lmpact of DNA base excision repair on neurodegeneration: Implications for treatment and diagnostics
- Prosjektnummer
- 46060921
- Ansvarlig person
- Magnar Bjørås
- Institusjon
- NTNU, IKOM
- Prosjektkategori
- Flerårig prosjekt
- Helsekategori
- Neurological
- Forskningsaktivitet
- 1. Underpinning
This project has revealed new knowledge about the impact of genome dynamics that might have implication for patients in long term. Of particular interest this project has revealed new knowledge about neuroinflammation that has resulted in an innovation project screening for novel small molecules protecting against neuronal tissue loss after brain injury (i.e. brain stroke).
Dette prosjektet har gjort det mylig for oss å komme i kontakt med relevante pasient grupper med nevrodegenerativ sykdom. Vi planlegger en ny studie for å følge opp resultater fra dette prosjektet som inkluderer vevsprøver fra pasientene.
Resultatene fra dette prosjektet er fortsatt iet for tidlig stadium til at resultatene kan implementers ipraksis.
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.
Nat Commun 2019 Nov 29;10(1):5460. Epub 2019 nov 29
PMID: 31784530
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren.
Biomolecules 2019 Nov 28;9(12). Epub 2019 nov 28
PMID: 31795137
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone.
Mol Neurobiol 2020 Feb;57(2):997-1008. Epub 2019 okt 25
PMID: 31654318
Diverse functions of DNA glycosylases processing oxidative base lesions in brain.
DNA Repair (Amst) 2019 09;81():102665. Epub 2019 jul 8
PMID: 31327582
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies.
Dis Model Mech 2018 10 24;11(10). Epub 2018 okt 24
PMID: 30254085
Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation.
J Perinat Med 2018 Dec 19;47(1):114-124.
PMID: 30020889
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients.
Sci Rep 2018 Jun 29;8(1):9817. Epub 2018 jun 29
PMID: 29959348
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Sci Rep 2017 Nov 08;7(1):15050. Epub 2017 nov 8
PMID: 29118367
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA.
Mitochondrion 2018 05;40():16-28. Epub 2017 sep 8
PMID: 28893634
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.
Sci Rep 2017 Jun 29;7(1):4384. Epub 2017 jun 29
PMID: 28663564
Novel UCHL1 mutations reveal new insights into ubiquitin processing.
Hum Mol Genet 2017 03 15;26(6):1217-1218.
PMID: 28334853
Novel UCHL1 mutations reveal new insights into ubiquitin processing.
Hum Mol Genet 2017 03 15;26(6):1031-1040.
PMID: 28007905
Neil3 induced neurogenesis protects against prion disease during the clinical phase.
Sci Rep 2016 Nov 25;6():37844. Epub 2016 nov 25
PMID: 27886261
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic-ischemic encephalopathy model.
Cell Death Dis 2016 Jul 28;7(7):e2320. Epub 2016 jul 28
PMID: 27468695
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell Rep 2015 Dec 29;13(12):2671-8. Epub 2015 des 17
PMID: 26711335
Impact of oxidative DNA damage repair on brain
- Disputert:
- februar 2017
- Hovedveileder:
- Magnar Bjørås
- Wei Wang Forsker
- Per Arne Aas Prosjektdeltaker
- Jing Ye Forsker
- Magnar Bjørås Prosjektleder
- Katja Scheffler Forsker
- Vuk Palibrk Postdoktorstipendiat
- Ying Ye Forsker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU