yeung SK, Krupic D, Hoyer K, Jaeger B, Ren D, Pfuhl G, Klevjer K, Corral-Frías NS, Frias-Armenta M, Lucas MY, Torres AO, Toro M, Delgado LGJ, Vega D, Solas SÁ, Vilar R, Massoni S, Frizzo T, Bran A, Vaidis DC, Vieira L, Paris B, Capizzi M, Coelho GLH, Greenburgh A, Whitt CM, Tullett AM, Du X, Volz L, Bosma MJ, Karaarslan C, Sarioguz E, Allred TB, Korbmacher M, Colloff MF, Lima TJS, Ribeiro MFF, Verharen JPH, Karekla M, Karashiali C, Sunami N, Jaremka LM, Storage D, Habib S, Studzinska A, Hanel PHP, Holford DL, Sirota M, Wolfe K, Chiu F, Theodoropoulou A, Ahn ER, Lin Y, Westgate EC, Brohmer H, Hofer G, Dujols O, Vezirian K, Feldman G, Travaglino GA, Ahmed A, Li M, Bosch J, Torunsky N, Bai H, Manavalan M, Song X, Walczak RB, Zdybek P, Friedemann M, Rosa AD, Kozma L, Alves SG, Lins S, Pinto IR, Correia RC, Babincák P, Banik G, Rojas-Berscia LM, Varella MAC, Uttley J, Beshears JE, Thommesen KK, Behzadnia B, Geniole SN, Silan MA, Maturan PLG, Vilsmeier JK, Tran US, Izquierdo SM, Mensink MC, Sorokowski P, Groyecka-Bernard A, Radtke T, Adoric VC, Carpentier J, Özdogru AA, Joy-Gaba JA, Hedgebeth MV, Ishii T, Wichman AL, Röer JP, Ostermann T, Davis WE, Suter L, Papachristopoulos K, Zabel C, Ebersole CR, Chartier CR, Mallik PR, Urry HL, Buchanan EM, Coles NA, Primbs MA, Basnight-Brown DM, IJzerman H, Forscher PS, Moshontz H

A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.

Nat Hum Behav 2021 08;5(8):1089-1110. Epub 2021 aug 2

PMID: 34341554

Askelund AD, Hegemann L, Allegrini AG, Corfield EC, Ask H, Davies NM, Andreassen OA, Havdahl A, Hannigan LJ

The genetic architecture of differentiating behavioral and emotional problems in early life

Biological Psychiatry, in press (accepted 24th Dec 2024). Part of PhD dissertation

Lund IO*, Hannigan LJ*, Ask H, Askelund AD, Hegemann L, Corfield EC, Wootton RE, Ahmadzadeh Y, Davey Smith G, McAdams TA, Ystrom E, Havdahl A

Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches

BMC Medicine, in press (accepted 18th Dec 2024) *joint first

Askelund, A., Hegemann, L., Allegrini, A., Corfield, E., Ask, H., Davies, N., Andreassen, O., Havdahl, A., & Hannigan, L.

The genetic architecture of differentiating behavioural and emotional problems in early life

2023 [Preprint]. ResearchSquare. https://doi.org/10.21203/rs.3.rs-3223835/v1

Hegemann, L., Corfield, E. C., Askelund, A. D., Allegrini, A. G., Askeland, R. B., Ronald, A., Ask, H., Pourcain, B. S., Andreassen, O. A., Hannigan, L. J., & Havdahl, A.

Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study

medRxiv 2023. https://doi.org/10.1101/2023.09.20.23295829

A Askelund, RE Wootton, FA Torvik, RB Lawn, H Ask, E Corfield, MC Magnus, T Reichborn-Kjennerud, P Magnus, OA Andreassen, C Stoltenberg, G Davey Smith, NM Davies, A Havdahl, LJ Hannigan

Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study [Registered Report Stage 1 Protocol]

https://springernature.figshare.com for BMC Medicine, 2022

Adrian Dahl Askelund, Helga Ask, Eivind Ystrom, Alexandra Havdahl, Laurie John Hannigan

Exploring the differentiation of behavioural and emotional problems across childhood: a prospective longitudinal cohort study

PsyArXiv doi: 10.31234/osf.io/d8qfb, 2022

Laurie John Hannigan, Ingunn Olea Lund, Adrian Dahl Askelund, Eivind Ystrom, Elizabeth Corfield, Helga Ask, Alexandra Havdahl

Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems

PsyArXiv doi:10.31234/osf.io/g5p9f, 2022

Doktorgrader
Jo Adrian Dahl Askelund

The differentiation of mental health problems in early life: Causes and consequences

Disputert:
september 2024
Hovedveileder:
Laurie John Hannigan, Alexandra Havdahl
Deltagere
  • Anne-Siri Øyen Prosjektdeltaker
  • Helga Ask Prosjektdeltaker
  • George Davey Smith Internasjonal samarbeidspartner
  • Neil Davies Internasjonal samarbeidspartner
  • Thalia Eley Internasjonal samarbeidspartner
  • Jean-Baptiste Pingault Internasjonal samarbeidspartner
  • Jo Adrian Dahl Askelund Doktorgradsstipendiat (finansiert av denne bevilgning)
  • Ted Reichborn-Kjennerud Medveileder
  • Laurie Hannigan Prosjektleder
  • Alexandra Karoline Saasen Havdahl Medveileder

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

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