Charactrisation of protein complexes in zebra fish models and brains from patients with Parkinson's Disease - Complementary funnctional analysis of neuronal death and development of clinical biomarkers of the disease
- Prosjektnummer
- 911556
- Ansvarlig person
- Simon Geir Møller
- Institusjon
- Helse Stavanger HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Neurological
- Forskningsaktivitet
- 1. Underpinning, 4. Detection and Diagnosis
Proteome analysis reveals roles of L-DOPA in response to oxidative stress in neurons.
BMC Neurosci 2014;15():93. Epub 2014 jul 31
PMID: 25082231
Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin ß2.
Mol Cell Biol 2014 Aug;34(16):3024-40. Epub 2014 jun 9
PMID: 24912681
PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons.
J Neurosci Res 2014 Sep;92(9):1167-77. Epub 2014 mai 2
PMID: 24798695
Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.
J Biol Chem 2014 May 23;289(21):14458-69. Epub 2014 apr 9
PMID: 24719325
New insight into neurodegeneration: the role of proteomics.
Mol Neurobiol 2014 Jun;49(3):1181-99. Epub 2013 des 10
PMID: 24323427
Zebrafish brain proteomics reveals central proteins involved in neurodegeneration.
J Neurosci Res 2014 Jan;92(1):104-15. Epub 2013 okt 5
PMID: 24123299
Structure of Cu(I)-Bound DJ-1 Reveals a Biscysteinate Metal Binding Site at the Homodimer Interface: Insights into Mutational Inactivation of DJ-1 in Parkinsonism.
J Am Chem Soc 2013 Oct 21. Epub 2013 okt 21
PMID: 24144264
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity.
J Biol Chem 2013 Aug 2;288(31):22809-20. Epub 2013 jun 21
PMID: 23792957
The value of Arabidopsis research in understanding human disease states.
Curr Opin Biotechnol 2011 Apr;22(2):300-7. Epub 2010 des 6
PMID: 21144728
ROS removal by DJ-1: Arabidopsis as a new model to understand Parkinson disease.
Plant Signal Behav 2010 Aug;5(8). Epub 2010 aug 9
PMID: 20671441
The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation.
J Cell Sci 2010 May;123(Pt 10):1644-51. Epub 2010 apr 20
PMID: 20406884
Iron-sulfur clusters: biogenesis, molecular mechanisms, and their functional significance.
Antioxid Redox Signal 2011 Jul;15(1):271-307. Epub 2011 feb 3
PMID: 20812788
Subcellular?a-synuclein states show altered behavior in neurodegeneration
2015 Nature Communications, revised version submitted
LRRK2 knockdown in zebrafish causes developmental defects, neurodegeneration and synuclein aggregation
2015 Resubmission to J. Exp. Biol. planned March 2015
Complimentary approaches to Parkinsons Disease
Foredrag Stavanger, 2011
Plants, zebrafish and humans: A powerful approach to understand a complex disease
Foredrag Stavanger, 2011
The benefits of multiple models for Parkinson's Disease research
Foredrag New York, 2011
Understanding cell death and survival in Parkinsons Disease
Foredrag New York, 2011
- Simon Geir Møller Prosjektleder
- Ramavati Pal Postdoktor
- Guido Alves Prosjektdeltaker
- Jan Petter Larsen Prosjektdeltaker
- Mohammed Gebriel Ph.d.-kandidat
- Ketan Patil Ph.d.-kandidat
- Indranil Basak Ph.d.-kandidat
- Rashed Abdullah Ph.d.-kandidat
- Benny Bjørkblom Postdoktor
- Dominik Piston Ph.d.-kandidat
- Shubhangi Prabhudesai Postdoktor
- Mohammed Gebrel Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest