Molecular mechanisms of inflammation
- Prosjektnummer
- 46039200
- Ansvarlig person
- Terje Espevik
- Institusjon
- NTNU, IKM
- Prosjektkategori
- Flerårig prosjekt 2010
- Helsekategori
- Cardiovascular, Infection, Inflammatory and Immune System
- Forskningsaktivitet
- 5. Treatment Developement
A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
J Biol Chem 2015 Feb 6;290(6):3209-22. Epub 2014 des 11
PMID: 25505250
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF.
Immunobiology 2014 Oct;219(10):786-92. Epub 2014 jul 5
PMID: 25053140
A vital role for complement in heart disease.
Mol Immunol 2014 Oct;61(2):126-34. Epub 2014 jul 16
PMID: 25037633
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Nat Immunol 2014 Aug;15(8):727-37. Epub 2014 jun 22
PMID: 24952505
Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice.
J Immunol 2014 Jun 1;192(11):5324-31. Epub 2014 apr 30
PMID: 24790148
Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease.
Inflamm Bowel Dis 2014 Jun;20(6):995-1003.
PMID: 24739633
Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release.
J Immunol 2014 Mar 15;192(6):2837-45. Epub 2014 feb 19
PMID: 24554772
Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation.
J Immunol 2013 Nov 1;191(9):4769-77. Epub 2013 sep 23
PMID: 24062486
TLR3 mediates release of IL-1ß and cell death in keratinocytes in a caspase-4 dependent manner.
J Dermatol Sci 2013 Oct;72(1):45-53. Epub 2013 jun 12
PMID: 23845419
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2.
Clin Exp Immunol 2013 Sep;173(3):502-11.
PMID: 23668802
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Cardiovasc Res 2013 Jul 1;99(1):164-74. Epub 2013 apr 10
PMID: 23580606
Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis.
PLoS One 2013;8(2):e56818. Epub 2013 feb 13
PMID: 23468882
The induction of cytokines by polycation containing microspheres by a complement dependent mechanism.
Biomaterials 2013 Jan;34(3):621-30. Epub 2012 okt 24
PMID: 23103159
Dynamics of immune effector mechanisms during infection with Mycobacterium avium in C57BL/6 mice.
Immunology 2013 Oct;140(2):232-43.
PMID: 23746054
Activation and regulation of the inflammasomes.
Nat Rev Immunol 2013 Jun;13(6):397-411.
PMID: 23702978
(De-) oiling inflammasomes.
Immunity 2013 Jun 27;38(6):1088-90.
PMID: 23809158
Bride and groom in systemic inflammation--the bells ring for complement and Toll in cooperation.
Immunobiology 2012 Nov;217(11):1047-56.
PMID: 22964230
Enhanced expression of CXCL10 in inflammatory bowel disease: potential role of mucosal Toll-like receptor 3 stimulation.
Inflamm Bowel Dis 2013 Feb;19(2):265-74.
PMID: 22685032
Alginates induce differentiation and expression of CXCR7 and CXCL12/SDF-1 in human keratinocytes--the role of calcium.
J Biomed Mater Res A 2012 Oct;100(10):2803-12. Epub 2012 mai 24
PMID: 22623322
Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies.
Cancer Sci 2012 Jul;103(7):1230-7. Epub 2012 apr 27
PMID: 22435758
The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.
Nat Commun 2012;3():707. Epub 2012 feb 28
PMID: 22426228
Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein.
J Mol Recognit 2012 Feb;25(2):74-81.
PMID: 22290768
Oligodeoxynucleotides inhibit Toll-like receptor 3 mediated cytotoxicity and CXCL8 release in keratinocytes.
Exp Dermatol 2012 Jan;21(1):7-12. Epub 2011 nov 14
PMID: 22082188
Differential effect of inhibiting MD-2 and CD14 on LPS- versus whole E. coli bacteria-induced cytokine responses in human blood.
Adv Exp Med Biol 2012;946():237-51.
PMID: 21948372
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model.
Acta Biomater 2011 Jun;7(6):2566-78. Epub 2011 mar 12
PMID: 21402181
Cellular sources and inducers of cytokines present in acute wound fluid.
Wound Repair Regen 2011 May-Jun;19(3):337-47. Epub 2011 mar 3
PMID: 21371163
Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells.
FEMS Immunol Med Microbiol 2011 Feb;61(1):63-75. Epub 2010 nov 3
PMID: 21054580
The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*.
J Intern Med 2012 May;271(5):436-43. Epub 2012 jan 16
PMID: 22211640
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes.
Immunity 2010 Oct;33(4):583-96. Epub 2010 okt 7
PMID: 20933442
CpG-oligodeoxynucleotide inhibits Smad-dependent bone morphogenetic protein signaling: effects on myeloma cell apoptosis and in vitro osteoblastogenesis.
J Immunol 2010 Sep;185(6):3131-9. Epub 2010 aug 11
PMID: 20702733
Inflammasomes and host defenses against bacterial infections.
Curr Opin Microbiol. 2013 Feb;16(1):23-31. PMID: 23318142
Host defense mechanisms in Mycobacterium avium infection
- Disputert:
- april 2013
- Hovedveileder:
- Trude Helen Flo
The Innate Immune System - A paradoxical Mediator of Host Defense, Tissue Repair and Collateral Damage
- Disputert:
- november 2012
- Hovedveileder:
- Terje Espevik
Toll-like receptor-mediated inflammatory responses in keratinocytes
- Disputert:
- september 2012
- Hovedveileder:
- Terje Espevik
Characterization of innate inflammatory responses in acute and chronic wounds
- Disputert:
- desember 2011
- Hovedveileder:
- Terje Espevik
Inflammatory responses against Gram negative bacteria induced by TLR4 and NLRP12
- Disputert:
- juni 2011
- Hovedveileder:
- Terje Espevik
- Trude Helen Flo Forskningsgruppeleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU