Translational Psychiatry: The BDNF hypothesis of synaptic plasticity and depression
- Prosjektnummer
- 911353
- Ansvarlig person
- Clive Bramham
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Mental Health
- Forskningsaktivitet
- 1. Underpinning
Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.
PLoS One 2009;4(10):e7534. Epub 2009 okt 21
PMID: 19844571
Novel translational control in Arc-dependent long term potentiation consolidation in vivo.
J Biol Chem 2009 Nov;284(46):31498-511. Epub 2009 sep 15
PMID: 19755425
Impairment of in vivo theta-burst long-term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle.
Hippocampus 2009 Feb;19(2):130-40.
PMID: 18767067
Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1.
PLoS One 2009;4(3):e4885. Epub 2009 mar 17
PMID: 19290048
Local protein synthesis, actin dynamics, and LTP consolidation.
Curr Opin Neurobiol 2008 Oct;18(5):524-31. Epub 2008 okt 14
PMID: 18834940
The immediate early gene arc/arg3.1: regulation, mechanisms, and function.
J Neurosci 2008 Nov;28(46):11760-7.
PMID: 19005037
Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers.
Neuroscience 2008 Jul;154(4):1568-75. Epub 2008 mai 21
PMID: 18555615
Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications.
Prog Brain Res 2007;163():453-71.
PMID: 17765733
Dendritic mRNA: transport, translation and function.
Nat Rev Neurosci 2007 Oct;8(10):776-89.
PMID: 17848965
Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.
J Neurosci 2007 Sep;27(39):10445-55.
PMID: 17898216
Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: induction of immunity-linked genes.
Neuroscience 2007 Sep;148(4):925-36. Epub 2007 jul 21
PMID: 17764852
The Arc of synaptic memory
Exp Brain Res, 2009 PMID. 19690847DOI:10.1007/s00221-009-1959-2.
Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in
Neural Plasticity, epub. Q4 2008
Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentia
Neural Plast 2007: 26496. PMID: 18301726 (Denne kom ikke i pubmed før 2008)
Chronic fluoxetine induces brain-region specific upregulation of genes associated with BDNF-induced long-term potentiation.
Neural Plasticity, vol. 2007, Article ID 26496, 9 pages. Doi:10.1155/2007/26496
Translational regulation of long-term potentiation in the dentate gyrus
- Disputert:
- desember 2009
- Hovedveileder:
- Clive Bramham
Mechanisms of synaptic plasticity in the rat dentate gyrus in vivo
- Disputert:
- juni 2008
- Hovedveileder:
- Clive Bramham
The role of the immediate early gene Arc/Arg3.1 in long-term potentiation and neurogenesis
- Disputert:
- juni 2008
- Hovedveileder:
- Clive Bramham
LTP mechanisms in the dentate gyrus in vivo: BDNF signaling, translation control, and gene function
- Disputert:
- april 2007
- Hovedveileder:
- Clive Bramham
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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