Targeting Autophagy in Disease Prevention and Therapy
- Prosjektnummer
- 46055500-3
- Ansvarlig person
- Ulrike Neckmann
- Institusjon
- NTNU, NT-fak
- Prosjektkategori
- Toppfinansiering 2013
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis, 5. Treatment Developement
DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy.
Free Radic Biol Med 2016 Jan;90():158-72. Epub 2015 nov 14
PMID: 26585906
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.
Blood Cancer J 2016 Jul 15;6(7):e446. Epub 2016 jul 15
PMID: 27421095
Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.
Oncotarget 2016 Oct 25;7(43):70845-70856.
PMID: 27683126
The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells.
Autophagy 2015;11(9):1636-51.
PMID: 26237736
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.
Clin Cancer Res 2015 Aug 15;21(16):3759-70. Epub 2015 apr 24
PMID: 25910952
MRI reveals the in vivo cellular and vascular response to BEZ235 in ovarian cancer xenografts with different PI3-kinase pathway activity.
Br J Cancer 2015 Feb 3;112(3):504-13. Epub 2014 des 23
PMID: 25535727
Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction.
J Biol Chem 2014 Oct 17;289(42):29097-111. Epub 2014 aug 25
PMID: 25160620
Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines as highly potent EGFR-TK inhibitors with Src-family activity.
Eur J Pharm Sci 2014 Aug 1;59():69-82. Epub 2014 apr 24
PMID: 24769040
Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor.
Eur J Med Chem 2014 Mar 21;75():354-74. Epub 2014 jan 31
PMID: 24556149
Autophagy as a survival mechnism or a cause of disease
- Disputert:
- mars 2016
- Hovedveileder:
- Geir Bjørkøy
A Dual Role of Autophagy in Disease Prevention and Drug Resistance
- Disputert:
- desember 2015
- Hovedveileder:
- Geir Bjørkøy
- Ulrike Neckmann Doktorgradsstipendiat
- Geir Bjørkøy Forskningsgruppeleder
- Camilla Izabel Wolowczyk Doktorgradsstipendiat
- Kristian Kobbenes Starheim Forsker
- Sonja Benedikte Andersen Prosjektdeltaker
- Kristine Pettersen Postdoktorstipendiat
- Jennifer Melanie Mildenberger Doktorgradsstipendiat
- Ida Johansson Postdoktorstipendiat
- Tonje Strømmen Steigedal Prosjektdeltaker
- Ulrike Neckman Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU