Patofysiologi ved fedme
- Prosjektnummer
- 911519
- Ansvarlig person
- Gunnar Mellgren
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Strategiske midler - fedme
- Helsekategori
- Metabolic and Endocrine
- Forskningsaktivitet
- 2. Aetiology
ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
Sci Transl Med 2014 Jul 30;6(247):247ra103.
PMID: 25080478
Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats.
Nutr Diabetes 2014;4():e124. Epub 2014 jun 30
PMID: 24979153
COL6A3 expression in adipocytes associates with insulin resistance and depends on PPAR? and adipocyte size.
Obesity (Silver Spring) 2014 Aug;22(8):1807-13. Epub 2014 apr 10
PMID: 24719315
Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study.
BMC Surg 2014;14():8. Epub 2014 feb 11
PMID: 24517247
Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.
Cell 2014 Jan 16;156(1-2):343-58.
PMID: 24439387
Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice.
Am J Physiol Endocrinol Metab 2014 Jan 15;306(2):E210-24. Epub 2013 des 3
PMID: 24302006
Energy intake, nutritional status and weight reduction in patients one year after laparoscopic sleeve gastrectomy.
Springerplus 2013;2():352. Epub 2013 jul 30
PMID: 23961416
Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements.
Obesity (Silver Spring) 2013 Dec;21(12):2495-503. Epub 2013 jun 13
PMID: 23512832
Predictors for remission of major components of the metabolic syndrome after biliopancreatic diversion with duodenal switch (BPDDS).
Obes Surg 2013 Jan;23(1):80-6.
PMID: 23011463
cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1.
Endocrinology 2013 Apr;154(4):1513-27. Epub 2013 mar 5
PMID: 23462962
The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss.
Int J Obes (Lond) 2012 Sep;36(9):1195-202. Epub 2011 des 6
PMID: 22143616
Tissue-specific effects of bariatric surgery including mitochondrial function.
J Obes 2011;2011():435245. Epub 2011 jan 12
PMID: 21274278
Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue.
PLoS One 2011;6(6):e20481. Epub 2011 jun 17
PMID: 21698093
Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome.
J Biol Chem 2011 Aug;286(32):28382-95. Epub 2011 jun 16
PMID: 21680746
Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss.
PLoS One 2010;5(6):e11033. Epub 2010 jun 9
PMID: 20543949
A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation.
Biochim Biophys Acta 2009 Nov;1791(11):1076-83. Epub 2009 jul 3
PMID: 19577662
Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats.
Biochim Biophys Acta 2009 Apr;1791(4):254-62. Epub 2009 jan 31
PMID: 19416649
Health-related quality of life and paid work participation after duodenal switch.
Obes Surg 2010 Mar;20(3):340-5. Epub 2009 apr 8
PMID: 19352783
Predictors for health-related quality of life in patients accepted for bariatric surgery.
Surg Obes Relat Dis 2009 May-Jun;5(3):329-33. Epub 2008 des 14
PMID: 19342310
Cancer incidence and mortality after treatment with folic acid and vitamin B12.
JAMA 2009 Nov;302(19):2119-26.
PMID: 19920236
Impact of diabetes on treatment-induced changes in left ventricular structure and function in hypertensive patients with left ventricular hypertrophy. The LIFE study.
Nutr Metab Cardiovasc Dis 2009 Jun;19(5):306-12. Epub 2009 mar 19
PMID: 19303268
Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism
Foredrag (selektert abstrakt) European Congress on Obesity, Lyon, 2012
Novel candidate obesity genes in human adipose tissue
Foredrag (invitert) European Congress on Obesity, Lyon, 2012
Candidate genes for fat regain after weight cycling in mice
Genetic and Molecular Basis of Obesity, Keystone Symposia, Santa Fe, USA, 2012
Prediction of obesity candidate genes by multiple gene expression analyses of adipose tissue
18th European Congress on Obesity (ECO2011); 2011-05-25
Differential Expression of Inflammatory and Metabolic Genes in Adipose Tissue of Patients with Primary Huperparathyroidism
Endocrine Societies annual meeting, ENDO 2011; 2011-06-04
The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss
ECO2011; 2011-05-23
Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity
International Congress of Obesity 2010; 2010-07-11
From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery
Endocrine journal 2010 ;Volum 57. s. S429-S429
Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissue in Morbid Obesity and after Profound Fat Loss
ENDO 2010; 2010-06-19
Bariatric surgery dramatically alters global gene expression in adipose tissue
Norsk Selskap for endokrinologi, Årsmøte, 2009
Hva kan vi lære av sykelig fedme? Fedme og genekspresjon
Ernæringskonferansen, UiB, 2009
Bothering defecation, mental well-being and social functioning after duodenal switch
17th European Congress on Obesity, 2009
Bariatrisk kirurgi på Voss sjukehus – våre erfaringar.
Vestlandske gastroforum, 2009
Adipose tissue transcriptomics. Integrative search for obesity candidate genes
- Disputert:
- juni 2011
- Hovedveileder:
- Gunnar Mellgren
- Ottar Nygård Prosjektdeltaker
- Vivian Lohmann Veum Ph.d.-kandidat
- Margit Solsvik Prosjektdeltaker
- Hans Jørgen Nielsen Prosjektdeltaker
- Simon E Nitter Dankel Postdoktor
- Dag Jone Stokke Fadnes Ph.d.-kandidat
- Arne-Christian Mohn Prosjektdeltaker
- Villy Våge Prosjektdeltaker
- Bjørn Gunnar Nedrebø Prosjektdeltaker
- Gunnar Mellgren Prosjektleder
- Anne Jessica Svärd Postdoktor
- Johan Fernø Postdoktor
- Jørn V. Sagen Prosjektdeltaker
- Oddrun Anita Gudbrandsen Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest