Necrotizing enterocolitis and bowel perforation in preterm infants - risk factors, epidemiology and long-term follow-up.

Necrotizing enterocolitis and bowel perforation in preterm infants – risk factors, epidemiology and long-term follow-up*Approved midway evaluation may 2023 *Taught nurses completing a Masters in advanced clinical nursing *Collected data for substudy 2 *Some results from substudy 2 were presented at “jENS 5th Congress of joint European Neonatal Societies” in Rome in august 2023 *Completed required scientific communication *NEC conference, UKThe first half of 2023 was spent collecting and analyzing data for substudy 2. In May I had my midway evaluation where I got good feedback & advice going forward with the remainder of my project. Taught nurses completing a Masters in advanced clinical nursing at Lovisenberg Diakonale Høgskole, 23/8 2023. Subject for the lecture was: Observation and evaluation of newborn infants with suspected necrotizing enterocolitis. The last half of 2023 has been spent completing paper 2: Surgery for acquired and congenital intestinal injuries in very preterm infants - a Norwegian population-based study. This paper is soon to be submitted. Some results from substudy 2 were presented at “jENS 5th Congress of joint European Neonatal Societies” in Rome in august 2023 as an oral poster presentation. I have gathered the required scientific communication points. (formidlingspoeng oppnådd). In November I attended the ESPGHAN MONOTHEMATIC CONFERENCE: NEC in Newcastle, UK.

Necrotizing enterocolitis and bowel perforation in preterm infants - risk factros, epidemiology and long-term follow-up.*Jan-Jun 2022: 2022 HLTH6224 Research Methods, University of Southampton. Online course *Poster presentation, 10th International Conference on Clinical Neonatology 2022, Torino, Italy *Oral poster presentation, EAPS, Barcelona, October 2022 *Publication in The Journal of Pediatrics, October 2022.In january i enrolled in a 6 month online course at The University of Southampton. The course was titled "Research Methods" with a duration of 150 hrs (30 online course hours and 120 guided independent study hours) with a summative assessment/exam in June which I passed. In May I attended the 10th International Conference on Clinical Neonatology in Torino, Italy. I presented a poster titled; "Early empirical antibiotics and adverse clinical outcomes in very preterm infants – a nationwide study" which was based on results from subtudy 1 in PhD project. I presented the same poster, but orally, at the European Academy of Paediatric Societies in Barcelona, Spain, in October 2022. I completed my first article, Early Empirical Antibiotics and Adverse Clinical Outcomes in Infants Born Very Preterm: A Population-based Cohort. I was joint first author of this paper which was published in The Journal of Pediatrics in October 2022. From September to December 2022 I have travelled to the various NICUs in Norway where they perform paediatric bowel surgery som collect data for sub-study 2 of my project. Going forward I will start analyzing the collected data which will result in an article planned to be submitted in spring 2023.

Progress in 2021• Finalizing the manuscript for substudy 1 • Completed and passed the course " Epidemiologiske metoder og prinsipper" at UiB, 3 studypoints • Preparing a detailed questionnaire to obtain relevant information required in substudy 3In 2021 I have mainly focused on substudy 1 which entails data analysis, interpretation & drafting a manuscript. The manuscript is now at the finishing stages & we plan to submit for publication within the next month. Throughout this work I have gained knowledge of and experience at using SPSS. I completed the course "Epidemiologiske metoder og prinsipper" at UiB and passed the exam, obtaining 3 further studypoints. This was a six day long course with lectures & group work followed by a home exam. For substudy 3 I require clinical details from the bowel surgery included infants have undergone. I have prepared a detailed questionnaire/form for surgeons to fill out when reviewing files of included infants, ensuring that all relevant information is obtained easily, consistently & accurately. I've kept updated on relevant publications and have had regular ongoing tutoring and feedback from my mentor.

Progress in 2020• Statistics course, spring 2020 UiS • Good Clinical Practice course, Stavanger University Hospital 05.02.2020 (6 hours) • Medmet 1 University of Bergen - 8 studypoints • Endnote course organized by Stavanger Univ Hosp library 14/9/20 • Questionnaire translation from english to norwegian to be used in substudy 3 • Webinar NEC 3-4/12/20 ESPGHANDuring this year I have focused on completing some of the compulsory courses required & have passed exams crediting me with 13 studypoints in total. I have passed the Medmet 1 course which is a basic course in Medical and Health Related Research. This was a two week long course with lectures, group work & presentations, followed by an online multiple choice examination & a written essay paper. I have also undertaken a one day course in good clincial practice (GCP) organised by the research departement at Stavanger University Hospital. I have familiarized myself with Endnote & completed a course organized by the library at Stavanger University Hospital. For substudy 1, we are in the process of analyzing the data, & have started writing our paper, with the aim of publishing this spring. For substudy 3 I have gotten approval of my translation of the PedsQL Gastrointetsinal Symtpoms Scales questionnaire from english to norwegian, & I am now in the testing phase & once this process is complete I will start distributing the questionnaires to participants in my research. ESPGHAN (The European Society for Paediatric Gastroenterology Hepatology and Nutrition) organised a 2 day webinar in November on Nectrotizing Enterocolitis where reasearchers & clinicians interested in NEC worldwide participated. This was a very useful conference which furthered my knowledge about NEC.

Necrotizing enterocolitis and bowel perforation in preterm infants - risk factors, epidemiology and long-term follow-up.The project was presented at the Nordic Neonatal Meeting in Helsinki, Finland in November 2019. The work of translating the questionnaires to be used in sub-study 3 is under way.Primary objective: To increase knowledge on risk factors, epidemiology and short- and long-term prognosis among very preterm infants with surgical NEC and/or bowel perforation in the neonatal period. Secondary objectives: 1. To identify whether duration of antibiotic exposure is associated with increased risk for NEC and/or death among vey preterm infants. 2. To quantify the "burden of NEC and/or bowel perforation" among VPIs in Sweden and Norway, using population-based data. 3. To collect long-term follow-up data in school age on quality of life, growth, development, nutritional status and persistent gastrointestinal symptoms among very preterm infants surviving surgery for NEC and/or bowel perforation in the neonatal period. The project was presented at the Nordic Neonatal Meeting in Helsinki, Finland in November 2019. This was a 15 minute oral presentation, with useful feedback from the audience. The work of translating the questionnaires to be used in sub-study 3 from english to norwegian is under way.