The mechanistic basis of enterocromaffin cell function in health and disease.
- Prosjektnummer
- 46036900
- Ansvarlig person
- Bjørn Gustafsson
- Institusjon
- NTNU, IKM
- Prosjektkategori
- Forskerstipend 2010
- Helsekategori
- Oral and Gastrointestinal
- Forskningsaktivitet
- 1. Underpinning
The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease.
PLoS One 2013;8(4):e62607. Epub 2013 apr 26
PMID: 23638125
REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation.
Cell Tissue Res 2013 Jun;352(3):639-46. Epub 2013 mar 22
PMID: 23519454
Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis.
PLoS One 2013;8(2):e56818. Epub 2013 feb 13
PMID: 23468882
Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD.
PLoS One 2013;8(1):e54543. Epub 2013 jan 31
PMID: 23382912
Gastric carcinoids (neuroendocrine neoplasms).
Gastroenterol Clin North Am 2013 Jun;42(2):381-97. Epub 2013 mar 1
PMID: 23639647
The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion.
Am J Physiol Gastrointest Liver Physiol 2012 Feb;302(3):G397-405. Epub 2011 okt 28
PMID: 22038827
Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies.
Cancer Sci 2012 Jul;103(7):1230-7. Epub 2012 apr 27
PMID: 22435758
In situ hybridization in human and rodent tissue by the use of a new and simplified method.
Appl Immunohistochem Mol Morphol 2013 Mar;21(2):185-9.
PMID: 22688353
Differential signal pathway activation and 5-HT function: the role of gut enterochromaffin cells as oxygen sensors.
Am J Physiol Gastrointest Liver Physiol 2012 Nov;303(10):G1164-73. Epub 2012 aug 30
PMID: 22936271
A man in his 30s with recurrent vomiting and abdominal pain relieved by hot showers.
Tidsskr Nor Laegeforen 2011 Nov;131(21):2134-6.
PMID: 22048212
Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia.
PLoS One 2011;6(8):e22457. Epub 2011 aug 11
PMID: 21853033
The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats.
BMC Endocr Disord 2011;11():11. Epub 2011 mai 26
PMID: 21615901
The archaic distinction between functioning and nonfunctioning neuroendocrine neoplasms is no longer clinically relevant.
Langenbecks Arch Surg 2011 Dec;396(8):1145-56. Epub 2011 apr 27
PMID: 21523447
The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors.
Endocrinol Metab Clin North Am 2011 Mar;40(1):111-34, viii.
PMID: 21349414
The epidemiology of gastroenteropancreatic neuroendocrine tumors.
Endocrinol Metab Clin North Am 2011 Mar;40(1):1-18, vii.
PMID: 21349409
Parietal cell activation by arborization of ECL cell cytoplasmic projections is likely the mechanism for histamine induced secretion of hydrochloric acid.
Scand J Gastroenterol 2011 May;46(5):531-7. Epub 2011 feb 23
PMID: 21342027
Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation.
Diabetes Obes Metab 2011 Jun;13(6):551-8.
PMID: 21320265
Endoscopic, Histological and Transcriptomic Characterization of TNBS-Colitis in Rats, a Model for IBD
Gastroenterology Vol. 142, Issue 5, Supplement 1, Page S-876
Hypoxia, Adenosine, and Adenosine Receptor 2B as Pathophysiological Regulators of Gut Enterochromaffin Cell Serotonin Synthesis
Gastroenterology 2011;140:S-639-S-640
Hypoxia and Gut Neuroendocrine Cells: The Role of HIF-1a, Nf?B and Serotonin Production From Enterochromaffin Cells in Intestina
Gastroenterology 2011;140:S-698.
SNP Identification of Common Gene Alterations in Crohn's Disease and Familial Neuroendocrine Tumors: Concordant Expression of Im
Gastroenterology Vol. 138, Issue 5, Supplement 1, Page S-564
Intestinal Ischemia Activates Local Production and Secretion of Serotonin From Enterochromaffin Cells That May Trigger Cascade R
Gastroenterology Vol. 138, Issue 5, Supplement 1, Pages S-576-S-577
Coloskopi med biopsi ved 2,4,6-trinitrobenzensulfonsyre (TNBS) indusert kolitt hos rotte
Oral presentasjon ved NGF-årsmøte, Lillehammer, 10-12 februar 2011
Neuroendocrine regulation in 2,4,6-trinitrobenzenesulfonic acid (TNBS) colitis in the rat
Oral presentasjon ved NET-work Europe, Uppsala, 26-28 januar 2011:
- Bjørn Gustafsson Forsker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU