Targeting metabolic pathways in malignant brain tumours
- Prosjektnummer
- 911683
- Ansvarlig person
- Rolf Bjerkvig
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies.
Adv Drug Deliv Rev 2014 Sep 30;76():98-115. Epub 2014 jul 28
PMID: 25078721
Identification of a novel lytic peptide for the treatment of solid tumours.
Genes Cancer 2014 May;5(5-6):186-200.
PMID: 25061502
In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways.
Int J Mol Sci 2014;15(5):8773-94. Epub 2014 mai 16
PMID: 24840574
U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells.
Cancer Med 2014 Aug;3(4):812-24. Epub 2014 mai 8
PMID: 24810477
Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers?
Biochim Biophys Acta 2014 Aug;1846(1):66-74. Epub 2014 apr 18
PMID: 24747768
Bevacizumab treatment for human glioblastoma. Can it induce cognitive impairment?
Neuro Oncol 2014 May;16(5):754-6.
PMID: 24733853
Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes.
Acta Neuropathol 2014 Feb;127(2):203-19. Epub 2013 okt 24
PMID: 24154962
Tumor versus Stromal Cells in Culture-Survival of the Fittest?
PLoS One 2013;8(12):e81183. Epub 2013 des 2
PMID: 24349039
Expansive growth of two glioblastoma stem-like cell lines is mediated by bFGF and not by EGF.
Radiol Oncol 2013;47(4):330-7. Epub 2013 okt 8
PMID: 24294177
Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.
PLoS One 2013;8(9):e76623. Epub 2013 sep 27
PMID: 24086756
Loss of adipocyte specification and necrosis augment tumor-associated inflammation.
Adipocyte 2013 Jul;2(3):176-83. Epub 2013 apr 19
PMID: 23991365
Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids.
Exp Cell Res 2013 Oct;319(17):2637-48. Epub 2013 aug 19
PMID: 23968587
Gene set based integrated data analysis reveals phenotypic differences in a brain cancer model.
PLoS One 2013;8(7):e68288. Epub 2013 jul 9
PMID: 23874576
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
PLoS One 2013;8(3):e59773. Epub 2013 mar 19
PMID: 23527265
In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme.
Mol Imaging 2013 May;12(3):161-72.
PMID: 23490442
Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells.
Brain 2013 May;136(Pt 5):1462-75. Epub 2013 mar 4
PMID: 23460667
EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis.
Acta Neuropathol 2013 May;125(5):683-98. Epub 2013 feb 22
PMID: 23429996
Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model.
Cancer Res 2013 Apr 15;73(8):2445-56. Epub 2013 feb 19
PMID: 23423977
The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells.
Neuro Oncol 2013 Mar;15(3):269-78. Epub 2012 des 20
PMID: 23258843
Tumor vasculature: the Achilles' heel of cancer?
Expert Opin Ther Targets 2013 Jan;17(1):7-20. Epub 2012 nov 2
PMID: 23121690
Spontaneous transformation of stem cells in vitro and the issue of cross-contamination.
Int J Biol Sci 2012;8(7):1051-2; discussion 1053-4. Epub 2012 aug 15
PMID: 22949886
The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling.
Blood 2012 Jul;120(4):847-57. Epub 2012 jun 12
PMID: 22692509
Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI.
J Nucl Med 2012 Jul;53(7):1135-45. Epub 2012 jun 11
PMID: 22689925
In vivo models of primary brain tumors: pitfalls and perspectives.
Neuro Oncol 2012 Aug;14(8):979-93. Epub 2012 jun 7
PMID: 22679124
Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis.
Angiogenesis 2012 Sep;15(3):481-95. Epub 2012 mai 22
PMID: 22614697
Molecular mechanisms of temozolomide resistance in glioblastoma multiforme.
Expert Rev Anticancer Ther 2012 May;12(5):635-42.
PMID: 22594898
Cellular host responses to gliomas.
PLoS One 2012;7(4):e35150. Epub 2012 apr 23
PMID: 22539956
The regulation of cysteine cathepsins and cystatins in human gliomas.
Int J Cancer 2012 Oct;131(8):1779-89. Epub 2012 mar 9
PMID: 22287159
Comment to: "Spontaneous transformation of adult mesenchymal stem cells from cynomolgus macaques in vitro" by Z. Ren et al. Exp. Cell Res. 317 (2011) 2950-2957: spontaneous transformation of mesenchymal stem cells in culture: facts or fiction?
Exp Cell Res 2012 Mar;318(5):441-3. Epub 2011 des 27
PMID: 22227410
NUMB does not impair growth and differentiation status of experimental gliomas.
Exp Cell Res 2011 Dec;317(20):2864-73. Epub 2011 sep 12
PMID: 21939656
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma.
Acta Neuropathol 2011 Oct;122(4):495-510. Epub 2011 aug 24
PMID: 21863242
Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma.
PLoS One 2011;6(7):e23062. Epub 2011 jul 29
PMID: 21829586
Differential activity of NADPH-producing dehydrogenases renders rodents unsuitable models to study IDH1R132 mutation effects in human glioblastoma.
J Histochem Cytochem 2011 May;59(5):489-503. Epub 2011 feb 10
PMID: 21527585
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma.
Proc Natl Acad Sci U S A 2011 Mar;108(9):3749-54. Epub 2011 feb 14
PMID: 21321221
Critical appraisal of the side population assay in stem cell and cancer stem cell research.
Cell Stem Cell 2011 Feb;8(2):136-47.
PMID: 21295271
A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients.
Neuropathol Appl Neurobiol 2011 Feb;37(2):189-205.
PMID: 20819169
Multimodal imaging of physiologic changes induced by anti-angiogenic therapy in glioblastoma
- Disputert:
- januar 2014
- Hovedveileder:
- Frits Alan Thorsen
Mesenchymal stem cells in cancer research; Biosafety and characterization of in vitro models
- Disputert:
- desember 2012
- Hovedveileder:
- Rolf bjerkvig
Promyelocytic Leukemia Bodies – Function and Dynamics
- Disputert:
- desember 2012
- Hovedveileder:
- Rolf Bjerkvig
Molecular mechanisms of drug resistance in glioblastoma multiforme
- Disputert:
- desember 2011
- Hovedveileder:
- Rolf Bjerkvig
- Olivier Keunen Postdoktor
- Morten Lund-Johansen Medveileder
- Heidi Espedal Ph.d.-kandidat
- Nina Obad Ph.d.-kandidat
- Per Øystein Sakariassen Postdoktor
- Rolf Bjerkvig Leder av forskningsgruppe
- Eli Renate Gruner Prosjektdeltaker
- Frits Alan Thorsen Hovedveileder
- Simone Niclou Medveileder
- Fred Fack Postdoktor
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest