Separate gene and protein expression profiling of the malignant and stromal cell compartment in tumors
- Prosjektnummer
- 911382
- Ansvarlig person
- Jian Wang
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskerutdanning - postdoc
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients.
Neuropathol Appl Neurobiol 2011 Feb;37(2):189-205.
PMID: 20819169
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma.
Proc Natl Acad Sci U S A 2011 Mar;108(9):3749-54. Epub 2011 feb 14
PMID: 21321221
Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.
PLoS One 2011;6(7):e23062. Epub 2011 jul 29
PMID: 21829586
Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide.
BMC Cancer 2011 Dec;11(1):524. Epub 2011 des 20
PMID: 22185371
aB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells.
Am J Pathol 2010 Oct;177(4):1618-28. Epub 2010 sep 2
PMID: 20813964
Glioma cell populations grouped by different cell type markers drive brain tumor growth.
Cancer Res 2010 Jun;70(11):4274-9. Epub 2010 mai 11
PMID: 20460538
Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment.
Gene Ther 2010 Feb;17(2):202-16. Epub 2009 okt 15
PMID: 19829315
A reproducible brain tumour model established from human glioblastoma biopsies.
BMC Cancer 2009;9():465. Epub 2009 des 29
PMID: 20040089
Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein.
Mol Cancer Res 2009 Nov;7(11):1792-802. Epub 2009 nov 10
PMID: 19903770
iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype.
Mol Cell Proteomics 2009 Nov;8(11):2595-612. Epub 2009 aug 12
PMID: 19674965
Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype.
Neuropathol Appl Neurobiol 2009 Aug;35(4):380-93.
PMID: 19508445
Two distinct tumor phenotypes isolated from glioblastomas show different MRS characteristics.
NMR Biomed 2008 Oct;21(8):830-8.
PMID: 18613001
The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling.
Oncogene 2008 Sep;27(39):5182-94. Epub 2008 mai 12
PMID: 18469852
Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma.
Clin Cancer Res 2008 Mar;14(5):1571-80.
PMID: 18316582
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells.
Int J Cancer 2008 Feb;122(4):761-8.
PMID: 17955491
Tumor-associated glial cells promote growth of GBM xenografts in eGFP NOD/Scid mice
2011 SNO meeting
Targeting the tumor stroma: a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartmen
Fifth International Conference on Tumor Microenvironment: Progression, Therapy, and Prevention, 2009 Versailles, France
Phenotypic modulation of experimental gliomas: progression from gliomatosis cerebri-like lesions to glioblastoma
The 3rd Quadrennial Meeting of the World Federation of Neuro-Oncology, 2009 Yokohama, Japan
Targeting the tumor stroma – a novel therapeutic strategy based on separate analysis of the malignant and stromal cell compartme
AACR meeting 2008
Xenografted brain tumours for modelling glioma biology
- Disputert:
- mars 2008
- Hovedveileder:
- Per Øyvind Enger
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest