Obesity and inflammation-related diseases. Mitochondrial function and adipokines as novel targets.
- Prosjektnummer
- 911396
- Ansvarlig person
- Rolf K. Berge
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Inflammatory and Immune System
- Forskningsaktivitet
- 3. Prevention
Synthesis of novel PPARa/? dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design program protobuild.
Org Biomol Chem 2010 Dec. Epub 2010 des 15
PMID: 21157612
Effects of dietary lipid, vitamins and minerals on total amounts and redox status of glutathione and ubiquinone in tissues of Atlantic salmon (Salmo salar): a multivariate approach.
Br J Nutr 2010 Oct;104(7):980-8. Epub 2010 jun 14
PMID: 20540821
Platelet activating factor stimulates arachidonic acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase A2.
Arch Dermatol Res 2010 Apr;302(3):221-7. Epub 2009 des 30
PMID: 20041255
Dietary supplementation of tetradecylthioacetic acid increases feed intake but reduces body weight gain and adipose depot sizes in rats fed on high-fat diets.
Diabetes Obes Metab 2009 Nov;11(11):1034-49. Epub 2009 sep 9
PMID: 19740081
A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation.
Biochim Biophys Acta 2009 Nov;1791(11):1076-83. Epub 2009 jul 3
PMID: 19577662
Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats.
Br J Nutr 2009 Sep;102(6):803-15. Epub 2009 mar 19
PMID: 19298684
Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation.
Diabetes Obes Metab 2009 Apr;11(4):304-14.
PMID: 19267708
Synthesis and analysis of novel glycerolipids for the treatment of metabolic syndrome.
J Med Chem 2009 Feb;52(4):1172-9.
PMID: 19175322
A casein diet added isoflavone-enriched soy protein favorably affects biomarkers of steatohepatitis in obese Zucker rats.
Nutrition 2009 May;25(5):574-80. Epub 2008 des 20
PMID: 19101115
Combination of fish oil and fish protein hydrolysate reduces the plasma cholesterol level with a concurrent increase in hepatic cholesterol level in high-fat-fed Wistar rats.
Nutrition 2009 Jan;25(1):98-104. Epub 2008 aug 26
PMID: 18752928
Short-term and long-term case fatality in 11 878 patients hospitalized with a first acute myocardial infarction, 1979-2001: the Western Norway cardiovascular registry.
Eur J Cardiovasc Prev Rehabil 2009 Oct;16(5):621-7.
PMID: 19512933
Dietary single cell protein reduces fatty liver in obese Zucker rats.
Br J Nutr 2008 Oct;100(4):776-85. Epub 2008 mar 18
PMID: 18346305
Fatty Acid Incubation of Myotubues from Humans with Type 2 Diabetes Leads to Enhanced Release of Beta Oxidation Products Due to Impaired Fatty Acid Oxidation: Effects of Tetradecylthioacetic Acid and Eicosapentaenoic Acid.
Diabetes 2008 Dec. Epub 2008 des 9
PMID: 19066312
Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women.
J Nutr 2008 May;138(5):914-20.
PMID: 18424601
The role of PPARa activation in liver and muscle
PPAR Res,2010
Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in patients with psoriasis
Scand.J. Clin. Invest.
Different adipose tissue depots: their role in the development of metabolic syndrome and their response to hypolipidemic agents
J.Obesity
Tetradecyltjioacetic acid increases hepatic miotchondrial beta-oxidation and alters fatty acid composition in a mouse model of c
Lipids
The combination of fish oil and 3-thia fatty acid improves plasma lipid levels and fish-induced oxidative stress
submitted
Dietary intake of long-chain n-3 polyunsaturated fatty acids and coronary events in Norwegian patients with coronary artery dise
accepted
Tetradecylthioacetic acid and fish oil induce changes,both separatly and synergistically, in lipid metabolism and fatty acid com
submitted
Dietary intake of long chain n-3 fatty acids and cardiovascular events in patients with coronary artery disease.
Submitted to Am. J. Clin. Nutr.
Betaine excretion in urine is associated with components of the metabolic syndrome and microalbuminuria.
Submitted.
Investigation of combinatorial effects of bioactive lipids in a long term high-fat animal study.
Manuscript in preparation.
Dietary isoflavone-enriched soy protein and biomarkers of steatohepatitis in obese Zucker rats.
In Press Nutrition
atty acid incubation of myotubes from Humans with Type 2 diabets leads to enhanced release of beta-oxidation products because of
Accepted in Diabetes,March 2009.
Clinical trial: atlantic salmon diet in patients with active ulcerative colitis - positive effects on disease activity and lipi
Submitted to Alimentary Pharmacology and Therapeutics.
Peroxisome proliferator-activated receptors and mitochondria in relation to lifestyle-related diseases.
- Disputert:
- juni 2008
- Hovedveileder:
- Rolf K. Berge
Anti-inflammatory effects of bioactive fatty acids in relation to atherosclerosis
- Disputert:
- mai 2008
- Hovedveileder:
- Rolf Berge
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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