Phenotypic heterogeneity of human glucokinase (MODY2) mutations. Structure, function and regulatory mechanisms
- Prosjektnummer
- 911385
- Ansvarlig person
- Ingvild Aukrust
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskerutdanning - postdoc
- Helsekategori
- Metabolic and Endocrine
- Forskningsaktivitet
- 5. Treatment Developement
SUMOylation of pancreatic glucokinase regulates its cellular stability and activity.
J Biol Chem 2013 Feb 22;288(8):5951-62. Epub 2013 jan 7
PMID: 23297408
GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.
Biochim Biophys Acta 2012 Nov;1822(11):1705-15. Epub 2012 jul 20
PMID: 22820548
Binding of ATP at the active site of human pancreatic glucokinase--nucleotide-induced conformational changes with possible implications for its kinetic cooperativity.
FEBS J 2011 Jul;278(13):2372-86. Epub 2011 mai 31
PMID: 21569204
Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.
Pediatr Diabetes 2008 Oct;9(5):442-9. Epub 2008 apr 9
PMID: 18399931
Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions.
FEBS J 2008 May;275(10):2467-81. Epub 2008 apr 7
PMID: 18397317
SUMOylation of Pancreatic Glucokinase Regulates its Cellular Stability and Activity.
Keystone Symposia, Colorado, januar 2013
GCK-MODY due to protein misfolding, cellular self-association and degradation
Keystone Symposia, Colorado, januar 2013
Functional characterization of two HNF-1A mutations associated with early or late onset diabetes
Fourth Meeting of the EASD Study Group on Genetics of Diabetes (EASD-SGGD), mai 2013
GCK-MODY due to protein misfolding, cellular self-association and degradation
American Diabetes Association meeting, Philadelphia, USA, June 2012
SUMOylation of pancreatic glucokinase regulates its cellular stability and activity.
EASD-meeting, Bratislava, Slovakia.
GCK-MODY associated with protein misfolding, cellular self-association and degradation.
EASD-meeting, Bratislava, Slovakia.
Novel mechanisms for the potential cellular regulation of glucokinase by SUMOylation
Boston Ithaca Islet Club Meeting, Providence, RI, USA, May 2010. Oral presentation
Post-translational modification of glucokinase by SUMOylation
Diabetes/Islet Bology, Keystone Symposia Conference, Whistler, British Columbia, Canada, April 2010. Poster presentation
SUMOylation of pancreatic glucokinase regulates its cellular stability and activity
10th BBB Junior Scientist Mini-Symposium, Bergen, Norway, December 2010. Oral presentation
Ubiquitination and SUMOylation of human glucokinase
Keystone Symposia "The many faces of ubiquitin", Copper Mountain, Colorado, USA, 11.-16. januar 2009
Ubiquitination and SUMOylation of human glucokinase
EASD Study Group on Genetics of Diabetes "The Genotypes and Phenotypes of Diabetes", Solstrand, Bergen, Norge, 22.-26. april 2009
Phentoypic heterogeneity of mutations in glucokinase causing GCK-MODY (MODY2) diabetes
- Disputert:
- juni 2012
- Hovedveileder:
- Lise Bjørkhaug Gundersen og Pål Rasmus Njølstad
Human pancreatic glucokinase
- Disputert:
- oktober 2012
- Hovedveileder:
- Pål Rasmus Njølstad
- Oddmund Søvik Prosjektdeltaker
- Janne Molnes Prosjektdeltaker
- Torgeir Flatmark Prosjektdeltaker
- Maria Negahdar Ph.d.-kandidat
- Lise Bj. Gundersen Prosjektdeltaker
- Pål Rasmus Njølstad Leder av forskningsgruppe
- Ingvild Aukrust Postdoktor
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest