Translational Development of Preclinical Models and Therapies in Haematological Malignancies and Cancer
- Prosjektnummer
- 911884
- Ansvarlig person
- Emmet Mc Cormack
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Blood, Cancer
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.
Cell Death Dis 2016 Dec 01;7(12):e2497. Epub 2016 des 1
PMID: 27906185
A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer.
J Control Release 2016 Dec 10;243():172-181. Epub 2016 okt 12
PMID: 27744037
Proceedings from the 1st Insights in Hematology Symposium, Cluj-Napoca, Romania March 11-12, 2016.
Rom J Intern Med 2016 Sep 01;54(3):157-160.
PMID: 27658163
The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer.
PLoS One 2016;11(6):e0158208. Epub 2016 jun 28
PMID: 27352023
Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes.
Biomaterials 2016 Jul;95():11-21. Epub 2016 apr 6
PMID: 27108402
Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying ?-secretase Inhibitors.
Mol Ther 2016 May;24(5):926-36. Epub 2016 feb 26
PMID: 26916284
Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia.
Oncotarget 2016 Feb 16;7(7):8105-18.
PMID: 26812881
Xenograft Models of Primary Acute Myeloid Leukemia for the Development of Imaging Strategies and Evaluation of Novel Targeted Therapies.
Curr Pharm Biotechnol 2016;17(1):42-51.
PMID: 26278528
Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.
Head Neck 2016 Apr;38 Suppl 1():E1177-87. Epub 2015 aug 14
PMID: 26275210
Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells.
Pharmacol Res 2016 Nov;113(Pt A):216-227. Epub 2016 aug 16
PMID: 27543462
Single-cell proteomics: potential implications for cancer diagnostics.
Expert Rev Mol Diagn 2016;16(5):579-89. Epub 2016 mar 21
PMID: 26895397
Development of Personalized Molecular Therapy for Acute Myeloid Leukemia.
Curr Pharm Biotechnol 2016;17(1):20-9.
PMID: 26420051
Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma.
PLoS One 2015;10(8):e0135220. Epub 2015 aug 7
PMID: 26252891
Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging.
PLoS One 2015;10(6):e0131037. Epub 2015 jun 25
PMID: 26110789
4-Alkylated Silver-N-Heterocyclic Carbene (NHC) Complexes with Cytotoxic Effects in Leukemia Cells.
ChemMedChem 2015 Sep;10(9):1522-7. Epub 2015 aug 6
PMID: 26250720
Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells.
Oncoscience 2014;1(8):529-39. Epub 2014 aug 6
PMID: 25594060
SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute Myeloid Leukemia stem cells.
Cell Stem Cell 2014 Oct 2;15(4):431-46.
PMID: 25280219
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia.
Mol Cancer 2014;13():116. Epub 2014 mai 21
PMID: 24885082
First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma.
PLoS One 2014;9(3):e89527. Epub 2014 mar 4
PMID: 24594904
Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft.
Mol Imaging Biol 2014 Feb;16(1):53-62.
PMID: 23877869
A knockout Combo: eradicating AML Stem Cells with TKI plus SIRT1 inhibition.
Cell Stem Cell 2014 Oct 2;15(4):395-7.
PMID: 25280212
Single-cell immune signatures? in patients with chronic phase chronic myeloid leukemia (CML) treated with nilotinib
ESH, 2015
Imaging Myeloid Malignancies with the Proliferation Marker 18F-FLT in Patient Derived Xenograft Models
CCBIO annual meeting, Solstrand, Bergen, 2015
In vivo imaging of a nitroreductase reporter gene with 18F-FMISO
EMIM, Tubingen, Germany, 2015
Preclinical PET/CT imaging of a nitroreductase reporter gene with 18F-- FMISO
WMIC, Honolulu, Hawaii, USA, 2015
Gadolinium-incorporated mesoporous silica nanoparticles for MR imaging: long playing contrast agents.
ISMRM, Toronto, Canada, 2015
Synthetic studies towards nitroreductase-activated fluorescent probes
World Molecular Imaging Congress Honolulu, Hawaii, 2015
Synthetic studies towards nitroreductaseactivated fluorescent probes
MedViz Conference, Bergen, Norway, 2015
Synthesis of CytoCy5S and its active esters for optical imaging
10th European Molecular Imaging Meeting Tu¨bingen, Germany, 2015)
Synthesis of CytoCy5S and its NHS ester for optical imaging
30th Organic Chemistry Winter Meeting Skeikampen, Norway, 2015
Imaging Myeloid Malignancies with the Proliferation Marker 18F-FLT in Patient Derived Xenograft Models
CCBIO meetin, Solstrand, Bergen, Norway, 2015
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
Chemotherapy, 2014
Novel pre-clinical models of myelodysplastic syndrome (MDS)
Experimental Hematology, 2014
CLONAL EVOLUTION IN PRIMARY RESISTANT AML ASSESSED BY GENETIC AND MOLECULAR PROFILING, SINGLE CELL SIGNALLING PROFILING
HAEMATOLOGICA, 2014
REPURPOSING PHENOTHIAZINE CHLORPROMAZINE IN THERAPEUTIC TARGETING OF LEUKEMIC STEM CELLS
HAEMATOLOGICA, 2014
Ovarian Cancer: A Clinical Challenge Requiring Basic Answers
- Disputert:
- mai 2014
- Hovedveileder:
- Line Bjørge, Bjørn Tore Gjertsen, Emmet Mc Cormack
- Veronika Mamaeva Postdoktor
- Tara Helen Dowling Ph.d.-kandidat
- Stein-Erik Gullaksen Ph.d.-kandidat
- Caroline Benedicte Nitter Engen Ph.d.-kandidat
- Calum Leitch Ph.d.-kandidat
- Øystein Bruserud Prosjektdeltaker
- Mihaela Lucia Popa Prosjektdeltaker
- Bjørn Tore Gjertsen Medveileder
- Astrid Olsnes Kittang Medveileder
- Sahba Shafiee Ph.d.-kandidat
- Zinayida Fandalyuk Prosjektdeltaker
- Pascal Gelebart Postdoktor
- Emmet Mc Cormack Prosjektleder
- Line Bjørge Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest