Stroma-targeting: a directed approach aimed at tumor stroma fibroblasts
- Prosjektnummer
- 911409
- Ansvarlig person
- Donald Gullberg
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.
Matrix Biol 2010 Apr;29(3):166-76. Epub 2009 nov 12
PMID: 19913614
The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation.
J Biol Chem 2010 Apr;285(14):10434-45. Epub 2010 feb 2
PMID: 20129924
Integrins.
Cell Tissue Res 2010 Jan;339(1):269-80. Epub 2009 aug 20
PMID: 19693543
Integrins during evolution: evolutionary trees and model organisms.
Biochim Biophys Acta 2009 Apr;1788(4):779-89. Epub 2009 jan 7
PMID: 19161977
Alpha11 integrin in the human cornea: importance in development and disease.
Invest Ophthalmol Vis Sci 2009 Nov;50(11):5044-53. Epub 2009 jun 10
PMID: 19516006
Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase.
Proc Natl Acad Sci U S A 2009 Jul;106(29):12109-14. Epub 2009 jul 8
PMID: 19587235
A role for alpha11beta1 integrin in the human periodontal ligament.
J Dent Res 2009 Jul;88(7):621-6.
PMID: 19641149
The alpha11beta1 integrin has a mechanistic role in control of interstitial fluid pressure and edema formation in inflammation.
Arterioscler Thromb Vasc Biol 2009 Nov;29(11):1864-70. Epub 2009 sep 3
PMID: 19729609
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.
Blood 2009 Nov;114(23):4897-906. Epub 2009 sep 29
PMID: 19789387
Shift happens--a paradigm shift for the role of integrins in fibrosis.
Matrix Biol 2009 Sep;28(7):383.
PMID: 19880051
Identification of the First Prokaryotic Collagen Sequence Motif That Mediates Binding to Human Collagen Receptors, Integrins {al
J Biol Chem. 2008 Dec 26;283(52):36168-75. Epub 2008 Nov 5.
The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential ther
Microcirculation. 2008 May;15(4):283-96. Review
How to keep that stemmy-ness: stem cells in the spotlight.
Matrix Biol. 2008 Apr;27(3):161-2
Transcriptional regulation of integrin a11
- Disputert:
- juni 2008
- Hovedveileder:
- Donald Gullberg
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest