Disease- and treatment-induced immunomodulation in acute myeloid leukemia (AML)
Effects of cytarabine on activation of human T cells - cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid.
BMC Pharmacol Toxicol 2015;16():12. Epub 2015 mai 2
Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells.
Oncoscience 2014;1(8):529-39. Epub 2014 aug 6
Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect.
Br J Haematol 2014 Jan;164(2):200-11. Epub 2013 okt 23
The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia.
Clin Epigenetics 2013;5(1):13. Epub 2013 aug 1
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine.
BMC Pharmacol Toxicol 2013;14():35. Epub 2013 jul 11
Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: Will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions?
Curr Cancer Drug Targets 2013 Jan;13(1):30-47.
Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.
Br J Haematol 2012 Feb;156(4):468-80. Epub 2011 des 13
Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies.
Bone Marrow Res 2011;2011():570796. Epub 2010 okt 4
Future perspectives: should Th17 cells be considered as a possible therapeutic target in acute myeloid leukemia patients receiving allogeneic stem cell transplantation?
Cancer Immunol Immunother 2011 Dec;60(12):1669-81. Epub 2011 okt 12
Is there a scientific basis for a recommended standardization of collection and cryopreservation of peripheral blood stem cell grafts?
Cytotherapy 2011 Sep;13(8):1013-24. Epub 2011 apr 20
Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis.
Oncol Rep 2011 Jun;25(6):1549-56. Epub 2011 mar 22
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC Immunol 2010;11():38. Epub 2010 jul 9
Combination of intensive chemotherapy and anticancer vaccines in the treatment of human malignancies: the hematological experience.
J Biomed Biotechnol 2010;2010():692097. Epub 2010 jun 2
Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).
Apoptosis 2010 Aug;15(8):946-55.
Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease.
Eur Cytokine Netw 2010 Mar;21(1):40-9.
Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release.
Expert Opin Investig Drugs 2010 Feb;19(2):169-83.
Signal transduction in peripheral blood leukocytes following treatment with khat extract, cathinone, cathine and norephedrine.
Submitted to Journal of Leukocyte Biology Dec. 2011
Effects in vitro on T lymphocytes of the antileukemic drugs ATRA, valproic acid and cytarabine.
To be submitted april 2012
Future Perspectives: Therapeutic Targeting of Notch Signalling May Become a Strategy in Patients Receiving Stem Cell Transplan..
Bone Marrow Research
The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxi..