Tumor suppressor proteins p53 and NPM1/nucleophosmin in targeted therapy of hematological malignancies
- Prosjektnummer
- 911497
- Ansvarlig person
- Bjørn Tore Gjertsen
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.
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[In Process Citation].
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Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.
Leukemia 2012 May;26(5):910-7. Epub 2011 nov 8
PMID: 22064349
Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia.
Oncogene 2012 Mar;31(12):1533-45. Epub 2011 aug 22
PMID: 21860418
Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis.
Oncol Rep 2011 Jun;25(6):1549-56. Epub 2011 mar 22
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Stratification of pediatric acute myeloid leukemia through cancer cell gene-expression profiling.
Expert Rev Anticancer Ther 2011 Mar;11(3):355-7.
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Untangling the intracellular signalling network in cancer--a strategy for data integration in acute myeloid leukaemia.
J Proteomics 2011 Mar;74(3):269-81. Epub 2010 nov 12
PMID: 21075225
Combination of the histone deacetylase inhibitor valproic acid with oral hydroxyurea or 6-mercaptopurin can be safe and effective in patients with advanced acute myeloid leukaemia--a report of five cases.
Hematology 2010 Oct;15(5):338-43.
PMID: 20863429
Hypoxia increases HIF-1a expression and constitutive cytokine release by primary human acute myeloid leukaemia cells.
Eur Cytokine Netw 2010 Sep;21(3):154-64. Epub 2010 aug 20
PMID: 20729179
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC Immunol 2010;11():38. Epub 2010 jul 9
PMID: 20618967
Clinical proteomics of myeloid leukemia.
Genome Med 2010;2(6):41. Epub 2010 jun 29
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Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia.
Nutr Cancer 2010 Jul;62(5):574-83.
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Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment.
J Cell Biochem 2010 Oct;111(3):574-84.
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Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation.
J Immunol 2010 Apr;184(8):4547-56. Epub 2010 mar 17
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Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
Proc Natl Acad Sci U S A 2010 Jan;107(3):1124-9. Epub 2009 des 28
PMID: 20080645
Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB.
Leuk Res 2010 Jan;34(1):77-84. Epub 2009 sep 27
PMID: 19786302
Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells.
Leuk Res 2009 Feb;33(2):276-87. Epub 2008 aug 8
PMID: 18691757
A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated with the combination of valproic acid, theophylline and all-trans retinoic acid.
Leuk Res 2009 Jun;33(6):779-87. Epub 2008 nov 12
PMID: 19007987
Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators.
Br J Haematol 2009 Jan;144(1):53-68. Epub 2008 okt 30
PMID: 19016730
Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia.
BMC Cancer 2009;9():77. Epub 2009 mar 5
PMID: 19265549
Targeted therapy in acute myeloid leukaemia: current status and future directions.
Expert Opin Investig Drugs 2009 Apr;18(4):433-55.
PMID: 19335274
The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells.
Br J Haematol 2009 Jun;145(6):761-74. Epub 2009 apr 20
PMID: 19388934
Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells.
Toxicology 2009 Sep;263(2-3):108-16. Epub 2009 jul 8
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Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model.
Neoplasia 2009 Aug;11(8):812-22.
PMID: 19649211
Cancer therapy targeted at cellular signal transduction mechanisms: strategies, clinical results, and unresolved issues.
Eur J Pharmacol 2009 Dec;625(1-3):6-22. Epub 2009 okt 18
PMID: 19836383
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines.
Mol Cancer 2009;8():101. Epub 2009 nov 13
PMID: 19912650
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acut
Blood Cancer Journal (2011) 1, e4; doi:10.1038/bcj.2011.2
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest