Perturbation of cAMP signaling to improve drug delivery and cancer cell death
- Prosjektnummer
- 911740
- Ansvarlig person
- Stein Ove Døskeland
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Blood
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment.
Appl Microbiol Biotechnol 2014 Jan;98(2):603-10. Epub 2013 okt 26
PMID: 24158735
Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds.
J Enzyme Inhib Med Chem 2014 Apr 3. Epub 2014 apr 3
PMID: 24697298
Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.
Mar Drugs 2014 Apr;12(4):2036-53. Epub 2014 apr 3
PMID: 24705501
Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.
PLoS One 2014;9(4):e94926. Epub 2014 apr 16
PMID: 24740327
Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia.
Eur J Pharm Biopharm 2014 Sep;88(1):186-93. Epub 2014 apr 18
PMID: 24747809
Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression.
Biochem Biophys Res Commun 2014 Jul 4;449(3):357-63. Epub 2014 mai 17
PMID: 24845383
Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines.
Proteomics 2014 Sep;14(17-18):1971-6. Epub 2014 aug 8
PMID: 25044641
4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.
ACS Chem Biol 2014 Nov 21;9(11):2646-55. Epub 2014 sep 25
PMID: 25203327
New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities.
Bioorg Chem 2014 Dec;57():108-15. Epub 2014 sep 26
PMID: 25305721
Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells.
Mar Drugs 2013;11(2):332-49. Epub 2013 jan 30
PMID: 23364682
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.
Cell Death Dis 2013;4():e516. Epub 2013 feb 28
PMID: 23449452
Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid-induced maturation of acute promyelocytic leukemia cells.
Mol Pharmacol 2013 May;83(5):1057-65. Epub 2013 mar 1
PMID: 23455313
DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms.
PLoS One 2013;8(7):e67925. Epub 2013 jul 4
PMID: 23861833
Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.
Biochem Biophys Res Commun 2013 Aug 9;437(4):603-8. Epub 2013 jul 12
PMID: 23850619
Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen.
BMC Cancer 2013;13():341. Epub 2013 jul 11
PMID: 23841896
The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner.
Biochim Biophys Acta 2012 Dec;1818(12):3000-9. Epub 2012 jul 25
PMID: 22842546
Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.
PLoS One 2012;7(7):e41222. Epub 2012 jul 19
PMID: 22829929
Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells.
PLoS One 2012;7(3):e34114. Epub 2012 mar 27
PMID: 22479536
Abrogation of anthracycline and ischemia-reperfusion induced injury by cell signaling modulators.
- Disputert:
- oktober 2013
- Hovedveileder:
- Stein Døskeland (50%) og Anne Jonassen (50%)
The cAMP regulated transcriptome
- Disputert:
- februar 2012
- Hovedveileder:
- Stein Ove Døskeland
- Stein Ove Døskeland Prosjektleder
- Frode Selheim Prosjektdeltaker
- Reidun Kopperud Prosjektdeltaker
- Ronja Bjørnstad Prosjektdeltaker
- Gro Gausdal Postdoktor
- Lene Elisabeth Myhren Ph.d.-kandidat
- Lars Herfindal Prosjektdeltaker
- Rolf K. Reed Prosjektdeltaker
- Øystein Bruserud Prosjektdeltaker
- Reidun Kristin Kopperud Prosjektdeltaker
- Bjørn Tore Gjertsen Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest