Interstitial fibrosis-its role for organ damage
- Prosjektnummer
- 911356
- Ansvarlig person
- Bjarne M.Iversen
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 2. Aetiology
AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.
Am J Physiol Renal Physiol 2009 Jul;297(1):F163-8. Epub 2009 apr 22
PMID: 19386725
Angiotensin II-induced contraction is attenuated by nitric oxide in afferent arterioles from the nonclipped kidney in 2K1C.
Am J Physiol Renal Physiol 2009 Jan;296(1):F78-86. Epub 2008 okt 22
PMID: 18945823
Dendritic Cells Loaded with Tumor Antigens and a Dual Immunostimulatory and Anti-Interleukin 10-Specific Small Interference RNA Prime T Lymphocytes against Leukemic Cells.
Transl Oncol 2009 Dec;2(4):242-6.
PMID: 19956385
The alpha11beta1 integrin has a mechanistic role in control of interstitial fluid pressure and edema formation in inflammation.
Arterioscler Thromb Vasc Biol 2009 Nov;29(11):1864-70. Epub 2009 sep 3
PMID: 19729609
Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model.
Neoplasia 2009 Aug;11(8):812-22.
PMID: 19649211
Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats.
Am J Physiol Regul Integr Comp Physiol 2009 Jul;297(1):R26-33. Epub 2009 apr 1
PMID: 19339678
Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia.
Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H735-44. Epub 2009 jan 16
PMID: 19151248
Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma.
BMC Cancer 2009;9():446. Epub 2009 des 17
PMID: 20017908
Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma.
PLoS One 2009;4(12):e8149. Epub 2009 des 4
PMID: 19997591
Hyperoxic treatment induces mesenchymal-to-epithelial transition in a rat adenocarcinoma model.
PLoS One 2009;4(7):e6381. Epub 2009 jul 28
PMID: 19636430
Adriamycin alters glomerular endothelium to induce proteinuria.
J Am Soc Nephrol 2009 Jan;20(1):114-22. Epub 2008 des 10
PMID: 19073829
Infusion of hypertonic saline/starch during cardiopulmonary bypass reduces fluid overload and may impact cardiac function.
Acta Anaesthesiol Scand 2010 Apr;54(4):485-93. Epub 2009 okt 29
PMID: 19878097
Percutaneous left ventricular assist device can prevent acute cerebral ischaemia during ventricular fibrillation.
Resuscitation 2009 Oct;80(10):1197-203. Epub 2009 jul 23
PMID: 19631443
Sympathectomy suppresses tumor growth and alters gene-expression profiles in rat tongue cancer.
Eur J Oral Sci 2009 Aug;117(4):351-61.
PMID: 19627344
Sensory pulpal nerve fibres and trigeminal ganglion neurons express IL-1RI: a potential mechanism for development of inflammatory hyperalgesia.
Int Endod J 2009 Nov;42(11):978-86. Epub 2009 sep 1
PMID: 19732182
Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice.
Arthritis Res Ther 2009;11(1):R18. Epub 2009 feb 6
PMID: 19200376
Characterization of the dental lymphatic system and identification of cells immunopositive to specific lymphatic markers.
Eur J Oral Sci 2009 Feb;117(1):34-42.
PMID: 19196316
Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage.
Nephrol Dial Transplant 2008 Mar;23(3):896-903. Epub 2007 okt 31
PMID: 17977875
Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension.
Am J Physiol Regul Integr Comp Physiol 2008 Feb;294(2):R438-47. Epub 2007 nov 21
PMID: 18032469
Low birth weight increases risk for end-stage renal disease.
J Am Soc Nephrol 2008 Jan;19(1):151-7. Epub 2007 des 5
PMID: 18057216
Glomerular charge barrier and development of proteinuria in passive Heymann nephritis.
Kidney Blood Press Res 2008;31(3):203-9. Epub 2008 jun 10
PMID: 18544954
Preeclampsia and the risk of end-stage renal disease.
N Engl J Med 2008 Aug;359(8):800-9.
PMID: 18716297
Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats.
Am J Physiol Regul Integr Comp Physiol 2008 Dec;295(6):R1866-73. Epub 2008 okt 8
PMID: 18843091
High interstitial fluid pressure in rat tongue cancer is related to increased lymph vessel area, tumor size, invasiveness and decreased body weight.
J Oral Pathol Med 2008 Mar;37(3):137-44.
PMID: 18251937
Identification of a Ca2+-sensing receptor in rat trigeminal ganglia, sensory axons, and tooth dental pulp.
Calcif Tissue Int 2008 Jan;82(1):57-65. Epub 2008 jan 4
PMID: 18175029
Plasma protein charge: a major determinant of fluid exchange.
Acta Physiol (Oxf) 2008 Dec;194(4):253.
PMID: 19032291
Peritumoral TNFalpha administration influences tumour stroma structure and physiology independently of growth in DMBA-induced mammary tumours.
Scand J Clin Lab Invest 2008 Apr. Epub 2008 apr 9
PMID: 18609121
A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions.
FASEB J 2008 Sep;22(9):3120-8. Epub 2008 mai 21
PMID: 18495755
The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential therapeutic consequences.
Microcirculation 2008 May;15(4):283-96.
PMID: 18464158
Isolation of rat trachea interstitial fluid and demonstration of local cytokine production in lipopolysaccharide-induced systemic inflammation.
J Appl Physiol 2008 Mar;104(3):809-20. Epub 2008 jan 10
PMID: 18187613
Pre-treatment with insulin before ischemia reduces infarct size in Langendorff perfused rat hearts.
Acta Physiol (Oxf) 2008 Sep. Epub 2008 sep 17
PMID: 18801053
Myasthenia gravis sera have no effect on cardiomyocytes in vitro.
J Neuroimmunol 2008 Sep;201-202():74-9. Epub 2008 jul 15
PMID: 18632164
Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion.
Basic Res Cardiol 2008 Sep;103(5):444-53. Epub 2008 mai 23
PMID: 18500485
A secreted collagen- and fibronectin-binding streptococcal protein modulates cell-mediated collagen gel contraction and interstitial fluid pressure.
J Biol Chem 2008 Jan;283(3):1234-42. Epub 2007 nov 13
PMID: 18003607
Integrin alphavbeta3 acts downstream of insulin in normalization of interstitial fluid pressure in sepsis and in cell-mediated collagen gel contraction.
Am J Physiol Heart Circ Physiol 2008 Aug;295(2):H555-60. Epub 2008 jun 13
PMID: 18552165
A hyperosmolar-colloidal additive to the CPB-priming solution reduces fluid load and fluid extravasation during tepid CPB.
Perfusion 2008 Jan;23(1):57-63.
PMID: 18788219
Long-term risk of cancer in membranous nephropathy patients.
Am J Kidney Dis 2007 Sep;50(3):396-403.
PMID: 17720518
Three-Dimensional Ultrasonography can Detect the Modulation of Kidney Volume in Two-Kidney, One-Clip Hypertensive Rats.
Ultrasound Med Biol 2007 Dec;33(12):1882-8. Epub 2007 aug 6
PMID: 17689181
Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension.
Am J Physiol Renal Physiol 2007 Sep;293(3):F839-45. Epub 2007 jun 27
PMID: 17596529
Short-term ANG II produces renal vasoconstriction independent of TP receptor activation and TxA2/isoprostane production.
Am J Physiol Renal Physiol 2007 Sep;293(3):F860-7. Epub 2007 jun 13
PMID: 17567934
Physiology and pathology of collagen receptors.
Acta Physiol (Oxf) 2007 Jul;190(3):179-87.
PMID: 17581134
Sympathectomy decreases size and invasiveness of tongue cancer in rats.
Neuroscience 2007 Nov;149(3):715-25. Epub 2007 aug 16
PMID: 17916410
Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma.
Proc Natl Acad Sci U S A 2007 Aug;104(35):13966-71. Epub 2007 aug 22
PMID: 17715296
Hyperoxia retards growth and induces apoptosis, changes in vascular density and gene expression in transplanted gliomas in nude rats.
J Neurooncol 2007 Nov;85(2):191-202. Epub 2007 jun 8
PMID: 17557137
Spontaneous coronary artery dissection in a female with antiphospholipid syndrome.
Heart Lung Circ 2007 Apr;16(2):120-2. Epub 2007 feb 26
PMID: 17324624
Effects of preload alterations on peak early diastolic mitral annulus velocities evaluated by tissue Doppler echocardiography.
Eur J Anaesthesiol 2007 Feb;24(2):159-65.
PMID: 17202014
Intraoperative fluid balance during cardiopulmonary bypass: effects of different mean arterial pressures.
Perfusion 2007 Jul;22(4):273-8.
PMID: 18181516
Fluid overload during cardiopulmonary bypass is effectively reduced by a continuous infusion of hypertonic saline/dextran (HSD).
Scand Cardiovasc J 2008 Feb;42(1):63-70.
PMID: 17896202
Low perfusion pressure during CPB may induce cerebral metabolic and ultrastructural changes.
Scand Cardiovasc J 2007 Oct;41(5):331-8.
PMID: 17852788
Elevated flow rate during cardiopulmonary bypass is associated with fluid accumulation.
J Thorac Cardiovasc Surg 2007 Sep;134(3):587-93.
PMID: 17723803
Lowering of interstitial fluid pressure after neurogenic inflammation in mouse skin is partly dependent on mast cells.
Am J Physiol Heart Circ Physiol 2007 Apr;292(4):H1821-7. Epub 2006 des 8
PMID: 17158654
Low-level laser therapy (GaAs lambda = 904 nm) reduces inflammatory cell migration in mice with lipopolysaccharide-induced peritonitis.
Photomed Laser Surg 2007 Aug;25(4):245-9.
PMID: 17803379
Renal vascular L-arginine metabolism, NO release and contraction in Angiotensin II hypertensive rats
FASEB J. 2009 23:606.6
Renal damage in the non-clipped kidney in two kidney one clip rat is most pronounced in the juxtamedullary cortex.
FASEB J. 2009 23:1017.12
Structure and function of the dentin-pulp complex .
Ingles Endodontics 6.Eds Chapter 5, page 118-150,2008
Low birth weight increases risk for end-stage renal disease
JASN, Epub des.2007
Histology and Physiology of the dental pulp
Ingle's Endodontics,Chapter 5,119-151, 2007
High interstitial fluid pressure in rat tong cancer is related to increased lymph vessel area
Journal of Oral Pathology and Medicine 10.1111/j.1600-0714,2007
Pulp-dentin and periodontal anatomy and physiology
Essential Endodontology Chaperter 2,9-41,2007.
Studies on the tissue microenvironment and secretion of signalling substances with special focus on trachea and spleen
- Disputert:
- juni 2009
- Hovedveileder:
- Helge Wiig
Effect of sympathectomy on experimental tongue tumors
- Disputert:
- november 2009
- Hovedveileder:
- Karin Johanne heyeraas
Experimental renovascular hypertension. Tetradecythioacetic acid as a potential new treatment
- Disputert:
- april 2008
- Hovedveileder:
- Bjarne M.Iversen
Microvascular exchange and local cytokine production during acute inflammation
- Disputert:
- september 2008
- Hovedveileder:
- Helge Wiig
New knowledge on edema pathophysiology derived from animals involving increased fluid dranage and reduced lymph drain
- Disputert:
- januar 2007
- Hovedveileder:
- Helge Wiig
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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