eRapport

Causes, development and consequences of sleep problems and fatigue: The SAFE project

Prosjekt
Prosjektnummer
2021045
Ansvarlig person
Laurie Hannigan
Institusjon
Lovisenberg Diakonale Sykehus
Prosjektkategori
Postdoktorstipend
Helsekategori
Mental Health, Neurological, Disputed aetiology and other
Forskningsaktivitet
2. Aetiology, 4. Detection and Diagnosis
Rapporter
2024
In 2024, the project fellow completed (1) the quality control of the MoBa genotype data, a crucial preparatory step required to fulfil the SAFE project aims (which is being used by numerous research groups); and (2) the investigation of the genetic architecture of mother-reported and clinically diagnosed sleep problems in children and adolescents.The SAFE fellow has continued to lead the quality control (QC), phasing, imputation, and post-imputation QC of the MoBa genotype data; this work was submitted for publication in 2024. The resulting data has been used in the SAFE project to answer important questions about how common genetic variants are linked to sleep problems and fatigue. In particular, we have used the data to determine if mother-reported and clinically diagnosed sleep problems in children and adolescents have a genetic contribution (pre-registration: https://doi.org/10.17605/OSF.IO/DNTY8). The results from the analyses of approximately 63,000 individuals revealed common genetic factors are associated with sleep problems, with SNP-based heritability estimates ranging from 8-17%. Sex differences were observed in the underlying genetic architecture of sleep problems. Furthermore, significant positive genetic correlations were observed between sleep problems in childhood and adolescence and psychiatric disorders, such as post-traumatic stress disorder, depression, and attention-deficit hyperactivity disorder. We have drafted a manuscript detailing these results, which will be submitted for publication in early 2025. Similarly, we have continued working on the analysis plan entitled “Investigating the relationship between sleep phenotypes and neurodevelopmental conditions in children and adolescents from the Norwegian Mother, Father, and Child Cohort Study (MoBa)”. During 2024, additional adolescent self-report data from the MoBa youth questionnaire was received, for the age period 13-15 years. Therefore, we have worked on harmonising the new data, with the adolescent self-report data we already had access to from the MoBa 14 year questionnaire. The new results from these analyses show that children and adolescents with neurodevelopmental conditions experience higher levels of sleep problems, with very small effects of neurodevelopment polygenic scores on sleep duration. In early 2025, we will conduct the sensitivity analyses detailed in the analysis plan before submitting these findings for publication. Throughout the SAFE fellow’s research visit to the MRC Integrative Epidemiology Unit at the University of Bristol, they have been preparing to investigate the causal risk factors and consequences of sleep problems. Through training materials, conferences, workshops, seminars, and regular meetings with the fellow's local host Professor Gibran Hemani (as detailed in the research stays abroad section) the fellow now has the knowledge required to appropriately perform the causality and consequences analyses included in the SAFE project. Additionally, the SAFE fellow continues to contribute to national and international collaborations, including the Psychiatric Genomics Consortium (PGC), EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium, and Personality Disorders Genomics consortium. Continued participation in these working groups allows the SAFE project early access to the largest summary statistics for these disorders, which will be used in SAFE to perform genetic correlation, polygenic score, and Mendelian randomisation analyses. Throughout 2024, the SAFE fellow was the first author on one conference presentation (lightning talk) and one seminar presentation. Additionally, they were a co-author on 13 published articles, 5 pre-print manuscripts, and 9 conference presentations. Work on the SAFE project will continue throughout 2025.

The project fellow has completed 7.25 months (based on having a 100% position until mid-September when it reduced to 50%) at the University of Bristol, UK. During this time the fellow has formed gained valuable knowledge and experiences in addition to expanding their collaboration network. For example, the fellow has gained the knowledge required to complete aim 3 of the SAFE project. This was achieved in a number of ways, including (1) completing the Bristol Medical School Causal inferences in Epidemiology: Concepts and Methods, Statistical Methods for Mediation Analysis, and Mendelian Randomisation (MR) short courses through their materials and recordings training; (2) attending the sixth MR conference and completing the Intermediate MR pre-conference course; (3) attend numerous seminar series (MRC Integrative Epidemiology Unit (IEU), Mendelian randomization, molecular epidemiology, and immunopsychiatry series); (4) attending the Mendelian randomization program, immunopsychiatry program, and IEU retreats; and (5) discussing the SAFE project at regular meeting with the fellow's local host Professor Gibran Hemani. Additionally, the fellow has disseminated SAFE findings by presenting their research at the IEU monthly meeting and gained teaching experience through tutoring the Bristol Medical School Introduction to R and Genetic Epidemiology short courses. The research visit continues in 2025.

2023
During 2023, the postdoctoral fellow conducted planning, analytical, and dissemination activities key to SAFE project. These research activities investigated (1) the genetic architecture of sleep problems in children and adolescents and (2) the relationship between sleep phenotypes and neurodevelopmental conditions in children and adolescents.On March 3, the postdoctoral fellow submitted a pre-registration entitled “Investigating the genetic architecture of sleep problems in childhood and adolescence in the Norwegian Mother, Father, and Child Cohort Study (MoBa)” (https://doi.org/10.17605/OSF.IO/DNTY8). The fellow conducted these analyses and presented the results at the international Behavior Genetics Association conference in Mucria, Spain on June 24. The results indicate that common genetic variants contribute to clinically diagnosed sleep problems in children and adolescents. These findings will be submitted for publication early in 2024. Similarly, the analysis plan entitled “Investigating the relationship between sleep phenotypes and neurodevelopmental conditions in children and adolescents from the Norwegian Mother, Father, and Child Cohort Study (MoBa)” was finalised. Preliminary analyses were conducted, and the results were presented (in poster format) at the World Congress of Psychiatric Genetics in Montreal, Canada on October 11. The preliminary results show that children and adolescents with neurodevelopmental conditions experience higher levels of both clinically diagnosed and mother-reported sleep problems. These analyses are ongoing and will be submitted for publication in 2024. The SAFE fellow has continued to lead the quality control (QC) of the MoBa genotype data a crucial preparatory step in fulfilling the main goals of the SAFE projects. Throughout 2023, work has been conducted to complete the QC of the sex chromosomes and mitochondrial DNA in the largest subpopulation of MoBa. The results from this effort are being incorporated into the initial pre-print (which describes the autosomal QC pipeline) and will be submitted for publication early in 2024. This data will be used to answer important questions about how common genetic variants are linked to problems such as sleep and fatigue. Additionally, the SAFE fellow continues to contribute to national and international collaborations, including the Psychiatric Genomics Consortium (PGC). In 2023, they submitted summary statistics for the Tic Disorders and autism ICD-10 item code genome-wide association meta-analyses. Continued participation in these working groups allow us early access to the largest summary statistics for these disorders, which will be used in the SAFE project to estimate genetic correlations and polygenic risk scores (statistical analyses that will be conducted in aim 2 of the SAFE project). Furthermore, our collaboration with the PGC enabled the SAFE fellow to attend the Trainers Development Program, in October, to learn statistical approaches to conduct multi-ancestry analysis. Throughout 2023, the postdoctoral fellow was the first author on two conference presentations (one oral and one poster) and was co-author on 7 published articles, 11 pre-print manuscripts, 10 conference presentations (5 oral and 5 poster), and 1 seminar presentation. The fellow applied to the HSØ November call for 2024 mobility grant funding for ongoing projects and was awarded 11 months funding to undertake two 5.5 month research stays in the UK. Work on the SAFE project will continue until November 30, 2024.

No

2022
In 2022, the postdoctoral fellow was the first author on one pre-print, one conference (poster) presentation, two institutional seminars, and one University of Oslo workshop (session included both lecture and practical sessions), and was co-author on four articles (including 1 pre-print) and seven conference presentations (3 oral and 4 poster).In 2022, the postdoctoral fellow led the quality control (QC) of the MoBa genotype data - a crucial preparatory step in fulfilling the main goals of the SAFE projects. This was completed for the autosomes (chromosome 1-22) for the largest subpopulation (European) of MoBa during the spring. In total, 207,569 unique individuals (90% of the genotyped individuals) and 6,981,748 genetic variants passed the MoBaPsychGen QC pipeline, meaning that they are now available to be analysed by researchers in the SAFE project (and others) to answer important questions about how common genetic variants are linked to problems such as sleep and fatigue. MoBa contains a highly complex relatedness structure, with a variety of family groupings. This meant that the SAFE fellow had to develop a novel, robust QC pipeline, in which within-generation and across-generation first-degree, second-degree, and third-degree relationships were identified at several stages. The individuals passing post-imputation QC comprised 64,471 families ranging in size from singletons to 84 unique individuals. The relationships identified include 287 monozygotic twin pairs, 22,884 full siblings (including dizygotic twin pairs), 117,004 parent-offspring pairs, 23,299 second-degree relative pairs, and 10,828 third-degree relative pairs. Knowing about and accounting for these family groupings is essential to allow the upcoming SAFE analyses to be carried out correctly. The results of the QC process led by the SAFE fellow have been published as a pre-print on BioRxiv, and presented as a poster at the World Congress of Psychiatric Genetics. The next steps in this section of the projects are to quality control of the sex chromosomes in the largest subpopulation of MoBa. Once this is completed the other subpopulations of MoBa will be incorporated into the pipeline, and the overall results will be submitted in a high-quality peer-reviewed journal. The robustly quality-controlled genetic data from the MoBaPsychGen pipeline will be used for all upcoming analyses in the SAFE project, which will utilise the unique extended family structure to address the novel research questions in the project. Analysis plans have been compiled for the two core SAFE analytic projects, the first of which is due to be pre-registered in February 2023 - meaning that work on it can then begin. The main goal of this project will be to investigate the genetic predisposition of sleep problems, across sex and developmental stages, at levels of increasing specificity and severity of symptoms. Similar work on fatigue is planned for later in 2023; this work is currently being planned in conjunction with user representatives, whose input is considered crucial to ensure correct handling of a sensitive topic in which user experiences have historically not always been appropriately acknowledged. Additionally, the postdoctoral fellow continues to contribute to national and international collaborations, including the Psychiatric Genomics Consortium (PGC). Continued participation in these working groups allow us early access to the largest summary statistics for these disorders, which will be used in the SAFE project to estimate genetic correlations and polygenic risk scores (statistical analyses that will be conducted in aim 2 of the SAFE project). Work on the SAFE project will continue until November 2024.

NO

2021
The SAFE project commenced in December 2021 with the employment of Elizabeth Corfield, PhD, as the postdoctoral research fellow. She is currently undertaking the quality control of the MoBa genotype data that will be used for all analyses in the project.Sleep problems and fatigue conditions are prevalent and increasing over time, and are associated with functional impairments, reduced quality of life, and risk of suicide. A crucial barrier to developing effective prevention and treatment interventions is that the causal mechanisms underlying the development of sleep problems and fatigue are largely unknown. The SAFE project is designed to meet this challenge by using prospective, longitudinal data from the world’s largest pregnancy cohort, the Norwegian Mother, Father, and Child Cohort (MoBa). The objective of the SAFE project is to increase our understanding of the mechanisms underlying sleep problems and fatigue. Specifically, the SAFE project will: 1. Characterize the genetic influences on sleep problems and fatigue during development from birth to adulthood in males and females; 2. Examine the joint genetic and environmental architecture of sleep problems and fatigue with other co-occurring health problems; 3. Identify causal risk factors and consequences of sleep problems and fatigue; and 4. Investigate genetic and environmental pathways of intergenerational transmission. Over the first year of the SAFE project, postdoctoral fellow Elizabeth Corfield will begin carrying out analyses to investigate the genetic predisposition of sleep problems and fatigue, across sex and developmental stages, at three levels of increasing specificity and severity of symptoms. She will then examine the joint genetic and environmental architecture of sleep problems and fatigue, both within and across the sleep problems and fatigue spectra, as well as with co-occurring conditions. It is anticipated that preliminary results from the project will be shared via conference presentations and preprinted manuscripts during the next reporting period.

No

Vitenskapelige artikler
Hegemann L, Corfield EC, Askelund AD, Allegrini AG, Askeland RB, Ronald A, Ask H, St Pourcain B, Andreassen OA, Hannigan LJ, Havdahl A

Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.

Mol Autism 2024 Jun 07;15(1):25. Epub 2024 jun 7

PMID: 38849897

Bakken NR, Parker N, Hannigan LJ, Hagen E, Parekh P, Shadrin A, Jaholkowski P, Frei E, Birkenæs V, Hindley G, Hegemann L, Corfield EC, Tesli M, Havdahl A, Andreassen OA

Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders.

J Child Psychol Psychiatry 2024 Oct 27. Epub 2024 okt 27

PMID: 39462222

Wootton RE, Dack K, Jones HJ, Riglin L, Madley-Dowd P, Borges C, Pagoni P, Roth C, Brantsæter AL, Corfield EC, Stoltenberg C, Øyen AS, Davey Smith G, Ask H, Thapar A, Stergiakouli E, Havdahl A

Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.

Psychol Med 2024 Sep 09;54(12):1. Epub 2024 sep 9

PMID: 39248077

Hughes AM, Torvik FA, van Bergen E, Hannigan LJ, Corfield EC, Andreassen OA, Ystrom E, Ask H, Smith GD, Davies NM, Havdahl A

Parental education and children's depression, anxiety, and ADHD traits, a within-family study in MoBa.

NPJ Sci Learn 2024 Jul 18;9(1):46. Epub 2024 jul 18

PMID: 39025869

Solberg BS, Kvalvik LG, Instanes JT, Hartman CA, Klungsøyr K, Li L, Larsson H, Magnus P, Njølstad PR, Johansson S, Andreassen OA, Bakken NR, Bekkhus M, Austerberry C, Smajlagic D, Havdahl A, Corfield EC, Haavik J, Gjestad R, Zayats T

Maternal Fiber Intake During Pregnancy and Development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father, and Child Cohort Study.

Biol Psychiatry 2024 May 01;95(9):839. Epub 2023 des 22

PMID: 38142720

Askelund AD, Wootton RE, Torvik FA, Lawn RB, Ask H, Corfield EC, Magnus MC, Reichborn-Kjennerud T, Magnus PM, Andreassen OA, Stoltenberg C, Davey Smith G, Davies NM, Havdahl A, Hannigan LJ

Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study.

BMC Med 2024 Apr 12;22(1):155. Epub 2024 apr 12

PMID: 38609914

Frach L, Barkhuizen W, Allegrini AG, Ask H, Hannigan LJ, Corfield EC, Andreassen OA, Dudbridge F, Ystrom E, Havdahl A, Pingault JB

Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study.

Mol Psychiatry 2024 Apr;29(4):951. Epub 2024 jan 16

PMID: 38225381

Sunde HF, Eftedal NH, Cheesman R, Corfield EC, Kleppesto TH, Seierstad AC, Ystrom E, Eilertsen EM, Torvik FA

Genetic similarity between relatives provides evidence on the presence and history of assortative mating.

Nat Commun 2024 Mar 26;15(1):2641. Epub 2024 mar 26

PMID: 38531929

Hernandez MH, Cohen JM, Skåra KH, Grindstad TK, Lee Y, Magnus P, Njølstad PR, Andreassen OA, Corfield EC, Havdahl A, Molden E, Furu K, Magnus MC, Hernaez A

Placental efflux transporters and antiseizure or antidepressant medication use impact birth weight in MoBa cohort.

iScience 2024 Mar 15;27(3):109285. Epub 2024 feb 20

PMID: 38455980

D'Urso S, Moen GH, Hwang LD, Hannigan LJ, Corfield EC, Ask H, Johannson S, Njølstad PR, Beaumont RN, Freathy RM, Evans DM, Havdahl A

Intrauterine Growth and Offspring Neurodevelopmental Traits: A Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa).

JAMA Psychiatry 2024 Feb 01;81(2):144.

PMID: 37878341

Hernáez Á, Lee Y, Page CM, Skåra KH, Håberg SE, Magnus P, Njølstad PR, Andreassen OA, Corfield EC, Havdahl A, Fraser A, Burgess S, Lawlor DA, Magnus MC

Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father, and Child Cohort Study.

Hum Reprod 2024 Feb 01;39(2):436.

PMID: 37949105

Hernáez Á, Skåra KH, Page CM, Mitter VR, Hernández MH, Magnus P, Njølstad PR, Andreassen OA, Corfield EC, Havdahl A, Næss Ø, Brumpton B, Åsvold BO, Lawlor DA, Fraser A, Magnus MC

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study.

BMC Med 2024 Jan 25;22(1):35. Epub 2024 jan 25

PMID: 38273336

Strom NI, Verhulst B, Bacanu SA, Cheesman R, Purves KL, Gedik H, Mitchell BL, Kwong AS, Faucon AB, Singh K, Medland S, Colodro-Conde L, Krebs K, Hoffmann P, Herms S, Gehlen J, Ripke S, Awasthi S, Palviainen T, Tasanko EM, Peterson RE, Adkins DE, Shabalin AA, Adams MJ, Iveson MH, Campbell A, Thomas LF, Winsvold BS, Drange OK, Børte S, Ter Kuile AR, Nguyen TH, Meier SM, Corfield EC, Hannigan L, Levey DF, Czamara D, Weber H, Choi KW, Pistis G, Couvy-Duchesne B, Van der Auwera S, Teumer A, Karlsson R, Garcia-Argibay M, Lee D, Wang R, Bjerkeset O, Stordal E, Bäckmann J, Salum GA, Zai CC, Kennedy JL, Zai G, Tiwari AK, Heilmann-Heimbach S, Schmidt B, Kaprio J, Kennedy MM, Boden J, Havdahl A, Middeldorp CM, Lopes FL, Akula N, McMahon FJ, Binder EB, Fehm L, Ströhle A, Castelao E, Tiemeier H, Stein DJ, Whiteman D, Olsen C, Fuller Z, Wang X, Wray NR, Byrne EM, Lewis G, Timpson NJ, Davis LK, Hickie IB, Gillespie NA, Milani L, Schumacher J, Woldbye DP, Forstner AJ, Nöthen MM, Hovatta I, Horwood J, Copeland WE, Maes HH, McIntosh AM, Andreassen OA, Zwart JA, Mors O, Børglum AD, Mortensen PB, Ask H, Reichborn-Kjennerud T, Najman JM, Stein MB, Gelernter J, Milaneschi Y, Penninx BW, Boomsma DI, Maron E, Erhardt-Lehmann A, Rück C, Kircher TT, Melzig CA, Alpers GW, Arolt V, Domschke K, Smoller JW, Preisig M, Martin NG, Lupton MK, Luik AI, Reif A, Grabe HJ, Larsson H, Magnusson PK, Oldehinkel AJ, Hartman CA, Breen G, Docherty AR, Coon H, Conrad R, Lehto K, , Deckert J, Eley TC, Mattheisen M, Hettema JM

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

medRxiv 2024 Jul 05. Epub 2024 jul 5

PMID: 39006447

Hannigan LJ, Lund IO, Dahl Askelund A, Ystrom E, Corfield EC, Ask H, Havdahl A

Genotype-environment interplay in associations between maternal drinking and offspring emotional and behavioral problems.

Psychol Med 2024 Jan;54(1):203. Epub 2023 nov 6

PMID: 37929303

Wootton RE, Lawn RB, Magnus MC, Treur JL, Corfield EC, Njølstad PR, Andreassen OA, Lawlor DA, Munafò MR, Håberg SE, Davey Smith G, Reichborn-Kjennerud T, Magnus P, Havdahl A

Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa).

BMC Med 2023 Apr 03;21(1):125. Epub 2023 apr 3

PMID: 37013617

Skodvin SN, Gjessing HK, Jugessur A, Romanowska J, Page CM, Corfield EC, Lee Y, Håberg SE, Gjerdevik M

Statistical methods to detect mother-father genetic interaction effects on risk of infertility: A genome-wide approach.

Genet Epidemiol 2023 Oct;47(7):503. Epub 2023 aug 28

PMID: 37638522

Demontis D, Walters GB, Athanasiadis G, Walters R, Therrien K, Nielsen TT, Farajzadeh L, Voloudakis G, Bendl J, Zeng B, Zhang W, Grove J, Als TD, Duan J, Satterstrom FK, Bybjerg-Grauholm J, Bækved-Hansen M, Gudmundsson OO, Magnusson SH, Baldursson G, Davidsdottir K, Haraldsdottir GS, Agerbo E, Hoffman GE, Dalsgaard S, Martin J, Ribasés M, Boomsma DI, Soler Artigas M, Roth Mota N, Howrigan D, Medland SE, Zayats T, Rajagopal VM, , , Nordentoft M, Mors O, Hougaard DM, Mortensen PB, Daly MJ, Faraone SV, Stefansson H, Roussos P, Franke B, Werge T, Neale BM, Stefansson K, Børglum AD

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.

Nat Genet 2023 Feb;55(2):198. Epub 2023 jan 26

PMID: 36702997

Askeland RB, Hannigan LJ, O'Connell KS, Corfield EC, Frei O, Thapar A, Smith GD, Reichborn-Kjennerud T, Andreassen OA, Ask H, Havdahl A

Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood.

Transl Psychiatry 2023 Jun 23;13(1):222. Epub 2023 jun 23

PMID: 37353490

Guintivano J, Byrne EM, Kiewa J, Yao S, Bauer AE, Aberg KA, Adams MJ, Campbell A, Campbell ML, Choi KW, Corfield EC, Havdahl A, Hucks D, Koen N, Lu Y, Mægbæk ML, Mullaert J, Peterson RE, Raffield LM, Sallis HM, Sealock JM, Walker A, Watson HJ, Xiong Y, Yang JMK, Anney RJL, Gordon-Smith K, Hubbard L, Jones LA, Mihaescu R, Nyegaard M, Pardiñas AF, Perry A, Saquib N, Shadyab AH, Viktorin A, Andreassen OA, Bigdeli TB, Davis LK, Dennis CL, Di Florio A, Dubertret C, Feng YA, Frey BN, Grigoriadis S, Gloaguen E, Jones I, Kennedy JL, Krohn H, Kunovac Kallak T, Li Y, Martin NG, McIntosh AM, Milgrom J, Munk-Olsen T, Oberlander T, Olsen CM, Ramoz N, Reichborn-Kjennerud T, Robertson Blackmore E, Rubinow D, Skalkidou A, Smoller JW, Stein DJ, Stowe ZN, Taylor V, Tebeka S, Tesli M, Van Lieshout RJ, van den Oord EJCG, Vigod SN, Werge T, Westlye LT, Whiteman DC, Zar HJ, , Wray N, Meltzer-Brody S, Sullivan P

Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression.

Am J Psychiatry 2023 Dec 01;180(12):884. Epub 2023 okt 18

PMID: 37849304

Howe LJ, Nivard MG, Morris TT, Hansen AF, Rasheed H, Cho Y, Chittoor G, Ahlskog R, Lind PA, Palviainen T, van der Zee MD, Cheesman R, Mangino M, Wang Y, Li S, Klaric L, Ratliff SM, Bielak LF, Nygaard M, Giannelis A, Willoughby EA, Reynolds CA, Balbona JV, Andreassen OA, Ask H, Baras A, Bauer CR, Boomsma DI, Campbell A, Campbell H, Chen Z, Christofidou P, Corfield E, Dahm CC, Dokuru DR, Evans LM, de Geus EJC, Giddaluru S, Gordon SD, Harden KP, Hill WD, Hughes A, Kerr SM, Kim Y, Kweon H, Latvala A, Lawlor DA, Li L, Lin K, Magnus P, Magnusson PKE, Mallard TT, Martikainen P, Mills MC, Njølstad PR, Overton JD, Pedersen NL, Porteous DJ, Reid J, Silventoinen K, Southey MC, Stoltenberg C, Tucker-Drob EM, Wright MJ, , , Hewitt JK, Keller MC, Stallings MC, Lee JJ, Christensen K, Kardia SLR, Peyser PA, Smith JA, Wilson JF, Hopper JL, Hägg S, Spector TD, Pingault JB, Plomin R, Havdahl A, Bartels M, Martin NG, Oskarsson S, Justice AE, Millwood IY, Hveem K, Naess Ø, Willer CJ, Åsvold BO, Koellinger PD, Kaprio J, Medland SE, Walters RG, Benjamin DJ, Turley P, Evans DM, Davey Smith G, Hayward C, Brumpton B, Hemani G, Davies NM

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.

Nat Genet 2022 May;54(5):581. Epub 2022 mai 9

PMID: 35534559

Havdahl A, Wootton RE, Leppert B, Riglin L, Ask H, Tesli M, Bugge Askeland R, Hannigan LJ, Corfield E, Øyen AS, Andreassen OA, Tilling K, Davey Smith G, Thapar A, Reichborn-Kjennerud T, Stergiakouli E

Associations Between Pregnancy-Related Predisposing Factors for Offspring Neurodevelopmental Conditions and Parental Genetic Liability to Attention-Deficit/Hyperactivity Disorder, Autism, and Schizophrenia: The Norwegian Mother, Father and Child Cohort Study (MoBa).

JAMA Psychiatry 2022 Aug 01;79(8):799.

PMID: 35793100

Pingault JB, Barkhuizen W, Wang B, Hannigan LJ, Eilertsen EM, Corfield E, Andreassen OA, Ask H, Tesli M, Askeland RB, Davey Smith G, Stoltenberg C, Davies NM, Reichborn-Kjennerud T, Ystrom E, Havdahl A

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study.

Mol Psychiatry 2023 Apr;28(4):1731. Epub 2022 nov 16

PMID: 36385167

Pettersen JH, Eilertsen E, Hegemann L, Hannigan LJ, Lund IO, Johannesen PM, Corfield EC, Ystrom E, Andreassen OA, Havdahl A, Brandlistuen RE, Ask H

Intra-familial dynamics of mental distress during the Covid-19 lockdown

medRxiv, Posted 2024 Dec 5, https://doi.org/10.1101/2024.12.04.24318462

Hubers N, Page CM, Pool R, Mbarek H, Lambalk N, Mijatovic V, Ligthart L, van Dongen J, Corfield EC, Beck JJ, Ehli EA, Martin NG, Willemsen G, Haberg S, Harris JR, Hottenga J, Boomsma DI

Genetically Informed Methods Uncover the Low Polygenicity of Natural Dizygotic Twinning and Highlight Its Role in Female Fertility and Infertility

medRxiv, Posted 2024 Dec 3, https://doi.org/10.1101/2024.12.02.24318308

Streit, Awasthi, Hall, Niarchou, Marouli, Babajide, Braun, Frank, Zillich, Callies, Avetyan, Zillich, Naamanka, Aherrahrou, Ahmad, Ask, Batzler, Benros, Brand-de Wilde, Brunak, Bruun, Christoffersen, Colodro-Conde, Coombes, Corfield, et al

Genome-wide association study of borderline personality disorder identifies six loci and highlights shared risk with mental and somatic disorders

medRxiv, Posted 2024 Nov 13, https://doi.org/10.1101/2024.11.12.24316957

Gui A, Hollowell A, Wigdor EM, Morgan MJ, Hannigan LJ, Corfield EC, Odintsova V, Hottenga J, Wong A, Pool R, Cullen H, Wilson S, Warrier V, Eilertsen EM, Andreassen OA, Middeldorp CM, St Pourcain B, Bartels M, Boomsma DI Hartmann CA, Robinson EB, et al

Genome-wide association meta-analysis of age at onset of walking

medRxiv, Posted 2024 May 8

EC Corfield, O Frei, AA Shadrin, ... , OA Andreassen, A Havdahl

The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1

bioRxiv, 2022

Deltagere
  • Laurie Hannigan Prosjektleder
  • Ole Andreas Andreassen Prosjektdeltaker
  • Helga Ask Prosjektdeltaker
  • Ziada Ayorech Prosjektdeltaker
  • Elizabeth Corfield Postdoktorstipendiat (finansiert av denne bevilgning)
  • George Davey Smith Prosjektdeltaker
  • Neil Davies Prosjektdeltaker
  • Siri Eldevik Håberg Prosjektdeltaker
  • Alexandra Karoline Saasen Havdahl Prosjektdeltaker
  • Maria Christine Magnus Prosjektdeltaker
  • Per Magnus Prosjektdeltaker
  • Ruth Mitchell Prosjektdeltaker
  • Anne-Siri Øyen Prosjektdeltaker
  • Ted Reichborn-Kjennerud Prosjektdeltaker
  • Børge Sivertsen Prosjektdeltaker
  • Patrick Sullivan Internasjonal samarbeidspartner
  • Lill-Iren Schou Trogstad Prosjektdeltaker
  • Kari Tveito Prosjektdeltaker

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

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