Infrastruktur proteomikk
- Prosjektnummer
- 46040500
- Ansvarlig person
- Geir Slupphaug
- Institusjon
- NTNU, IKM
- Prosjektkategori
- Nytt infrastrukturtiltak
- Helsekategori
- Cancer, Infection, Inflammatory and Immune System, Stroke, Generic Health Relevance
- Forskningsaktivitet
- 4. Detection and Diagnosis, 5. Treatment Developement
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes Dev 2015 Oct 1;29(19):2037-53. Epub 2015 sep 24
PMID: 26404942
Aerobic interval training reduces inducible ventricular arrhythmias in diabetic mice after myocardial infarction.
Basic Res Cardiol 2015;110(4):44. Epub 2015 jun 26
PMID: 26112154
Cell cycle regulation of human DNA repair and chromatin remodeling genes.
DNA Repair (Amst) 2015 Jun;30():53-67. Epub 2015 mar 28
PMID: 25881042
Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells.
PLoS One 2015;10(3):e0119857. Epub 2015 mar 13
PMID: 25769101
Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal ß-oxidation.
Plant Physiol 2015 Feb;167(2):493-506. Epub 2014 des 8
PMID: 25489022
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA Repair (Amst) 2015 Jan;25():60-71. Epub 2014 nov 24
PMID: 25486549
Off-target responses in the HeLa proteome subsequent to transient plasmid-mediated transfection.
Biochim Biophys Acta 2015 Jan;1854(1):84-90. Epub 2014 nov 5
PMID: 25448019
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell Rep 2015 Dec 29;13(12):2671-8. Epub 2015 des 17
PMID: 26711335
Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model.
Photodiagnosis Photodyn Ther 2015 Mar;12(1):58-66. Epub 2015 jan 6
PMID: 25575731
PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.
Cell Signal 2015 Jul;27(7):1478-87. Epub 2015 mar 20
PMID: 25797046
Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs.
Phytother Res 2015 Jun;29(6):825-34. Epub 2015 jan 30
PMID: 25640685
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
Eur J Clin Pharmacol 2015 Nov 28. Epub 2015 nov 28
PMID: 26613955
A kinetic-based approach to understanding heterologous mevalonate pathway function in E. coli.
Biotechnol Bioeng 2015 Jan;112(1):111-9. Epub 2014 aug 19
PMID: 24981116
Error-free versus mutagenic processing of genomic uracil--relevance to cancer.
DNA Repair (Amst) 2014 Jul;19():38-47. Epub 2014 apr 18
PMID: 24746924
Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase.
Biochim Biophys Acta 2014 May;1842(5):734-8. Epub 2014 feb 18
PMID: 24560885
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.
PLoS One 2014;9(6):e98729. Epub 2014 jun 10
PMID: 24914785
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.
Mol Immunol 2014 Jul;60(1):23-31. Epub 2014 apr 18
PMID: 24747958
Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.
Exp Cell Res 2014 Mar 10;322(1):178-92. Epub 2014 jan 13
PMID: 24434356
Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.
Biomed Res Int 2014;2014():921296. Epub 2014 jun 30
PMID: 25101299
A targeted proteomics toolkit for high-throughput absolute quantification of Escherichia coli proteins.
Metab Eng 2014 Sep 7;26C():48-56. Epub 2014 sep 7
PMID: 25205128
Eating behavior and glucagon-like peptide-1-producing cells in interposed ileum and pancreatic islets in rats subjected to ileal interposition associated with sleeve gastrectomy.
Obes Surg 2013 Jan;23(1):39-49.
PMID: 22949011
Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.
DNA Repair (Amst) 2013 Mar 1;12(3):188-95. Epub 2012 des 29
PMID: 23276627
Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase.
DNA Repair (Amst) 2013 Jan 1;12(1):80-6. Epub 2012 des 8
PMID: 23228472
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Mol Cell 2013 Jan 10;49(1):18-29. Epub 2012 nov 21
PMID: 23177736
Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving.
Physiol Rep 2013 Nov;1(6):e00169. Epub 2013 nov 24
PMID: 24400168
A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.
J Mol Biol 2013 Jan 23;425(2):424-43. Epub 2012 nov 23
PMID: 23183374
An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.
PLoS One 2013;8(2):e55493. Epub 2013 feb 6
PMID: 23405159
A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.
DNA Repair (Amst) 2013 Sep;12(9):699-706. Epub 2013 jun 3
PMID: 23742752
Atrial myocyte function and Ca2+ handling is associated with inborn aerobic capacity.
PLoS One 2013;8(10):e76568. Epub 2013 okt 16
PMID: 24146891
mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored.
DNA Repair (Amst) 2012 Jan;11(1):82-91. Epub 2011 des 5
PMID: 22153281
Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.
DNA Repair (Amst) 2012 Jun;11(6):587-93. Epub 2012 apr 6
PMID: 22483865
Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.
Nucleic Acids Res 2012 Jul;40(13):6070-81. Epub 2012 apr 6
PMID: 22492624
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
DNA Repair (Amst) 2012 Jun;11(6):559-69. Epub 2012 apr 20
PMID: 22521144
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Res 2012 Aug;40(14):6620-31. Epub 2012 apr 24
PMID: 22532610
Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis.
Proteome Sci 2011;9():45. Epub 2011 aug 4
PMID: 21816076
XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage.
Environ Mol Mutagen 2011 Oct;52(8):623-35. Epub 2011 jul 22
PMID: 21786338
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Nucleic Acids Res 2011 Oct;39(19):8430-44. Epub 2011 jul 10
PMID: 21745813
Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.
