Biological Markers and Novel Targets in Aggressive Breast and Prostate Cancer
- Prosjektnummer
- 911628
- Ansvarlig person
- Lars A. Akslen
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis, 6. Treatment Evaluation
Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study.
Diagn Pathol 2014 Dec 19;9(1):230. Epub 2014 des 19
PMID: 25522915
Evaluation of Ki67 expression across distinct categories of breast cancer specimens: a population-based study of matched surgical specimens, core needle biopsies and tissue microarrays.
PLoS One 2014;9(11):e112121. Epub 2014 nov 6
PMID: 25375149
Frequencies of KIT and GNAQ mutations in acral melanoma.
J Cutan Pathol 2014 Nov;41(11):893-4. Epub 2014 nov 3
PMID: 25363280
The effect on melanoma risk of genes previously associated with telomere length.
J Natl Cancer Inst 2014 Oct;106(10). Epub 2014 sep 17
PMID: 25231748
Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations.
Gynecol Oncol 2014 Sep;134(3):599-606. Epub 2014 jul 1
PMID: 24995579
Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis.
Tissue Eng Part A 2014 Oct;20(19-20):2590-603. Epub 2014 aug 21
PMID: 24957363
An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.
PLoS One 2014;9(6):e98787. Epub 2014 jun 6
PMID: 24905342
Switch in FOXA1 status associates with endometrial cancer progression.
PLoS One 2014;9(5):e98069. Epub 2014 mai 21
PMID: 24849812
1.5-T multiparametric MRI using PI-RADS: a region by region analysis to localize the index-tumor of prostate cancer in patients undergoing prostatectomy.
Acta Radiol 2015 Apr;56(4):500-11. Epub 2014 mai 12
PMID: 24819231
Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas.
Lab Invest 2014 Jul;94(7):752-65. Epub 2014 mai 5
PMID: 24791743
Stathmin protein level, a potential predictive marker for taxane treatment response in endometrial cancer.
PLoS One 2014;9(2):e90141. Epub 2014 feb 25
PMID: 24587245
Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors.
Mol Cancer Res 2014 May;12(5):754-64. Epub 2014 feb 26
PMID: 24574516
GRK3 is essential for metastatic cells and promotes prostate tumor progression.
Proc Natl Acad Sci U S A 2014 Jan 28;111(4):1521-6. Epub 2014 jan 13
PMID: 24434559
Landscape of genomic alterations in cervical carcinomas.
Nature 2014 Feb 20;506(7488):371-5. Epub 2013 des 25
PMID: 24390348
Frequency of somatic BRAF mutations in melanocytic lesions from patients in a CDK4 melanoma family.
Pigment Cell Melanoma Res 2014 Jan;27(1):149-51. Epub 2013 nov 21
PMID: 24256466
Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas.
Br J Cancer 2014 Jan 7;110(1):107-14. Epub 2013 okt 31
PMID: 24178757
Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer.
Cancer 2014 Feb 15;120(4):603-10. Epub 2013 okt 25
PMID: 24166148
A positive real-time elastography is an independent marker for detection of high-risk prostate cancers in the primary biopsy setting.
BJU Int 2014 May;113(5b):E90-7. Epub 2013 nov 27
PMID: 24053494
Nestin expression is associated with aggressive cutaneous melanoma of the nodular type.
Mod Pathol 2014 Mar;27(3):396-401. Epub 2013 sep 13
PMID: 24030749
Lack of estrogen receptor-a is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma.
Clin Cancer Res 2013 Mar 1;19(5):1094-105. Epub 2013 jan 14
PMID: 23319822
Microvessel proliferation by co-expression of endothelial nestin and Ki-67 is associated with a basal-like phenotype and aggressive features in breast cancer.
Breast 2013 Jun;22(3):282-8. Epub 2012 jul 26
PMID: 22840462
High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.
Gynecol Oncol 2013 Feb;128(2):327-34. Epub 2012 des 4
PMID: 23219661
Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97% of significant prostate cancers.
Scand J Urol 2013 Jun;47(3):211-6. Epub 2012 okt 4
PMID: 23035756
Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants.
J Med Genet 2013 Apr;50(4):264-70. Epub 2013 feb 5
PMID: 23384855
Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers.
PLoS One 2013;8(2):e54873. Epub 2013 feb 5
PMID: 23393560
Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial.
Eur J Cancer 2013 Nov;49(16):3431-41. Epub 2013 aug 8
PMID: 23932335
High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition.
Clin Cancer Res 2013 May 1;19(9):2331-41. Epub 2013 mar 28
PMID: 23538402
Vascular proliferation is associated with survival in pancreatic ductal adenocarcinoma.
APMIS 2013 Nov;121(11):1037-46. Epub 2013 mar 13
PMID: 23489215
Low-molecular contrast agent dynamic contrast-enhanced (DCE)-MRI and diffusion-weighted (DW)-MRI in early assessment of bevacizumab treatment in breast cancer xenografts.
J Magn Reson Imaging 2013 Nov;38(5):1043-53. Epub 2013 mar 21
PMID: 23908122
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
Cancer Discov 2013 May;3(5):578-89. Epub 2013 apr 30
PMID: 23633432
Analysis of Latvian familial melanoma patients shows novel variants in the noncoding regions of CDKN2A and that the CDK4 mutation R24H is a founder mutation.
Melanoma Res 2013 Jun;23(3):221-6.
PMID: 23546221
Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas.
Diagn Pathol 2013;8():80. Epub 2013 mai 15
PMID: 23675755
Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs.
Stem Cell Res Ther 2013 May 17;4(3):52. Epub 2013 mai 17
PMID: 23683577
Variation in inflammatory cytokine/growth-factor genes and mammographic density in premenopausal women aged 50-55.
PLoS One 2013;8(6):e65313. Epub 2013 jun 7
PMID: 23762340
Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients.
Breast Cancer Res Treat 2013 Aug;140(3):463-73. Epub 2013 jul 31
PMID: 23901018
Dynamic contrast-enhanced MRI in endometrial carcinoma identifies patients at increased risk of recurrence.
Eur Radiol 2013 Oct;23(10):2916-25. Epub 2013 jun 4
PMID: 23732687
Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway.
Langenbecks Arch Surg 2013 Aug;398(6):869-74. Epub 2013 jun 19
PMID: 23778974
Malignant melanoma--diagnosis, treatment and follow-up in Norway.
Tidsskr Nor Laegeforen 2013 Oct;133(20):2154-9.
PMID: 24172628
ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas.
Mod Pathol 2013 Mar;26(3):428-34. Epub 2012 okt 19
PMID: 23080032
Efficient in vivo vascularization of tissue-engineering scaffolds.
J Tissue Eng Regen Med 2011 Apr;5(4):e52-62. Epub 2010 sep 23
PMID: 20865694
Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model.
Exp Cell Res 2011 Jan;317(2):234-47. Epub 2010 okt 20
PMID: 20969863
Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer.
Br J Cancer 2011 Jun;105(1):9-12. Epub 2011 jun 14
PMID: 21673677
Vascular proliferation is increased in basal-like breast cancer.
Breast Cancer Res Treat 2011 Dec;130(3):1063-71. Epub 2011 aug 28
PMID: 21874512
Vascular proliferation is a prognostic factor in breast cancer.
Breast Cancer Res Treat 2012 Jun;133(2):501-10. Epub 2011 sep 27
PMID: 21947750
In vivo MRI and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts.
J Magn Reson Imaging 2012 May;35(5):1098-107. Epub 2011 des 14
PMID: 22170753
Prognostic markers in cutaneous melanoma with emphasis on proliferation and tumor necrosis
- Disputert:
- januar 2013
- Hovedveileder:
- Lars A. Akslen
Molecular studies of sporadic and hereditary cutaneous malignant melanoma
- Disputert:
- desember 2013
- Hovedveileder:
- Lars A. Akslen, Anders Molven (delt)
Endometrial carcinoma: a step closer to individualized therapy?
- Disputert:
- september 2013
- Hovedveileder:
- Helga Birgitte Salvesen
Angiogenesis and Epithelial-Mesenchymal Transition in Prostate Cancer
- Disputert:
- september 2011
- Hovedveileder:
- LARS A AKSLEN
- Yngve Nygård Ph.d.-kandidat
- Christian Beisland Prosjektdeltaker
- Karin Collett Prosjektdeltaker
- Jarle Arnes Prosjektdeltaker
- Karsten Gravdal Prosjektdeltaker
- Ole Johan Halvorsen Prosjektdeltaker
- Anna Blois Postdoktor
- Monica Mannelqvist Prosjektdeltaker
- Even Birkeland Postdoktor
- Elisabeth Wik Postdoktor
- Gøril Knutsvik Ph.d.-kandidat
- Ingunn Marie Stefansson Prosjektdeltaker
- Lars A. Akslen Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest