Nevroforskning og bevegelsesforstyrrelser i relasjon til eldre
- Prosjektnummer
- 911511
- Ansvarlig person
- Jan Petter Larsen
- Institusjon
- Helse Stavanger HF
- Prosjektkategori
- Strategiske midler - bevegelsesforstyrrelser
- Helsekategori
- Neurological
- Forskningsaktivitet
- 1. Underpinning
Progressive degeneration of dopaminergic neurons through TRP channel-induced cell death.
J Neurosci 2014 Apr 23;34(17):5738-46.
PMID: 24760834
CSF Aß42 predicts early-onset dementia in Parkinson disease.
Neurology 2014 May 20;82(20):1784-90. Epub 2014 apr 18
PMID: 24748671
Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.
J Biol Chem 2014 May 23;289(21):14458-69. Epub 2014 apr 9
PMID: 24719325
The factor structure of the UPDRS motor scores changes during early Parkinson's disease.
Parkinsonism Relat Disord 2014 Jun;20(6):617-21. Epub 2014 mar 19
PMID: 24685659
New insight into neurodegeneration: the role of proteomics.
Mol Neurobiol 2014 Jun;49(3):1181-99. Epub 2013 des 10
PMID: 24323427
Proteome analysis reveals roles of L-DOPA in response to oxidative stress in neurons.
BMC Neurosci 2014;15():93. Epub 2014 jul 31
PMID: 25082231
Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin ß2.
Mol Cell Biol 2014 Aug;34(16):3024-40. Epub 2014 jun 9
PMID: 24912681
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons.
J Neurosci Res 2014 Sep;92(9):1167-77. Epub 2014 mai 2
PMID: 24798695
Parkinson's disease and age: The obvious but largely unexplored link.
Exp Gerontol 2015 Aug;68():33-8. Epub 2014 sep 26
PMID: 25261764
Natural history of falls in a population-based cohort of patients with Parkinson's disease: an 8-year prospective study.
Parkinsonism Relat Disord 2014 Oct;20(10):1059-64. Epub 2014 jul 9
PMID: 25048614
Motor symptoms after deep brain stimulation of the subthalamic nucleus.
Acta Neurol Scand 2015 May;131(5):298-304. Epub 2014 okt 23
PMID: 25346142
Progression and survival in Parkinson's disease with subthalamic nucleus stimulation.
Acta Neurol Scand 2014 Nov;130(5):292-8. Epub 2014 feb 4
PMID: 24495107
Mapping cortical atrophy in Parkinson's disease patients with dementia.
J Parkinsons Dis 2013;3(1):69-76.
PMID: 23938313
Importance of motor vs. non-motor symptoms for health-related quality of life in early Parkinson's disease.
Parkinsonism Relat Disord 2013 Nov;19(11):1027-32. Epub 2013 aug 2
PMID: 23916654
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.
J Biol Chem 2013 Aug 2;288(31):22809-20. Epub 2013 jun 21
PMID: 23792957
Prognosis of mild cognitive impairment in early Parkinson disease: the Norwegian ParkWest study.
JAMA Neurol 2013 May;70(5):580-6.
PMID: 23529397
Cerebrospinal fluid Aß levels correlate with structural brain changes in Parkinson's disease.
Mov Disord 2013 Mar;28(3):302-10. Epub 2013 feb 13
PMID: 23408705
Treatment in early Parkinson's disease: the Norwegian ParkWest study.
Acta Neurol Scand 2013 Aug;128(2):107-13. Epub 2012 nov 29
PMID: 23190324
Verbal memory is associated with structural hippocampal changes in newly diagnosed Parkinson's disease.
J Neurol Neurosurg Psychiatry 2013 Jan;84(1):23-8. Epub 2012 nov 15
PMID: 23154124
Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease.
Neurobiol Aging 2013 Jun;34(6):1708.e7-13. Epub 2012 nov 13
PMID: 23153929
Cerebrospinal fluid amyloid-ß and phenotypic heterogeneity in de novo Parkinson's disease.
J Neurol Neurosurg Psychiatry 2013 May;84(5):537-43. Epub 2012 okt 31
PMID: 23117496
Autonomic symptoms and dopaminergic treatment in de novo Parkinson's disease.
Acta Neurol Scand 2013 Apr;127(4):290-4. Epub 2012 sep 23
PMID: 22998158
Frequencies of falls and associated features at different stages of Parkinson's disease.
Eur J Neurol 2013 Jan;20(1):160-6. Epub 2012 jul 21
PMID: 22816560
Parkinson disease: associated disorders in the Norwegian population based incident ParkWest study.
Parkinsonism Relat Disord 2013 Jan;19(1):53-5. Epub 2012 jul 26
PMID: 22841686
Number of CAG repeats in POLG1 and its association with Parkinson disease in the Norwegian population.
Mitochondrion 2012 Nov;12(6):640-3. Epub 2012 aug 29
PMID: 22963882
Subjective sleep problems in patients with early Parkinson's disease.
Eur J Neurol 2012 Dec;19(12):1575-81. Epub 2012 jun 30
PMID: 22747791
Fatigue in early Parkinson's disease. Minor inconvenience or major distress?
Eur J Neurol 2012 Jul;19(7):963-8. Epub 2012 feb 16
PMID: 22340430
Psychometric properties of the Starkstein Apathy Scale in patients with early untreated Parkinson disease.
Am J Geriatr Psychiatry 2012 Feb;20(2):142-8.
PMID: 22064613
Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment.
Neurobiol Aging 2012 Sep;33(9):2113-24. Epub 2011 aug 3
PMID: 21813212
Analysis of the chloroplast proteome in arc mutants and identification of novel protein components associated with FtsZ2.
Plant Mol Biol 2012 Dec. Epub 2012 des 6
PMID: 23225155
Emerging facets of plastid division regulation.
Planta 2013 Feb;237(2):389-98. Epub 2012 sep 11
PMID: 22965912
In vivo phosphorylation of FtsZ2 in Arabidopsis thaliana.
Biochem J 2012 Sep;446(3):517-21.
PMID: 22823492
Increased risk of leg motor restlessness but not RLS in early Parkinson disease.
Neurology 2011 Nov;77(22):1941-6. Epub 2011 nov 9
PMID: 22076542
The economic impact of cognitive impairment in Parkinson's disease.
Mov Disord 2011 Jul;26(8):1541-4. Epub 2011 apr 29
PMID: 21538519
Verbal memory in drug-naive, newly diagnosed Parkinson's disease. The retrieval deficit hypothesis revisited.
Neuropsychology 2011 Jan;25(1):114-24.
PMID: 20954781
Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: frequent but mild.
Mov Disord 2011 Jan;26(1):65-72. Epub 2010 okt 5
PMID: 20925070
CSF amyloid ß38 as a novel diagnostic marker for dementia with Lewy bodies.
J Neurol Neurosurg Psychiatry 2011 Feb;82(2):160-4. Epub 2010 nov 3
PMID: 21047883
Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism.
Neurology 2011 Oct;77(14):1357-62. Epub 2011 sep 21
PMID: 21940621
Mild cognitive impairment in Parkinson's disease.
Curr Neurol Neurosci Rep 2011 Aug;11(4):371-8.
PMID: 21487730
Cognitive correlates of visual hallucinations in dementia associated with Parkinson's disease.
Mov Disord 2011 Apr;26(5):824-9. Epub 2011 mar 21
PMID: 21437985
Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease.
PLoS Curr 2011;3():RRN1242. Epub 2011 jun 17
PMID: 21731882
The value of Arabidopsis research in understanding human disease states.
Curr Opin Biotechnol 2011 Apr;22(2):300-7. Epub 2010 des 6
PMID: 21144728
Iron-sulfur clusters: biogenesis, molecular mechanisms, and their functional significance.
Antioxid Redox Signal 2011 Jul;15(1):271-307. Epub 2011 feb 3
PMID: 20812788
Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate.
Nat Neurosci 2011 Mar;14(3):305-13. Epub 2011 feb 6
PMID: 21297631
Ventricular enlargement and mild cognitive impairment in early Parkinson's disease.
Mov Disord 2011 Feb;26(2):297-301. Epub 2010 des 13
PMID: 21412836
Ventricular enlargement and mild cognitive impairment in early Parkinson's disease.
Mov Disord 2010 Dec. Epub 2010 des 13
PMID: 21154970
Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis.
Neurology 2010 Sep;75(12):1062-9.
PMID: 20855849
Differential effect of environmental risk factors on postural instability gait difficulties and tremor dominant Parkinson's disease.
Mov Disord 2010 Sep;25(12):1847-52.
PMID: 20669310
Are dysautonomic and sensory symptoms present in early Parkinson's disease?
Acta Neurol Scand Suppl 2010.
PMID: 20586740
CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study.
J Neurol Neurosurg Psychiatry 2010 Oct;81(10):1080-6. Epub 2010 jun 14
PMID: 20547614
The role of APOE alleles in incident Parkinson's disease. The Norwegian ParkWest Study.
Acta Neurol Scand 2010 Dec;122(6):438-41.
PMID: 20456244
The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation.
J Cell Sci 2010 May;123(Pt 10):1644-51. Epub 2010 apr 20
PMID: 20406884
Gray matter correlations of cognition in incident Parkinson's disease.
Mov Disord 2010 Apr;25(5):629-33.
PMID: 20213820
Caregiver distress associated with neuropsychiatric problems in patients with early Parkinson's disease: the Norwegian ParkWest study.
Acta Neurol Scand 2010 Dec;122(6):418-24.
PMID: 20175757
Apathy in drug-naïve patients with incident Parkinson's disease: the Norwegian ParkWest study.
J Neurol 2010 Feb;257(2):217-23. Epub 2009 aug 25
PMID: 19705051
Disturbance of automatic auditory change detection in dementia associated with Parkinson's disease: A mismatch negativity study.
Neurobiol Aging 2010 Jan;31(1):104-13. Epub 2008 apr 18
PMID: 18395939
What predicts mortality in Parkinson disease?: a prospective population-based long-term study.
Neurology 2010 Oct;75(14):1270-6.
PMID: 20921512
A 12-year population-based study of psychosis in Parkinson disease.
Arch Neurol 2010 Aug;67(8):996-1001.
PMID: 20697051
Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia.
Mov Disord 2010 Apr;25(6):687-8.
PMID: 20437538
Use of drugs with anticholinergic effect and impact on cognition in Parkinson's disease: a cohort study.
J Neurol Neurosurg Psychiatry 2010 Feb;81(2):160-5. Epub 2009 sep 21
PMID: 19770163
Parkinson's disease and hospital admissions: frequencies, diagnoses and costs.
Acta Neurol Scand 2010 Jan;121(1):38-43. Epub 2009 sep 10
PMID: 19744137
Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study.
J Neurol Neurosurg Psychiatry 2009 Nov;80(11):1279-82.
PMID: 19864662
Health state values during the first year of drug treatment in early-stage Parkinson's disease: a prospective, population-based, cohort study.
Drugs Aging 2009;26(11):973-80.
PMID: 19848442
Brain atrophy and white matter hyperintensities in early Parkinson's disease(a).
Mov Disord 2009 Nov;24(15):2233-41.
PMID: 19768730
The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson's disease.
J Neurol Neurosurg Psychiatry 2009 Aug;80(8):928-30.
PMID: 19608786
White matter hyperintensities do not impact cognitive function in patients with newly diagnosed Parkinson's disease.
Neuroimage 2009 Oct;47(4):2083-9. Epub 2009 jun 16
PMID: 19539037
Pain and its relationship to depression in Parkinson disease.
Am J Geriatr Psychiatry 2009 Apr;17(4):269-75.
PMID: 19322934
APOE alleles in Parkinson disease and their relationship to cognitive decline: a population-based, longitudinal study.
J Geriatr Psychiatry Neurol 2009 Sep;22(3):166-70. Epub 2009 mar 25
PMID: 19321880
Incidence of Parkinson's disease in Norway: the Norwegian ParkWest study.
J Neurol Neurosurg Psychiatry 2009 Aug;80(8):851-7. Epub 2009 feb 25
PMID: 19246476
Parkinson's disease and nursing home placement: the economic impact of the need for care.
Eur J Neurol 2009 Feb;16(2):194-200.
PMID: 19146640
Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study.
Neurology 2009 Mar;72(13):1121-6. Epub 2008 nov 19
PMID: 19020293
Parkinson’s Disease; What Can We Learn from Long-term Cohort Studies?
ACNR 2011 July/August;11(3):9-12
Early Parkinson’s Disease - Incidence, clinical features and quality of life in a population-based cohort study
- Disputert:
- juni 2014
- Hovedveileder:
- Ole-Bjørn Tysnes
Interaction partners and oxidation dependent complex formation of the Parkinson’s disease associated protein DJ-1
- Disputert:
- november 2013
- Hovedveileder:
- Simon Geir Møller
Structural brain MRI and cognition in newly diagnosed Parkinson's disease
- Disputert:
- november 2010
- Hovedveileder:
- Jan Petter Larsen
Depression in Parkinson's disease
- Disputert:
- mai 2010
- Hovedveileder:
- Dag Aarsland
Apathy in Parkinson's disease
- Disputert:
- april 2010
- Hovedveileder:
- Jan Petter Larsen
Clinical progression and prognosis of Parkinson's disease
- Disputert:
- desember 2010
- Hovedveileder:
- Guido Alves
Economic aspects of Parkinson's disease
- Disputert:
- november 2009
- Hovedveileder:
- Jan Petter Larsen
- Simon Geir Møller Prosjektleder
- Janete Chung Postdoktor
- Jodi Grødem Prosjektdeltaker
- Kristin Aaser Lunde Ph.d.-kandidat
- Marthe Førland Ph.d.-kandidat
- Johannes Lange Prosjektdeltaker
- Anita Laugaland Prosjektdeltaker
- Lise Løvereide Prosjektdeltaker
- Karen Simonsen Prosjektdeltaker
- Ingrid Leiknes Prosjektdeltaker
- Ingvild Dalen Prosjektdeltaker
- Anders Bjørnestad Prosjektdeltaker
- Lena Kristin Tholfsen Prosjektdeltaker
- Elin Bjelland Forsaa Prosjektdeltaker
- Michaela D Gjerstad Prosjektdeltaker
- Kenn Freddy Pedersen Prosjektdeltaker
- Guido Alves Prosjektdeltaker
- Marianne Kjærandsen Prosjektdeltaker
- Liv Kari Håland Prosjektdeltaker
- Ineke HogenEsch Prosjektdeltaker
- Jane Kastet Prosjektdeltaker
- Aliaksei Labusau Prosjektdeltaker
- Wenche Telstad Prosjektdeltaker
- Siri Bruun Prosjektdeltaker
- Solgunn Ongre Prosjektdeltaker
- Karen Herlofson Prosjektdeltaker
- Kristoffer Haugarvoll Prosjektdeltaker
- Geir Olve Skeie Prosjektdeltaker
- Marit Arnevik Renså Prosjektdeltaker
- Bernd Mueller Prosjektdeltaker
- Ole-Bjørn Tysnes Prosjektleder
- Jan Petter Larsen Prosjektleder
- Dominik Piston Ph.d.-kandidat
- Øystein Vesterli Tveiten Ph.d.-kandidat
- Brage Brakedal Ph.d.-kandidat
- Lena Kristin Enger Ph.d.-kandidat
- Ylva Hiorth Ph.d.-kandidat
- Sigurbjørg Stefansdottir Ph.d.-kandidat
- Kira de Klerk Ph.d.-kandidat
- Maria Doitsidou Postdoktor
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest