Lipogenic effects of psychotrophic drugs: Mechanisms of clinical relevance
- Prosjektnummer
- 911365
- Ansvarlig person
- Johan Fernø
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskerutdanning - postdoc
- Helsekategori
- Mental Health
- Forskningsaktivitet
- 5. Treatment Developement
Hypothalamic lipotoxicity and the metabolic syndrome.
Biochim Biophys Acta 2010 Mar;1801(3):350-61. Epub 2009 sep 29
PMID: 19796707
Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia.
Pharmacopsychiatry 2011 Jan;44(1):15-20. Epub 2010 sep 6
PMID: 20821366
Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells.
J Psychopharmacol 2011 Jul;25(7):924-33. Epub 2010 sep 13
PMID: 20837565
Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.
Mol Psychiatry 2010 May;15(5):463-72. Epub 2008 okt 21
PMID: 18936756
Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver.
Psychopharmacology (Berl) 2009 Mar;203(1):73-84. Epub 2008 okt 30
PMID: 18989661
Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells.
BMC Pharmacol 2009;9():10. Epub 2009 aug 29
PMID: 19715613
Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?
Mol Psychiatry 2009 Mar;14(3):308-17. Epub 2008 jan 15
PMID: 18195716
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest