eRapport

Strengthening NTNU Low Birth Weight Life in national and international networks

Prosjekt
Prosjektnummer
30283
Ansvarlig person
Kari A. Indredavik Evensen
Institusjon
St. Olavs Hospital, Barne- og ungdomsklinikken
Prosjektkategori
50 % forskerstipend (Felles Forskningsutvalg)
Helsekategori
Mental Health, Musculoskeletal, Neurological
Forskningsaktivitet
1. Underpinning, 2. Aetiology
Rapporter
2024
With the overarching aim to improve health and quality of life for individuals born preterm, the NTNU Low Birth Weight Life research group has established an acknowledged position and a key role in creating a data platform for joint international and multidisciplinary research.The research group is led by Professor Evensen, Department of Clinical and Molecular Medicine, NTNU, with multidisciplinary collaboration involving other departments at NTNU and St. Olavs Hospital. The team has been partner in a European Horizon 2020 project: Research on European Children and Adults born Preterm (RECAP Preterm), responsible for data processing and delivery, and authoring publications. The group collaborates with the national Project Extreme Prematurity and is part of an international network: Adults born Preterm International Collaboration (APIC). Aiming to improve health and quality of life for individuals born preterm with low birth weight, the primary objective of this proposal is to strengthen the NTNU Low Birth Weight Life in national and international networks. This involves three secondary objectives: 1) Build competence through infrastructure and collaborations, 2) Participate and manage data sharing in APIC and Post-RECAP networks and 3) Supervise PhDs and author publications to fulfil international obligations. The measures will strengthen NTNU Low Birth Weight Life as an attractive and active international partner in future research. The project includes novel research with potential benefits for individuals born with low birth weight, health care providers and society. It complies with strategic priorities of Central Norway Regional Health Authorities, St. Olavs Hospital and NTNU, by involving clinically relevant research that is close to the patients. Furthermore, this multidisciplinary research is of international significance and quality. Even though the quality of intensive care in neonates has improved during the latest decades and survival of the most immature infants has increased, neonatal and short-term morbidity among preterm born children has remained relatively unchanged. In sum, this reflects an increase in the number of newborns at risk of later adverse outcomes. New knowledge on long-term outcome of preterm birth can improve health and services for these individuals as well as the next generations born with low birth weight. The multidisciplinary design of NTNU Low Birth Weight Life as well as partner-projects in APIC and RECAP Preterm holds the potential to reveal connections between various clinical domains, which can indicate new preventive, supportive and treatment measures for those affected, with the overarching goal to improve health and quality of life. Moreover, results can guide public health policy relevant for both community and specialised health care services. The project will provide important contributions to paediatric and internal medicine, mental health disciplines for children, adolescents and adults, movement sciences and habilitation, and inform educational and societal support systems. Dissemination and implementation of results will ensure evidence-based practice in assessment and treatment within these disciplines, and importantly contribute to identify multidisciplinary needs for low birth weight individuals. The collaboration with other research institutions in Norway and participation in international research activities (APIC and RECAP Preterm) will further strengthen and extend the quality of research in the NTNU/St. Olavs team. Management of the RECAP Preterm NTNU node involves innovative solutions for data sharing and joint analyses that will promote research using population cohorts far beyond the research at NTNU.
2023
With the overarching aim to improve health and quality of life for individuals born preterm, the NTNU Low Birth Weight Life research group has established an acknowledged position and a key role in creating a data platform for joint international and multidisciplinary research.The research group is led by Professor Evensen, Department of Clinical and Molecular Medicine, NTNU, with multidisciplinary collaboration involving other departments at NTNU and St. Olavs Hospital. The team has been partner in a European Horizon 2020 project: Research on European Children and Adults born Preterm (RECAP Preterm), responsible for data processing and delivery, and authoring publications. The group collaborates with the national Project Extreme Prematurity and is part of an international network: Adults born Preterm International Collaboration (APIC). Aiming to improve health and quality of life for individuals born preterm with low birth weight, the primary objective of this proposal is to strengthen the NTNU Low Birth Weight Life in national and international networks. This involves three secondary objectives: 1) Build competence through infrastructure and collaborations, 2) Participate and manage data sharing in APIC and Post-RECAP networks and 3) Supervise PhDs and author publications to fulfil international obligations. The measures will strengthen NTNU Low Birth Weight Life as an attractive and active international partner in future research. The project includes novel research with potential benefits for individuals born with low birth weight, health care providers and society. It complies with strategic priorities of Central Norway Regional Health Authorities, St. Olavs Hospital and NTNU, by involving clinically relevant research that is close to the patients. Furthermore, this multidisciplinary research is of international significance and quality. Even though the quality of intensive care in neonates has improved during the latest decades and survival of the most immature infants has increased, neonatal and short-term morbidity among preterm born children has remained relatively unchanged. In sum, this reflects an increase in the number of newborns at risk of later adverse outcomes. New knowledge on long-term outcome of preterm birth can improve health and services for these individuals as well as the next generations born with low birth weight. The multidisciplinary design of NTNU Low Birth Weight Life as well as partner-projects in APIC and RECAP Preterm holds the potential to reveal connections between various clinical domains, which can indicate new preventive, supportive and treatment measures for those affected, with the overarching goal to improve health and quality of life. Moreover, results can guide public health policy relevant for both community and specialised health care services. The project will provide important contributions to paediatric and internal medicine, mental health disciplines for children, adolescents and adults, movement sciences and habilitation, and inform educational and societal support systems. Dissemination and implementation of results will ensure evidence-based practice in assessment and treatment within these disciplines, and importantly contribute to identify multidisciplinary needs for low birth weight individuals. The collaboration with other research institutions in Norway and participation in international research activities (APIC and RECAP Preterm) will further strengthen and extend the quality of research in the NTNU/St. Olavs team. Management of the RECAP Preterm NTNU node involves innovative solutions for data sharing and joint analyses that will promote research using population cohorts far beyond the research at NTNU.
Vitenskapelige artikler
Aakvik KAD, Benum SD, Tikanmäki M, Hovi P, Räikkönen K, Harris SL, Woodward LJ, Darlow BA, Indredavik MS, Lydersen S, Mork PJ, Kajantie E, Evensen KAI

Physical activity and cognitive function in adults born very preterm or with very low birth weight-an individual participant data meta-analysis.

PLoS One 2024;19(2):e0298311. Epub 2024 feb 13

PMID: 38349926

Jussinniemi L, Kulmala MK, Aakvik KAD, Benum SD, Jørgensen APM, Balasuriya CND, Stunes AK, Syversen U, Indredavik MS, Andersson S, Hovi P, Evensen KAI, Kajantie E

Body composition in adults born preterm with very low birth weight.

Pediatr Res 2024 Apr;95(5):1316. Epub 2023 nov 16

PMID: 37973945

Benum SD, Aakvik KAD, Jørgensen APM, Jussinniemi L, Kulmala M, Vollsæter M, Kajantie E, Evensen KAI

Motor abilities in adults born with very low birthweight: A study of two birth cohorts from Finland and Norway.

Dev Med Child Neurol 2024 Sep;66(9):1190. Epub 2024 feb 18

PMID: 38369576

Kulmala M, Jørgensen APM, Aakvik KAD, Jussinniemi L, Benum SD, Ingvaldsen SH, Austeng D, Kajantie E, Evensen KAI, Majander A, Morken TS

Visual function in adults born preterm with very low birth weight-A two-country birth cohort study.

Acta Ophthalmol 2024 Feb;102(1):49. Epub 2023 mai 12

PMID: 37172142

Ingvaldsen SH, Jørgensen AP, Grøtting A, Sand T, Eikenes L, Håberg AK, Indredavik MS, Lydersen S, Austeng D, Morken TS, Evensen KAI

Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight.

Sci Rep 2024 Feb 01;14(1):2624. Epub 2024 feb 1

PMID: 38297018

Hollund IMH, Aakvik KAD, Benum SD, Ingvaldsen SH, Lydersen S, Tikanmäki M, Hovi P, Räikkönen K, Kajantie E, Johnson S, Marlow N, Baumann N, Wolke D, Indredavik MS, Evensen KAI

Mental health, pain and tiredness in adults born very preterm or with very low birthweight.

Acta Paediatr 2024 Jan;113(1):72. Epub 2023 okt 3

PMID: 37787099

Mehl CV, Lærum AMW, Reitan SK, Indredavik MS, Evensen KAI

Self-reported mental health difficulties were of limited use when screening for psychiatric diagnoses in adults born small for gestational age at term.

Acta Paediatr 2024 May;113(5):1040. Epub 2024 feb 12

PMID: 38345095

Taiar H, Benum SD, Aakvik KAD, Evensen KAI

Motor outcomes in individuals born small for gestational age at term: a systematic review.

BMC Pediatr 2024 Nov 11;24(1):718. Epub 2024 nov 11

PMID: 39528981

Mendonça M, Ni Y, Baumann N, Darlow BA, Horwood J, Doyle LW, Cheong JLY, Anderson PJ, Bartmann P, Marlow N, Johnson S, Kajantie E, Hovi P, Nosarti C, Indredavik MS, Evensen KAI, Räikkönen K, Heinonen K, van der Pal S, Woodward LJ, Harris S, Eves R, Wolke D

Romantic and sexual relationships of young adults born very preterm: An individual participant data meta-analysis.

Acta Paediatr 2024 Dec;113(12):2513. Epub 2024 sep 10

PMID: 39252537

Jørgensen APM, Kulmala M, Austeng D, Evensen KAI, Kajantie E, Majander A, Morken TS

Foveal thickness and its association with visual acuity in adults born preterm with very low birth weight: A two-country birth cohort study.

Acta Ophthalmol 2024 Dec;102(8):942. Epub 2024 mai 29

PMID: 38809004

Fjørtoft T, Brandal M, Adde L, Osland S, Rygh H, Ustad T, Evensen KAI

Neurodevelopmental outcome at two years of age and predictive value of General Movement Assessment in infants exposed to alcohol and/or drugs during pregnancy: a prospective cohort study.

BMC Pediatr 2024 Sep 21;24(1):598. Epub 2024 sep 21

PMID: 39304852

Martínez-Shaw ML, Evensen KAI, Melero S, Sánchez-Sandoval Y

Health-related quality of life in children born preterm at school age: the mediating role of social support and maternal stress.

Front Psychol 2024;15():1463804. Epub 2024 des 2

PMID: 39687562

Robinson R, Girchenko P, Pulakka A, Heinonen K, Lähdepuro A, Lahti-Pulkkinen M, Hovi P, Tikanmäki M, Bartmann P, Lano A, Doyle LW, Anderson PJ, Cheong JLY, Darlow BA, Woodward LJ, Horwood LJ, Indredavik MS, Evensen KAI, Marlow N, Johnson S, de Mendonca MG, Kajantie E, Wolke D, Räikkönen K

ADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study.

Pediatr Res 2023 Apr;93(5):1399. Epub 2022 jan 7

PMID: 34997222

Bolbocean C, van der Pal S, Van Buuren S, Anderson PJ, Bartmann P, Baumann N, Cheong JLY, Darlow BA, Doyle LW, Evensen KAI, Horwood J, Indredavik MS, Johnson S, Marlow N, Mendonça M, Ni Y, Wolke D, Woodward L, Verrips E, Petrou S

Health-Related Quality-of-Life Outcomes of Very Preterm or Very Low Birth Weight Adults: Evidence From an Individual Participant Data Meta-Analysis.

Pharmacoeconomics 2023 Jan;41(1):93. Epub 2022 okt 26

PMID: 36287335

Mehl CV, Benum SD, Aakvik KAD, Kongsvold A, Mork PJ, Kajantie E, Evensen KAI

Physical activity and associations with health-related quality of life in adults born small for gestational age at term: a prospective cohort study.

BMC Pediatr 2023 Aug 28;23(1):430. Epub 2023 aug 28

PMID: 37641030

Eriksen MM, Hollund IMH, Laerum AMW, Indredavik MS, Evensen KAI

Mental health in adults born preterm with very low birth weight at 14 and 26 years of age assessed by the Strengths and Difficulties Questionnaire.

Acta Paediatr 2023 Jan;112(1):69. Epub 2022 okt 11

PMID: 36168740

Ingvaldsen SH, Hansen TI, Håberg AK, Moholdt V, Evensen KAI, Dammann O, Austeng D, Morken TS

Visual function correlates with neurodevelopment in a population cohort of school-aged children born extremely preterm.

Acta Paediatr 2023 Apr;112(4):753. Epub 2023 jan 19

PMID: 36627478

Rimol LM, Rise HH, Evensen KAI, Yendiki A, Løhaugen GC, Indredavik MS, Brubakk AM, Bjuland KJ, Eikenes L, Weider S, Håberg A, Skranes J

Atypical brain structure mediates reduced IQ in young adults born preterm with very low birth weight.

Neuroimage 2023 Feb 01;266():119816. Epub 2022 des 14

PMID: 36528311

Hollund IMH, Aakvik KAD, Benum SD, Ingvaldsen SH, Lydersen S, Tikanmäki M, Hovi P, Räikkönen K, Kajantie E, Johnson S, Marlow N, Baumann N, Wolke D, Indredavik MS, Evensen KAI.

Mental health, pain and tiredness in adults born very preterm or with very low birthweight.

Acta Paediatr 2024;113(1):72-80. Epub 2023 Oct 3.

Doktorgrader
Anna Perregaard Munch Jørgensen

Visual function and retinal structure alterations in adults born preterm with very low birth weight

Disputert:
juni 2024
Hovedveileder:
Tora Sund Morken
Sigrid Hegna Ingvaldsen

Visuopathy of prematurity: Brain MRI alterations, neurodevelopment, and visual outcomes in children and adults born preterm

Disputert:
september 2023
Hovedveileder:
Tora Sund Morken
Deltagere
  • Bruker representanter Prosjektdeltaker
  • Prematur foreningen Prosjektdeltaker
  • Artur Rocha Prosjektdeltaker
  • Dieter Wolke Prosjektdeltaker
  • Eero Kajantie Prosjektdeltaker
  • Maria Vollsæter Prosjektdeltaker
  • Thomas Halvorsen Prosjektdeltaker
  • Siri Weider Prosjektdeltaker
  • Ann-Mari Brubakk Prosjektdeltaker
  • Marit Sæbø Indredavik Prosjektdeltaker
  • Kari Ravndal Risnes Prosjektdeltaker
  • Stian Lydersen Prosjektdeltaker
  • Silje Dahl Benum Doktorgradsstipendiat
  • Kristina Anna Djupvik Aakvik Doktorgradsstipendiat
  • Ingrid Marie Husby Hollund Forsker
  • Tora Sund Morken Prosjektdeltaker
  • Kari A. Indredavik Evensen Prosjektleder

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

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