Search for druggable upregulated proteins in therapy-resistant AML cells
The end-users are patients with AML. The project leader and many of the project participants have contact with cancer patients and their relatives, as well as others interested in cancer, in part through popular science lectures organised by DNK. The project participants have also close contact with Drs. Ø. Bruserud and BT Gjertsen, who treat AML patients on daily basis and receive their inputs. A subproject not commented in this report (due to space considerations) is to understand how hydroxy-urea and thio-guanine interact to kill AML cells, based on their beneficial effects in clinical studies, and the apparently high user-satisfaction (low grade of side effects, also in weak and elderly patients) reported by the patients undergoing such therapy (B.T. Gjertsen, pers. communic.)
Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression.
Sci Rep 2017 Aug 18;7(1):8725. Epub 2017 aug 18
Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives.
Bioorg Med Chem 2017 04 01;25(7):2285-2293. Epub 2017 feb 28
Increased microvascular permeability in mice lacking Epac1 (Rapgef3).
Acta Physiol (Oxf) 2017 Feb;219(2):441-452. Epub 2016 mai 17
Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling.
Nutr Metab (Lond) 2016;13():87. Epub 2016 nov 28
Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells.
Bioorg Med Chem 2015 Nov 15;23(22):7313-23. Epub 2015 okt 24
Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.
Mar Drugs 2015 Oct;13(10):6505-20. Epub 2015 okt 22
B56d-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.
J Clin Invest 2015 Aug 3;125(8):3051-62. Epub 2015 jul 13
cAMP-Dependent Protein Kinase A (PKA)-Mediated c-Myc Degradation Is Dependent on the Relative Proportion of PKA-I and PKA-II Isozymes.
Mol Pharmacol 2015 Sep;88(3):469-76. Epub 2015 jun 23
Assessing Cyclic Nucleotide Recognition in Cells: Opportunities and Pitfalls for selective Receptor activation
hapter 4. pp 61 - 80 in: In CRC series on Methods in Signal Transduction, Vol. title “Cyclic nucleotide signaling”. Editor: Xiaodong Cheng. CRC Press, Taylor & Francis, Boca Raton, London, New York. isbn = 1482235560, 2015
Exchange proteins directly activated by cAMP
- september 2017
- Marit Bakke
Physiological roles of Epac: characterisation of gene knockout models
- juni 2017
- Marit Bakke