NAT-enzymer og deres rolle ved kreft, genetiske syndrom og fedme
- Prosjektnummer
- 911883
- Ansvarlig person
- Thomas Arnesen
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer, Congenital Disorders, Metabolic and Endocrine
- Forskningsaktivitet
- 2. Aetiology, 5. Treatment Developement
Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion.
Sci Rep 2016 Dec 20;6():39118. Epub 2016 des 20
PMID: 27996020
A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity.
Mol Cell Proteomics 2016 Nov;15(11):3361-3372. Epub 2016 sep 30
PMID: 27694331
The world of protein acetylation.
Biochim Biophys Acta 2016 Oct;1864(10):1372-401. Epub 2016 jun 11
PMID: 27296530
First Things First: Vital Protein Marks by N-Terminal Acetyltransferases.
Trends Biochem Sci 2016 Sep;41(9):746-60. Epub 2016 aug 3
PMID: 27498224
Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases.
Sci Rep 2016 Aug 24;6():31627. Epub 2016 aug 24
PMID: 27555049
Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency.
Hum Mutat 2016 Aug;37(8):755-64. Epub 2016 mai 4
PMID: 27094817
Crystal Structure of the Golgi-Associated Human Na-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.
Structure 2016 Jul 06;24(7):1044-56. Epub 2016 jun 16
PMID: 27320834
NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment.
Sci Rep 2015;5():16022. Epub 2015 nov 2
PMID: 26522270
Naa10 in development and disease.
Oncotarget 2015 Oct 27;6(33):34041-2.
PMID: 26431279
The N-terminal acetyltransferase Naa10 is essential for zebrafish development.
Biosci Rep 2015;35(5). Epub 2015 aug 6
PMID: 26251455
Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis.
Nat Commun 2015;6():7640. Epub 2015 jul 17
PMID: 26184543
Holding it together: Naa60 at the Golgi.
Oncotarget 2015 Jun 30;6(18):15726-7.
PMID: 26164078
(Hyper)tension release by N-terminal acetylation.
Trends Biochem Sci 2015 Aug;40(8):422-4. Epub 2015 mai 28
PMID: 26027460
N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects.
Proteomics 2015 Jul;15(14):2385-401. Epub 2015 jun 16
PMID: 25914051
N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.
Proteomics 2015 Jul;15(14):2436-46. Epub 2015 jun 5
PMID: 25886145
Molecular, cellular, and physiological significance of N-terminal acetylation.
Int Rev Cell Mol Biol 2015;316():267-305. Epub 2015 feb 25
PMID: 25805127
An organellar na-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.
Cell Rep 2015 Mar 3;10(8):1362-74. Epub 2015 feb 26
PMID: 25732826
Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
Hum Mol Genet 2015 Apr 1;24(7):1956-76. Epub 2014 des 8
PMID: 25489052
De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females.
Eur J Hum Genet 2015 May;23(5):602-9. Epub 2014 aug 6
PMID: 25099252
A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant.
Mol Cell Proteomics 2014 Aug;13(8):2031-41. Epub 2014 jan 9
PMID: 24408909
Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas.
Endocr Relat Cancer 2014 Feb;21(1):L1-4. Epub 2014 jan 8
PMID: 24179102
Regulation of protein N-terminal acetylation
- Disputert:
- oktober 2016
- Hovedveileder:
- Thomas Arnesen
The protein N-terminal acetyltransferase C (NatC) – Functional implications and evolutionary conservation
- Disputert:
- mai 2016
- Hovedveileder:
- Thomas Arnesen
Functional analysis of Na-acetyltransferase 10 (NAA10) variants identified in patients with genetic disorders
- Disputert:
- mars 2015
- Hovedveileder:
- Thomas Arnesen
N-terminal acetyltransferases NatC and NatF: cellular functions and substrates
- Disputert:
- februar 2014
- Hovedveileder:
- Thomas Arnesen
Substrates and Cellular functions of the human N-terminal acetyltransferases NatA and NatC
- Disputert:
- april 2014
- Hovedveileder:
- Thomas Arnesen
- Anette Heie Prosjektdeltaker
- Katrin Brauckhoff Prosjektdeltaker
- Michael Bruno Eric Marie Prosjektdeltaker
- Marianne Goris Ph.d.-kandidat
- Henriette Aksnes Prosjektdeltaker
- Håvard Foyn Prosjektdeltaker
- Adrian Drazic Prosjektdeltaker
- Sylvia Varland Ph.d.-kandidat
- Camilla Osberg Ph.d.-kandidat
- Rasmus Moen Ree Ph.d.-kandidat
- Svein Isungset Støve Prosjektdeltaker
- Line Merethe Myklebust Prosjektdeltaker
- Thomas Arnesen Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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