Molecular marker and target discovery in prostate cancer by transcriptional reprogramming of prostate cells
- Prosjektnummer
- 911626
- Ansvarlig person
- Karl-Henning Kalland
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses.
Oncotarget 2015 Nov 24;6(37):39676-91.
PMID: 26485755
ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma.
Oncotarget 2015 Sep 29;6(29):28440-52.
PMID: 26308378
Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer.
Oncotarget 2015 Apr 30;6(12):10634-45.
PMID: 25860936
Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.
Oncotarget 2015 Jan 20;6(2):1327-39.
PMID: 25415225
Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations.
Gynecol Oncol 2014 Sep;134(3):599-606. Epub 2014 jul 1
PMID: 24995579
High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors.
Br J Cancer 2014 Jul 8;111(1):78-84. Epub 2014 mai 22
PMID: 24853175
Switch in FOXA1 status associates with endometrial cancer progression.
PLoS One 2014;9(5):e98069. Epub 2014 mai 21
PMID: 24849812
Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene.
Oncotarget 2014 Feb 28;5(4):1052-61.
PMID: 24658009
Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors.
Mol Cancer Res 2014 May;12(5):754-64. Epub 2014 feb 26
PMID: 24574516
MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells.
Int J Cancer 2013 Aug 1;133(3):544-55. Epub 2013 feb 27
PMID: 23354685
p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model.
PLoS One 2013;8(5):e62547. Epub 2013 mai 1
PMID: 23658742
Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling.
Cancer Res 2013 Dec 1;73(23):7090-100. Epub 2013 okt 7
PMID: 24101153
Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation.
BMC Cancer 2012;12():21. Epub 2012 jan 17
PMID: 22251838
Loss of GPER identifies new targets for therapy among a subgroup of ERa-positive endometrial cancer patients with poor outcome.
Br J Cancer 2012 May;106(10):1682-8. Epub 2012 mar 13
PMID: 22415229
Lipocalin 2 expression is associated with aggressive features of endometrial cancer.
BMC Cancer 2012;12():169. Epub 2012 mai 6
PMID: 22559235
Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer.
Proc Natl Acad Sci U S A 2012 May;109(22):8699-704. Epub 2012 mai 15
PMID: 22589302
ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas.
Mod Pathol 2013 Mar;26(3):428-34. Epub 2012 okt 19
PMID: 23080032
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer.
Br J Cancer 2012 Dec;107(12):1997-2004. Epub 2012 okt 25
PMID: 23099803
High-Throughput Mutation Profiling of Primary and Metastatic Endometrial Cancers Identifies KRAS, FGFR2 and PIK3CA to Be Frequently Mutated.
PLoS One 2012;7(12):e52795. Epub 2012 des 27
PMID: 23300780
Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer.
PLoS One 2011;6(1):e14632. Epub 2011 jan 31
PMID: 21297939
Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model.
Exp Cell Res 2011 Jan;317(2):234-47. Epub 2010 okt 20
PMID: 20969863
Effect of the phytochemical crinumaquine on prostate and prostate cancer cell lines.
Annual Meeting American Association for Cancer Research. Chicago IL, USA, 3. apr. 2012. Abstract 4762.
miR203 induces mesenchymal to epithelial transition via repressing SNAI2 and activating P-cadherin in prostate cells.
Annual Meeting American Association for Cancer Research. Chicago IL, USA, 3. apr. 2012. Abstract 4128.
The transcription factor p63 induces selected gene expression modules associated with mesenchymal to epithelial transition.
Annual Meeting American Association for Cancer Research. Chicago IL, USA, 2. apr. 2012. Abstract 1290.
Generation of a stepwise prostate carcinogenesis model
- Disputert:
- mai 2013
- Hovedveileder:
- Karl-Henning Kalland
ERG and SIM2 transcription factors in prostate cancer
- Disputert:
- januar 2011
- Hovedveileder:
- Karl-Henning Kalland
- Yi Qu Postdoktor
- Xisong Ke Prosjektdeltaker
- Anne Margrete Øyan Prosjektdeltaker
- Karl-Henning Kalland Prosjektleder
- Jan Roger Olsen Ph.d.-kandidat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest