Immunopathology of autoimmune Addison's disease: Development of novel diagnostics and predictive biomarkers
- Prosjektnummer
- 911735
- Ansvarlig person
- Eystein Husebye
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Inflammatory and Immune System, Metabolic and Endocrine
- Forskningsaktivitet
- 2. Aetiology, 5. Treatment Developement
Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency.
J Intern Med 2014 Feb;275(2):104-15. Epub 2013 des 16
PMID: 24330030
Continuous subcutaneous hydrocortisone infusion versus oral hydrocortisone replacement for treatment of addison's disease: a randomized clinical trial.
J Clin Endocrinol Metab 2014 May;99(5):1665-74. Epub 2014 feb 11
PMID: 24517155
The effect of types I and III interferons on adrenocortical cells and its possible implications for autoimmune Addison's disease.
Clin Exp Immunol 2014 Jun;176(3):351-62.
PMID: 24666275
Altered DNA methylation profile in Norwegian patients with Autoimmune Addison's Disease.
Mol Immunol 2014 Jun;59(2):208-16. Epub 2014 mar 22
PMID: 24667071
Functional studies of novel CYP21A2 mutations detected in Norwegian patients with congenital adrenal hyperplasia.
Endocr Connect 2014;3(2):67-74. Epub 2014 apr 15
PMID: 24671123
A novel cell-based assay for measuring neutralizing autoantibodies against type I interferons in patients with autoimmune polyendocrine syndrome type 1.
Clin Immunol 2014 Jul;153(1):220-7. Epub 2014 mai 2
PMID: 24792136
High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients.
J Immunol 2014 Sep 1;193(5):2118-26. Epub 2014 jul 25
PMID: 25063864
Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors.
J Immunol 2014 Oct 15;193(8):3880-90. Epub 2014 sep 17
PMID: 25230752
Interleukin-2 and subunit alpha of its soluble receptor in autoimmune Addison's disease--an association study and expression analysis.
Autoimmunity 2015 Mar;48(2):100-7. Epub 2014 okt 27
PMID: 25347332
Circadian hormone profiles and insulin sensitivity in patients with Addison's disease: a comparison of continuous subcutaneous hydrocortisone infusion with conventional glucocorticoid replacement therapy.
Clin Endocrinol (Oxf) 2015 Jul;83(1):28-35. Epub 2015 jan 12
PMID: 25400085
CYP21A2 polymorphisms in patients with autoimmune Addison's disease, and linkage disequilibrium to HLA risk alleles.
Eur J Endocrinol 2014 Dec;171(6):743-50. Epub 2014 sep 23
PMID: 25249698
Putative candidate genes for canine hypoadrenocorticism (Addison's disease) in multiple dog breeds.
Vet Rec 2014 Nov 1;175(17):430. Epub 2014 aug 14
PMID: 25124887
Association of autoimmune Addison's disease with alleles of STAT4 and GATA3 in European cohorts.
PLoS One 2014;9(3):e88991. Epub 2014 mar 10
PMID: 24614117
Anti-cytokine autoantibodies preceding onset of autoimmune polyendocrine syndrome type I features in early childhood.
J Clin Immunol 2013 Nov;33(8):1341-8. Epub 2013 okt 26
PMID: 24158785
BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.
Sci Transl Med 2013 Oct 9;5(206):206ra139.
PMID: 24107778
A candidate gene analysis of canine hypoadrenocorticism in 3 dog breeds.
J Hered 2013 Nov-Dec;104(6):807-20. Epub 2013 aug 31
PMID: 23997205
Multisteroid LC-MS/MS assay for glucocorticoids and androgens, and its application in Addison's disease.
Endocr Connect 2013 Jun 14. Epub 2013 jun 14
PMID: 23825158
Autoantibodies targeting neurotransmitter biosynthetic enzymes in attention-deficit/hyperactivity disorder (ADHD).
Eur Child Adolesc Psychiatry 2014 Feb;23(2):115-7. Epub 2013 mai 28
PMID: 23712861
Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice.
Clin Exp Immunol 2013 Mar;171(3):263-72.
PMID: 23379432
MHC class II association study in eight breeds of dog with hypoadrenocorticism.
Immunogenetics 2013 Apr;65(4):291-7. Epub 2013 jan 29
PMID: 23358933
Screening for X-linked adrenoleukodystrophy among adult men with Addison's disease.
Clin Endocrinol (Oxf) 2013 Sep;79(3):316-20. Epub 2013 mai 20
PMID: 23346902
Autoantibodies against aromatic amino acid hydroxylases in patients with autoimmune polyendocrine syndrome type 1 target multiple antigenic determinants and reveal regulatory regions crucial for enzymatic activity.
Immunobiology 2013 Jun;218(6):899-909. Epub 2012 okt 26
PMID: 23182718
Induction of CXCL10 chemokine in adrenocortical cells by stimulation through toll-like receptor 3.
Mol Cell Endocrinol 2013 Jan 5;365(1):75-83. Epub 2012 sep 16
PMID: 22989785
Quality of life in European patients with Addison's disease: validity of the disease-specific questionnaire AddiQoL.
J Clin Endocrinol Metab 2012 Feb;97(2):568-76. Epub 2011 nov 16
PMID: 22090270
Radioligand-binding assay reveals distinct autoantibody preferences for type I interferons in APS I and myasthenia gravis subgroups.
J Clin Immunol 2012 Apr;32(2):230-7. Epub 2011 nov 30
PMID: 22127461
Autoimmune polyendocrine syndrome type 1: an extensive longitudinal study in Sardinian patients.
J Clin Endocrinol Metab 2012 Apr;97(4):1114-24. Epub 2012 feb 16
PMID: 22344197
Genetic, anthropometric and metabolic features of adult Norwegian patients with 21-hydroxylase deficiency.
Eur J Endocrinol 2012 Oct;167(4):507-16. Epub 2012 jul 16
PMID: 22802425
[In Process Citation].
Tidsskr Nor Laegeforen 2012 Oct;132(18):2043-4.
PMID: 23038193
PhD
- Disputert:
- februar 2012
- Hovedveileder:
- Dag Undlien
PhD
- Disputert:
- februar 2012
- Hovedveileder:
- Eystein Husebye
- Eystein Sverre Husebye Prosjektleder
- Kristian Løvås Prosjektdeltaker
- Marianne Øksnes Ph.d.-kandidat
- Paal Methlie Ph.d.-kandidat
- Ingeborg Brønstad Ph.d.-kandidat
- Anette Susanne Bøe Wolff Prosjektdeltaker
- Bergithe Eikeland Oftedal Postdoktor
- Lars Ertesvåg Breivik Postdoktor
- Kine Susann Waade Edvardsen Ph.d.-kandidat
- Eirik Bratland Prosjektdeltaker
- Richard Alexander Hellesen Ph.d.-kandidat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest