Glucokinase - the glucose sensor of the pancreatic beta-cell. From crystal structure to diabetes diagnosis and therapy.
- Prosjektnummer
- 911167
- Ansvarlig person
- Janne Molnes
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Korttidsstipend
- Helsekategori
- Endocrinology & Metabolism
- Forskningsaktivitet
- Grunnforskning
Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.
Pediatr Diabetes 2008 Oct;9(5):442-9. Epub 2008 apr 9
PMID: 18399931
Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions.
FEBS J 2008 May;275(10):2467-81. Epub 2008 apr 7
PMID: 18397317
Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation.
J Biol Chem 2007 Aug;282(31):22757-64. Epub 2007 jun 8
PMID: 17561510
From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.
Diabetes 2006 Jun;55(6):1713-22.
PMID: 16731834
Human glucokinase is modified by SUMOylation
Poster EMBO Kurs: Ubiquitin and Sumo, Split, Kroatia, 12-18 Sept. 2008
Novel mechanisms for the cellular regulation of the glucose sensor glucokinase
Foredrag, Nordic Network in Endocrinology and Diabetes, Göteborg 24. Sept, 2008
Glucokinase - The glucose sensor of the pancreatic beta-cell. Structure, function and regulatory mechanisms.
Foredrag, Norges Diabetes Forbunds Stipendiatkonferanse, Gardermoen, 25.-26. Sept 2008.
Activation of Human Glucokinase by Free Polyubiquitin Chains and its Ubiquitin-dependent Cotranslational Proteosomal Degradation
EASD’s Study Group for the Genetics in Diabetes (SGGD), Malaga, Spania, okt 2007: Poster
Glukokinase - en sentral regulator av insulinsekresjonen
Diabetesforum nr 4 2007
Glucokinase – the glucose sensor in the pancreatic β-cell. Structure, modification and function; implications for diagnosis
Abstract. Nordic Network in endocrinology and diabetes 2006.
Substrate-induced conformational transitions in wild-type and mutant forms of human pancreatic glucokinase
Abstrakt. Genetics of Hyperglycemia, Helsingør, Danmark, 2006.
Characterization of mutations in glucokinase reveals different mechanisms of enzyme regulation
Abstrakt. Genetics of Hyperglycemia, Helsingør, Danmark, 2006.
Ubiquitination of the pancreatic glucose sensor glucokinase
Abstrakt. Norsk Biokjemisk Selskaps 42. kontaktmøte, Storefjell 19. - 22. januar 2006.
Substrate-induced conformational states and transitions in human pancreatic glucokinase. Relation to the kinetic cooperativity o
Abstrakt. Norsk Biokjemisk Selskaps 42. kontaktmøte, Storefjell 19. - 22. januar 2006.
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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