J Biol Chem 2011 May;286(19):16669-80. Epub 2011 mar 23
PMID: 21454529
Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways.
Photochem Photobiol Sci 2011 Jul;10(7):1137-45. Epub 2011 mar 30
PMID: 21448498
The autoantigen Pso p27: a post-translational modification of SCCA molecules.
Autoimmunity 2011 May;44(3):229-34. Epub 2011 jan 14
PMID: 21231892
Structural characteristics of a novel antifreeze protein from the longhorn beetle Rhagium inquisitor.
Insect Biochem Mol Biol 2011 Feb;41(2):109-17. Epub 2010 nov 13
PMID: 21078390
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Res 2011 Apr;39(8):e55. Epub 2011 feb 7
PMID: 21300643
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nat Commun 2011;2():172. Epub 2011 feb 1
PMID: 21285950
Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.
Nucleic Acids Res 2010 Oct;38(19):6447-55. Epub 2010 jun 4
PMID: 20525795
Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3).
J Biol Chem 2010 Aug;285(32):24904-14. Epub 2010 mai 28
PMID: 20511230
Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.
DNA Repair (Amst) 2010 Jul;9(7):785-95. Epub 2010 mai 13
PMID: 20466601
Purification and characterisation of an unusual DNA glycosylase in diatoms
3rd Erling Seeberg Symposium on DNA Repair; 2012-06-19 - 2012-06-24
Ubiquitin independent proteosomal degradation of Uracil DNA Glycosylase 2
3rd Erling Seeberg Symposium; 2012-06-19 - 2012-06-24
Purification and characterisation of an unusual DNA glycosylase in diatoms
22nd International Diatom Symposium; 2012-08-26 - 2012-08-31
Proteomikk-kjernefasilitet ved NTNU/HMN Hva kan vi tilby av analyser?
Fredagsforedrag StOlav; 2012-05-25
The Proteomics and metabolomics core facility
NTNU Bioinformatics Network Seminar 2012; 2012-10-18 - 2012-10-19
The Trondheim node of NorProteomics.
7th Norwegian Proteomics society meeting; 2012-03-19 - 2012-03-20
Håndteringsstress og lagringstemperatur påvirker kvaliteten til oppdrettstorsk
Programkonferansen HAVBRUK 2012; 2012-04-16 - 2012-04-18
Uracil in DNA – Generation and Processing.
4th Genome Dynamics in Neuroscience, Genome Instability in Aging and Brain Disease; 2012-09-19 - 2012-09-22
Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of
EMBO Cancer Proteomics conf. 2011
Analysis of stress responses induced by hexylaminolevulinate-mediated photodynamic treatment
14th Congress of the European Society for Photobiology; 2011
Partial characterization of gelatinolytic activities in herring (Clupea harengus) and sardine (Sardina pilchardus) possibly invo
Food Chem.2010, 119: 675-683
Effects of Photodynamic Therapy on Protein Expression in Rat Bladder Cancer Cells
NTNU-trykk 2010
HEXYLAMINOLEVULINATE PHOTODYNAMIC TREATMENT OF CANCER CELL LINES
- Disputert:
- juni 2015
- Hovedveileder:
- Hans E. Krokan
Multiple layers of gene regulation: the cell cycle, epigenetics and ,microRNAs
- Disputert:
- mars 2015
- Hovedveileder:
- Hans E. Krokan
Uracil in DNA - necessary intermediate for antibody maturation and mutagenic lesion
- Disputert:
- juni 2015
- Hovedveileder:
- Hans E. Krokan
Therapeutic Targeting of Cardiac PI3K-AKT Signaling
- Disputert:
- oktober 2015
- Hovedveileder:
- Ulrik Wisløff
Proteomic approaches to improve cancer therapy - Identifying factors contributing to melphalan resistance in multiple myeloma..
- Disputert:
- mai 2014
- Hovedveileder:
- Geir Slupphaug
Preclinical studies of photodynamic therapy and photochemical internalization in bladder cancer
- Disputert:
- juni 2014
- Hovedveileder:
- Finn Drabløs
Multiple functions of base excision repair proteins: relevance to RNA quality control and B-cell lymphomagenesis
- Disputert:
- november 2014
- Hovedveileder:
- Hans Einar Krokan
Induction and Processing of Uracil in the human genome: Molecular regulation of Activation-Induced Cytidine Deaminase and UNG
- Disputert:
- mai 2013
- Hovedveileder:
- Geir Slupphaug
Proteomics analysis of proteins involved in DNA base repair and cancer therapy
- Disputert:
- mars 2012
- Hovedveileder:
- Geir Slupphaug
Mechanisms of Alkylation damage repair by human AlkB homologues
- Disputert:
- mai 2010
- Hovedveileder:
- Hans E. Krokan
DNA repair protein complexes, functionality and significance for repair efficiency and cell survival
- Disputert:
- august 2010
- Hovedveileder:
- Marit Otterlei
- Turid Nilsen Prosjektdeltaker
- Sissel Skarra Prosjektdeltaker
- Bent Håvard Hellum Prosjektdeltaker
- Anna Kusnierczyk Prosjektdeltaker
- Cathrine Broberg Vågbø Prosjektdeltaker
- Animesh Sharma Prosjektdeltaker
- Davi de Miranda Fonseca Prosjektleder
- Geir Slupphaug Prosjektleder
- Sissel Håvåg Prosjektdeltaker
- Lars Hagen Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU