Identification of novel treatment targets in neurodevelopmental disorders
- Prosjektnummer
- 911972
- Ansvarlig person
- Jan Haavik
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Mental Health
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
Prosjektet er utviklet i tett dialog med pasienter og andre potensielle brukere. Vi gjennomførte bla. nylig en stor brukerundersøkelse, der samtlige voksne ADHD-pasienter som var behandlet i Helse-Bergen ble spurt om deres erfaringer og prioriteringer for fremtiden. Flertallet var misfornøyd med tilbudet og det var særlig påpekt mangelfull informasjon og informasjon om nye og alternative behandlingsmetoder. Ettersom det er en stor mangel på kunnskap om nye behandlingsmetoder, er prosjektet en utviklet som en direkte respons på denne brukerundersøkelsen. I KGJebsen-senteret har vi et fast brukerpanel med fire representanter fra ADHD-Norge. I våre internasjonale prosjekter samarbeider vi tett med flere pasient-foreninger, inkludert ADHD-Europe.
Gender differences in psychiatric comorbidity: a population-based study of 40 000 adults with attention deficit hyperactivity disorder.
Acta Psychiatr Scand 2017 Dec 21. Epub 2017 des 21
PMID: 29266167
Correction to: Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study.
Eur Child Adolesc Psychiatry 2017 Dec 01. Epub 2017 des 1
PMID: 29196875
Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study.
Eur Child Adolesc Psychiatry 2017 Oct 05. Epub 2017 okt 5
PMID: 28983730
Adults with Attention Deficit Hyperactivity Disorder Report High Symptom Levels of Troubled Sleep, Restless Legs, and Cataplexy.
Front Psychol 2017;8():1621. Epub 2017 sep 20
PMID: 28979226
Implication of the APP Gene in Intellectual Abilities.
J Alzheimers Dis 2017;59(2):723-735.
PMID: 28671113
Prevalence and clinical correlates of insomnia in adults with attention-deficit hyperactivity disorder.
Acta Psychiatr Scand 2017 08;136(2):220-227. Epub 2017 mai 26
PMID: 28547881
SLC2A3 single-nucleotide polymorphism and duplication influence cognitive processing and population-specific risk for attention-deficit/hyperactivity disorder.
J Child Psychol Psychiatry 2017 Jul;58(7):798-809. Epub 2017 feb 22
PMID: 28224622
Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis.
Lancet Psychiatry 2017 Apr;4(4):310-319. Epub 2017 feb 16
PMID: 28219628
Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.
Expert Opin Ther Targets 2017 Feb;21(2):167-180. Epub 2016 des 26
PMID: 27973928
Vitamin levels in adults with ADHD.
BJPsych Open 2016 Nov;2(6):377-384. Epub 2016 des 13
PMID: 27990293
Implication of NOTCH1 gene in susceptibility to anxiety and depression among sexual abuse victims.
Transl Psychiatry 2016 Dec 13;6(12):e977. Epub 2016 des 13
PMID: 27959334
Exome chip analyses in adult attention deficit hyperactivity disorder.
Transl Psychiatry 2016 Oct 18;6(10):e923. Epub 2016 okt 18
PMID: 27754487
Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review.
J Atten Disord 2016 Sep 22. Epub 2016 sep 22
PMID: 27664125
Meta-analysis of the DRD5 VNTR in persistent ADHD.
Eur Neuropsychopharmacol 2016 Sep;26(9):1527-32. Epub 2016 jul 29
PMID: 27480019
Females With ADHD Report More Severe Symptoms Than Males on the Adult ADHD Self-Report Scale.
J Atten Disord 2016 Jul 25. Epub 2016 jul 25
PMID: 27461728
A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study.
J Neural Transm (Vienna) 2016 Aug;123(8):859-65. Epub 2016 apr 18
PMID: 27091191
Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder.
Am J Med Genet B Neuropsychiatr Genet 2016 Jul;171(5):733-47. Epub 2016 mar 29
PMID: 27021288
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins.
Amino Acids 2016 May;48(5):1221-9. Epub 2016 jan 29
PMID: 26825549
Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression.
Neurochem Int 2015 Nov;90():173-84. Epub 2015 sep 1
PMID: 26327310
Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE.
Am J Med Genet B Neuropsychiatr Genet 2015 Jul 14. Epub 2015 jul 14
PMID: 26172220
On the role of NOS1 ex1f-VNTR in ADHD-allelic, subgroup, and meta-analysis.
Am J Med Genet B Neuropsychiatr Genet 2015 Jun 18. Epub 2015 jun 18
PMID: 26086921
Paraneoplastic syndrome-associated neuronal antibodies in adult ADHD.
J Neuroimmunol 2015 Nov 15;288():87-91. Epub 2015 sep 1
PMID: 26531699
Common variants in the ARC gene are not associated with cognitive abilities.
Brain Behav 2015 Oct;5(10):e00376. Epub 2015 sep 3
PMID: 26516611
Genome-wide analysis of attention deficit hyperactivity disorder in Norway.
PLoS One 2015;10(4):e0122501. Epub 2015 apr 13
PMID: 25875332
Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment
The Journal of the American Academy of Child & Adolescent Psychiatry's (JAACAP). Published online: November 25, 2017. DOI: http://dx.doi.org/10.1016/j.jaac.2017.11.013
Genetic susceptibility across neuropsychiatric disorders - genome-wide, candidate gene and interaction analyses”
- Disputert:
- oktober 2016
- Hovedveileder:
- Jan Haavik
- Ingeborg Winge Prosjektdeltaker
- Petri Kursula Leder av forskningsgruppe
- Kaya Kvarme Jacobsen Ph.d.-kandidat
- Rune Kleppe Prosjektdeltaker
- Jan Haavik Prosjektleder
- Elaheh Mahootchi Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest