eRapport

Vitenskapelig stilling innenfor fedme og helse (5-årig, oppstart 2013)

Prosjekt
Prosjektnummer
90032000
Ansvarlig person
Catia Martins
Institusjon
NTNU, IKOM
Prosjektkategori
Forskningsinfrastruktur
Helsekategori
Metabolic and Endocrine
Forskningsaktivitet
6. Treatment Evaluation, 7. Disease Management
Rapporter
2019 - sluttrapport
Summary of activities (research, teachning, administration) for 2019 During 2019, I have supervised 2 PhD students and 2 master students. I have published 3 papers, 2 as last author and 2 as a co-author. One of the papers was published on the best journal in the nutrition field (Am J Clin Nutr - impact factor 6.6). I was the coordinator of two 7.5-credit modules at master level. 1. Publications in 2019 - Sousa AS, Mendes J, Guerra RS, Padrão P, Moreira P, Santos A, Borges N, Afonso C, Martins C, Ferro G, Amaral TF. Amaral Sitting time and associated factors among Portuguese older adults: results from Nutrition UP 65. Eur J Ageing. 2019 Accepted for publication - Lyngstad A, Nymo S, Coutinho SR, Rehfeld JF, Truby H, Kulseng B and Martins C. Investigating the effect of sex and ketosis on weight loss-induced changes in appetite. Am J Clin Nutr. 2019; 109(6):1511-8. - Nymo S, Coutinho SR, Rehfeld JF, Truby H, Kulseng B and Martins C. Physiological predictors of weight regain at 1 year follow-up in weight-reduced obese adults. Obesity. 2019; 27(6):925-31. 2. Supervision 2 PhD students (one 1st year and the other 2nd year) and 2 master students 3. Teaching I have been the coordinator of the modules KLH3101 and KLH3103, where I have also taught approximately 60-70% of the overall lectures. 5. Management Leader of the Unit for Clinical medicine and metabolic related diseases, at IKOM Overall summary: This 5 year academic position funded for 5 years by Helse Midt-Norge allowed me to establihsed myself as an expert in the obesity field. This can be seen by the fact that I have applied in 2018 for the position of Full Professor, which was granted in February 2019. I have also applyed in 2018 for a sabbatical leave, which was granted by the Faculty and for which I got funding also from Helse Midt-Norge. I have started my sabbatical leave at the University of Alabama, Birmingham (UAB) in August 2019, which will last for 1 year. I have been collaborating with world experts in the field of energy metabolism and ketogenic diets (namely Prof. Gary Hunter, Prof. Barbara Gower, Prof. James Hill and Prof. Eric Plaisance). This Collaboration has resulted already in several orginal papers and review papers. This position has also allowed the especialisation in Obesity and Health, within the master in Clinical Health Sciences) to continue. My position has allowed for this master to continue and I teach 2 of the 4 obesity specific modules and am deeply involved in the supervision of the master students and administrative duties. My position, by allowing the especialisation in Obesity and Health, within the master in Clinical Health Sciences) to continue has contributted greatly for the graduation of master students with knowledge and expertise within the Obesity field. This will certainly improve the quality fo the Health services provided to this patient population, both in the short- and long-term.

By establishing myself as a leader in the Obesity field in Midt-Norge, I belive I have greatly contributed to the dissemination of knowledge to both master students (I teach at the especialisation in Obesity and Health - master in Clinical Health Sciences), health Professionals (through seminars) and the general community (through popular science)

2018
During 2018, my first 2 PhD students graduated. I have published 6 papers as last author in top Nutrition/Obesity journals. I have supervised 3 master students to completion. I was the coordinator of two 7.5-credit modules at master level. I have received a PhD grant from Helse Midt-Norge.1. Publications in 2018 - Coutinho, Silvia dos Santos Ribeiro F; With, Emilie Føyen; Rehfeld, Jens F.; Kulseng, Bård Eirik; Truby, Helen; Martins, Catia. The impact of rate of weight loss on body composition and compensatory mechanisms during weight reduction: A randomized control trial. Clinical Nutrition 2018 ;Volum 37.(4) s. 1154-1162 - Nymo, Siren; Coutinho, Silvia dos Santos Ribeiro F; Torgersen, Linn-Christin H.; Bomo, Ola Jakob; Haugvaldstad, Ingrid; Truby, Helen; Kulseng, Bård Eirik; Martins, Catia. Timeline of changes in adaptive physiological responses, at the level of energy expenditure, with progressive weight loss. British Journal of Nutrition 2018 ;Volum 120.(2) s. 141-149. - Bøhler, Linn; dos Santos Ribeiro F. Coutinho, Silvia; Rehfeld, Jens F.; Morgan, Linda; Martins, Catia. Differences in the postprandial release of appetite-related hormones between active and inactive men. International Journal of Sport Nutrition & Exercise Metabolism 2018 ;Volum 28.(6) s. 602-610 - dos Santos Ribeiro F. Coutinho, Silvia; Rehfeld, Jens Frederik; Holst, Jens Juul; Kulseng, Bård Eirik; Martins, Catia. Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity. American Journal of Physiology. Endocrinology and Metabolism 2018 ;Volum 315.(1) s. E91-E98. - Nymo, Siren; Coutinho, Silvia dos Santos Ribeiro F; Vestbostad, I.; Kulseng, Bård Eirik; Martins, Catia; Truby, Helen; Rehfeld, Jens Frederik. Investigation of the long-term sustainability of changes in appetite after weight loss. International Journal of Obesity 2018 - Coutinho SR, Halset EH, Gåsbakk S, Rehfeld JF, Kulseng B, Truby H, Martins C. Compensatory mechanisms activated with intermittent energy restriction: A randomized control trial. Clin Nutr. 2018 Jun;37(3):815-823. - Mer sulten etter slanking. Gemini February 2018 2. Funding I have received a PhD grant (600 000 NOK for running costs) from Helse Midt-Norge for 3 years to look at the "Effects of sleeve gastrectomy versus diet-induced weight loss on homeostatic and hedonic appetite markers and gut microbiota". I have received a mobility grant from Helse Midt Norge to take a 1-year sabbatical leave at the University of Alabama Birmingham. This sabbatical leave for the academic year 2019/2020 was approved by the Faculty. 3. Supervision 3 PhD students (2 of them to completion) 4 master students (3 of them to completion) 4. Teaching Have been the coordinator of the modules KLH3101 and KLH3103, where I have also taught approximately 60-70% of the overall lectures. 5. Management Leader of the Unit for Clinical medicine and metabolic related diseases, at IKOM

Through teaching at the master in obesity and Health, supervision of master and PhD students and research, I belive this position has had a significant contribution over the last year to both patients and Health services.

2017
The year of 2017 was characterised by a good publication output (8 scientific papers), a very large supervision (7 master and 3 PhD students) and teaching load (coordination and teaching of 2 x 7.5 creidits modules). From August 2017 , I have also taken on the role of Leader of the Unit for Clinical medicine and metabolic related diseases at IKOM.Publications in 2017: 3 original papers as first author, 5 as last author, 1 as co-author, 2 popular science articles and participation in one radio program - Martins C. Weight loss maintenance – a tortuous path. Indremedisineren 2017; 4: 22-23. - Martins C and Norsett-Carr A. Obesity Knowledge amongst final year medical students in Norway. Obesity Facts. 2017; 1:545-558. - Leite JC, Keating E, Martins C, Delegue-Matos C, Almeida A, Azevedo L and Calhau C. Iodine status and iodized salt consumption in Portuguese school-aged children: the Iogeneration study. Nutrients 2017 May 5;9(5). pii: E458. doi: 10.3390/nu9050458. - Nymo S, Coutinho SR Jørgensen J, Rehfeld JF, Truby H, Kulseng B and Martins C. Timeline of changes in appetite during weight loss with a ketogenic diet. Int J Obes (Lond). 2017; 41(8):1224-1231. - Coutinho SR, With E, Rehfeld JF, Kulseng B, Truby H and Martins C. The impact of rate of weight loss on body composition and compensatory mechanisms during weight reduction: A randomized controlled trial. Clin Nutr, 2017 Apr 25. pii: S0261-5614(17)30147-4. doi: 10.1016/j.clnu.2017.04.008. [Epub ahead of print] - Coutinho SR, Halset EH, Gåsbakk S, Rehfeld JF, Kulseng B, Truby H and Martins C. Compensatory mechanisms activated with intermittent energy restriction: a randomized trial. Clin Nutr. 2017 Apr 7. pii: S0261-5614(17)30125-5. doi: 10.1016/j.clnu.2017.04.002. [Epub ahead of print] - Martins C, Aschehoug I, Ludviksen M, Holst J, Finlayson G, Wisloff U, Morgan L, King N and Kulseng B. High-intensity interval training, appetite and reward value of food in the obese. Med Sci Sports Exer. 2017; 49 (9): 1851-58. - Øvrebø B, Strømmen M, Kulseng B and Martins C. Bariatric Surgery versus Lifestyle Interventions for Severe Obesity: 5-Year Changes in Body Weight, Risk Factors and Comorbidities. Clin Obes 2017; 7(3):183-190. - Amundsen T, Strømmen M and Martins C. Suboptimal weight loss and weight regain after gastric bypass surgery - Postoperative status of energy intake, eating behavior, physical activity and psychometrics. Obes Surg. 2017: 27(5):1316-1323. - DagensMedisin, Norway 18th of December 2017. Studie: Medisinstudenetne vet lite om fedme - Adressavisen, Norway 10th August 2017 – NTNU studie knuser myte om slanking (page 1, 10 and 11) - NRK radio P1. Gjest i God Ettermiddag Trøndelag (14/08/2017) Er det farlig å gå raskt ned i vekt? Supervision (main supervisor): - 7 master students (2 of them defended in 2017) - 3 PhD students Teaching - Module coordinator of 2 x 7.5 credits modules (KLH3101 og KLH3103) Management: - Leader of the Unit for Clinical medicine and metabolic related diseases, since August 2017 Other: - Finishsed PEDUP (Pedagogical course at NTNU) - Got Likestillingsmidler from NTNU – 150000 NOK - Got 1.4 million NOK as drifstsmidler from Samarbeidsorganet

Not relevant

2016
I have been on maternity leave at 80% untill May 2016 and 50% untill 31st July 2016. Untill August 2016 my activities focused mainly on the supervision of 3 master and 3 PhD students. In August 2016 I started the supervision of 3 new master students, together with administrative duties, teaching planning, research and PEDUP course.Main outcomes during 2016: - 3 master students graduated - Got money for running costs associated with research from the Surgical department, St. Olavs Hospital – NOK 250.000 (Project title: Compensatory mechanisms to weight reduction and long-term weight loss maintenance”) - Internal examiner of 1 master student (master in Obesity and Health) - Pubmications: 1. Amundsen T, Strømmen M and Martins C. Suboptimal weight loss and weight regain after gastric bypass surgery - Postoperative status of energy intake, eating behavior, physical activity and psychometrics. Obes Surg (2016), DOI 10.1007/s11695-016-2475-7 2. Martins C, Kazacova I, Ludviksen M et al. High-intensity interval training and isocaloric moderate-intensity continuous training results in similar improvements in body composition and fitness in obese individuals. Int J Sports Nutr Exerc Metab, 2016;26(3):197-204 This study aimed to determine the effects of 12 weeks of isocaloric programs of high-intensity intermittent training (HIIT) or moderate-intensity continuous training (MICT) or a short-duration HIIT (1/2HIIT) inducing only half the energy deficit on a cycle ergometer, on body weight and composition, cardiovascular fitness, resting metabolism rate (RMR), respiratory exchange ratio (RER), nonexercise physical activity (PA) levels and fasting and postprandial insulin response in sedentary obese individuals. Forty-six sedentary obese individuals (30 women), with a mean BMI of 33.3 ± 2.9 kg/m2 and a mean age of 34.4 ± 8.8 years were randomly assigned to one of the three training groups: HIIT (n = 16), MICT (n = 14) or 1/2HIIT (n = 16) and exercise was performed 3 times/week for 12 weeks. Overall, there was a significant reduction in body weight, waist (p < .001) and hip (p < .01) circumference,, trunk and leg fat mass (FM; p < .01) and an increase in trunk and leg fat free mass (FFM; p < .01) and cardiovascular fitness (VO2max in ml/kg/min; p < .001) with exercise. However, no significant differences were observed between groups. There was no significant change in RMR, RER, nonexercise PA levels, fasting insulin or insulin sensitivity with exercise or between groups. There was a tendency for a reduction in AUC insulin with exercise (p = .069), but no differences between groups. These results indicate that isocaloric training protocols of HIIT or MICT (or 1/2HIIT inducing only half the energy deficit) exert similar metabolic and cardiovascular improvements in sedentary obese individuals. 3. Adressavisen, Norway 10th of August 2016 – Full uenighet om sucker og honing (first and 4rd page)
2015
I have been the coordinator of two modules in the master in Obesity and Health, taught approximately 60% of the lectures in both modules, been the main supervisor of 13 master students and currently the main supervisor of 3 PhD students.My work as an Associate Professor in Obesity and Health as focused on the following areas: - Teaching: I have been the coordinator of two modules in the master in Obesity and Health: KLH3101 (“Obesity and Health I: Definition, causes and consequences”) and KLH3103 ( “Obesity treatment I - Behavioral interventions, diet and exercise”) and have been teaching approximately 60% of the lectures on these modules, in the form of formal lectures, practical classes and group work. I have also been the responsible for making and marking the exams. I have developed student feedback forms and use them systematically every year to readjust the curriculum of the modules. - Supervision: I have supervised successfully, as main supervisor 10 master students and I am currently the main supervisor of 3 master and 3 PhD students. I have also supervised 2 medical students (hovedoppgave). I have been received the award of "Best teacher of the academic year 2014/2015 at the Department of Cancer Research and Molecular Medicine, NTNU" for my efforts in teaching and supervision in connection with the master in Obesity and Health. - Administrative duties: I have been involved in several meeting aiming at evaluating and further developing the master in obesity and health - Research: I have published several papers with Obesity, body composition and exercise in peer reviewer scientific papers. I have also been active in popular science and have add my research in the local newspapers, radio and TV. Scientific papers: 1. Martins C, Kazacova I, Ludviksen M et al. High-intensity interval training and isocaloric moderate-intensity continuous training results in similar improvements in body composition and fitness in obese individuals. Int J Sports Nutr Exerc Metab, 2015 (Epub ahead of print) 2. Roekenes J, Strømmen M, Kulseng B and Martins C. The Impact of Feet Callosities, Arm Posture, and Usage of Electrolyte Wipes on Body Composition by Bioelectrical Impedance Analysis in Morbidly Obese Adults. Obes Facts. 2015; 8(6):364-72. 3. Finbråten AK, Martins C, Andersen GL, et al. Assessment of body composition in children with cerebral palsy: A cross-sectional study in Norway. Dev Med Child Neurol, 2015; 57(9):858-64 4. Salamati S, Martins C and Kulseng B. Bakers’ yeast (Saccharomyces cerevisiae) antigen in obese and normal weight subjects. Clin Obes, 2015; 5(1):42-7. 5. Martins C, Stensvold D, Finlayson G et al. Effect of moderate and high intensity acute exercise on appetite in overweight/ obese individuals. Med Sci Sports Exerc, 2015;47(1):40-8. 6. Larsen I, Welde B, Martins C and Tjønna AE. High and moderate intensity aerobic exercise and excess post-exercise oxygen consumption in men with metabolic syndrome. Scand J Med Sci Sports, 2014;24(3):e174-9. 7. King NA, Horner K, Hills AP, Byrne NA, Wood RE, Bryant E, Caudwell P, Finlayson G, Gibbons C, Hopkins M, Martins C, and Blundell JE. The Interaction Between Exercise, Appetite, and Food Intake: Implications for Weight Control. Am J Lifest Med, February 6, 2013, doi: 10.1177/1559827613475584 8. Martins C, Strømmen M and Kulseng B. Longer Length of First Stay in Intermittent Residential Programs Is Associated with Larger Weight Loss at 1 and 2 years. Obes Facts, 2013; 6(3):288-296. 9. Martins C, Kulseng B, Rehfeld JF, King NA and Blundell JE. Impact of chronic exercise on appetite control in overweight and obese individuals. Med Sci Sports Exerc, 2013; 45(5): 805-812. Popular Science: - Schrödingers katt, NRK1, Norway 8th of January 2014 – Jan-Erik starter slankinga - VG, Norway, 28th of August 2014, 20 eksperter: Mitt aller beste slanke-råd, side 1 og 13 - NRK radio, Kveldsåpent, Norway 25th of August 2014 – NTNU skal forske på 5:2 dietten - Addressavisen, Norway 19th August 2014 – Skal forske på 5:2-dietten (Will research 5:2 diet) - Addressavisen, Norway 13th August 2013 – Rask slanking kan gi bedre resultater (Rapid weight loss can give better results) I have been on maternity leave from May 2015 till now.
Vitenskapelige artikler
Lyngstad A, Nymo S, Coutinho SR, Rehfeld JF, Truby H, Kulseng B, Martins C

Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite.

Am J Clin Nutr 2019 06 01;109(6):1511-1518.

PMID: 31070711

Nymo S, Coutinho SR, Rehfeld JF, Truby H, Kulseng B, Martins C

Physiological Predictors of Weight Regain at 1-Year Follow-Up in Weight-Reduced Adults with Obesity.

Obesity (Silver Spring) 2019 06;27(6):925-931. Epub 2019 apr 20

PMID: 31004405

Nymo S, Coutinho SR, Eknes PH, Vestbostad I, Rehfeld JF, Truby H, Kulseng B, Martins C

Investigation of the long-term sustainability of changes in appetite after weight loss.

Int J Obes (Lond) 2018 Aug;42(8):1489-1499. Epub 2018 jun 21

PMID: 29930313

Nymo S, Coutinho SR, Torgersen LH, Bomo OJ, Haugvaldstad I, Truby H, Kulseng B, Martins C

Timeline of changes in adaptive physiological responses, at the level of energy expenditure, with progressive weight loss.

Br J Nutr 2018 Jul;120(2):141-149. Epub 2018 mai 7

PMID: 29733003

Coutinho SR, Rehfeld JF, Holst JJ, Kulseng B, Martins C

Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity.

Am J Physiol Endocrinol Metab 2018 Jul 01;315(1):E91-E98. Epub 2018 jan 23

PMID: 29360396

Coutinho SR, With E, Rehfeld JF, Kulseng B, Truby H, Martins C

The impact of rate of weight loss on body composition and compensatory mechanisms during weight reduction: A randomized control trial.

Clin Nutr 2018 Aug;37(4):1154-1162. Epub 2017 apr 25

PMID: 28479016

Coutinho SR, Halset EH, Gåsbakk S, Rehfeld JF, Kulseng B, Truby H, Martins C

Compensatory mechanisms activated with intermittent energy restriction: A randomized control trial.

Clin Nutr 2018 Jun;37(3):815-823. Epub 2017 apr 7

PMID: 28446382

Bøhler L, Coutinho SR, Rehfeld JF, Morgan L, Martins C

Differences in the Postprandial Release of Appetite-Related Hormones Between Active and Inactive Men.

Int J Sport Nutr Exerc Metab 2018 Nov 01;28(6):602-610. Epub 2018 aug 3

PMID: 29431535

Nymo S, Coutinho SR, Jørgensen J, Rehfeld JF, Truby H, Kulseng B, Martins C

Timeline of changes in appetite during weight loss with a ketogenic diet.

Int J Obes (Lond) 2017 Aug;41(8):1224-1231. Epub 2017 apr 25

PMID: 28439092

Martins C, Aschehoug I, Ludviksen M, Holst J, Finlayson G, Wisloff U, Morgan L, King N, Kulseng B

High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese.

Med Sci Sports Exerc 2017 Sep;49(9):1851-1858.

PMID: 28398946

Øvrebø B, Strømmen M, Kulseng B, Martins C

Bariatric surgery versus lifestyle interventions for severe obesity: 5-year changes in body weight, risk factors and comorbidities.

Clin Obes 2017 Jun;7(3):183-190. Epub 2017 mar 20

PMID: 28320081

Martins C, Norsett-Carr A

Obesity Knowledge among Final-Year Medical Students in Norway.

Obes Facts 2017 Nov 22;10(6):545-558. Epub 2017 nov 22

PMID: 29161687

Costa Leite J, Keating E, Pestana D, Cruz Fernandes V, Maia ML, Norberto S, Pinto E, Moreira-Rosário A, Sintra D, Moreira B, Costa A, Silva S, Costa V, Martins I, Castro Mendes F, Queirós P, Peixoto B, Carlos Caldas J, Guerra A, Fontoura M, Leal S, Moreira R, Palmares Carvalho I, Matias Lima R, Martins C, Delerue-Matos C, Almeida A, Azevedo L, Calhau C

Iodine Status and Iodised Salt Consumption in Portuguese School-Aged Children: The Iogeneration Study.

Nutrients 2017 May 05;9(5). Epub 2017 mai 5

PMID: 28475154

Amundsen T, Strømmen M, Martins C

Suboptimal Weight Loss and Weight Regain after Gastric Bypass Surgery-Postoperative Status of Energy Intake, Eating Behavior, Physical Activity, and Psychometrics.

Obes Surg 2017 May;27(5):1316-1323.

PMID: 27914028

Martins C, Kazakova I, Ludviksen M, Mehus I, Wisloff U, Kulseng B, Morgan L, King N

High-Intensity Interval Training and Isocaloric Moderate-Intensity Continuous Training Result in Similar Improvements in Body Composition and Fitness in Obese Individuals.

Int J Sport Nutr Exerc Metab 2016 Jun;26(3):197-204. Epub 2015 okt 19

PMID: 26479856

Roekenes J, Strømmen M, Kulseng B, Martins C

The Impact of Feet Callosities, Arm Posture, and Usage of Electrolyte Wipes on Body Composition by Bioelectrical Impedance Analysis in Morbidly Obese Adults.

Obes Facts 2015;8(6):364-72. Epub 2015 nov 20

PMID: 26584161

Salamati S, Martins C, Kulseng B

Baker's yeast (Saccharomyces cerevisiae) antigen in obese and normal weight subjects.

Clin Obes 2015 Feb;5(1):42-7. Epub 2014 nov 18

PMID: 25611585

Martins C, Stensvold D, Finlayson G, Holst J, Wisloff U, Kulseng B, Morgan L, King NA

Effect of moderate- and high-intensity acute exercise on appetite in obese individuals.

Med Sci Sports Exerc 2015 Jan;47(1):40-8.

PMID: 24824772

Finbråten AK, Martins C, Andersen GL, Skranes J, Brannsether B, Júlíusson PB, Syversen U, Stevenson RD, Vik T

Assessment of body composition in children with cerebral palsy: a cross-sectional study in Norway.

Dev Med Child Neurol 2015 Sep;57(9):858-64. Epub 2015 apr 1

PMID: 25827868

Sousa AS, Mendes J, Guerra RS, Padrão P, Moreira P, Santos A, Borges N, Afonso C, Martins C, Ferro G, Amaral TF

Sitting time and associated factors among Portuguese older adults: results from Nutrition UP 65

European Journal of aging

Doktorgrader
Silvia dos Santos Ribeiro F Coutinho

An investigation of potential variables affecting the physiological adaptations to weight loss.

Disputert:
februar 2018
Hovedveileder:
Catia Martins
Siren Nymo

Timeline of adaptive physiological responses with progressive weight loss in individuals with obesity on a very-low energy diet

Disputert:
juni 2018
Hovedveileder:
Catia Martins
Deltagere
  • Catia Martins Forskningsgruppeleder

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