eRapport

Diagnostic and prognostic neuroimaging biomarkers in dementia with Lewy bodies

Prosjekt
Prosjektnummer
F-12511
Ansvarlig person
Miguel German Borda
Institusjon
Helse Stavanger HF
Prosjektkategori
Doktorgradsstipend
Helsekategori
Mental Health, Musculoskeletal, Neurological
Forskningsaktivitet
3. Prevention, 4. Detection and Diagnosis
Rapporter
2022 - sluttrapport
Abstract Introduction Alzheimer's Disease and Lewy body dementia are the two most common neurodegenerative dementias. They have a progressive course with devastating consequences for the people living with these diseases and their families, but there are large individual variations. Finding early markers and markers of progression and prognosis could promote actions to improve the quality of life of the people affected with these diseases. Nutrition and muscle status are closely related and have systemic functions and interactions that affect the brain. This thesis describes the role of nutritional and muscle status biomarkers in the prognosis of people diagnosed with mild Alzheimer's disease, Lewy body dementia, and mild subjective cognitive decline. Methods For the aim of this thesis, I used data from 2 community-based prospective Norwegian multicenter cohort studies: DemVest (The Dementia Study of Western Norway) and DDI (Dementia Disease Initiation). In DemVest, patients with mild dementia, defined as a Mini-Mental Status Examination (MMSE) score; equal or higher to 20 or Clinical Dementia Rating (CDR) global score equal to 1, with different types of dementia, were included. The DDI study was designed to investigate early cognitive impairment and dementia markers. DDI participants included in this thesis were those classified as having Subjective cognitive decline (SCD) according to the SCD-I framework. Comprehensive clinical assessments, including measures of cognition, daily functioning and anthropometric measurement, blood samples, and brain MRI were performed in both studies. Brain morphology was studied using FreeSurfer segmentation and muscle morphology using slice O-Matic software. Results This thesis findings first indicate that nutritional status has an essential role in the 5-year prognosis of people living with dementia in the capacity to perform daily life activities and mortality. Second, the quality of the muscle, here the muscle of the tongue, and its amount of fat infiltration were associated with malnutrition onset in people with dementia. Finally, in patients with SCD, muscle function measured with the timed up and go test (TUG) was associated with cognitive decline. TUG, in addition, was associated with cortical thickness in areas related with cognitive and motor functioning. Conclusion Nutritional and muscular status predict prognosis in people with SCD and with dementia. These findings suggest that interventions focused on these areas may improve outcomes such as cognition, function, and survival in these groups. This work elucidates the importance of nutrition and muscle for the prognosis of patients with dementia and cognitive decline. Which is very relevant right now because there are available therapies that can have a positive effect in these areas. Paper II is one of the first studies to investigate the association of the iMAT and muscle volume of tongue and masseter in dementia. This study also provides the possibility to further study a potential new tool to determine muscle volume in a more practical way within the dementia diagnosis process. Also, this study give insight in new relevant prognostic biomarkers. Likewise, paper III this study shows the utility of cheap and accessible method, the TUG, to predict cognitive deterioration in people at pre dementia stages.
2021
This project describes the role of the nutritional and muscle status biomarkers for the prognosis of people diagnosed with mild Alzheimer disease and Lewy body dementia and the risk of cognitive decline in healthy older adults and those diagnosed with subjective cognitive decline.Introduction: Alzheimer's Disease and Lewy body dementia are the two most common neurodegenerative dementias. They have devastating consequences for the people living with these diseases and their families. Finding early markers and targets of progression and prognosis could promote actions to improve the quality of life of the people affected with these diseases. Nutrition and muscle status are closely related and have systemic functions and interactions that affect the brain. This project describes the role of the nutritional and muscle status biomarkers for the prognosis of people diagnosed with mild Alzheimer disease and Lewy body dementia and the risk of cognitive decline in healthy older adults and those diagnosed with subjective cognitive decline. Methods: For these aims, I used data from 2 community-based prospective Norwegian multicentre cohort studies: the DemVest (The Dementia Study of Western Norway) and the DDI (Dementia Disease Initiation). In DemVest patients with mild dementia, defined as a Mini-Mental Status Examination (MMSE) score greater or equal to 20, or Clinical Dementia Rating (CDR) global score equal to 1 were included. 223 patients with Different types of dementia were included. The nationwide DDI study is designed to investigate early markers of cognitive impairment and dementia. Participants were classified as SCD according to the SCD-I framework. Comprehensive clinical assessments, blood samples, and brain MRI were performed in both studies. Brain morphology was studied using freesurfer segmentation and muscle morphology using slice O-Matic software. Results: This work shows first, that nutritional status has an important role in the 5-year prognosis of people living with dementia from diagnosis. This in several domains, In the capacity to perform daily life activities and in the risk of mortality. Second, the status of the muscle, here the muscle of the tongue and its amount of fat infiltration is associated with malnutrition and can predict malnutrition in persons with dementia. Finally, the function of the muscle measured with the timed up and go test predicted cognitive decline in people without dementia, was associated with low brain cortical thickness in areas related to working memory, motor, somatosensorial, executive, and integration tasks. Conclusion: Nutritional and Muscular status are markers that have a role in predicting prognosis in people with or without dementia. Interventions focused on these areas are may improve outcomes such as cognition, function, and survival in people with dementia.
2020
This study offers an opportunity to identify novel neuroimaging markers in combination with other useful biomarkers in the clinical as NPS in DLB, capitalizing on data from a variety of sources. This is important not only for diagnosis but also for prognosis, as well as an improved understanding of disease mechanisms.I am confident that our findings will make a difference in the way we currently understand, differentiate, diagnose, and treat DLB, which will improve the lives of people with DLB and their careers, as well as reducing societal costs. This Ph.D. project will be based on 3 papers. In the first one, which is published I have reported how neuropsychiatric symptoms are associated with the rate of functional decline in people with AD and LBD, independent of cognitive impairment. These results highlight the relevance of early detection and intervention of NPSs, which may also reduce functional decline. Next papers I am working on would integrate NPS and imaging biomarkers as pronostic/diagnostic biomarkers.
Vitenskapelige artikler
Borda MG, Aarsland D, Cano-Gutiérrez CA, Pérez-Zepeda MU

Actions to be taken for improving functional prognosis in dementia.

J Neurol Sci 2022 Mar 15;434():120156. Epub 2022 jan 22

PMID: 35085958

Borda MG, Pérez-Zepeda MU, Jaramillo-Jimenez A, Chaudhuri KR, Tovar-Rios DA, Wallace L, Batzu L, Rockwood K, Tysnes OB, Aarsland D, Alves G

Frailty in Parkinson's disease and its association with early dementia: A longitudinal study.

Parkinsonism Relat Disord 2022 Jun;99():51. Epub 2022 mai 13

PMID: 35598420

Castellanos-Perilla N, Borda MG, Cataño S, Giraldo S, Vik-Mo AO, Aarsland D, Rao RT

Specific depressive symptoms are related with different patterns of alcohol use in community-dwelling older adults.

Arch Gerontol Geriatr 2022 Jul-Aug;101():104696. Epub 2022 mar 27

PMID: 35364452

Perez-Zepeda MU, Almeda-Valdes P, Fernandez-Villa JM, Gomez-Arteaga RC, Borda MG, Cesari M

Thyroid stimulating hormone levels and geriatric syndromes: secondary nested case-control study of the Mexican Health and Aging Study.

Eur Geriatr Med 2022 Feb;13(1):139. Epub 2021 okt 2

PMID: 34601711

Jaramillo-Jimenez A, Ying Y, Ren P, Xiao Z, Zhang Q, Wang J, Rong H, Borda MG, Bonanni L, Aarsland D, Wu D

Prodromal Dementia With Lewy Bodies and Recurrent Panic Attacks as the First Symptom: A Case Report.

Front Neurol 2022;13():839539. Epub 2022 apr 13

PMID: 35493812

Borda MG, Castellanos-Perilla N, Tovar-Rios DA, Ferreira D, Duque G, Aarsland D

Tongue muscle mass is associated with total grey matter and hippocampal volumes in Dementia with Lewy Bodies.

Arch Gerontol Geriatr 2022 May-Jun;100():104647. Epub 2022 feb 1

PMID: 35134612 - Inngår i doktorgradsavhandlingen

Borda MG, Jaramillo-Jimenez A, Giil LM, Tovar-Rios DA, Soennesyn H, Aarsland D

Body mass index trajectories and associations with cognitive decline in people with Lewy body dementia and Alzheimer's disease.

Health Sci Rep 2022 May;5(3):e590. Epub 2022 mai 2

PMID: 35509416

Borda MG, Bani Hassan E, Weon JH, Wakabayashi H, Tovar-Rios DA, Oppedal K, Aarsland D, Duque G

Muscle Volume and Intramuscular Fat of the Tongue Evaluated With MRI Predict Malnutrition in People Living With Dementia: A 5-Year Follow-up Study.

J Gerontol A Biol Sci Med Sci 2022 Feb 03;77(2):228.

PMID: 34338751 - Inngår i doktorgradsavhandlingen

Borda MG, Ayala Copete AM, Tovar-Rios DA, Jaramillo-Jimenez A, Giil LM, Soennesyn H, Gómez-Arteaga C, Venegas-Sanabria LC, Kristiansen I, Chavarro-Carvajal DA, Caicedo S, Cano-Gutierrez CA, Vik-Mo A, Aarsland D

Association of Malnutrition with Functional and Cognitive Trajectories in People Living with Dementia: A Five-Year Follow-Up Study.

J Alzheimers Dis 2021;79(4):1713-1722.

PMID: 33459715 - Inngår i doktorgradsavhandlingen

Borda MG, Aarsland D, Tovar-Rios DA, Giil LM, Ballard C, Gonzalez MC, Brønnick K, Alves G, Oppedal K, Soennesyn H, Vik-Mo AO

Neuropsychiatric Symptoms and Functional Decline in Alzheimer's Disease and Lewy Body Dementia.

J Am Geriatr Soc 2020 Oct;68(10):2257-2263. Epub 2020 aug 1

PMID: 32738062 - Inngår i doktorgradsavhandlingen

Deltagere
  • Audun Osland Vik-Mo Medveileder
  • Kolbjørn Kallesten Brønnick Medveileder
  • Ketil Oppedal Medveileder
  • Miguel Germàn Borda Ph.d.-kandidat
  • Dag Årsland Hovedveileder

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

Alle henvendelser rettes til Faglig rapportering, Helse Vest

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