The role of the urokinase plasminogen activator system in gastric carcinogenesis
- Prosjektnummer
- 46056627
- Ansvarlig person
- Kristin G Nørsett
- Institusjon
- NTNU, IKM
- Prosjektkategori
- Forskerstipend 2012
- Helsekategori
- Oral and Gastrointestinal
- Forskningsaktivitet
- 1. Underpinning
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors.
Eur J Med Chem 2016 Nov 29;124():583-607. Epub 2016 aug 31
PMID: 27614407
Chiral 6-aryl-furo[2,3-d]pyrimidin-4-amines as EGFR inhibitors.
Eur J Med Chem 2016 Aug 25;119():278-99. Epub 2016 apr 25
PMID: 27235841
Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion.
Biochem Biophys Res Commun 2016 Jun 17;475(1):119-24. Epub 2016 mai 11
PMID: 27179776
PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa.
Peptides 2016 May;79():83-94. Epub 2016 mar 30
PMID: 27038741
Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines as highly potent EGFR-TK inhibitors with Src-family activity.
Eur J Pharm Sci 2014 Aug 1;59():69-82. Epub 2014 apr 24
PMID: 24769040
Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells.
BMC Cancer 2017; 17:68, http://rdcu.be/oHze
PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa
Submitted
Gastrin activates autophagy and protects cells from cisplatin induced cell death
Submitted
Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion
Manuscript in preparation
PAI-1 inhibits gastrin induced proliferation of the gastric oxyntic mucosa
51thNBS Contact Meeting, Longearbyen, Feb 2015
PAI-1 inhibits gastrin induced proliferation of the gastric oxyntic mucosa
51th NBS Contact Meeting, Longearbyen, Feb 2015.
NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells.
EMBO Conference: Nuclear receptors: Linking molecules, genomes and physiology. Sorrento, Italy, Sept, 2013.
Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion.
50th NBS Contact Meeting, Røros, Jan 2014.
Gastrin influences autophagy and vesicular transport in gastric adenocarcinoma cells.
50th NBS Contact Meeting, Røros, Jan 2014.
Gastrin activates NR4A2 and influences the nucleo-cytoplasmatic scuttling in gastric adenocarcinoma cells.
50th NBS Contact Meeting, Røros, Jan 2014.
NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells.
PLoS One. 2013 Sep 27;8(9):e76234.
FRAP analysis of NR4A2 protein in gastric adenocarcinoma cells.
5th NorMIC Meeting, Bergen, oktober 2012
Understanding cellular responses induced by gastrin in gastric adenocarcinoma cells
- Disputert:
- desember 2015
- Hovedveileder:
- Liv Thommesen
- Steffen Bugge Prosjektdeltaker
- Svein Jacob Kaspersen Prosjektdeltaker
- Guri Solum Prosjektdeltaker
- J Dinesh Kumar Prosjektdeltaker
- Bjørn Munkvold Prosjektdeltaker
- Patricia Gjertrud Mjønes Doktorgradsstipendiat
- Reidar Fossmark Prosjektdeltaker
- Andrea Varro Prosjektdeltaker
- Ingunn Bakke Prosjektdeltaker
- Jin Han Prosjektdeltaker
- Sabin Bhandari Prosjektdeltaker
- Barbara Niederdorfer Prosjektdeltaker
- Eirik Sundby Prosjektdeltaker
- Bård Helge Hoff Prosjektdeltaker
- Geir Bjørkøy Prosjektdeltaker
- Vidar Beisvåg Prosjektdeltaker
- Arnar Flatberg Prosjektdeltaker
- Arne Kristian Sandvik Prosjektdeltaker
- Shalini Vasudev Rao Postdoktorstipendiat
- Liv Thommesen Forskningsgruppeleder
- Kristin Gabestad Nørsett Prosjektleder
- Sabin Bhandari Doktorgradsstipendiat
- Pieter Boekema Prosjektdeltaker
- Patricia Mjønes Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU