Trondheim Clinical MR Metabolomics Lab
- Prosjektnummer
- 46040200
- Ansvarlig person
- Ingrid Gribbestad
- Institusjon
- NTNU, ISB
- Prosjektkategori
- Flerårig prosjekt 2010
- Helsekategori
- Cancer, Cardiovascular
- Forskningsaktivitet
- 4. Detection and Diagnosis, 6. Treatment Evaluation
Identification of metabolites from 2D 1 H- 13 C HSQC NMR using peak correlation plots.
BMC Bioinformatics 2014 Dec 16;15(1):413. Epub 2014 des 16
PMID: 25511422
Metabolic characterization of triple negative breast cancer.
BMC Cancer 2014;14():941. Epub 2014 des 12
PMID: 25495193
Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer.
BMC Med Genomics 2014;7():50. Epub 2014 aug 12
PMID: 25115192
IDH1 R132H mutation generates a distinct phospholipid metabolite profile in glioma.
Cancer Res 2014 Sep 1;74(17):4898-907. Epub 2014 jul 8
PMID: 25005896
Metabolomic biomarkers in serum and urine in women with preeclampsia.
PLoS One 2014;9(3):e91923. Epub 2014 mar 17
PMID: 24637620
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.
Breast Cancer Res 2014;16(1):R5. Epub 2014 jan 21
PMID: 24447408
Quantitative (31)P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts.
Magn Reson Med 2014 Jun;71(6):1973-81. Epub 2013 jul 22
PMID: 23878023
Phospholipase D1 and choline kinase-a are interactive targets in breast cancer.
Cancer Biol Ther 2014 May;15(5):593-601. Epub 2014 feb 20
PMID: 24556997
Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by (31) P MRS.
NMR Biomed 2014 Jun;27(6):692-9. Epub 2014 apr 24
PMID: 24764256
Metabolic changes in psoriatic skin under topical corticosteroid treatment.
BMC Dermatol 2013;13():8. Epub 2013 aug 14
PMID: 23945194
Proton magnetic resonance metabolomic characterization of ovarian serous carcinoma effusions: chemotherapy-related effects and comparison with malignant mesothelioma and breast carcinoma.
Hum Pathol 2013 Sep;44(9):1859-66. Epub 2013 mai 6
PMID: 23656974
Spermine and citrate as metabolic biomarkers for assessing prostate cancer aggressiveness.
PLoS One 2013;8(4):e62375. Epub 2013 apr 23
PMID: 23626811
Feasibility of MR metabolomics for immediate analysis of resection margins during breast cancer surgery.
PLoS One 2013;8(4):e61578. Epub 2013 apr 17
PMID: 23613877
2-hydroxyglutarate as a magnetic resonance biomarker for glioma subtyping.
Transl Oncol 2013 Apr;6(2):92-8. Epub 2013 apr 1
PMID: 23544162
Metabolic profiles of brain metastases.
Int J Mol Sci 2013;14(1):2104-18. Epub 2013 jan 22
PMID: 23340650
Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer.
Breast Cancer Res 2013 Feb 28;15(1):R16. Epub 2013 feb 28
PMID: 23448424
Spatially matched in vivo and ex vivo MR metabolic profiles of prostate cancer -- investigation of a correlation with Gleason score.
NMR Biomed 2013 May;26(5):600-6. Epub 2012 des 27
PMID: 23280546
Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts.
Mol Oncol 2013 Feb;7(1):130-42. Epub 2012 okt 23
PMID: 23142657
Differentiating diffuse World Health Organization grade II and IV astrocytomas with ex vivo magnetic resonance spectroscopy.
Neurosurgery 2013 Feb;72(2):186-95; discussion 195.
PMID: 23147779
Serum levels of choline-containing compounds are associated with aerobic fitness level: the HUNT-study.
PLoS One 2012;7(7):e42330. Epub 2012 jul 30
PMID: 22860113
Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer.
Proc Natl Acad Sci U S A 2012 Sep;109(38):E2506; author reply E2507. Epub 2012 jul 31
PMID: 22851771
Changes in gene transcription underlying the aberrant citrate and choline metabolism in human prostate cancer samples.
Clin Cancer Res 2012 Jun;18(12):3261-9. Epub 2012 apr 17
PMID: 22510345
Lactate and glycine-potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers.
NMR Biomed 2012 Nov;25(11):1271-9. Epub 2012 mar 8
PMID: 22407957
Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.
NMR Biomed 2012 Sep;25(9):1033-42. Epub 2012 jan 26
PMID: 22279038
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy.
BMC Cancer 2012;12():39. Epub 2012 jan 25
PMID: 22277092
Predicting long-term survival and treatment response in breast cancer patients receiving neoadjuvant chemotherapy by MR metabolic profiling.
NMR Biomed 2012 Feb;25(2):369-78. Epub 2011 aug 8
PMID: 21823183
MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer.
NMR Biomed 2011 Jul;24(6):673-90.
PMID: 21793073
Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy.
Mol Oncol 2011 Jun;5(3):224-41. Epub 2011 apr 23
PMID: 21536506
(13) C High-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns.
NMR Biomed 2011 Dec;24(10):1243-52. Epub 2011 apr 4
PMID: 21462378
HR MAS MR spectroscopy in metabolic characterization of cancer.
Curr Top Med Chem 2011;11(1):2-26.
PMID: 20809888
Alignment of high resolution magic angle spinning magnetic resonance spectra using warping methods.
Anal Chim Acta 2010 Dec;683(1):1-11. Epub 2010 sep 24
PMID: 21094376
Merging transcriptomics and metabolomics--advances in breast cancer profiling.
BMC Cancer 2010;10():628. Epub 2010 nov 16
PMID: 21080935
Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models.
BMC Cancer 2010;10():433. Epub 2010 aug 17
PMID: 20716336
Magnetic resonance metabolomics of intact tissue: a biotechnological tool in cancer diagnostics and treatment evaluation.
Cancer Res 2010 Sep;70(17):6692-6. Epub 2010 aug 10
PMID: 20699363
Monitoring the Effect of Docetaxel Treatment in MCF7 Xenografts Using Multimodal In Vivo and Ex Vivo Magnetic Resonance Methods, Histopathology, and Gene Expression.
Transl Oncol 2010;3(4):252-63. Epub 2010 aug 1
PMID: 20689767
Discrimination of patients with microsatellite instability colon cancer using 1H HR MAS MR spectroscopy and chemometric analysis.
J Proteome Res 2010 Jul;9(7):3664-70.
PMID: 20507057
Cancer tissue metabolomics
Norwegian Society for magnetic resonance, 2012
Prospects of high field MR spectroscopy and MR metabolomics
MR Core Facility opening, 2012
Citrat og Spermin som markører for aggressiv prostatakreft
De norske kirurgiske foreninger, 2012
Choline and phosphatidylcholine are associated with aerobic capacity: the HUNT-Study.
Cardiovascular research 2012
Choline and phosphatidylcholine are associated with aerobic capacity: the HUNT-Study.
Frontiers in Caridovascular Biology 2012
Laktat og glycin - mulige metabolske markører for brystkreftprognose, analysert med MR spektroskopi (MRS)
Høstmøtet Norsk Kirurgisk Forening 2012
CLASSIFICATION OF TUMOR AND NON-INVOLVED BREAST TISSUE USING HR-MAS MR SPECTROSCOPY.
XIII Chemometrics in Analytical Chemistry; 2012
Metabolic changes in citrate and spermine concentrations can predict prostate cancer aggressiveness.
ESMRMB 2012
Metabolic changes in citrate and spermine concentrations can predict prostate cancer agressiveness.
ESUR 2012
Metabolic changes in indolent and aggressive prostate cancer - correlations with the Gleason grading system.
Regional forskningskonferanse HMN 2012
Metabolomics changes in citrate and spermine concentrations can predict prostate cancer aggressiveness.
EMUC 2012
Spermine and citrate as MR biomarkers for predicting prostate cancer aggressiveness.
Personalized Cancer Care 2012
Giskeødegård, Guro F.; Geurts, Brigitte; Sitter, Beathe; Fjøsne, Hans Erikssønn; Lundgren, Steinar; Buydens, Lutgarde M. C.; Pos
ESMRMB 2012
Metabolic characterization of triple negative breast cancers.
ESMRMB 2012
Metabolic characterization of triple negative breast cancers. Metabolic characterization of triple negative breast cancers.
Personalized Cancer Care 2012
HR MAS MRS studies of breast cancer biopsies for defining clinically relevant sub-groups
National PhD Conference in Medical Imaging; 2012
Citrate as a biomarker in discriminating aggressive from indolent form of prostate cancer by MR metabolomics-correlation with th
National PhD Conference in Medical Imaging; 2012
Differentiating diffuse WHO grade II and IV Astrocytomas using ex vivo MR Spectroscopy.
ESM
31P MRS of basal-like and luminal-like breast tumor xenografts in vivo and in vitro.
National PhD Conference in Medical Imaging; 2012
31P MRS of breast cancer.
Opening of MR Core Facility 2012
Metabolic responses to VEGF inhibition in patient-derived breast cancer xenografts.
EACR 2012
Spatially matched in vivo and ex vivo MR metabolic profiles of prostate cancer – Investigation of correlation with Gleason score
ESUR 2012
Spatially matched in vivo and ex vivo MR metabolic profiles of prostate cancer – Investigation of correlation with Gleason score
EMUC 2012
Spatially matched in vivo and ex vivo MR metabolic profiles of prostate cancer – Investigation of correlation with Gleason score
Regional forskningskonferanse HMN 2012
Spatially matched in vivo and ex vivo MR metabolic profiles of prostate cancer. Investigation of a correlation with Gleason scor
Instituttseminar, ISB, 2012
Quantitative 1H HR-MAS using LC Model shows glutamate, choline, glycerophosphocholine, and glucose as biomarkers of prostate can
ISMRM 2012
– Viktig å finne de med dårlig prognose tidlig
www.stolav.no nyheter 2012
Fresh prostate tissue procurement suitable for integrative genomic and metabolic profiling
European association of urology 2011
Effects of targeting the glycerophosphocholine phosphodiesterase GDPD5 in breast cancer models
Int. society of MR in Medicine (ISMRM) 2011
Metabolic profiles of three breast cancer subgroups studied with HR-MAS MRS
Int. society of MR in Medicine (ISMRM) 2011
Spatially matched in vivo and ex vivo MR molecular profiling of prostate cancer.
ESMRMB; 2011
31P MRS of basal- and luminal-like breast tumor xenografts in vivo and in vitro
ESMRMB 2011
In vivo 3D 31P MR spectroscopic imaging of human brain tumors growing orthotopic in the mouse.
ESMRMB 2011
The choline signatures of brain tumor subgroups.
ESMRMB 2011
Low aerobic fitness is associated with altered levels of choline-containing metabolites in human serum.
ESMRMB 2011
Assessment of metabolic responses to PI3K inhibition in basal-like breast cancer xenografts using HR MAS MRS.
ESMRMB; 2011
Revealing MR metabolic biomarkers for breast cancer prognosis.
ESMRMB; 2011
Spatially matched in vivo and ex vivo MR molecular profiling of prostate cancer.
ESMRMB; 2011
Correlation Between In Vivo 1H MRS and Ex Vivo 1H HR MAS in Spatially Matched Regions in Prostate Cancer Patients.
ISMRM 2011
Detection of MR metabolic biomarkers for breast cancer prognosis.
Metabomeeting; 2011
MR metabolomics i biomedisinsk forskning.
Helse, Medisin, Teknikk 2011 (2) s. 8-14
Early vascular response to bevacizumab treatment measured by DCE-MRI in breast cancer xenografts.
Medical Imaging PhD seminar; 2011
Metabolic profiles of three breast cancer subgroups studied with HR-MAS MRS.
ESMRMB 2011
HR MAS MRS analyser av brystkreftvev
Informasjonsmøte NeoAva prosjektet 2011
Gigamaskin for kroppsdeler i mikrostørrelse
NRK [Internett] 20.01.2011
Verdens mest avanserte MR-laboratorium
Forskning.no [Internett] 19.01.2011
Åpning av MR Metabolomics lab
NRK Trøndelag [Radio] 20.01.2011
NTNU i verdenstoppen på MR
Adresseavisen 2011
Detection of MR metabolic biomarkers for breast cancer prognosis
MI lab day; 10.11.2011
13C HR-MAS MR spektroskopi-analyser av brystkreftxenografter.
Regional Forskningskonferanse HMN-NTNU; 2011
GDPD5 expression correlates with choline metabolite profiles in human breast cancer.
FUGE workshop; 2011, Haukeland
Midt-Nytt 18.40
NRK Midt-Nytt (TV), 29.09.2011
Silencing the glycerophosphocholine phosphodiesterase GDPD5 reduced breast tumor growth and modulated tumor choline phospholipid
ISMRM MR Cancer workshop; 2010-09-19 - 2010-09-22
Alignment of high resolution magic angle spinning MR spectroscopy data.
12th International Conference on Chemometrics in Analytical Chemistry; 2010-10-18 - 2010-10-21
Molekylær og funksjonell MR.
FUGE Workshop; 2010-09-01 - 2010-09-03
MR Cancer Group med i to av Jebsen-sentrene.
www.universitetsavisa.no 2010
MR metabolomics of Cancer Tissue.
Kreftavdelingen St. Olavs Hospital; 2010-11-01
MRI- Functional and metabolic possibilities.
Man in extreme environments; 2010-12-16 - 2010-12-17
Prinsipper for metabolske studier in vivo og in vitro av brystkreft.
Ullevål Symposium; 2010-10-21 - 2010-10-22
13C HR-MAS MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expressi
ISMRM Cancer Workshopo; 2010-09-19 - 2010-09-22
Evaluating the prognostic value of breast cancer biomarker candidates identified by HR-MAS MRS tissue analysis.
Improving Cancer Treatment with Advanced MR; 2010-09-19 - 2010-09-22
High-throughput metabolomics using NMR. High-througput omics
Bioinformatikk Nettverksmøte; 2010-09-28 - 2010-09-28
Hva har FUGE prosjektene generert av kunnskap og ideer?
FUGE Workshop; 2010-09-02 - 2010-09-03
Molekylær og funksjonell MR av brystkreft.
Mamma Midt; 2010-09-10 - 2010-09-10
Development and application of phosphorous MR techniques for diagnostic, prognostic and therapeutic assessment of cancer
- Disputert:
- mai 2014
- Hovedveileder:
- Tone Frost Bathen
Characterization of breast cancer using MR metabolomics and gene expression analysis
- Disputert:
- oktober 2012
- Hovedveileder:
- Ingrid S. Gribbestad
MR imaging and spectroscopy in prostate and colon cancer diagnostics
- Disputert:
- september 2012
- Hovedveileder:
- Ingrid S. Gribbestad
MR metabolic characterization of locally advanced breast cancer
- Disputert:
- mars 2012
- Hovedveileder:
- Ingrid S. Gribbestad
Molecular and functional characterization of breast cancer through a combination of MR imaging, transcriptomics and metabolomics
- Disputert:
- januar 2012
- Hovedveileder:
- Ingrid S. Gribbestad
- Riyas M Vettukattil Postdoktorstipendiat
- Saurabh Sayajirao Gorad Doktorgradsstipendiat
- Ailin Falkmo Hansen Doktorgradsstipendiat
- Hanna Maja Tunset Doktorgradsstipendiat
- Leslie Euceda Wood Doktorgradsstipendiat
- Tonje Husby Haukaas Doktorgradsstipendiat
- Guro Giskeødegård Postdoktorstipendiat
- Maria Dung Cao Postdoktorstipendiat
- Torill Eidhammer Sjøbakk Prosjektdeltaker
- May-Britt Tessem Forsker
- Siver Andreas Moestue Postdoktorstipendiat
- Tone Frost Bathen Prosjektleder
- Saurabh Sayajirao Gorad Doktorgradsstipendiat
- Morteza Esmaeili Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU