Kjernefasilitet for væskestrømscytometri og celle-sortering
- Prosjektnummer
- 911505
- Ansvarlig person
- Bjørn Tore Gjertsen
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Blood, Cancer, Infection, Inflammatory and Immune System, Generic Health Relevance
- Forskningsaktivitet
- 1. Underpinning, 4. Detection and Diagnosis
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation.
Oncotarget 2015 Feb 20;6(5):2794-811.
PMID: 25605239
Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients.
Cancer Immunol Immunother 2015 Mar;64(3):337-47. Epub 2014 nov 22
PMID: 25416072
Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006).
Eur J Haematol 2014 Aug 1. Epub 2014 aug 1
PMID: 25082346
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia.
Mol Cancer 2014;13():116. Epub 2014 mai 21
PMID: 24885082
SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute Myeloid Leukemia stem cells.
Cell Stem Cell 2014 Oct 2;15(4):431-46.
PMID: 25280219
First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma.
PLoS One 2014;9(3):e89527. Epub 2014 mar 4
PMID: 24594904
Deficient phosphorylation of Stat1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta.
PLoS One 2014;9(2):e88632. Epub 2014 feb 19
PMID: 24586361
Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia.
Leukemia 2014 Aug;28(8):1738-42. Epub 2014 feb 27
PMID: 24573384
Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft.
Mol Imaging Biol 2014 Feb;16(1):53-62.
PMID: 23877869
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival.
J Immunol 2014 Dec 15;193(12):6192-206. Epub 2014 nov 7
PMID: 25381437
Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer.
Eur J Cancer 2014 Dec;50(18):3262-70. Epub 2014 okt 10
PMID: 25310894
A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma.
J Transl Med 2014 Oct 4;12(1):278. Epub 2014 okt 4
PMID: 25280402
Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma.
PLoS One 2014;9(9):e108414. Epub 2014 sep 30
PMID: 25268630
U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells.
Cancer Med 2014 Aug;3(4):812-24. Epub 2014 mai 8
PMID: 24810477
Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties.
PLoS One 2014;9(7):e101365. Epub 2014 jul 2
PMID: 24988307
Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis.
Tissue Eng Part A 2014 Oct;20(19-20):2590-603. Epub 2014 aug 21
PMID: 24957363
Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets.
BMC Biotechnol 2014;14():57. Epub 2014 jun 21
PMID: 24952598
Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors.
Cell Rep 2014 Jun 26;7(6):1926-39. Epub 2014 jun 5
PMID: 24910432
Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation.
Stem Cell Res Ther 2014;5(1):23. Epub 2014 feb 17
PMID: 24533904
In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells.
Leuk Res Treatment 2014;2014():143479. Epub 2014 jan 8
PMID: 24527217
Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells.
Scand J Immunol 2014 Jan;79(1):20-6.
PMID: 24219556
Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia.
Eur J Pharm Biopharm 2014 Sep;88(1):186-93. Epub 2014 apr 18
PMID: 24747809
4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.
ACS Chem Biol 2014 Nov 21;9(11):2646-55. Epub 2014 sep 25
PMID: 25203327
Irritable bowel syndrome and chronic fatigue 6 years after giardia infection: a controlled prospective cohort study.
Clin Infect Dis 2014 Nov 15;59(10):1394-400. Epub 2014 aug 12
PMID: 25115874
Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children.
J Infect Dis 2015 May 15;211(10):1541-9. Epub 2014 nov 25
PMID: 25425696
Immunotherapies influence the influenza vaccination response in multiple sclerosis patients: an explorative study.
Mult Scler 2014 Jan 16;20(8):1074-1080. Epub 2014 jan 16
PMID: 24436455
Matrix M(TM) adjuvanted virosomal H5N1 vaccine induces balanced Th1/Th2 CD4(+) T cell responses in man.
Hum Vaccin Immunother 2014;10(8):2408-16.
PMID: 25424948
Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: Will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions?
Curr Cancer Drug Targets 2013 Jan;13(1):30-47.
PMID: 22873213
Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer.
Cancer Res 2013 Feb 15;73(4):1276-86. Epub 2012 des 10
PMID: 23233739
Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia.
Blood 2013 Feb 14;121(7):e34-42. Epub 2012 des 12
PMID: 23243270
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors.
Cancer Immunol Immunother 2013 Apr;62(4):773-85. Epub 2012 des 22
PMID: 23263452
Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients.
Leukemia 2013 Jul;27(7):1520-6. Epub 2013 jan 18
PMID: 23328954
Expression of TP53 isoforms p53ß or p53? enhances chemosensitivity in TP53(null) cell lines.
PLoS One 2013;8(2):e56276. Epub 2013 feb 11
PMID: 23409163
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.
Cell Death Dis 2013;4():e516. Epub 2013 feb 28
PMID: 23449452
cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases.
Int J Oncol 2013 May;42(5):1815-21. Epub 2013 mar 8
PMID: 23483263
Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors.
Expert Opin Investig Drugs 2013 May;22(5):551-63.
PMID: 23586877
Tunneling nanotube (TNT) formation is independent of p53 expression.
Cell Death Differ 2013 Aug;20(8):1124. Epub 2013 jun 14
PMID: 23764777
Gel2DE - a software tool for correlation analysis of 2D gel electrophoresis data.
BMC Bioinformatics 2013;14():215. Epub 2013 jul 6
PMID: 23829206
Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen.
BMC Cancer 2013;13():341. Epub 2013 jul 11
PMID: 23841896
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine.
BMC Pharmacol Toxicol 2013;14():35. Epub 2013 jul 11
PMID: 23845085
Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents.
Clin Epigenetics 2013;5(1):12. Epub 2013 jul 30
PMID: 23898968
The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia.
Clin Epigenetics 2013;5(1):13. Epub 2013 aug 1
PMID: 23915396
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.
Cancer Discov 2013 Dec;3(12):1416-29. Epub 2013 sep 20
PMID: 24056683
Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma.
Blood 2013 Oct 3;122(14):2443-52. Epub 2013 aug 27
PMID: 23982172
p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model.
PLoS One 2013;8(5):e62547. Epub 2013 mai 1
PMID: 23658742
Evaluating extracellular matrix influence on adherent cell signaling by cold trypsin phosphorylation-specific flow cytometry.
BMC Cell Biol 2013;14():36. Epub 2013 aug 19
PMID: 23957395
Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells.
Scand J Immunol 2013 Apr;77(4):246-54.
PMID: 23442246
No association of primary Sjögren's syndrome with Fc? receptor gene variants.
Genes Immun 2013 Jun;14(4):234-7. Epub 2013 apr 4
PMID: 23552400
Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas.
Scand J Immunol 2013 Sep;78(3):291-7.
PMID: 23790073
In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome.
Arthritis Res Ther 2013;15(5):R114.
PMID: 24025795
Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA).
Biochem Biophys Res Commun 2013 Jan 11;430(2):573-8. Epub 2012 des 7
PMID: 23228666
Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival.
Oncotarget 2013 Sep;4(9):1527-46.
PMID: 24127551
Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level.
J Neuroimmunol 2013 Nov 15;264(1-2):71-83. Epub 2013 aug 31
PMID: 24045166
Establishment of a novel dsRed NOD/Scid mouse strain to investigate the host and tumor cell compartments.
Cancer Invest 2013 May;31(4):221-30. Epub 2013 mar 22
PMID: 23521006
EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis.
Acta Neuropathol 2013 May;125(5):683-98. Epub 2013 feb 22
PMID: 23429996
Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course.
BMC Gastroenterol 2013;13():28. Epub 2013 feb 12
PMID: 23399438
Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.
Leukemia 2012 May;26(5):910-7. Epub 2011 nov 8
PMID: 22064349
Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation.
ChemMedChem 2012 Dec;7(12):2134-43. Epub 2012 okt 19
PMID: 23086693
Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks.
Eur J Haematol 2012 Dec;89(6):478-90. Epub 2012 okt 26
PMID: 23046151
Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines.
Cell Biol Toxicol 2012 Aug;28(4):201-12. Epub 2012 mar 16
PMID: 22422053
Immunogenic effects of recombinant interferon-beta therapy disrupt the JAK/STAT pathway in primary immune cells from patients with multiple sclerosis.
Mult Scler 2012 Aug;18(8):1116-24. Epub 2012 jan 27
PMID: 22287540
The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner.
PLoS One 2012;7(2):e31217. Epub 2012 feb 21
PMID: 22363584
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Proc Natl Acad Sci U S A 2012 Apr;109(17):6662-7. Epub 2012 mar 26
PMID: 22451913
Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation.
BMC Cancer 2012;12():21. Epub 2012 jan 17
PMID: 22251838
Implantable microenvironments to attract hematopoietic stem/cancer cells.
Proc Natl Acad Sci U S A 2012 Nov;109(48):19638-43. Epub 2012 nov 12
PMID: 23150542
S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest.
Oral Oncol 2012 Mar;48(3):219-25. Epub 2011 okt 26
PMID: 22032898
A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients.
Neuropathol Appl Neurobiol 2011 Feb;37(2):189-205.
PMID: 20819169
Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.
PLoS One 2011;6(7):e23062. Epub 2011 jul 29
PMID: 21829586
Critical appraisal of the side population assay in stem cell and cancer stem cell research.
Cell Stem Cell 2011 Feb;8(2):136-47.
PMID: 21295271
Distinct phenotypes of plasma cells in spleen and bone marrow of autoimmune NOD.B10.H2b mice.
Autoimmunity 2011 Aug;44(5):415-26. Epub 2011 feb 21
PMID: 21332424
Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses.
BMC Immunol 2011;12():2. Epub 2011 jan 5
PMID: 21208424
Phenotypic diversity of peripheral blood plasma cells in primary Sjögren's syndrome.
Scand J Immunol 2011 Jan;73(1):18-28.
PMID: 21128999
Dendritic cell populations in patients with self-reported food hypersensitivity.
Int J Gen Med 2011;4():389-96. Epub 2011 mai 15
PMID: 21625415
Bromelain treatment leads to maturation of monocyte-derived dendritic cells but cannot replace PGE2 in a cocktail of IL-1ß, IL-6, TNF-a and PGE2.
Scand J Immunol 2011 Aug;74(2):135-43.
PMID: 21449940
Efficient in vivo vascularization of tissue-engineering scaffolds.
J Tissue Eng Regen Med 2011 Apr;5(4):e52-62. Epub 2010 sep 23
PMID: 20865694
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma.
Acta Neuropathol 2011 Oct;122(4):495-510. Epub 2011 aug 24
PMID: 21863242
MAPKs ERK and p38, but not JNK phosphorylation, modulate IL-6 and TNF-a secretion following OK-432 in vitro stimulation of purified human monocytes.
Scand J Immunol 2011 Aug;74(2):114-25.
PMID: 21388428
Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.
Br J Haematol 2012 Feb;156(4):468-80. Epub 2011 des 13
PMID: 22150087
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
Proc Natl Acad Sci U S A 2010 Jan;107(3):1124-9. Epub 2009 des 28
PMID: 20080645
Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation.
J Immunol 2010 Apr;184(8):4547-56. Epub 2010 mar 17
PMID: 20237290
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer.
Oncogene 2011 Mar;30(12):1436-48. Epub 2010 nov 8
PMID: 21057535
High content screening: seeing is believing.
Trends Biotechnol 2010 May;28(5):237-45. Epub 2010 mar 24
PMID: 20346526
Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track - letter.
Cancer Res 2010 Aug;70(15):6393-6. Epub 2010 jul 14
PMID: 20631079
Glioma cell populations grouped by different cell type markers drive brain tumor growth.
Cancer Res 2010 Jun;70(11):4274-9. Epub 2010 mai 11
PMID: 20460538
Distinct roles of myosin Va in membrane remodeling and exocytosis of secretory granules.
Traffic 2010 May;11(5):637-50.
PMID: 20149155
A novel imaging-based high-throughput screening approach to anti-angiogenic drug discovery.
Cytometry A 2010 Jan;77(1):41-51.
PMID: 19834964
aB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells.
Am J Pathol 2010 Oct;177(4):1618-28. Epub 2010 sep 2
PMID: 20813964
Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.
Cancer Res 2009 Jul;69(13):5331-9. Epub 2009 jun 9
PMID: 19509230
Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome.
Blood 2009 Oct;114(16):3439-47. Epub 2009 aug 11
PMID: 19671918
Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy.
PLoS One 2009;4(7):e6314. Epub 2009 jul 20
PMID: 19617915
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines.
Mol Cancer 2009;8():101. Epub 2009 nov 13
PMID: 19912650
Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB.
Leuk Res 2010 Jan;34(1):77-84. Epub 2009 sep 27
PMID: 19786302
Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells.
Leuk Res 2009 Feb;33(2):276-87. Epub 2008 aug 8
PMID: 18691757
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis.
Blood 2009 Apr;113(14):3172-81. Epub 2009 jan 30
PMID: 19182210
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acut
Blood Cancer J. 2011: 1, e4 (doi:10.1038/bcj.2011.2)
Risk stratification and therapy response monitoring by phosphoprotein profiles in acute myeloid leukaemia
- Disputert:
- august 2013
- Hovedveileder:
- Bjørn Tore Gjertsen
- Rebecca Jane Cox Brokstad Prosjektdeltaker
- Kurt Hanevik Prosjektdeltaker
- Sonia Gavasso Prosjektdeltaker
- Martha Chekenya Enger Prosjektdeltaker
- Silke Appel Prosjektdeltaker
- Bjørn Tore Gjertsen Prosjektdeltaker
- James Lorens Prosjektdeltaker
- Per Øyvind Enger Prosjektdeltaker
- Andre Sulen Ph.d.-kandidat
- Jørn Skavland Postdoktor
- Yenan Bryceson Prosjektdeltaker
- Sten Ture Roland Jonsson Prosjektdeltaker
- Einar Klæboe Kristoffersen Prosjektdeltaker
- Marianne Enger Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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