Identifikasjon av biomarkører for å finne årsaken til multippel sklerose
- Prosjektnummer
- 911653
- Ansvarlig person
- Øivind Grytten Torkildsen
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Neurological
- Forskningsaktivitet
- 4. Detection and Diagnosis
Brukermedvirkning i planlegging av prosjekt og problemstilling.
Safety and efficacy of autologous hematopoietic stem cell transplantation for multiple sclerosis in Norway.
Mult Scler 2020 Dec;26(14):1889-1897. Epub 2019 des 13
PMID: 31833798
An Update on Vitamin D and Disease Activity in Multiple Sclerosis.
CNS Drugs 2019 Dec;33(12):1187-1199.
PMID: 31686407
International consensus on quality standards for brain health-focused care in multiple sclerosis.
Mult Scler 2019 Nov;25(13):1809-1818. Epub 2018 nov 1
PMID: 30381987
The Norwegian translation of the brief international cognitive assessment for multiple sclerosis (BICAMS).
Mult Scler Relat Disord 2019 Nov;36():101408. Epub 2019 sep 21
PMID: 31610403
Fingolimod downregulates brain sphingosine-1-phosphate receptor 1 levels but does not promote remyelination or neuroprotection in the cuprizone model.
J Neuroimmunol 2020 02 15;339():577091. Epub 2019 okt 31
PMID: 31739156
Risk of cancer among multiple sclerosis patients, siblings, and population controls: A prospective cohort study.
Mult Scler 2020 10;26(12):1569-1580. Epub 2019 okt 1
PMID: 31573834
α-Linolenic acid is associated with MRI activity in a prospective cohort of multiple sclerosis patients.
Mult Scler 2019 06;25(7):987-993. Epub 2018 jun 4
PMID: 29862891
Neurofilament Light Chain as a Biomarker in Multiple Sclerosis.
Front Neurol 2019;10():338. Epub 2019 apr 5
PMID: 31024432
B cell depletion in the treatment of multiple sclerosis.
Expert Opin Biol Ther 2019 03;19(3):261-271. Epub 2019 jan 23
PMID: 30632834
Serum levels of leptin and adiponectin are not associated with disease activity or treatment response in multiple sclerosis.
J Neuroimmunol 2018 Oct 15;323():73-77. Epub 2018 jul 24
PMID: 30196837
Response to 'Seasonal variation of vitamin D and Epstein-Barr virus antibody in multiple sclerosis patients', a comment letter regarding 'Vitamin D, HLA-DRB1 and Epstein-Barr virus antibody levels in a prospective cohort of multiple sclerosis patients'.
Eur J Neurol 2018 09;25(9):e104.
PMID: 30134049
Effects of vitamin D on axonal damage during de- and remyelination in the cuprizone model.
J Neuroimmunol 2018 Aug 15;321():61-65. Epub 2018 jun 1
PMID: 29957389
Neurofilament light chain predicts disease activity in relapsing-remitting MS.
Neurol Neuroimmunol Neuroinflamm 2018 Jan;5(1):e422. Epub 2017 nov 28
PMID: 29209636
Level of education and multiple sclerosis risk over a 50-year period: Registry-based sibling study.
Mult Scler 2017 Feb;23(2):213-219. Epub 2016 jul 11
PMID: 27207453
Effect of high-dose vitamin D3 supplementation on antibody responses against Epstein-Barr virus in relapsing-remitting multiple sclerosis.
Mult Scler 2017 Mar;23(3):395-402. Epub 2016 jul 11
PMID: 27325604
In-Depth Cerebrospinal Fluid Quantitative Proteome and Deglycoproteome Analysis: Presenting a Comprehensive Picture of Pathways and Processes Affected by Multiple Sclerosis.
J Proteome Res 2017 Jan 06;16(1):179-194. Epub 2016 okt 26
PMID: 27728768
An update on cladribine for relapsing-remitting multiple sclerosis.
Expert Opin Pharmacother 2017 Oct;18(15):1627-1635. Epub 2017 sep 11
PMID: 28858531
Glitazone use associated with reduced risk of Parkinson's disease.
Mov Disord 2017 Nov;32(11):1594-1599. Epub 2017 sep 1
PMID: 28861893
Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome.
J Neurol Neurosurg Psychiatry 2016 Feb;87(2):126-9. Epub 2015 feb 25
PMID: 25716934
WT1 and interferon-ß-vitamin D association in MS: a longitudinal study.
Acta Neurol Scand 2016 Apr;133(4):309-12. Epub 2015 jun 2
PMID: 26037530
Disease-modifying treatments for multiple sclerosis - a review of approved medications.
Eur J Neurol 2016 Jan;23 Suppl 1():18-27.
PMID: 26563094
Can vitamin D reduce inflammation in relapsing-remitting multiple sclerosis?
Expert Rev Neurother 2016;16(3):233-5. Epub 2016 feb 12
PMID: 26796244
Label-free analysis of human cerebrospinal fluid addressing various normalization strategies and revealing protein groups affected by multiple sclerosis.
Proteomics 2016 Apr;16(7):1154-65.
PMID: 26841090
Detection of varicella-zoster virus DNA during medullary and brainstem relapses in multiple sclerosis.
BMJ Case Rep 2016 Feb 23;2016(). Epub 2016 feb 23
PMID: 26907823
Botulinum Toxin as Monotherapy in Symptomatic Trigeminal Neuralgia.
Headache 2016 Jun;56(6):1035-9. Epub 2016 mar 17
PMID: 26992044
Vitamin D, HLA-DRB1 and Epstein-Barr virus antibody levels in a prospective cohort of multiple sclerosis patients.
Eur J Neurol 2016 Jun;23(6):1064-70. Epub 2016 mar 21
PMID: 26998820
No association of tobacco use and disease activity in multiple sclerosis.
Neurol Neuroimmunol Neuroinflamm 2016 Aug;3(4):e260. Epub 2016 jul 14
PMID: 27458599
[Not Available].
Tidsskr Nor Laegeforen 2016 Sep;136(16):1363. Epub 2016 sep 13
PMID: 27637056
The Brain Proteome of the Ubiquitin Ligase Peli1 Knock-Out Mouse during Experimental Autoimmune Encephalomyelitis.
J Proteomics Bioinform 2016 Sep;9(9):209-219. Epub 2016 sep 12
PMID: 27746629
Family planning, pregnancy and breastfeeding in multiple sclerosis.
Tidsskr Nor Laegeforen 2016 Nov;136(20):1726-1729. Epub 2016 nov 8
PMID: 27830907
Cerebrospinal fluid proteomics in multiple sclerosis.
Biochim Biophys Acta 2015 Jul;1854(7):746-56. Epub 2014 des 16
PMID: 25526888
Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.
Mult Scler 2015 Jul;21(8):1013-24. Epub 2015 feb 13
PMID: 25680984
Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model.
Neurochem Int 2015 Apr-May;83-84():28-40. Epub 2015 mar 2
PMID: 25744931
Vitamin D status and effect of interferon-ß1a treatment on MRI activity and serum inflammation markers in relapsing-remitting multiple sclerosis.
J Neuroimmunol 2015 Mar 15;280():21-8. Epub 2015 feb 11
PMID: 25773151
Impact of the environment on multiple sclerosis.
Tidsskr Nor Laegeforen 2015 May 19;135(9):856-60. Epub 2015 mai 19
PMID: 25991624
The Norwegian Multiple Sclerosis Registry and Biobank.
Acta Neurol Scand 2015;132(199):24-8.
PMID: 26046555
Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades.
Acta Neurol Scand 2015;132(199):29-36.
PMID: 26046556
Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.
Proteomics 2015 Oct;15(19):3361-9. Epub 2015 sep 8
PMID: 26152395
Fingolimod does not enhance cerebellar remyelination in the cuprizone model.
J Neuroimmunol 2015 Aug 15;285():180-6. Epub 2015 jun 19
PMID: 26198937
Reply to comments on the review article 'Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades'.
Acta Neurol Scand 2015 Nov;132(5):368-9. Epub 2015 sep 15
PMID: 26369381
Vitamin D supplementation and systemic inflammation in relapsing-remitting multiple sclerosis.
J Neurol 2015 Dec;262(12):2713-21. Epub 2015 okt 1
PMID: 26429571
Body mass index influence interferon-beta treatment response in multiple sclerosis.
J Neuroimmunol 2015 Nov 15;288():92-7. Epub 2015 sep 26
PMID: 26531700
Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis.
J Neuroimmunol 2014 Jun 15;271(1-2):60-5. Epub 2014 mar 24
PMID: 24713402
Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis.
Mult Scler 2014 Dec;20(14):1833-40. Epub 2014 mai 19
PMID: 24842958
Effect of high-dose 1.25 dihydroxyvitamin D3 on remyelination in the cuprizone model.
APMIS 2014 Dec;122(12):1178-86. Epub 2014 mai 26
PMID: 24862867
[Re: Vitamin D--how much is enough, and is more better for your health?].
Tidsskr Nor Laegeforen 2014 May 27;134(10):1024-5. Epub 2014 mai 27
PMID: 24865723
Treatment-resistant immune thrombocytopenic purpura associated with LDN use in a patient with MS.
Neurol Neuroimmunol Neuroinflamm 2014 Oct;1(3):e25. Epub 2014 aug 21
PMID: 25340078
Month of birth and risk of multiple sclerosis: confounding and adjustments.
Ann Clin Transl Neurol 2014 Feb;1(2):141-4. Epub 2014 feb 4
PMID: 25356394
Reply to comment: Month of birth and risk of multiple sclerosis: confounding and adjustments.
Ann Clin Transl Neurol 2014 May;1(5):376-7. Epub 2014 apr 10
PMID: 25356407
Retinol levels are associated with magnetic resonance imaging outcomes in multiple sclerosis.
Mult Scler 2013 Apr;19(4):451-7. Epub 2012 aug 20
PMID: 22907941
Fat-soluble vitamins as disease modulators in multiple sclerosis.
Acta Neurol Scand Suppl 2013.
PMID: 23190287
Month of birth as a latitude-dependent risk factor for multiple sclerosis in Norway.
Mult Scler 2013 Jul;19(8):1028-34. Epub 2012 des 20
PMID: 23257620
Sex ratio of multiple sclerosis in persons born from 1930 to 1979 and its relation to latitude in Norway.
J Neurol 2013 Jun;260(6):1481-8. Epub 2013 jan 6
PMID: 23292231
Alpha-tocopherol and MRI outcomes in multiple sclerosis--association and prediction.
PLoS One 2013;8(1):e54417. Epub 2013 jan 22
PMID: 23349882
No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis.
Ann Neurol 2013 Mar;73(3):430-2. Epub 2013 feb 26
PMID: 23444327
Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation.
Nat Med 2013 May;19(5):595-602. Epub 2013 apr 21
PMID: 23603814
Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity.
PLoS One 2013;8(9):e75021. Epub 2013 sep 19
PMID: 24069377
[Neuromyelitis optica].
Tidsskr Nor Laegeforen 2013 Oct;133(19):2057-61.
PMID: 24129537
Deep gray matter demyelination detected by magnetization transfer ratio in the cuprizone model.
PLoS One 2013;8(12):e84162. Epub 2013 des 30
PMID: 24386344
[A man in his 60's with acute headache].
Tidsskr Nor Laegeforen 2012 Mar;132(6):671-3.
PMID: 22456151
?-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial.
Arch Neurol 2012 Aug;69(8):1044-51.
PMID: 22507886
Vitamin D and disease activity in multiple sclerosis before and during interferon-ß treatment.
Neurology 2012 Jul;79(3):267-73. Epub 2012 jun 13
PMID: 22700809
The cuprizone model: regional heterogeneity of pathology.
APMIS 2012 Aug;120(8):648-57. Epub 2012 feb 24
PMID: 22779688
A need for national registries and international collaborative research in multiple sclerosis.
Acta Neurol Scand Suppl 2012.
PMID: 23278648
Month of birth as a risk factor for multiple sclerosis: an update.
Acta Neurol Scand Suppl 2012.
PMID: 23278658
Vitamin D supplementation and monitoring in multiple sclerosis: who, when and wherefore.
Acta Neurol Scand Suppl 2012.
PMID: 23278659
Polyunsaturated fatty acids in multiple sclerosis therapy.
Acta Neurol Scand Suppl 2012.
PMID: 23278660
Fc? receptors in Norwegian multiple sclerosis patients and healthy controls.
Acta Neurol Scand Suppl 2012.
PMID: 23278662
Dietary vitamin D3 supplements reduce demyelination in the cuprizone model.
PLoS One 2011;6(10):e26262. Epub 2011 okt 20
PMID: 22028844
Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL 2013; 19: (S1) 74–558
High dose vitamin D3 improves remyelination and oligodendrocyte maturation in the cuprizone model
MULTIPLE SCLEROSIS JOURNAL. 2013; 19: (S1) 74–558
Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation.
Viruses 2012, 4, 3701-3730
Mutant alleles of the CYP27B1 gene are not associated with multiple sclerosis.
Annals of Neurology. Accepted manuscript online: 13 DEC 2012; DOI: 10.1002/ana.23833
Omega-3 tilskudd uten effekt ved MS.
Dagens medisin. 2012. http://www.dagensmedisin.no/nyheter/omega-3-tilskudd-uten-effekt-ved-ms/
Omega-3 tilskudd hjelper ikke MS-syke.
Forskning.no,2012. http://www.forskning.no/artikler/2012/april/319349
Omega-3 har ingen effekt mot MS.
Fysioterapeuten. 2012. http://www.fysioterapeuten.no/xp/pub/venstre/nyheter/594345
Ingen effekt av omega-3 tilskudd ved multippel sklerose.
Tidsskrift for den norske legeforening. 2012. http://tidsskriftet.no/article/2275692
Sykere med lave D-vitaminnivå.
Dagens medisin. 2012. http://www.dagensmedisin.no/nyheter/sykere-med-lave-d-vitaminniva/
Ny studie: Sykere med lite D-vitamin.
MS-forbundet. 2012. http://www.ms.no/forskning/d-vitamin-2/
Fødselsmåned er en breddegradsavhengig risikofaktor for MS I Norge.
Foredrag. Nevrodagene 2012
Month of birth among Norwegian MS patients.
Bergen International MS symposium 2012.
Omega-3 fatty acids treatment in relapsing-remitting multiple sclerosis
European Federation of Neurological Sciences (EFNS) 2011
Omega-3 Fatty Acid Treatment in Multiple Sclerosis (OFAMS study): a randomised, double-blind, placebo-controlled trial
European Council for Treatment and Research in Multiple Sclerosis (ECTRIMS) 2011
Etiologi ved MS – Gen-miljø interaksjoner
Årsmøtet for Norsk Nevrologisk forening 2011
Vitamin D gir lavere risiko for MS
Artikkel i ”MS-rapporten 2011”.
D-vitamin kan forebygge MS
MS-bladet. 21.12.2011
Vitamin A, D and E and inflammation in multiple sclerosis
- Disputert:
- februar 2017
- Hovedveileder:
- Trygve Holmøy
- Øivind Fredvik Torkildsen Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest