Bergen Stem Cell Consortium - katalysator for stamcelleforskning i Helse Vest
- Prosjektnummer
- 912007
- Ansvarlig person
- Tor Hervig
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Strategisk satsing - framtidsmedisin
- Helsekategori
- Generic Health Relevance
- Forskningsaktivitet
- 5. Treatment Developement
I Bergen Stem Cell Consortium er det ikke brukermedvirkning, men i prosjektene forskningsgruppene driver - er det omfattende brukermedvirkning. Dette er beskrevet i de enkelte prosjektene.
Xeno-Free Spheroids of Human Gingiva-Derived Progenitor Cells for Bone Tissue Engineering.
Front Bioeng Biotechnol 2020;8():968. Epub 2020 aug 19
PMID: 32974308
Comparative separation methods and biological characteristics of human placental and umbilical cord mesenchymal stem cells in serum-free culture conditions.
Stem Cell Res Ther 2020 05 19;11(1):183. Epub 2020 mai 19
PMID: 32430063
Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma.
Oncogene 2020 04;39(14):2934-2947. Epub 2020 feb 7
PMID: 32034308
Tyrosine kinase inhibitors and interferon-α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines.
FASEB J 2020 03;34(3):3773-3791. Epub 2020 jan 16
PMID: 31945226
Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells.
Pharmaceutics 2020 Feb 07;12(2). Epub 2020 feb 7
PMID: 32046005
The Emerging Role of CD24 in Cancer Theranostics-A Novel Target for Fluorescence Image-Guided Surgery in Ovarian Cancer and Beyond.
J Pers Med 2020 Nov 27;10(4). Epub 2020 nov 27
PMID: 33260974
Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia.
Cancers (Basel) 2020 Mar 17;12(3). Epub 2020 mar 17
PMID: 32192169
CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma.
EBioMedicine 2020 Jun;56():102782. Epub 2020 mai 23
PMID: 32454401
Near-Infrared Fluorescent Imaging for Monitoring of Treatment Response in Endometrial Carcinoma Patient-Derived Xenograft Models.
Cancers (Basel) 2020 Feb 06;12(2). Epub 2020 feb 6
PMID: 32041116
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines.
Drug Metab Dispos 2020 03;48(3):153-158. Epub 2019 des 23
PMID: 31871136
CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model.
EBioMedicine 2020 Jun;56():102783. Epub 2020 mai 23
PMID: 32454402
N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation.
Exp Neurol 2021 03;337():113536. Epub 2020 nov 29
PMID: 33264635
A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates.
Sci Rep 2020 10 28;10(1):18498. Epub 2020 okt 28
PMID: 33116175
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.
EMBO Mol Med 2020 Oct 07;12(10):e12146. Epub 2020 aug 25
PMID: 32840960
Patient-specific neural progenitor cells derived from induced pluripotent stem cells offer a promise of good models for mitochondrial disease.
Cell Tissue Res 2020 Apr;380(1):15-30. Epub 2020 jan 10
PMID: 31925525
Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts.
Cell Mol Life Sci 2020 Mar;77(6):1115-1133. Epub 2019 jul 3
PMID: 31270582
Dual Pro- and Anti-Inflammatory Features of Monocyte-Derived Dendritic Cells.
Front Immunol 2020;11():438. Epub 2020 mar 27
PMID: 32292402
Reprogrammed Cells Display Distinct Proteomic Signatures Associated with Colony Morphology Variability.
Stem Cells Int 2019;2019():8036035. Epub 2019 nov 18
PMID: 31827534
Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia.
J Cancer Res Clin Oncol 2019 Jul;145(7):1729-1749. Epub 2019 mai 20
PMID: 31111215
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.
Nature 2019 03;567(7746):43-48. Epub 2019 feb 13
PMID: 30760930
Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells.
Pharmaceutics 2019 Jul 06;11(7). Epub 2019 jul 6
PMID: 31284599
Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma.
Clin Cancer Res 2019 01 01;25(1):334-345. Epub 2018 nov 15
PMID: 30442683
In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress.
Acta Physiol (Oxf) 2020 04;228(4):e13433. Epub 2020 jan 8
PMID: 31872528
Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors.
Stem Cells 2020 04;38(4):542-555. Epub 2020 jan 22
PMID: 31828876
Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration.
J Tissue Eng 2019 Jan-Dec;10():2041731419852703. Epub 2019 mai 31
PMID: 31210921
HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.
iScience 2019 Jun 28;16():192-205. Epub 2019 mai 27
PMID: 31195238
Wood-based nanocellulose and bioactive glass modified gelatin-alginate bioinks for 3D bioprinting of bone cells.
Biofabrication 2019 04 26;11(3):035010. Epub 2019 apr 26
PMID: 30754034
Inflammatory responses and tissue reactions to wood-Based nanocellulose scaffolds.
Mater Sci Eng C Mater Biol Appl 2019 Apr;97():208-221. Epub 2018 des 2
PMID: 30678905
Cell therapy for orofacial bone regeneration: A systematic review and meta-analysis.
J Clin Periodontol 2019 06;46 Suppl 21():162-182.
PMID: 30623455
Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect.
Bone Rep 2019 Jun;10():100205. Epub 2019 apr 11
PMID: 31193299
Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells.
Sci Rep 2019 Nov 05;9(1):16031. Epub 2019 nov 5
PMID: 31690774
The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation.
Front Endocrinol (Lausanne) 2019;10():293. Epub 2019 mai 8
PMID: 31139151
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells.
Haematologica 2019 May;104(5):e229.
PMID: 31040234
Fibroblasts rescue oral squamous cancer cell from metformin-induced apoptosis via alleviating metabolic disbalance and inhibiting AMPK pathway.
Cell Cycle 2019 05;18(9):949-962. Epub 2019 apr 23
PMID: 31014173
Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma.
Cells 2019 02 21;8(2). Epub 2019 feb 21
PMID: 30795553
CCDC104 Antibodies and Mitosis of Cancer Cells.
Scand J Immunol 2018 02;87(2):109-110.
PMID: 29193323
Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino-terminal domain.
Pharmacol Res Perspect 2018 12;6(6):e00437. Epub 2018 nov 5
PMID: 30410767
Targeting Wnt/β-Catenin Signaling for Cancer Immunotherapy.
Trends Pharmacol Sci 2018 07;39(7):648-658. Epub 2018 apr 17
PMID: 29678298
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer.
Nat Chem Biol 2018 Jan;14(1):94-101. Epub 2017 okt 30
PMID: 29083417
Coating 3D Printed Polycaprolactone Scaffolds with Nanocellulose Promotes Growth and Differentiation of Mesenchymal Stem Cells.
Biomacromolecules 2018 Nov 12;19(11):4307-4319. Epub 2018 okt 18
PMID: 30296827
Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial.
Stem Cell Res Ther 2018 Aug 09;9(1):213. Epub 2018 aug 9
PMID: 30092840
In vitro cytotoxicity assessment of nanodiamond particles and their osteogenic potential.
J Biomed Mater Res A 2018 Jun;106(6):1697-1707. Epub 2018 mar 8
PMID: 29451353
Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model.
Stem Cell Res Ther 2018 01 31;9(1):23. Epub 2018 jan 31
PMID: 29386057
Bone tissue engineering in oral peri-implant defects in preclinical in vivo research: A systematic review and meta-analysis.
J Tissue Eng Regen Med 2018 Jan;12(1):e336-e349. Epub 2017 mai 31
PMID: 28095650
The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.
Pancreatology 2018 Jan;18(1):12-19. Epub 2017 des 5
PMID: 29233499
Elevated cerebrospinal fluid protein in POLG-related epilepsy: Diagnostic and prognostic implications.
Epilepsia 2018 Aug;59(8):1595-1602. Epub 2018 jun 19
PMID: 29920680
IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.
Int J Obes (Lond) 2019 11;43(11):2151-2162. Epub 2018 des 11
PMID: 30538277
Small molecule induces Wnt asymmetry in cancer.
Cell Cycle 2017 Jan 17;16(2):141-142. Epub 2016 sep 29
PMID: 27687486
An androgen response element driven reporter assay for the detection of androgen receptor activity in prostate cells.
PLoS One 2017;12(6):e0177861. Epub 2017 jun 1
PMID: 28570625
Anatomy and evolution of database search engines-a central component of mass spectrometry based proteomic workflows.
Mass Spectrom Rev 2020 05;39(3):292-306. Epub 2017 sep 13
PMID: 28902424
Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells.
Sci Rep 2017 Jul 06;7(1):4780. Epub 2017 jul 6
PMID: 28684784
Efficacy of Humanized Mesenchymal Stem Cell Cultures for Bone Tissue Engineering: A Systematic Review with a Focus on Platelet Derivatives.
Tissue Eng Part B Rev 2017 Dec;23(6):552-569. Epub 2017 jul 28
PMID: 28610481
A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration.
Macromol Biosci 2017 Jun;17(6). Epub 2017 jan 24
PMID: 28116858
Cytocompatibility of Wood-Derived Cellulose Nanofibril Hydrogels with Different Surface Chemistry.
Biomacromolecules 2017 04 10;18(4):1238-1248. Epub 2017 mar 16
PMID: 28263573
Axitinib blocks Wnt/ß-catenin signaling and directs asymmetric cell division in cancer.
Proc Natl Acad Sci U S A 2016 Aug 16;113(33):9339-44. Epub 2016 aug 1
PMID: 27482107
Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes.
BMC Cancer 2016 Jul 04;16():377. Epub 2016 jul 4
PMID: 27378372
Using Proteomics Bioinformatics Tools and Resources in Proteogenomic Studies.
Adv Exp Med Biol 2016;926():65-75.
PMID: 27686806
Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia.
Stem Cell Reports 2016 Mar 08;6(3):357-67. Epub 2016 feb 11
PMID: 26876668
Systemic Analysis of Regulated Functional Networks.
Methods Mol Biol 2016;1394():287-310.
PMID: 26700057
Exploring the potential of public proteomics data.
Proteomics 2016 Jan;16(2):214-25. Epub 2015 des 15
PMID: 26449181
Nigrostriatal denervation sine parkinsonism.
Brain 2016 Apr;139(Pt 4):e25. Epub 2016 jan 25
PMID: 26811251
The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORa and SRC-2 coactivator transcriptional activity.
Mol Cell Endocrinol 2016 Jan 05;419():92-101. Epub 2015 okt 9
PMID: 26455881
In Vivo Host Response and Degradation of Copolymer Scaffolds Functionalized with Nanodiamonds and Bone Morphogenetic Protein 2.
Adv Healthc Mater 2016 Mar;5(6):730-42. Epub 2016 feb 8
PMID: 26853449
Surfactant tuning of hydrophilicity of porous degradable copolymer scaffolds promotes cellular proliferation and enhances bone formation.
J Biomed Mater Res A 2016 Aug;104(8):2049-59. Epub 2016 apr 19
PMID: 27086867
3D printable Polycaprolactone-gelatin blends characterized for in vitro osteogenic potency
Reactive and Functional Polymers 146: 104445 (2020).
Xeno-free 3D Culture of Mesenchymal Stromal Cells For Bone Tissue Engineering
- Disputert:
- desember 2020
- Hovedveileder:
- Kamal Babikeir Eln Mustafa
Modelling mitochondrial disease in cardiomyocytes generated from patient induced stem cells
- Disputert:
- april 2018
- Hovedveileder:
- Laurence Bindoff
- Kamal Babikeir Eln Mustafa Leder av forskningsgruppe
- Helge Ræder Leder av forskningsgruppe
- Laurence Bindoff Leder av forskningsgruppe
- Jørn V. Sagen Leder av forskningsgruppe
- Emmet Martin Mc Cormack Leder av forskningsgruppe
- Bjørn Tore Gjertsen Prosjektdeltaker
- Kimberley Joanne Hatfield Prosjektdeltaker
- Karl-Henning Kalland Leder av forskningsgruppe
- Tor Hervig Leder av forskningsgruppe
- Einar Klæboe Kristoffersen Prosjektleder
- Tilo Wolf Eichler Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest