Fosfoprotein-proteomikk for identifikasjon av nye behandlingsmål. Flt3 reseptor-tyrosinkinase som modell for feilregulert proteinfosforylering i akutt myelogen leukemi
Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells.
Mol Cancer 2007;6():33. Epub 2007 mai 11
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53.
Blood 2007 Mar;109(6):2589-96. Epub 2006 nov 14
Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies.
Curr Pharm Biotechnol 2006 Jun;7(3):185-98.
Algal toxins as guidance to identify phosphoproteins with key roles in apoptotic cell death.
Curr Pharm Biotechnol 2006 Jun;7(3):209-15.
Single cell profiling of potentiated phospho-protein networks in cancer cells.
Cell 2004 Jul;118(2):217-28.
Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis.
Leukemia 2004 Dec;18(12):1989-96.
Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities.
Haematologica 2003 Apr;88(4):416-28.
The angioregulatory phenotype of native human acute myelogenous leukemia cells: influence of karyotype, Flt3 abnormalities and differentiation status.
Eur J Haematol 2003 Sep;71(3):163-73.
1. Quantitative proteomics analysis of the THP1 acute myeloid leukemia cell line after long-time stimulation with Flt3 ligand
Intracellular Transport and Signal Transduction in Cancer Biomedicine, Stalheim, The Nærøy Fjord. Norway. May 19th-23th 2007.
1. Quantitative proteomics on leukemia cells stimulated with Flt3 receptor tyrosine kinase ligand
Nordic Proteomics Network, Saka Hotel, Tallinn, August 2007
2. Quantitative proteomics on the THP1 AML cell line after long-time stimulation with Flt3 ligand
BCCR, Solstrand, Bergen. May 4th-5th 2007
3. Use of SILAC to investigate signaling targets of Flt3 receptor tyrosine kinase
The Norwegian Biochemical Society Contact Meeting. February 1th-3th 2007.
Approaches to discover members of the oncogenic Flt3 receptor tyrosine kinase signaling network
Protein modulation of Flt3 and Hdm2 by DNA damage, Flt3 ligand and kinase inhibitors in acute myeloid leukemia
Poster. European School of Hematology/AACR , Cascais, Portugal 2006
SILAC to identify signaling targets of Flt3 –a receptor tyrosine kinase often mutated in acute myeloid leukemia
Talk. Quantitative mass spectrometry seminar, Odese, Danmark 2006
Flt3-from gene to protein.
Innlegg. Bergen Conference on Cancer Research
Signalling network induced by mutated Flt3 tyrosine kinase.
National Proteomics Conference. Bergen
Mutations in Flt3 receptor tyrosine kinase and altered signaling in acute myeloid leukemia cells
Poster. FEMBS/EMBO course. Molecular mechanisms in signal tranduction in cancer.
Mutasjoner i tyrosin kinasen Flt3 ved akutt myelogen leukemi.
Nordisk Møte i Human Genetikk 2004
Therapy induced transition from acute myeloid leukemia with Flt3 length mutations to chronic myeloid leukemia with t(9;22)(q34;q
Proteomics Unit at UoB (PROBE): the Norwegian proteomics centre.
NBS Vintermøte 2004
Introduksjon i proteomikk
"Verdt å Vite" NRK Radio intervju
Advances in protein research
UoB International magazine 2003