High-intensity intermittent training to maximize metabolic and cardiovascular protection in obese individuals and type 2 diabetic patients
Prosjekt
- Prosjektnummer
- 46034900
- Ansvarlig person
- Catia Martins
- Institusjon
- NTNU, IKM
- Prosjektkategori
- Postdoc-stipend 2010
- Helsekategori
- Metabolic and Endocrine
- Forskningsaktivitet
- 7. Disease Management
Rapporter
I left this project in 2015, but have been trying to publish all the results.
Publications:
- Martins C, Kazacova I, Ludviksen M et al. High-intensity interval training and isocaloric moderate-intensity continuous training results in similar improvements in body composition and fitness in obese individuals. Int J Sports Nutr Exerc Metab, 2016;26(3):197-204
- Martins C, Stensvold D, Finlayson G et al. Effect of moderate and high intensity acute exercise on appetite in overweight/ obese individuals. Med Sci Sports Exerc, 2015;47(1):40-8.
- Martins C, Aschehoug I, Ludviksen M, Holst J, Finlayson G, Wisloff U, Morgan L, King N and Kulseng B. High-intensity Sprint interval training, appetite and reward value of food in obese individuals (a revised mansucript is now under evaluation at Med Scien Sports Med)
This projects suggest that high-intensity interval training produces similar outcomes as isocaloric moderate intensity continuous training regarding appetite, metabolism and weight loss in overweight and obese individuals.
Paper in press
- Martins C, Kazakova I, Ludviksen M, Mehus I, Wisloff U, Kulseng B, Morgan L, King N. High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals. Int J Sport Nutr Exerc Metab. 2015 Oct 19. [Epub ahead of print]Regarding study 2, High-intensity intermittent training to maximize metabolic and cardiovascular protection in obese individuals, a paper is now in press:
- Martins C, Kazakova I, Ludviksen M, Mehus I, Wisloff U, Kulseng B, Morgan L, King N. High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals. Int J Sport Nutr Exerc Metab. 2015 Oct 19. [Epub ahead of print]
Abstract:
This study aimed to determine the effects of 12 weeks of isocaloric programs of high-intensity intermittent training (HIIT) or moderate-intensity continuous training (MICT) (or a short-duration HIIT (1/2HIIT) inducing only half the energy deficit) on a cycle ergometer, on body weight and composition, cardiovascular fitness, resting metabolism rate (RMR), respiratory exchange ratio (RER), non-exercise physical activity (PA) levels and fasting and postprandial insulin response in sedentary obese individuals. Forty-six sedentary obese individuals (30 women), with a mean BMI of 33.3±2.9 kg/m2 and a mean age of 34.4±8.8 years were randomly assigned to one of the three training groups: HIIT (n=16), MICT (n=14) or 1/2HIIT (n=16) and exercise was performed 3 times/week for 12 weeks. Overall, there was a significant reduction in body weight, waist (p<0.001) and hip (p<0.01) circumference, trunk and leg fat mass (FM) (p<0.01) and an increase in trunk and leg fat free mass (FFM) (p<0.01) and cardiovascular fitness (VO2max in ml/kg/min) (p<0.001) with exercise. However, no significant differences were observed between groups. There was no significant change in RMR, RER, non-exercise PA levels, fasting insulin or insulin sensitivity with exercise or between groups. There was a tendency for a reduction in AUC insulin with exercise (p=0.069), but no differences between groups. These results indicate that isocaloric training protocols of HIIT or MICT (or 1/2HIIT inducing only half the energy deficit) exert similar metabolic and cardiovascular improvements in sedentary obese individuals.
Another paper on appetite is expected to be published in 2016. Here changes in subjective and objective markers of appetite after high-intensity interval training and Isocaloric moderate intensity continuos training, in obese individuals, will be compared.
I have been on maternity leave since May 2015 and on partial sick leave from January to May 2015.
Study 1 (Acute effects of high-intensity intermittent sprinting vs. moderate intensity continuous cycling on appetite control on obese volunteers) has been published in Med Sci Sports Exerc, 2015;47(1):40-8.
Study 2 still needs to be publishedStudy 1 (Acute effects of high-intensity intermittent sprinting vs. moderate intensity continuous cycling on appetite control on obese volunteers) has been published in Med Sci Sports Exerc, 2015;47(1):40-8. See manuscript in attachment.
Regarding study 2 (High-intensity intermittent training to maximize metabolic and cardiovascular protection in obese individuals), 2 manuscripts have been written:
A. “The impact of high-intensity intermittent exercise on body weight and composition, cardiovascular fitness and insulin response in obese sedentary individuals”
B. “The impact of high-intensity intermittent exercise on objective and subjective measures of appetite and reward value of food in obese individuals”
Paper A has been submitted to Med Sci Sports Exerc, but rejected. We are now working on a resubmition. Given that paper B cannot be submitted before paper A is accepted, this has been translated in further delays.
This Postdoc project has been carried out only at 50%. Moreover, approximately 1/3 of that time was used on teaching/supervision of MSc students/administrative duties at IKM (in connection with master in Obesity and Health – for more information please contact institute leader: Magne Børset). My contract has Postdoc has finished in midle Ausgut 2014.
The plan is to resubmite paper A and once that is accepted submite paper B. GIven that I am on partial sick leave at the moment and will start maternity leave on the first of May 2015, this will probbaly only happen in 2016.
Study 1 is complete and a manuscript been submitted to MSSE
Study 2 is also complete and 2 draft papers have been written. They should be submitted during the next couple of monthsThis Postdoc project has been carried out only at 50%. Moreover, approximately 1/3 of that time was used on teaching/supervision of MSC students/administrative duties at IKM (in connection with master in Obesity and Health – for more information please contact institute leader: Magne Børset)
Regarding study 1 (Acute effects of high-intensity intermittent sprinting vs. moderate intensity continuous cycling on appetite control on obese volunteers), statistical analysis was performed and a paper ("Effect of acute bouts of moderate and high intensity exercise on objective and subjective measures of appetite and reward value of food in obese individuals") has just been submitted to the journal Medicine in Science Sports and Exercise
Regarding study 2 (High-intensity intermittent training to maximize metabolic and cardiovascular protection in obese individuals), the measurement of insulin, active ghrelin, PYY3-36 and GLP-1 was performed in a total of 560 samples (35 participants X 2 (before and after the intervention) X 8 (time points: -10, 0, 30, 60, 90, 120, 150 and 180 minutes).
I have also written two draft papers: one on “The impact of high-intensity intermittent exercise on body weight and composition, cardiovascular fitness and insulin response in obese sedentary individuals” and the other on “The impact of high-intensity intermittent exercise on objective and subjective measures of appetite and reward value of food in obese individuals”. I hope to submit these two papers during the next couple of months.
Started data analysis in the acute study
Recruited a new group for the participnats for teh 12 week exercise interventionThis Postdoc project has been carried out only at 50%. Moreover, some of my time was used on teaching/administrative duties at IKM (in connection with master in Obesity and Health)
Study 1. Acute effects of high-intensity intermittent sprinting vs. moderate intensity continuous cycling on appetite control on obese volunteers
- Fasting and postprandial plasma samples (of 12 participants, 4 legs) were analysed by radioimunoassay for insulin and active ghrelin (waiting for results regarding PYY and GLP-1. Samples were sent to specialised lab at Copenhagen University, Denmark)
Study 2. High-intensity intermittent training to maximize metabolic and cardiovascular protection in obese individuals
- Advertised the study at NTNU and St. Olavs hospital websites and local newspapers
- Interviewed approximatly 50 potential participants
- Of these 50, 24 fullfilled all the inclusion/exclusion criteria and started the programme
- 17 participants finished the 12 week supervised exercise intervention.
- Supervision of exercise program in this group of participants (3 times/week)
- Submaximal fitness tests at week 4 and 8 for individual adjustment of the training program
- Collection of pre and post-intervention data(anthropometrics, body composition by DEXA, resting metabolic rate by indirect calorimetry, fitness level, fasting and postprandial blood samples, subjective feelings of hunger and fullness, ultrasound of the heart, food hedonics, food intake through a 3-day food diary, accelerometers...)
Ethical approval was obtained for both study 1 (Acute effects of high-intensity intermittent sprinting vs. moderate intensity continuous cycling on appetite control on obese volunteers) and study 2 (High-intensity intermittent training to maximize metabolic and cardiovascular protection in obese individuals).
For study 1, 10 participants were recruited and all finished the study.
For study 2, 23 participants were recruited, but only 18 finished the intervention.1. Acute study: Acute effects of high-intensity intermittent sprinting vs. moderate intensity continuous cycling on appetite control on obese volunteers - recruitment was very difficult due to the design of the study - crossover with 4 legs (3 types of acute exercise and a resting control condition). The aim was to recruit 12 participants. 10 participants were recruited, more 2 need to be added to finish the study and start analyzing the data. Fasting and postprandial blood samples were taken for a period of 3 hours, together with subjective measures of appetite using visual analogue scales. Food intake was assessed at the end of each trial using a test meal and throughout the day using a food diary. Physical activity after the end of each trial was also measured by the use of accelerometers.
2. Chronic study: High-intensity intermittent training to maximize metabolic and cardiovascular protection in obese individuals. This study involves 3 intervention groups (moderate intensity continuous cycling and high-intensity intermittent cycling isocaloric programs and high-intensity intermittent training using only half of the energy expenditure achieved in the other 2 groups) and the aim is to have at least 15 participants/group (n=45). 23 participants were recruited and 18 finished the intervention before Christmas. More two groups (of approximately 15 each) need to be recruited in the future before data can be analyzed.
A large battery of assessments was performed before and after the 12-week exercise program including fasting and postprandial blood samples, measurement of maximal oxygen uptake, resting metabolic rate, body composition, fat and muscle biopsies, flow mediated dilatation and left ventricular function using ultrasound. This together with the fact that participants had to come to the lab to exercise 3 times/week is likely to have contributed to the large dropout rate.
Vitenskapelige artikler
Martins C, Kazakova I, Ludviksen M, Mehus I, Wisloff U, Kulseng B, Morgan L, King N
High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals.
Int J Sport Nutr Exerc Metab 2016 Jun;26(3):197-204. Epub 2015 okt 19
PMID: 26479856
Deltagere
- Catia Martins Prosjektleder
- Ulrik Wisløff Prosjektleder
- Bård Eirik Kulseng Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU